Ignite Creation Date:
2025-12-24 @ 4:52 PM
Ignite Modification Date:
2026-01-01 @ 8:00 PM
Study NCT ID:
NCT06265350
Status:
RECRUITING
Last Update Posted:
2024-02-20
First Post:
2024-02-02
Is Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006528', 'term': 'Carcinoma, Hepatocellular'}, {'id': 'D008113', 'term': 'Liver Neoplasms'}], 'ancestors': [{'id': 'D000230', 'term': 'Adenocarcinoma'}, {'id': 'D002277', 'term': 'Carcinoma'}, {'id': 'D009375', 'term': 'Neoplasms, Glandular and Epithelial'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D008107', 'term': 'Liver Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000068258', 'term': 'Bevacizumab'}, {'id': 'D003452', 'term': 'Cryosurgery'}], 'ancestors': [{'id': 'D061067', 'term': 'Antibodies, Monoclonal, Humanized'}, {'id': 'D000911', 'term': 'Antibodies, Monoclonal'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}, {'id': 'D055011', 'term': 'Ablation Techniques'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 80}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-02-02', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-02', 'completionDateStruct': {'date': '2027-01-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-02-09', 'studyFirstSubmitDate': '2024-02-02', 'studyFirstSubmitQcDate': '2024-02-09', 'lastUpdatePostDateStruct': {'date': '2024-02-20', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2024-02-20', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-01-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Objective response rate (ORR)', 'timeFrame': '6 months', 'description': 'ORR, as determined based on tumor response according to RECIST 1.1, is defined as partial response and complete response.'}], 'secondaryOutcomes': [{'measure': 'Progression free survival (PFS)', 'timeFrame': '6 months', 'description': 'PFS is defined as the time from the date of inclusion to the date of the first objectively documented tumor progression or death due to any cause.'}, {'measure': 'Overall survival (OS)', 'timeFrame': '12 months', 'description': 'OS is the length of time from the date of inclusion until death from any cause.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Hepatocellular Carcinoma', 'Liver Cancer Stage IV', 'Pulmonary Metastases', 'Cadonilimab', 'Bevacizumab', 'Cryoablation']}, 'descriptionModule': {'briefSummary': 'This study intends to evaluate the efficacy and safety of cryoablation combined with Cardonilizumab and Bevacizumab in hepatocellular carcinoma with pulmonary metastases.', 'detailedDescription': 'For advanced hepatocellular carcinoma (HCC), the lung is the most common metastatic organ, accounting for 30-50% of extrahepatic diseases. The standard therapy for advanced HCC with lung metastases according to the Barcelona Clinic Liver Cancer (BCLC) criteria is system therapy.\n\nHowever, studies have proven that palliative ablation could improve the tumor controlling effect and the outcomes.\n\nCryoablation is a treatment method that involves freezing tumors at extremely low temperatures to destroy and eliminate them. This therapeutic approach can result in the death of tumor cells through necrosis and also stimulate immune targeting of tumor cells. These immune responses occur as a result of tumor cell death caused by the ablation procedure. In comparison to conventional cancer therapies, cryoablation has minimal adverse reactions and has the potential to promote a more extensive and effective release of self-generated antigens into the bloodstream.\n\nTargeting vascular endothelial growth factor (VEGF) could reduce VEGF-mediated immunosuppression within the tumor. The IMbrave150 study of atezolizumab and bevacizumab versus sorafenib demonstrated response rates of 29.8% vs 12%, respectively, and median overall survival of 19.8 months in the combination arm versus 13.4 months in the sorafenib (P \\<0.001). Bevacizumab could enhance anti-PD-1 and anti-programmed death ligand 1 (PD-L1) efficacy by reversing VEGF-mediated immunosuppression and promoting T-cell infiltration in tumors (2).\n\nCadonilimab is a first-in-class bispecific, humanized IgG1 antibody targeting PD-1 and CTLA-4, which has the potential to boost immune surveillance in tumors. Preclinical studies have shown that its tetravalent design enhances its high binding activity in the tumor microenvironment. With no Fc binding, Cadonilimab could eliminate a series of functions mediated by the Fc receptor, which contribute to a poor safety profile in clinical settings.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. primary or recurrent HCC;\n2. synchronous metastases (within one month after diagnosing of HCC) or asynchronous metastases (more than one month after diagnosis of HCC);\n3. pulmonary-only metastases \\>5 and ≤10;\n4. metastases diameter ≤ 5 cm;\n5. intrahepatic tumors ≤5, and tumor burden ≤1/2 liver volume;\n6. PVTT type Vp≤3;\n7. patients underwent first-line system therapy failure, the first-line system included tyrosine kinase inhibitor (TKI), such as Sorafenib or Lenvatinib, with or without PD-1 or PDL1 inhibitor;\n8. the intrahepatic tumors were effectively controlled and pulmonary metastases were no progression, and the controlled intrahepatic tumors were defined as partial or stable response according to modified Response Evaluation Criteria in Solid Tumors (mRECIST);\n9. locoregional therapy (including TACE or HAIC) were also included;\n10. Child-Pugh class A or B;\n11. PS 0 or 1;\n12. no history of other malignancies.\n\nExclusion Criteria:\n\n1. under 18 years or over 75 years;\n2. metastases \\>10\n3. non-lung metastases;\n4. incomplete clinical data;\n5. metastases diameter \\> 5 cm;\n6. intrahepatic tumors \\> 5, and tumor burden \\> 1/2 liver volume;\n7. PVTT type Vp 4;\n8. lost to follow-up within 3 months.'}, 'identificationModule': {'nctId': 'NCT06265350', 'briefTitle': 'Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases', 'organization': {'class': 'OTHER', 'fullName': 'Sun Yat-sen University'}, 'officialTitle': 'Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases: A Single-center, Prospective, Randomized Controlled Phase II Study', 'orgStudyIdInfo': {'id': 'Liver Project 5'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Bevacizumab+Cadonilimab group', 'description': 'Patients accepted Bevacizumab (7.5mg/kg，Q3W， IV) plus Cadonilimab (375mg，Q3W， IV)', 'interventionNames': ['Drug: Cadonilimab', 'Drug: Bevacizumab']}, {'type': 'EXPERIMENTAL', 'label': 'Cryoablation+Bevacizumab+Cadonilimab', 'description': 'Patients accepted Cryoablation of pulmanary metastases combined with Bevacizumab (7.5mg/kg，Q3W， IV) and Cadonilimab (375mg，Q3W， IV)', 'interventionNames': ['Drug: Cadonilimab', 'Drug: Bevacizumab', 'Procedure: Cryoablation']}], 'interventions': [{'name': 'Cadonilimab', 'type': 'DRUG', 'description': 'Cadonilimab, 375mg，Q3W， IV', 'armGroupLabels': ['Bevacizumab+Cadonilimab group', 'Cryoablation+Bevacizumab+Cadonilimab']}, {'name': 'Bevacizumab', 'type': 'DRUG', 'description': 'Bevacizumab, 7.5mg/kg，Q3W， IV', 'armGroupLabels': ['Bevacizumab+Cadonilimab group', 'Cryoablation+Bevacizumab+Cadonilimab']}, {'name': 'Cryoablation', 'type': 'PROCEDURE', 'description': 'Patients accepted Cryoablation of pulmanary metastases', 'armGroupLabels': ['Cryoablation+Bevacizumab+Cadonilimab']}]}, 'contactsLocationsModule': {'locations': [{'zip': '510000', 'city': 'Guanzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Qunfang Zhou, MD', 'role': 'CONTACT', 'email': 'zhouqun988509@163.com', 'phone': '86 19868000115'}], 'facility': 'Sun Yat-sen University Cancer Center', 'geoPoint': {'lat': 23.06828, 'lon': 113.37117}}, {'zip': '510000', 'city': 'Guanzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Qunfang Zhou, MD', 'role': 'CONTACT', 'email': 'zhouqun988509@163.com', 'phone': '8619868000115'}], 'facility': 'Sun Yat-sen University Cancer Center', 'geoPoint': {'lat': 23.06828, 'lon': 113.37117}}], 'centralContacts': [{'name': 'Qunfang Zhou, MD', 'role': 'CONTACT', 'email': 'zhouqun988509@163.com', 'phone': '86 19868000115'}], 'overallOfficials': [{'name': 'Zhimei Hunag, MD', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Sun Yat-sen University'}, {'name': 'Jinhua Huang, MD', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Sun Yat-sen University'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Sun Yat-sen University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Clinical Professor', 'investigatorFullName': 'Zhou Qunfang', 'investigatorAffiliation': 'Sun Yat-sen University'}}}}