Ignite Creation Date:
2025-12-24 @ 4:42 PM
Ignite Modification Date:
2026-02-02 @ 11:18 PM
Study NCT ID:
NCT02906566
Status:
COMPLETED
Last Update Posted:
2019-04-16
First Post:
2016-02-26
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Retinol on Human Skin Aging in East Asian Descent
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'D014801', 'term': 'Vitamin A'}], 'ancestors': [{'id': 'D012176', 'term': 'Retinoids'}, {'id': 'D002338', 'term': 'Carotenoids'}, {'id': 'D011090', 'term': 'Polyenes'}, {'id': 'D000475', 'term': 'Alkenes'}, {'id': 'D006839', 'term': 'Hydrocarbons, Acyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D053138', 'term': 'Cyclohexenes'}, {'id': 'D003510', 'term': 'Cyclohexanes'}, {'id': 'D003516', 'term': 'Cycloparaffins'}, {'id': 'D006840', 'term': 'Hydrocarbons, Alicyclic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D013729', 'term': 'Terpenes'}, {'id': 'D004224', 'term': 'Diterpenes'}, {'id': 'D010860', 'term': 'Pigments, Biological'}, {'id': 'D001685', 'term': 'Biological Factors'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'alschang@stanford.edu', 'phone': '650-721-7195', 'title': 'Dr. Anne L. Chang', 'organization': 'Stanford University'}, 'certainAgreement': {'piSponsorEmployee': True}}, 'adverseEventsModule': {'timeFrame': 'Up to 12 weeks.', 'eventGroups': [{'id': 'EG000', 'title': 'Older Group Ages 55-75', 'description': 'Participants received retinol lotion on one arm and placebo to match on the other arm.', 'otherNumAtRisk': 24, 'deathsNumAtRisk': 24, 'otherNumAffected': 4, 'seriousNumAtRisk': 24, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Young Group Ages 18-25', 'description': 'Participants in the group will give a tissue sample from one arm only for comparison.', 'otherNumAtRisk': 10, 'deathsNumAtRisk': 10, 'otherNumAffected': 0, 'seriousNumAtRisk': 10, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Upper respiratory infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 24, 'numEvents': 4, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 10, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT'}, {'term': 'Cough', 'stats': [{'groupId': 'EG000', 'numAtRisk': 24, 'numEvents': 2, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 10, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '24', 'groupId': 'OG000'}]}, {'units': 'genes', 'counts': [{'value': '56615', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Older Group Ages 55-75', 'description': 'Participants received retinol lotion on one arm and placebo to match on the other arm.'}], 'classes': [{'title': 'Upregulated', 'categories': [{'measurements': [{'value': '23', 'groupId': 'OG000'}]}]}, {'title': 'Downregulated', 'categories': [{'measurements': [{'value': '21', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Week 12', 'description': "Differences in transcript levels are reported as the number that were upregulated or downregulated in the participant's retinol-treated arm versus their placebo-treated arm.", 'unitOfMeasure': 'genes', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'genes', 'denomUnitsSelected': 'genes', 'populationDescription': 'Participants in the "Young Group Ages 18-25" attended a single study visit at week 1 to provide tissue samples for comparison purposes, and are not included in this analysis.'}, {'type': 'SECONDARY', 'title': 'Transepidermal Water Loss', 'denoms': [{'units': 'Participants', 'counts': [{'value': '21', 'groupId': 'OG000'}, {'value': '21', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Retinol Treated Arm', 'description': 'Participants in the older group (ages 55-75), retinol arm.'}, {'id': 'OG001', 'title': 'Placebo Treated Arm', 'description': 'Participants in the older group (ages 55-75), placebo arm.'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '17.1', 'spread': '10.2', 'groupId': 'OG000'}, {'value': '16.2', 'spread': '11.7', 'groupId': 'OG001'}]}]}, {'title': 'Week 12', 'categories': [{'measurements': [{'value': '9.4', 'spread': '6.7', 'groupId': 'OG000'}, {'value': '10.2', 'spread': '6.1', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline; Week 12', 'description': 'Transepidermal Water Loss of arm skin was measured in units of grams/hours/meters squared.', 'unitOfMeasure': 'g/h/m^2', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants in the "Young Group Ages 18-25" attended a single study visit at week 1 to provide tissue samples for comparison purposes, and are not included in this analysis.'}, {'type': 'SECONDARY', 'title': 'Severity of Arm Skin Wrinkling', 'denoms': [{'units': 'Participants', 'counts': [{'value': '20', 'groupId': 'OG000'}, {'value': '20', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Retinol Treated Arm', 'description': 'Participants in the older group (ages 55-75), retinol arm.'}, {'id': 'OG001', 'title': 'Placebo Treated Arm', 'description': 'Participants in the older group (ages 55-75), placebo arm.'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5.15', 'spread': '1.96', 'groupId': 'OG000'}, {'value': '5.5', 'spread': '1.59', 'groupId': 'OG001'}]}]}, {'title': 'Week 12', 'categories': [{'measurements': [{'value': '4.85', 'spread': '1.79', 'groupId': 'OG000'}, {'value': '5.175', 'spread': '1.28', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline; Week 12', 'description': 'Wrinkling was assessed by the investigator using a 10-point Likert scale (range 0 to 9, lower scores correspond to less wrinkling).', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants in the "Young Group Ages 18-25" attended a single study visit at week 1 to provide tissue samples for comparison purposes, and are not included in this analysis.'}, {'type': 'SECONDARY', 'title': 'Elasticity on Arm Skin', 'denoms': [{'units': 'Participants', 'counts': [{'value': '21', 'groupId': 'OG000'}, {'value': '21', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Retinol Treated Arm', 'description': 'Participants in the older group (ages 55-75), retinol arm.'}, {'id': 'OG001', 'title': 'Placebo Treated Arm', 'description': 'Participants in the older group (ages 55-75), placebo arm.'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '0.8623', 'spread': '0.0791', 'groupId': 'OG000'}, {'value': '0.8753', 'spread': '0.0464', 'groupId': 'OG001'}]}]}, {'title': 'Week 12', 'categories': [{'measurements': [{'value': '0.8587', 'spread': '0.0655', 'groupId': 'OG000'}, {'value': '0.8576', 'spread': '0.0684', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline; week 12', 'description': 'Elasticity was assessed using cutometry (R2 curve) as millimeters per second', 'unitOfMeasure': 'millimeters per second', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants in the "Young Group Ages 18-25" attended a single study visit at week 1 to provide tissue samples for comparison purposes, and are not included in this analysis.'}, {'type': 'SECONDARY', 'title': 'Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events', 'denoms': [{'units': 'Participants', 'counts': [{'value': '21', 'groupId': 'OG000'}, {'value': '21', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Retinol Treated Arm', 'description': 'Participants in the older group (ages 55-75), retinol arm.'}, {'id': 'OG001', 'title': 'Placebo Treated Arm', 'description': 'Participants in the older group (ages 55-75), placebo arm.'}], 'classes': [{'title': 'Dermatitis (Grade 1)', 'categories': [{'measurements': [{'value': '1', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}]}]}, {'title': 'Tingling sensation after application (Grade 1)', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Baseline through week 12', 'description': 'Skin and subcutaneous adverse events were assessed for this outcome and documented and scored according to CTCAE version 4.03.', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED', 'populationDescription': 'Participants in the "Young Group Ages 18-25" attended a single study visit at week 1 to provide tissue samples for comparison purposes, and are not included in this analysis.'}, {'type': 'PRIMARY', 'title': 'Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '10', 'groupId': 'OG000'}]}, {'units': 'genes', 'counts': [{'value': '56615', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Young Group Ages 18-25', 'description': 'Participants in the group will give a tissue sample from one arm only for comparison.'}], 'classes': [{'title': 'Downregulated', 'categories': [{'measurements': [{'value': '775', 'groupId': 'OG000'}]}]}, {'title': 'Upregulated', 'categories': [{'measurements': [{'value': '587', 'groupId': 'OG000'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Week 1', 'description': 'Differences in transcript levels are reported as the number of genes that were upregulated or downregulated in the Younger Group participant tissue samples, as compared to a baseline provided by tissue samples collected from the Older Group (prior to their treatment).', 'unitOfMeasure': 'genes', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'genes', 'denomUnitsSelected': 'genes', 'populationDescription': 'Only the participants in "Younger Group (ages 18-25)" are included in the analysis, since a comparison of the baseline data for the "Older Group (ages 55-75)" against itself is not clinically meaningful.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Older Group Ages 55-75', 'description': 'Participants received retinol lotion on one arm and placebo to match on the other arm.'}, {'id': 'FG001', 'title': 'Young Group Ages 18-25', 'description': 'Participants in the group will give a tissue sample from one arm only for comparison.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numUnits': '48', 'numSubjects': '24'}, {'groupId': 'FG001', 'numUnits': '10', 'numSubjects': '10'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numUnits': '42', 'numSubjects': '21'}, {'groupId': 'FG001', 'numUnits': '10', 'numSubjects': '10'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numUnits': '6', 'numSubjects': '3'}, {'groupId': 'FG001', 'numUnits': '0', 'numSubjects': '0'}]}]}], 'typeUnitsAnalyzed': 'Arms', 'preAssignmentDetails': '110 participants were consented; 34 participants were assigned to a study arm.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '24', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '34', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Older Group Ages 55-75', 'description': 'Participants received retinol lotion on one arm and placebo to match on the other arm.'}, {'id': 'BG001', 'title': 'Young Group Ages 18-25', 'description': 'Participants in the group will give a tissue sample from one arm only for comparison.'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '11', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '21', 'groupId': 'BG002'}]}, {'title': '>=65 years', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '13', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '66', 'spread': '4.7', 'groupId': 'BG000'}, {'value': '21.7', 'spread': '3.1', 'groupId': 'BG001'}, {'value': '51.7', 'spread': '21.5', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '24', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '34', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Asian', 'measurements': [{'value': '24', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '34', 'groupId': 'BG002'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Black or African American', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'White', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '24', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '34', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}], 'populationDescription': 'Participants who were assigned to a treatment arm were included in the analysis.'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2016-10-12', 'size': 109064, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2019-02-20T18:36', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE4'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'OTHER', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 110}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2015-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-03', 'completionDateStruct': {'date': '2018-03-09', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-03-25', 'studyFirstSubmitDate': '2016-02-26', 'resultsFirstSubmitDate': '2019-02-27', 'studyFirstSubmitQcDate': '2016-09-14', 'lastUpdatePostDateStruct': {'date': '2019-04-16', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2019-03-25', 'studyFirstPostDateStruct': {'date': '2016-09-20', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2019-04-16', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2018-03-09', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Older Group, Retinol Versus Placebo)', 'timeFrame': 'Week 12', 'description': "Differences in transcript levels are reported as the number that were upregulated or downregulated in the participant's retinol-treated arm versus their placebo-treated arm."}, {'measure': 'Number of Genes Upregulated or Downregulated as Assessed by RNA Sequencing (Younger Group Versus Older Group as Baseline)', 'timeFrame': 'Week 1', 'description': 'Differences in transcript levels are reported as the number of genes that were upregulated or downregulated in the Younger Group participant tissue samples, as compared to a baseline provided by tissue samples collected from the Older Group (prior to their treatment).'}], 'secondaryOutcomes': [{'measure': 'Transepidermal Water Loss', 'timeFrame': 'Baseline; Week 12', 'description': 'Transepidermal Water Loss of arm skin was measured in units of grams/hours/meters squared.'}, {'measure': 'Severity of Arm Skin Wrinkling', 'timeFrame': 'Baseline; Week 12', 'description': 'Wrinkling was assessed by the investigator using a 10-point Likert scale (range 0 to 9, lower scores correspond to less wrinkling).'}, {'measure': 'Elasticity on Arm Skin', 'timeFrame': 'Baseline; week 12', 'description': 'Elasticity was assessed using cutometry (R2 curve) as millimeters per second'}, {'measure': 'Count of Participants With Skin and Subcutaneous Adverse Events as a Measure of Type and Severity of Adverse Events', 'timeFrame': 'Baseline through week 12', 'description': 'Skin and subcutaneous adverse events were assessed for this outcome and documented and scored according to CTCAE version 4.03.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'conditions': ['Intrinsic Aging of Skin']}, 'descriptionModule': {'briefSummary': 'There has been increasing evidence for different rates of natural aging in humans and one of the best organs to study human aging is skin. Studies have demonstrated anti-aging effects of topical agents (such as creams, gels, lotions, or ointments) and one of them, retinol or vitamin A, was shown to decrease fine wrinkling in skin of older individuals. Additionally, studies of retinol in humans have largely occurred in white populations and so this study aims to focus on skin aging in individuals of East Asian descent as they represent a majority of the world population. This study aims to better characterize the molecular basis of rejuvenation effects and to potentially discover new topical agents with similar and/or more effective preservation of skin youthfulness.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* able to provide written informed consent\n* older group: age between 50 and 75 years\n* young group: age 18 to 25 years\n* all four grandparents of Han Chinese, Japanese, Korean descent\n* body mass index within normal or overweight range\n* no history of weight loss of \\>20 lbs within past 5 years\n\nExclusion Criteria:\n\n* skin condition in the areas of skin biopsy that would obscure results of analysis\n* topical creams or treatment to arms 2 weeks prior to study baseline visit\n* individuals with known hypersensitivity to retinoid class of agents (older group only)\n* prior anti-aging treatments to arms including retinol, microdermabrasion within 2 weeks of baseline visit\n* prior laser therapy or surgical procedure to arms\n* prior radiation or other trauma (extensive burns or abrasions) to arm skin\n* hormone-based therapy within 4 weeks of enrollment'}, 'identificationModule': {'nctId': 'NCT02906566', 'briefTitle': 'Retinol on Human Skin Aging in East Asian Descent', 'organization': {'class': 'OTHER', 'fullName': 'Stanford University'}, 'officialTitle': 'Discovery of Effects of Retinol on Human Skin Aging in Individuals of East Asian Descent', 'orgStudyIdInfo': {'id': '33762'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'OTHER', 'label': 'Older Group Ages 55-75', 'description': 'Active and Placebo. Participants received retinol lotion on one arm and placebo to match on the other arm.', 'interventionNames': ['Drug: Retinol', 'Drug: Placebo']}, {'type': 'NO_INTERVENTION', 'label': 'Young Group Ages 18-25', 'description': 'Participants in the group will give tissue sample only for comparison.'}], 'interventions': [{'name': 'Retinol', 'type': 'DRUG', 'description': 'Retinol in the form of vitamin A lotion', 'armGroupLabels': ['Older Group Ages 55-75']}, {'name': 'Placebo', 'type': 'DRUG', 'description': 'Placebo of Retinol', 'armGroupLabels': ['Older Group Ages 55-75']}]}, 'contactsLocationsModule': {'locations': [{'zip': '94603', 'city': 'Redwood City', 'state': 'California', 'country': 'United States', 'facility': 'Stanford Dermatology', 'geoPoint': {'lat': 37.48522, 'lon': -122.23635}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'No current plan to share data.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Stanford University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Associate Professor of Dermatology', 'investigatorFullName': 'Anne Chang', 'investigatorAffiliation': 'Stanford University'}}}}