Ignite Creation Date:
2025-12-24 @ 12:30 PM
Ignite Modification Date:
2025-12-30 @ 3:21 AM
Study NCT ID:
NCT02727361
Status:
COMPLETED
Last Update Posted:
2019-02-25
First Post:
2016-03-21
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Role of the Striatal Cholinergic System in the Pathophysiology of Dystonia
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D004421', 'term': 'Dystonia'}], 'ancestors': [{'id': 'D020820', 'term': 'Dyskinesias'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C062942', 'term': "2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole"}, {'id': 'D009682', 'term': 'Magnetic Resonance Spectroscopy'}, {'id': 'D014965', 'term': 'X-Rays'}], 'ancestors': [{'id': 'D013057', 'term': 'Spectrum Analysis'}, {'id': 'D002623', 'term': 'Chemistry Techniques, Analytical'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D060733', 'term': 'Electromagnetic Radiation'}, {'id': 'D055590', 'term': 'Electromagnetic Phenomena'}, {'id': 'D060328', 'term': 'Magnetic Phenomena'}, {'id': 'D055585', 'term': 'Physical Phenomena'}, {'id': 'D011827', 'term': 'Radiation'}, {'id': 'D011839', 'term': 'Radiation, Ionizing'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'HEALTH_SERVICES_RESEARCH', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 40}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2016-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-02', 'completionDateStruct': {'date': '2018-03-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-02-22', 'studyFirstSubmitDate': '2016-03-21', 'studyFirstSubmitQcDate': '2016-03-29', 'lastUpdatePostDateStruct': {'date': '2019-02-25', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2016-04-04', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2018-03-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Binding potential', 'timeFrame': 'Inclusion (V0)', 'description': 'Image (PET) of the intensity of fixation of Cholinergic tracer (Binding potential)'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Dystonia', 'Binding potential', 'FEOBV'], 'conditions': ['Dystonia']}, 'descriptionModule': {'briefSummary': 'Dystonia is defined as a syndrome of sustained muscle contractions resulting in repetitive movements and abnormal postures. DYT1 is the most common form of genetic dystonia, but the link between genomic mutations and phenotypic expression remains largely unknown. Furthermore, secondary forms of dystonia have highlighted the role of the basal ganglia, particularly the putamen in the pathophysiology of the disease. Experimental results in a genetic model of dystonia in rodents suggest that cholinergic inter-neurons (ACh-I) of the putamen play a critical role in the pathological process of plasticity in the cortico-striatal synapse. However, these results have not been demonstrated in humans.', 'detailedDescription': 'The purpose of this study is to demonstrate that the phenotype of dystonia is associated with the degree of striatal ACh-I alterations.\n\nIn this molecular imaging study, the investigators will directly test this hypothesis using a PET radiotracer of the vesicular acetylcholine transporter (VAT). Their goal is to explore the relationships between cholinergic dysfunction and clinical disease expression and the associated morphological and functional alterations. The experimental protocol will also include multimodal MRI, MRI diffusion tensor (to study the microscopic structure of white matter) and functional MRI of the resting state (to study the functional organization of cerebral cholinergic networks at rest).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Man or woman 18 to 75 years, with health insurance European health insurance card (for resident patients in EU), insurance by bilateral social security agreement signed between his country and France (for resident patients outside the EU)\n* Diagnosis of dystonia DYT1 confirmed by molecular biology (TORSINE- A gene mutation)\n* Patient who stopped his anticholinergic treatment 48 hours before imaging\n\nExclusion Criteria:\n\n* Patients who underwent surgery for deep brain stimulation or under cholinergic treatment.\n* Presence of a counter-indication for MRI\n* Presence of a counter-indication for TEP Scan with \\[18F\\]-FEOBV\n* Woman premenopausal without effective ongoing contraception (intrauterine device or combined hormonal)\n* Patient who underwent a PET examination in the previous month\n* Presence of any health problem preventing travel to the imaging service of the University Hospital\n* Being under the legal guardianship of another person or being unable to provide consent to participate\n* Pregnant or breastfeeding woman'}, 'identificationModule': {'nctId': 'NCT02727361', 'acronym': 'DYSCHOL', 'briefTitle': 'Role of the Striatal Cholinergic System in the Pathophysiology of Dystonia', 'organization': {'class': 'OTHER', 'fullName': 'University Hospital, Bordeaux'}, 'orgStudyIdInfo': {'id': 'CHUBX2014/20'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Cholinergic striatal imaging', 'description': 'Cholinergic striatal imaging (IRM and TEP) to compare the intensity of the binding of cholinergic tracer', 'interventionNames': ['Radiation: PET (Positron Emission Tomography) imaging', 'Other: MRI : Magnetic Resonance Imaging']}], 'interventions': [{'name': 'PET (Positron Emission Tomography) imaging', 'type': 'RADIATION', 'description': 'Molecular imaging using a PET radiotracer of the vesicular acetylcholine transporter.', 'armGroupLabels': ['Cholinergic striatal imaging']}, {'name': 'MRI : Magnetic Resonance Imaging', 'type': 'OTHER', 'description': 'Multimodal MRI, MRI diffusion tensor (to study the microscopic structure of white matter) and functional MRI of the resting state (to study the functional organization of cerebral cholinergic networks at rest).', 'armGroupLabels': ['Cholinergic striatal imaging']}]}, 'contactsLocationsModule': {'locations': [{'zip': '33076', 'city': 'Bordeaux', 'country': 'France', 'facility': 'CHU de Bordeaux', 'geoPoint': {'lat': 44.84124, 'lon': -0.58046}}], 'overallOfficials': [{'name': 'FERNANDEZ Philippe', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University Hospital, Bordeaux'}, {'name': 'BURBAUD Pierre', 'role': 'STUDY_CHAIR', 'affiliation': 'University of Bordeaux'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University Hospital, Bordeaux', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}