Ignite Creation Date:
2025-12-24 @ 5:00 PM
Ignite Modification Date:
2026-01-02 @ 1:11 AM
Study NCT ID:
NCT00004550
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2000-02-03
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000856', 'term': 'Anorexia Nervosa'}, {'id': 'D009771', 'term': 'Obsessive-Compulsive Disorder'}, {'id': 'D005879', 'term': 'Tourette Syndrome'}, {'id': 'D014256', 'term': 'Trichotillomania'}], 'ancestors': [{'id': 'D001068', 'term': 'Feeding and Eating Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}, {'id': 'D001008', 'term': 'Anxiety Disorders'}, {'id': 'D001480', 'term': 'Basal Ganglia Diseases'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D013981', 'term': 'Tic Disorders'}, {'id': 'D009069', 'term': 'Movement Disorders'}, {'id': 'D020271', 'term': 'Heredodegenerative Disorders, Nervous System'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}, {'id': 'D030342', 'term': 'Genetic Diseases, Inborn'}, {'id': 'D009358', 'term': 'Congenital, Hereditary, and Neonatal Diseases and Abnormalities'}, {'id': 'D065886', 'term': 'Neurodevelopmental Disorders'}, {'id': 'D007174', 'term': 'Disruptive, Impulse Control, and Conduct Disorders'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'enrollmentInfo': {'count': 400}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2000-01-28'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-04-21', 'completionDateStruct': {'date': '2008-04-21'}, 'lastUpdateSubmitDate': '2017-06-30', 'studyFirstSubmitDate': '2000-02-03', 'studyFirstSubmitQcDate': '2000-02-03', 'lastUpdatePostDateStruct': {'date': '2017-07-02', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2000-02-04', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['Screening', 'Longitudinal', 'Transition', 'Treatment', 'Comorbidity', 'Obsessive Compulsive Disorder', 'Evaluation', 'Follow-Up', 'OC Spectrum Disorders', 'OCD'], 'conditions': ['Anorexia Nervosa', 'Obsessive Compulsive Disorder', 'Tourette Syndrome', 'Trichotillomania']}, 'referencesModule': {'references': [{'pmid': '9160613', 'type': 'BACKGROUND', 'citation': 'Wiggs CL, Martin A, Altemus M, Murphy DL. Hypervigilance in patients with obsessive-compulsive disorder. Anxiety. 1996;2(3):123-9. doi: 10.1002/(SICI)1522-7154(1996)2:33.0.CO;2-Q.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to better understand the long-term progress of people with obsessive-compulsive disorder (OCD) and related conditions such as anorexia nervosa, Tourette syndrome, and trichotillomania.\n\nThis study involves the screening and follow-up of individuals with OCD and OCD-related disorders. Participants will be screened with a medical and psychiatric evaluation, questionnaires, and neurological testing. Participants will then have study visits every 4 to 12 weeks to undergo symptom and daily functioning evaluations, personality tests, blood and urine tests, memory tests, brain scans, and other clinical exams. Participants will be assessed with interviews and paper-and-pencil or computer-assisted tests. Participants may have the opportunity to participate in drug studies and to join a monthly OCD support group. At the end of the study, participants will be referred to community or private treatment centers.', 'detailedDescription': 'The purpose of this protocol is to allow for careful screening and follow-up of patients with obsessive-compulsive disorder (OCD) and OCD-related disorders for a variety of protocols, recording demographic and rating information over the long-term course of the OCD illness and associated anxiety and depression symptoms. Patients in this study will be asked to participate in the naturalistic baseline assessment phase to better understand the pathophysiology and long-term course of illness. As a part of this protocol, subjects will be systematically administered assessment measures including diagnostic and psychological screening tests, a psychiatric assessment, SCID I and SCID II interviews, as well as other rating scales. They will also be informed of their opportunity to participate in research procedures such as blood draws and MRI of the brain. Upon conclusion of their participation, they will be referred out to community/private treatment when appropriate. All will be offered participation in an ongoing support group. This protocol will serve as an entry point for individuals with OCD and OCD-related disorders to proceed into other investigation procedures.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': '* INCLUSION CRITERIA:\n\nIndividuals must fulfill DSM IV criteria for OCD or OCD-related disorders as determined by a complete psychiatric diagnostic interview (SCID-I, using DSM IV-TR).\n\nIndividuals must be capable of decision making, and able to comprehend the purpose of the study and to provide informed consent.\n\nIndividuals can be included if they have certain medical conditions that have been described to have a higher incidence of OCD/depression and anxiety disorders: e.g., individuals with underlying neurological or neuropsychiatric conditions (e.g., tic disorders or dystonias, including torticollis and blepharospasm), connective tissue disorders, but must show no other serious or acute medical illnesses as determined by a physical exam and standard laboratory examinations.\n\nIndividuals must be at least 18 years old.\n\nEXCLUSION CRITERIA:\n\nAlcohol or substance use or dependence of sufficient magnitude to require independent, concurrent treatment intervention (e.g., antabuse or opiate treatment, but not including self-help groups).\n\nCurrent history of aggressive behavior or current suicidal ideation with plan and intent.\n\nCurrent active psychosis.'}, 'identificationModule': {'nctId': 'NCT00004550', 'briefTitle': 'Evaluation and Follow-up of Individuals With Obsessive-Compulsive Disorder and Related Conditions', 'organization': {'class': 'NIH', 'fullName': 'National Institutes of Health Clinical Center (CC)'}, 'officialTitle': 'The Evaluation and Follow-up of Patients With Obsessive-Compulsive Disorder and OC Spectrum Disorders', 'orgStudyIdInfo': {'id': '000067'}, 'secondaryIdInfos': [{'id': '00-M-0067'}]}, 'contactsLocationsModule': {'locations': [{'zip': '20892', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'National Institutes of Health Clinical Center, 9000 Rockville Pike', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Institute of Mental Health (NIMH)', 'class': 'NIH'}}}}