Ignite Creation Date:
2025-12-24 @ 4:54 PM
Ignite Modification Date:
2026-01-01 @ 5:27 PM
Study NCT ID:
NCT06351150
Status:
RECRUITING
Last Update Posted:
2025-01-23
First Post:
2024-04-02
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D000804', 'term': 'Angiotensin II'}, {'id': 'D012965', 'term': 'Sodium Chloride'}], 'ancestors': [{'id': 'D000809', 'term': 'Angiotensins'}, {'id': 'D036361', 'term': 'Peptide Hormones'}, {'id': 'D006728', 'term': 'Hormones'}, {'id': 'D006730', 'term': 'Hormones, Hormone Substitutes, and Hormone Antagonists'}, {'id': 'D009479', 'term': 'Neuropeptides'}, {'id': 'D010455', 'term': 'Peptides'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D009842', 'term': 'Oligopeptides'}, {'id': 'D009419', 'term': 'Nerve Tissue Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D012898', 'term': 'Autacoids'}, {'id': 'D018836', 'term': 'Inflammation Mediators'}, {'id': 'D001685', 'term': 'Biological Factors'}, {'id': 'D002712', 'term': 'Chlorides'}, {'id': 'D006851', 'term': 'Hydrochloric Acid'}, {'id': 'D017606', 'term': 'Chlorine Compounds'}, {'id': 'D007287', 'term': 'Inorganic Chemicals'}, {'id': 'D017670', 'term': 'Sodium Compounds'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 214}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-07-23', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-04', 'completionDateStruct': {'date': '2027-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-01-21', 'studyFirstSubmitDate': '2024-04-02', 'studyFirstSubmitQcDate': '2024-04-02', 'lastUpdatePostDateStruct': {'date': '2025-01-23', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2024-04-08', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-06', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Proportion of subjects with blood pressure response at 3 hours after administration of study drug', 'timeFrame': '3 hours after dose', 'description': 'Defined as MAP ≥ 75 mmHg or MAP increase ≥ 10 mmHg from baseline compared to baseline without an increase in the dose of background vasoactive agents'}], 'secondaryOutcomes': [{'measure': 'Sequential Organ Failure Assessment (SOFA) total score', 'timeFrame': '48 hours after dose', 'description': 'Change from baseline in Sequential Organ Failure Assessment (SOFA) total score. The SOFA score evaluates organ failure according to the conditions of respiratory, blood, liver, cardiovascular, central nervous, kidney and other systems, is scored from 0 to 4, with a higher score representing more severe failure.'}, {'measure': 'Cardiovascular SOFA subscore', 'timeFrame': '48 hours after dose', 'description': 'Change from baseline in Sequential Organ Failure Assessment (SOFA) subscore. The SOFA score evaluates organ failure according to the conditions of respiratory, blood, liver, cardiovascular, central nervous, kidney and other systems, is scored from 0 to 4, with a higher score representing more severe failure.'}, {'measure': 'Mortality at Day 7', 'timeFrame': 'Day 7 after dose', 'description': 'All-cause mortality of subject at Day 7'}, {'measure': 'Mortality at Day 28', 'timeFrame': 'Day 28 after dose', 'description': 'All-cause mortality of subject at Day 28'}, {'measure': 'Proportion of subjects with blood pressure response at 1 hour after administration', 'timeFrame': '1 hour after dose', 'description': 'Defined as MAP ≥ 75 mmHg or MAP increase ≥ 10 mmHg from baseline compared to baseline without an increase in the dose of background vasoactive agents'}, {'measure': 'Proportion of subjects with blood pressure response at 2 hours after administration', 'timeFrame': '2 hours after dose', 'description': 'Defined as MAP ≥ 75 mmHg or MAP increase ≥ 10 mmHg from baseline compared to baseline without an increase in the dose of background vasoactive agents'}, {'measure': 'Change in background vasoactive agent dose from 0 to 48 hours', 'timeFrame': '48 hours after dose', 'description': 'Change in background vasoactive dose from baseline to 48 hours after dose'}, {'measure': 'Absolute change in blood lactate from 0 to 3 hours', 'timeFrame': '3 hours after dose', 'description': 'Absolute change in blood lactate from 0 to 3 hours'}, {'measure': 'Absolute change in blood lactate from 3 to 48 hours', 'timeFrame': '3 to 48 hours after dose', 'description': 'Absolute change in blood lactate from 3 to 48 hours'}, {'measure': 'Absolute change in heart rate from 0 to 3 hours', 'timeFrame': '3 hours after dose', 'description': 'Absolute change in heart rate from 0 to 3 hours'}, {'measure': 'Absolute change in heart rate from 3 to 48 hours', 'timeFrame': '3 to 48 hours after dose', 'description': 'Absolute change in heart rate from 3 to 48 hours'}, {'measure': 'Adverse events (AE)', 'timeFrame': 'From drug administration to the end of the study, a total of 28 days', 'description': 'Incidence and severity of adverse events (AE)'}, {'measure': 'Serious adverse events (SAE)', 'timeFrame': 'From drug administration to the end of the study, a total of 28 days', 'description': 'Incidence and severity of serious adverse events (SAE)'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Vasodilatory Shock']}, 'descriptionModule': {'briefSummary': 'A randomized, double-blind, placebo-controlled study on the treatment of refractory distributed shock with angiotensin II injection, with a random ratio of 1:1. Assuming a success rate of 25% for the main therapeutic endpoint in the control group and 50% for the experimental group, a total of 214 subjects will be enrolled, including 107 in the experimental group and 107 in the control group.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* age: 18 years to 75 years old, male or female;\n* diagnosis of distributive shock;\n* on the basis of the treatment of total vasoactive drugs dose \\> 0.2 μg/kg/min norepinephrine (or equivalent dose of another vasoactive drug: such as epinephrine \\> 0.2 μg/kg/min, dopamine \\> 30 μg/kg/min, phenylephrine \\> 2 μg/kg/min, vasopressin \\> 0.08 U/min) and continuous treatment for at least 6 hours and no more than 48 hours, the patient's mean arterial pressure can still only be maintained between 55 and 70 mmHg, or do not reach the target MAP assessed by clinicians, it can be diagnosed as refractory distributive shock.\n* have central venous access and arterial catheters, and are expected to be present for at least the first 48 hours of the study.\n* indwelling catheter, and expected to be present for at least the first 48 hours of the study.\n* patient has received at least 30 mL/kg of crystalloid or colloid volume in the previous 24 hours or has undergone adequate volume resuscitation in the opinion of the investigator.\n* patients must have one of the following criteria with clinical features of high-output shock\n\n 1. Central venous oxygen saturation (ScVO2) \\> 70% (via saturation catheter or central venous blood gas) and central venous pressure (CVP) \\> 8 mmHg.\n 2. cardiac index (CI) \\> 2.3 L/min/m2.\n* the patient or legal representative is willing and able to provide written informed consent and comply with all protocol requirements.\n\nExclusion Criteria:\n\n* Patients with burns \\> 20% of total body surface area;\n* Patients with cardiovascular (CV) SOFA score ≤ 3;\n* Patients with acute coronary syndrome requiring interventional therapy;\n* Patients treated with Extracorporeal Membrane Oxygenation (ECMO);\n* Patients with end-stage liver failure (Model for end-stage liver disease score (MELD) \\> 30).\n* Patients with a diagnosis of asthma or bronchospasm.\n* Patients with a diagnosis of acute mesenteric ischemia, or patients with suspected acute mesenteric ischemia.\n* Patients with a history, presence, or high suspicion of aortic dissection or abdominal aortic aneurysm, or patients diagnosed with aortic dissection or abdominal aortic aneurysm.\n* Patients who have been diagnosed with malignant tumor within the past 2 years, except for early malignant tumors (carcinoma in situ or stage I tumor) that have been radically treated or expected to recover after treatment, such as adequately treated thyroid cancer, cervical carcinoma in situ, basal cell or squamous cell carcinoma.\n* Patients with Raynaud's phenomenon, systemic sclerosis or vasospastic disease.\n* Patients with life expectancy ≤ 24 hours as assessed by the study physician.\n* Patients with active bleeding who are expected to require transfusion of \\> 4 units of packed red blood cells within 48 hours of study start.\n* Patients with active bleeding and hemoglobin \\< 7 g/dL or any other condition that contraindicates serial blood sampling.\n* Patients with absolute neutrophil count (ANC) \\< 1000 cells/mm3.\n* Patients with known hypersensitivity to angiotensin II injection and its excipients.\n* Patients who are currently participating in another interventional clinical trial.\n* Blood/urine pregnancy test should be performed for patients with known pregnancy at screening and those with clinical suspicion of pregnancy.\n* Patients who are considered unstable by the investigator or have any condition that would affect the safety of the study or the interpretation of the study results, or that would prevent the patient from completing the study, including but not limited to cardiovascular, gastrointestinal, hepatic, renal, neurological, musculoskeletal, infectious, endocrine, metabolic, hematological, psychiatric, or major physical disorders. For example: patients with arrhythmia, uncontrolled hyperglycemia, cerebrovascular disease, uncontrolled hypertension, autoimmune disease requiring daily use of ≥ 500 mg hydrocortisone or equivalent glucocorticoids, etc."}, 'identificationModule': {'nctId': 'NCT06351150', 'briefTitle': 'Efficacy and Safety of Angiotensin II Injection Versus Placebo in Patients With Refractory Distributed Shock', 'organization': {'class': 'INDUSTRY', 'fullName': 'Chia Tai Tianqing Pharmaceutical Group Co., Ltd.'}, 'officialTitle': 'A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Trial to Evaluate the Efficacy and Safety of Angiotensin II Injection in the Background Treatment of Catecholamines and Other Vasopressors in Chinese Adult Patients With Refractory Distributive Shock', 'orgStudyIdInfo': {'id': 'TQG3902-III-01'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Angiotensin Ⅱ Injection', 'description': 'Angiotensin II injection is administered via central vein, and the drug dosage is adjusted according to Mean Arterial Pressure (MAP), with an allowable dose of 1.25\\~160 ng/kg/min. Maximum 168 h.', 'interventionNames': ['Drug: Angiotensin II Injection']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo', 'description': 'The placebo is administered via central vein, and the drug dosage is adjusted according to MAP, with an allowable dose of 1.25\\~160 ng/kg/min. Maximum 168 h.', 'interventionNames': ['Drug: 0.9% sodium chloride injection']}], 'interventions': [{'name': 'Angiotensin II Injection', 'type': 'DRUG', 'description': '1、Angiotensin II injection is a naturally occurring octapeptide hormone in the human renin angiotensin aldosterone system (RAAS). It is the main effector molecule of the RAAS system and one of the strongest known vasoconstrictors, involved in neurohumoral regulation.', 'armGroupLabels': ['Angiotensin Ⅱ Injection']}, {'name': '0.9% sodium chloride injection', 'type': 'DRUG', 'description': '0.9% sodium chloride injection, not containing active ingredients.', 'armGroupLabels': ['Placebo']}]}, 'contactsLocationsModule': {'locations': [{'zip': '230011', 'city': 'Hefei', 'state': 'Anhui', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Li Yao, Doctor', 'role': 'CONTACT', 'email': 'ylirn168@163.com', 'phone': '13956061055'}], 'facility': "The Second People's Hospital of Hefei", 'geoPoint': {'lat': 31.86389, 'lon': 117.28083}}, {'zip': '241001', 'city': 'Wuhu', 'state': 'Anhui', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Weihua Lu, Doctor', 'role': 'CONTACT', 'email': 'Lwh683@126.com', 'phone': '13955370637'}], 'facility': 'The Frist Affiliated Hospital of Wannan Medical College', 'geoPoint': {'lat': 31.35259, 'lon': 118.42947}}, {'zip': '100070', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Guangzhi Shi, Doctor', 'role': 'CONTACT', 'email': 'zjfyanger@sina.com', 'phone': '13241078866'}], 'facility': 'Beijing Tiantan Hospital,Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100730', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yun Long, M.D.', 'role': 'CONTACT', 'email': 'yunlongxh@163.com', 'phone': '13911608699'}], 'facility': 'Peking Union Medical College Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '400010', 'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoli Han, Doctor', 'role': 'CONTACT', 'email': 'hxl093@163.com', 'phone': '13271943396'}], 'facility': 'The Frist Affiliated Hospital of Chongqing Medical University', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '350108', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongyan Li, Doctor', 'role': 'CONTACT', 'email': '1353626039@qq.com', 'phone': '13850153821'}], 'facility': "The people's Hospital of the University of traditional Chinese medicine in Fujian", 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '730000', 'city': 'Lanzhou', 'state': 'Gansu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Dongquan Zhang, Doctor', 'role': 'CONTACT', 'email': 'gostwarrior@163.com', 'phone': '13919284411'}], 'facility': 'Gansu Provincial Hospital', 'geoPoint': {'lat': 36.05701, 'lon': 103.83987}}, {'zip': '510062', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiangdong Guan, M.D.', 'role': 'CONTACT', 'email': 'guanxiangdong1962@163.com', 'phone': '13802925067'}], 'facility': 'The First Affiliated Hospital of Sun Yat sen University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510260', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhanguo Liu, M.D.', 'role': 'CONTACT', 'email': 'zhguoliu@163.com', 'phone': '18520711669'}], 'facility': 'Zhujiang Hospital of Southern Medical University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '510632', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Haiyan Yin, Doctor', 'role': 'CONTACT', 'email': 'yinhaiyan1867@126.com', 'phone': '13318831222'}], 'facility': 'The First Affiliated Hospital of Jinan University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '511518', 'city': 'Qingyuan', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jingwen Yang, M.D.', 'role': 'CONTACT', 'email': '00655@qyry.com', 'phone': '13542498765'}], 'facility': 'Qingyuan Hospital Affiliated to Guangzhou Medical University', 'geoPoint': {'lat': 23.7, 'lon': 113.03333}}, {'zip': '515041', 'city': 'Shantou', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yongru Chen, M.D.', 'role': 'CONTACT', 'email': 'ongruchen@126.com', 'phone': '13411969797'}], 'facility': 'The First Affiliated Hospital of Shantou University Medical College', 'geoPoint': {'lat': 23.35489, 'lon': 116.67876}}, {'zip': '518036', 'city': 'Shenzhen', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lei Huang, Doctor', 'role': 'CONTACT', 'email': 'hl0248@outlook.com', 'phone': '13510331883'}], 'facility': 'Peking University Shenzhen Hospital', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'zip': '543300', 'city': 'Guilin', 'state': 'Guangxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lin Han, Doctor', 'role': 'CONTACT', 'email': 'xhan0507@sina.com', 'phone': '1367719170'}], 'facility': "The People's Hospital of Guangxi Zhuang Autonomous Region", 'geoPoint': {'lat': 25.28022, 'lon': 110.29639}}, {'zip': '545026', 'city': 'Liuchow', 'state': 'Guangxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Guangyu Lv, M.D.', 'role': 'CONTACT', 'email': 'lgy197823@163.com', 'phone': '13977210130'}], 'facility': 'Liuzhou General Hospital', 'geoPoint': {'lat': 24.32405, 'lon': 109.40698}}, {'zip': '550004', 'city': 'Guiyang', 'state': 'Guizhou', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Feng Shen, Doctor', 'role': 'CONTACT', 'email': 'doctorshenfeng@163.com', 'phone': '13511999117'}], 'facility': 'The Affiliated Hospital of Guizhou Medical University', 'geoPoint': {'lat': 26.58333, 'lon': 106.71667}}, {'zip': '050031', 'city': 'Baoding', 'state': 'Hebei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhanbiao Yu, M.D.', 'role': 'CONTACT', 'email': 'daxiang285@sina.com', 'phone': '15188655821'}], 'facility': 'The Affiliated Hospital of Hebei University', 'geoPoint': {'lat': 38.87288, 'lon': 115.46246}}, {'zip': '150007', 'city': 'Harbin', 'state': 'Heilongjiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Mingyan Zhao, M.D.', 'role': 'CONTACT', 'email': 'mingyan0927@126.com', 'phone': '13796118989'}], 'facility': 'The First Affiliated Hospital of Harbin Medical University', 'geoPoint': {'lat': 45.75, 'lon': 126.65}}, {'zip': '233099', 'city': 'Bengbu', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yongsheng Zheng, M.D.', 'role': 'CONTACT', 'email': 'zsy0916@163.com', 'phone': '13955252796'}], 'facility': 'The First Affiliated Hospital of Bengbu Medical College'}, {'zip': '450052', 'city': 'Luoyang', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Qizhi Fu, M.D.', 'role': 'CONTACT', 'email': 'fuqizhi33@sina.com', 'phone': '13837944687'}], 'facility': 'The First Affiliated Hospital of Henan University of Science and Technology', 'geoPoint': {'lat': 34.67345, 'lon': 112.43684}}, {'zip': '450052', 'city': 'Zhengzhou', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tongwen Sun, M.D.', 'role': 'CONTACT', 'email': 'suntongwen@163.com', 'phone': '13838516916'}], 'facility': 'The First Affiliated Hospital of Zhengzhou University', 'geoPoint': {'lat': 34.75778, 'lon': 113.64861}}, {'zip': '430022', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'You Shang, M.D.', 'role': 'CONTACT', 'email': 'you_shanghust@163.com', 'phone': '15972127819'}], 'facility': 'Union Hospital, Tongji Medical College of huazhong university of science and technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '430060', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Shouzhi Fu, Doctor', 'role': 'CONTACT', 'email': 'fszfsz188@163.com', 'phone': '18186118296'}], 'facility': 'Wuhan Third Hospital', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': '140008', 'city': 'Changsha', 'state': 'Hunan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lina Zhang, M.D.', 'role': 'CONTACT', 'email': 'zln7095@163.com', 'phone': '15874875763'}], 'facility': 'Xiangya Hospital Central South University', 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '410001', 'city': 'Changsha', 'state': 'Hunan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xu Zhou, Doctor', 'role': 'CONTACT', 'email': 'zhouxumd@163.com', 'phone': '13907319339'}], 'facility': "Hunan Provincial People's Hospital", 'geoPoint': {'lat': 28.19874, 'lon': 112.97087}}, {'zip': '210029', 'city': 'Nanjing', 'state': 'Jiangsu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Quan Cao, M.D.', 'role': 'CONTACT', 'email': '2004caoquan@163.com', 'phone': '13851992695'}], 'facility': 'Jiangsu Province Hospital', 'geoPoint': {'lat': 32.06167, 'lon': 118.77778}}, {'zip': '214023', 'city': 'Wuxi', 'state': 'Jiangsu', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hongyang Xu, Doctor', 'role': 'CONTACT', 'email': '940216583@qq.com', 'phone': '13358110913'}], 'facility': "Wuxi People's Hospital", 'geoPoint': {'lat': 31.56887, 'lon': 120.28857}}, {'zip': '330006', 'city': 'Nanchang', 'state': 'Jiangxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Fen Liu, Doctor', 'role': 'CONTACT', 'email': '452848077@qq.com', 'phone': '13870603218'}], 'facility': 'The Frist Affiliated Hospital of Nanchang University', 'geoPoint': {'lat': 28.68396, 'lon': 115.85306}}, {'zip': '110004', 'city': 'Shenyang', 'state': 'Liaoning', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Bin Zang, Doctor', 'role': 'CONTACT', 'email': 'zangbin66@aliyun.com', 'phone': '18940251116'}], 'facility': 'Shengjing Hospital of China Medical University', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'zip': '710004', 'city': "Xi'an", 'state': 'Shaanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaochuang Wang, M.D.', 'role': 'CONTACT', 'email': '1585431074@qq.com', 'phone': '13772152935'}], 'facility': "The Second Affiliated Hospital of Xi'an Jiaotong University", 'geoPoint': {'lat': 34.25833, 'lon': 108.92861}}, {'zip': '250000', 'city': 'Jinan', 'state': 'Shandong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Chen Li, Doctor', 'role': 'CONTACT', 'email': 'intensive-1@163.com', 'phone': '18560081005'}], 'facility': 'Qilu Hospital of Shandong University', 'geoPoint': {'lat': 36.66833, 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