Ignite Creation Date:
2025-12-24 @ 5:08 PM
Ignite Modification Date:
2025-12-27 @ 8:15 PM
Study NCT ID:
NCT01244750
Status:
COMPLETED
Last Update Posted:
2022-06-30
First Post:
2010-11-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015464', 'term': 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive'}, {'id': 'D015466', 'term': 'Leukemia, Myeloid, Chronic-Phase'}], 'ancestors': [{'id': 'D007951', 'term': 'Leukemia, Myeloid'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D009196', 'term': 'Myeloproliferative Disorders'}, {'id': 'D001855', 'term': 'Bone Marrow Diseases'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'OTHER', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1494}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2010-12-02', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-06', 'completionDateStruct': {'date': '2020-01-08', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2022-06-28', 'studyFirstSubmitDate': '2010-11-15', 'studyFirstSubmitQcDate': '2010-11-18', 'lastUpdatePostDateStruct': {'date': '2022-06-30', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2010-11-19', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2020-01-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'The rate of Complete Cytogenetic Response', 'timeFrame': '12 months'}, {'measure': 'The duration of initial TKI treatment', 'timeFrame': '5-years from study index date', 'description': 'Initiation of first-line TKI, (whether Dasatinib, Imatinib, Nilotinib)'}, {'measure': 'The rate of discontinuation and treatment changes after initial TKI treatment', 'timeFrame': 'Every 6 months for a follow-up period of 5-years from study index date', 'description': 'Dates of switches in therapy from initial TKI treatment, Reasons for treatment discontinuation (i.e. side effects, mutations, etc.), Subsequent lines of CML treatments (start and stop dates)'}, {'measure': 'The rate of best response to therapy (i.e. hematologic, cytogenetic, molecular response)', 'timeFrame': 'Every 6 months for a follow-up period of 5-years from study index date', 'description': 'Results and dates of: all bone marrow aspirates, blood tests, cytogenetics, Polymerase Chain Reaction (PCR), Fluorescent In-Situ Hybridization (FISH), and Physical exam'}, {'measure': 'The adherence to treatment', 'timeFrame': 'Every 6 months for a follow-up period of 5-years from study index date', 'description': 'Morisky Medication Adherence Scale - 8 Items is a validated self-reported measure of medication adherence.'}], 'secondaryOutcomes': [{'measure': 'Impact of first-line treatment options on quality of life', 'timeFrame': 'Every 6 months', 'description': 'Questionnaires used for assessment:\n\nFunctional Assessment of Cancer Therapy - General (FACT-G), Cancer Therapy Satisfaction Questionnaire (CTSQ), MD Anderson Symptom Inventory - CML (MDASI-CML).'}, {'measure': 'Non-hematologic side effects from treatment affecting patient quality of life and outcomes', 'timeFrame': 'Every 6 months', 'description': 'Treatment discontinuations and changes'}, {'measure': 'Patient satisfaction with CML treatment', 'timeFrame': 'Every 6 months', 'description': 'Cancer Therapy Satisfaction Questionnaire (CTSQ)'}, {'measure': 'Patterns of disease monitoring as observed in a real-world setting', 'timeFrame': 'Every 6 months', 'description': 'MD Anderson Symptom Inventory - CML (MDASI-CML) Questionnaire - disease-specific module of the MDASI7 which is a brief measure of severity and impact of cancer-related symptoms on daily function'}, {'measure': 'Resource utilization associated with CML management', 'timeFrame': 'Every 6 months', 'description': 'To evaluate healthcare resource utilization, descriptive statistics will describe real-world disease monitoring patterns, frequency of testing, and resources used for disease management for each treatment cohort.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Chronic Phase - Chronic Myeloid Leukemia'], 'conditions': ['Chronic Myeloid Leukemia']}, 'referencesModule': {'references': [{'pmid': '30290003', 'type': 'DERIVED', 'citation': 'Hehlmann R, Cortes JE, Zyczynski T, Gambacorti-Passerini C, Goldberg SL, Mauro MJ, Michallet M, Simonsson B, Williams LA, Gajavelli S, DeGutis I, Sen GP, Paquette RL. Tyrosine kinase inhibitor interruptions, discontinuations and switching in patients with chronic-phase chronic myeloid leukemia in routine clinical practice: SIMPLICITY. Am J Hematol. 2019 Jan;94(1):46-54. doi: 10.1002/ajh.25306. Epub 2018 Oct 31.'}], 'seeAlsoLinks': [{'url': 'http://www.fda.gov/Safety/MedWatch/SafetyInformation/default.htm', 'label': 'FDA Safety Alerts and Recalls'}, {'url': 'http://www.BMSStudyConnect.com', 'label': 'BMS Clinical Trial Information'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to better understand the use of tyrosine kinase inhibitors (TKI) in patients newly diagnosed with CML and their quality of life in a real-world setting.', 'detailedDescription': 'Time Perspective : Most patients are expected to be a mix of retrospective and prospective data collection. Patients can be enrolled after their study index date (retrospective component) and have to be followed until 5 years from study index date are complete (time between enrollment and 5 year follow-up is the prospective component)'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Patients will be recruited at oncology practices or oncology centers linked to a hospital in the North Americas, Europe and potentially at additional sites in South America, and Asia', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Newly-diagnosed chronic phase chronic myeloid leukemia (CP-CML) patients who started their first-line Tyrosine Kinase Inhibitor (TKI) treatment on imatinib, dasatinib or nilotinib in accordance with the timelines below\n* 18 years or older at time of of CP-CML diagnosis\n\n a) Imatinib Cohorts\n* Patients who started their first-line Imatinib treatment between January 2, 2008 and September 30, 2010.Patients fitting this criterion are defined as retrospective Imatinib patients\n* Patients who started their first-line Imatinib treatment on or after October 1, 2010\n\n b) Dasatinib Cohort\n* Patients who started their first-line Dasatinib treatment after the drug was approved in this indication\n\n c) Nilotinib Cohort\n* Patients who started their first-line Nilotinib treatment after the drug was approved in this indication\n* Patients are also eligible when they have already switched to a subsequent therapy (TKI or other) at the time of enrollment, as long as their first-line and subsequent CML treatment information is available at site for data entry into the study Electronic Case Report Form (eCRF)\n* Receiving treatment at medical practice (eg. community-based, office-based, hospital-based, academic setting, oncology center)\n\nExclusion Criteria:\n\n* Patients who are participating in an interventional trial which may influence the management of their CML disease will be excluded\n\nDiscontinuation Criteria:\n\n* Enrolled patients who join an interventional trial which may influence the management of their CML disease will be excluded at the time of entry into the interventional trial'}, 'identificationModule': {'nctId': 'NCT01244750', 'acronym': 'SIMPLICITY', 'briefTitle': 'Studying First Line Treatment of Chronic Myeloid Leukemia (CML) in a Real-world Setting', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bristol-Myers Squibb'}, 'officialTitle': 'Studying Interventions for Managing Patients With Chronic Myeloid Leukemia (CML) in Chronic Phase: The 5-Year Prospective Cohort Study (SIMPLICITY)', 'orgStudyIdInfo': {'id': 'CA180-330'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'First line TKI treatment: Imatinib', 'description': 'Diagnosed CML patients who receive first line TKI treatment: Imatinib'}, {'label': 'First line TKI treatment: Nilotinib', 'description': 'Diagnosed CML patients who receive first line TKI treatment: Nilotinib'}, {'label': 'First line TKI treatment: Dasatinib', 'description': 'Diagnosed CML patients who receive first line TKI treatment: Dasatinib'}, {'label': 'Imatinib treated patients', 'description': 'Imatinib treated patients if their study index date is between January 2, 2008 and September 30, 2010'}]}, 'contactsLocationsModule': {'locations': [{'zip': '35661', 'city': 'Muscle Shoals', 'state': 'Alabama', 'country': 'United States', 'facility': 'Northwest Alabama Cancer Center', 'geoPoint': {'lat': 34.74481, 'lon': -87.66753}}, {'zip': '85016', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Arizona Oncology Associates, PC - HAL', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '86336', 'city': 'Sedona', 'state': 'Arizona', 'country': 'United States', 'facility': 'Arizona Oncology Associates, PC - NAHOA', 'geoPoint': {'lat': 34.86974, 'lon': -111.76099}}, {'zip': '85704', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'Arizona Oncology Associates, PC - HOPE', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '71913', 'city': 'Hot Springs', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Genesis Cancer Center', 'geoPoint': {'lat': 34.5037, 'lon': -93.05518}}, {'zip': '72401', 'city': 'Jonesboro', 'state': 'Arkansas', 'country': 'United States', 'facility': 'NEA Baptist Clinic', 'geoPoint': {'lat': 35.8423, 'lon': -90.70428}}, {'zip': '72205', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Little Rock Hematology Oncology Associates', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '92801', 'city': 'Anaheim', 'state': 'California', 'country': 'United States', 'facility': 'Pacific Cancer Medical Center, Inc', 'geoPoint': {'lat': 33.83529, 'lon': -117.9145}}, {'zip': '92025', 'city': 'Escondido', 'state': 'California', 'country': 'United States', 'facility': 'Southwest Cancer Care Medical Group', 'geoPoint': {'lat': 33.11921, 'lon': -117.08642}}, {'zip': '91741', 'city': 'Glendora', 'state': 'California', 'country': 'United States', 'facility': 'Wilshire Oncology Medical Group, Inc', 'geoPoint': {'lat': 34.13612, 'lon': -117.86534}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'University of Southern California', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'country': 'United States', 'facility': "St. Joseph's Hospital", 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '93030', 'city': 'Oxnard', 'state': 'California', 'country': 'United States', 'facility': 'PMK Medical Group, Inc. DBA Ventura', 'geoPoint': {'lat': 34.1975, 'lon': -119.17705}}, {'zip': '95204', 'city': 'Stockton', 'state': 'California', 'country': 'United States', 'facility': 'Stockton Hematology Oncology', 'geoPoint': {'lat': 37.9577, 'lon': -121.29078}}, {'zip': '96160', 'city': 'Truckee', 'state': 'California', 'country': 'United States', 'facility': 'Tahoe Forest Health System Cancer Center', 'geoPoint': {'lat': 39.32796, 'lon': -120.18325}}, {'zip': '80303', 'city': 'Boulder', 'state': 'Colorado', 'country': 'United States', 'facility': 'Rocky Mountain Cancer Centers', 'geoPoint': {'lat': 40.01499, 'lon': -105.27055}}, {'zip': '06040', 'city': 'Manchester', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Medical Oncology and Blood Disorders, LLP', 'geoPoint': {'lat': 41.77593, 'lon': -72.52148}}, {'zip': '06904', 'city': 'Stamford', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Stamford Hospital', 'geoPoint': {'lat': 41.05343, 'lon': -73.53873}}, {'zip': '20010', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'Washington Hospital Center, Washington Cancer Institute', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '20237', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': 'George Washington University', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33435', 'city': 'Boynton Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Hematology And Medical Oncology Of Southern Palm Beach County', 'geoPoint': {'lat': 26.52535, 'lon': -80.06643}}, {'zip': '33308', 'city': 'Fort Lauderdale', 'state': 'Florida', 'country': 'United States', 'facility': 'Broward Oncology Associates', 'geoPoint': {'lat': 26.12231, 'lon': -80.14338}}, {'zip': '33012', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'Palm Springs Research Institute', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '32207', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'Baptist Cancer Institute', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32209', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': 'University Of Florida', 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33805', 'city': 'Lakeland', 'state': 'Florida', 'country': 'United States', 'facility': 'Watson Clinic', 'geoPoint': {'lat': 28.03947, 'lon': -81.9498}}, {'zip': '34748', 'city': 'Leesburg', 'state': 'Florida', 'country': 'United States', 'facility': 'Central Florida Health Alliance', 'geoPoint': {'lat': 28.81082, 'lon': -81.87786}}, {'city': 'Miami', 'state': 'Florida', 'country': 'United States', 'facility': 'Baptist Cancer Center', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '34655', 'city': 'New Port Richey', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Cancer Specialists', 'geoPoint': {'lat': 28.24418, 'lon': -82.71927}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Cancer Centers of Florida', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32778', 'city': 'Tavares', 'state': 'Florida', 'country': 'United States', 'facility': 'Lake County Oncology and Hematology', 'geoPoint': {'lat': 28.80416, 'lon': -81.72563}}, {'zip': '32796', 'city': 'Titusville', 'state': 'Florida', 'country': 'United States', 'facility': 'Space Coast Cancer Center', 'geoPoint': {'lat': 28.61222, 'lon': -80.80755}}, {'zip': '30318', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Peachtree Hematology-Oncology', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30060', 'city': 'Marietta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Northwest Georgia Oncology Centers, PC', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '30342', 'city': 'Sandy Springs', 'state': 'Georgia', 'country': 'United States', 'facility': 'Georgia Cancer Specialist', 'geoPoint': {'lat': 33.92427, 'lon': -84.37854}}, {'zip': '31792', 'city': 'Thomasville', 'state': 'Georgia', 'country': 'United States', 'facility': 'Lewis Hall Singeltary Oncology Center', 'geoPoint': {'lat': 30.83658, 'lon': -83.97878}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': 'OnCare', 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96813', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Straub Clinical & Hospital', 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '96819', 'city': 'Honolulu', 'state': 'Hawaii', 'country': 'United States', 'facility': 'Kaiser Permanente Honolulu', 'geoPoint': {'lat': 21.30694, 'lon': -157.85833}}, {'zip': '60805', 'city': 'Evergreen Park', 'state': 'Illinois', 'country': 'United States', 'facility': 'Mahafzah Medical Center', 'geoPoint': {'lat': 41.72059, 'lon': -87.70172}}, {'zip': '60134', 'city': 'Geneva', 'state': 'Illinois', 'country': 'United States', 'facility': 'Delnor Community Hospital', 'geoPoint': {'lat': 41.88753, 'lon': -88.30535}}, {'zip': '61761', 'city': 'Normal', 'state': 'Illinois', 'country': 'United States', 'facility': 'Mid-Illinois Hem/Onc Asoc', 'geoPoint': {'lat': 40.5142, 'lon': -88.99063}}, {'zip': '60064', 'city': 'North Chicago', 'state': 'Illinois', 'country': 'United States', 'facility': 'North Chicago VA Medical Center', 'geoPoint': {'lat': 42.32558, 'lon': -87.84118}}, {'zip': '62794', 'city': 'Springfield', 'state': 'Illinois', 'country': 'United States', 'facility': 'Southern Illinois School of Medicine', 'geoPoint': {'lat': 39.80172, 'lon': -89.64371}}, {'zip': '61801', 'city': 'Urbana', 'state': 'Illinois', 'country': 'United States', 'facility': 'Carle Cancer Center', 'geoPoint': {'lat': 40.11059, 'lon': -88.20727}}, {'zip': '60190', 'city': 'Winfield', 'state': 'Illinois', 'country': 'United States', 'facility': 'Central DuPage Hospital', 'geoPoint': {'lat': 41.8617, 'lon': -88.1609}}, {'zip': '46016', 'city': 'Anderson', 'state': 'Indiana', 'country': 'United States', 'facility': "Saint John's Cancer Center", 'geoPoint': {'lat': 40.10532, 'lon': -85.68025}}, {'zip': '46237', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Indiana Blood and Marrow Transplantation', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '46260', 'city': 'Indianapolis', 'state': 'Indiana', 'country': 'United States', 'facility': 'Investigative Clinical Research of Indiana', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '47905', 'city': 'Lafayette', 'state': 'Indiana', 'country': 'United States', 'facility': 'Horizon Oncology Research, Inc', 'geoPoint': {'lat': 40.4167, 'lon': -86.87529}}, {'zip': '47150', 'city': 'New Albany', 'state': 'Indiana', 'country': 'United States', 'facility': 'Cancer Care Center, Inc. PC', 'geoPoint': {'lat': 38.28562, 'lon': -85.82413}}, {'zip': '50401', 'city': 'Mason City', 'state': 'Iowa', 'country': 'United States', 'facility': 'N. Iowa Mercy Cancer Center', 'geoPoint': {'lat': 43.15357, 'lon': -93.20104}}, {'zip': '67502', 'city': 'Hutchinson', 'state': 'Kansas', 'country': 'United States', 'facility': 'Hutchinson Clinic', 'geoPoint': {'lat': 38.06084, 'lon': -97.92977}}, {'zip': '66606', 'city': 'Topeka', 'state': 'Kansas', 'country': 'United States', 'facility': "Cotton O'Neil Cancer Center", 'geoPoint': {'lat': 39.04833, 'lon': -95.67804}}, {'zip': '67214', 'city': 'Wichita', 'state': 'Kansas', 'country': 'United States', 'facility': 'Cancer Center of Kansas', 'geoPoint': {'lat': 37.69224, 'lon': -97.33754}}, {'zip': '40503', 'city': 'Lexington', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Central Baptist Hospital', 'geoPoint': {'lat': 37.98869, 'lon': -84.47772}}, {'zip': '40202', 'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'facility': 'University of Louisville Hospital - Brown Cancer Center', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '40207', 'city': 'Saint Matthews', 'state': 'Kentucky', 'country': 'United States', 'facility': 'Consultants In Blood Disorders', 'geoPoint': {'lat': 38.25285, 'lon': -85.65579}}, {'zip': '70121', 'city': 'New Orleans', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Ochsner Clinic Foundation', 'geoPoint': {'lat': 29.95465, 'lon': -90.07507}}, {'zip': '71103', 'city': 'Shreveport', 'state': 'Louisiana', 'country': 'United States', 'facility': 'Willis-Knighton Cancer System', 'geoPoint': {'lat': 32.52515, 'lon': -93.75018}}, {'zip': '21044', 'city': 'Columbia', 'state': 'Maryland', 'country': 'United States', 'facility': 'Maryland Oncology Hematology Pa', 'geoPoint': {'lat': 39.24038, 'lon': -76.83942}}, {'zip': '21701', 'city': 'Frederick', 'state': 'Maryland', 'country': 'United States', 'facility': 'Frederick Memorial Hospital', 'geoPoint': {'lat': 39.41427, 'lon': -77.41054}}, {'zip': '02703', 'city': 'Attleboro', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Sturdy Hematology & Oncology Associates', 'geoPoint': {'lat': 41.94454, 'lon': -71.28561}}, {'zip': '02130', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Boston VA Healthcare System', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '02720', 'city': 'Fall River', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'South Coast Health System', 'geoPoint': {'lat': 41.70149, 'lon': -71.15505}}, {'zip': '02169', 'city': 'Quincy', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Commonwealth Hematology-Oncology, P.C.', 'geoPoint': {'lat': 42.25288, 'lon': -71.00227}}, {'zip': '01655', 'city': 'Worcester', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'UMass Medical Center', 'geoPoint': {'lat': 42.26259, 'lon': -71.80229}}, {'zip': '49503', 'city': 'Grand Rapids', 'state': 'Michigan', 'country': 'United States', 'facility': 'Cancer & Hematology Centers of Western Michigan', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '49007', 'city': 'Kalamazoo', 'state': 'Michigan', 'country': 'United States', 'facility': 'West Michigan Cancer Center', 'geoPoint': {'lat': 42.29171, 'lon': -85.58723}}, {'zip': '48910', 'city': 'Lansing', 'state': 'Michigan', 'country': 'United States', 'facility': 'Michigan State University', 'geoPoint': {'lat': 42.73253, 'lon': -84.55553}}, {'zip': '38801', 'city': 'Tupelo', 'state': 'Mississippi', 'country': 'United States', 'facility': 'North Mississippi Hematology & Oncology', 'geoPoint': {'lat': 34.25807, 'lon': -88.70464}}, {'zip': '65807', 'city': 'Springfield', 'state': 'Missouri', 'country': 'United States', 'facility': "St John's Clinic for Cancer and Hematology", 'geoPoint': {'lat': 37.21533, 'lon': -93.29824}}, {'zip': '59101', 'city': 'Billings', 'state': 'Montana', 'country': 'United States', 'facility': 'Billings Clinic', 'geoPoint': {'lat': 45.78329, 'lon': -108.50069}}, {'zip': '68105', 'city': 'Omaha', 'state': 'Nebraska', 'country': 'United States', 'facility': 'Omaha VAMC', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '03801', 'city': 'Portsmouth', 'state': 'New Hampshire', 'country': 'United States', 'facility': 'Portsmouth Regional Hospital', 'geoPoint': {'lat': 43.07704, 'lon': -70.75766}}, {'zip': '08690-3542', 'city': 'Does Not Exist', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Bms Clinical Research Center'}, {'zip': '07601', 'city': 'Hackensack', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Hackensack University Medical Center', 'geoPoint': {'lat': 40.88593, 'lon': -74.04347}}, {'zip': '07962', 'city': 'Morristown', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Hematology-Oncology Associates of Northern NJ, PA', 'geoPoint': {'lat': 40.79677, 'lon': -74.48154}}, {'zip': '08360', 'city': 'Vineland', 'state': 'New Jersey', 'country': 'United States', 'facility': 'Southern Oncology Hematology', 'geoPoint': 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