Ignite Creation Date:
2025-12-24 @ 4:30 PM
Ignite Modification Date:
2025-12-26 @ 4:05 AM
Study NCT ID:
NCT05445466
Status:
COMPLETED
Last Update Posted:
2025-11-06
First Post:
2022-06-17
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical Stimulation
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'submissionTracking': {'firstMcpInfo': {'postDateStruct': {'date': '2025-07-08', 'type': 'ACTUAL'}}}}, 'conditionBrowseModule': {'meshes': [{'id': 'D001714', 'term': 'Bipolar Disorder'}, {'id': 'D011618', 'term': 'Psychotic Disorders'}, {'id': 'D000087122', 'term': 'Mania'}], 'ancestors': [{'id': 'D000068105', 'term': 'Bipolar and Related Disorders'}, {'id': 'D019964', 'term': 'Mood Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}, {'id': 'D019967', 'term': 'Schizophrenia Spectrum and Other Psychotic Disorders'}, {'id': 'D019954', 'term': 'Neurobehavioral Manifestations'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'lizanopl@gmail.com', 'phone': '201-776-6708', 'title': 'Dr. Paulo Lizano', 'organization': 'BIDMC'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}, 'limitationsAndCaveats': {'description': 'Overall recruitment numbers were low which led to small numbers of subjects analyzed.'}}, 'adverseEventsModule': {'timeFrame': 'Adverse events were collected up to 3 months after tES treatment (10 sessions over 1 week) was completed.', 'eventGroups': [{'id': 'EG000', 'title': 'Active HD-tDCS', 'description': 'tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment', 'otherNumAtRisk': 5, 'deathsNumAtRisk': 5, 'otherNumAffected': 1, 'seriousNumAtRisk': 5, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Active Control (Alpha, 10 Hz)', 'description': 'Passive sham control; Two, twenty-minute sessions of passive sham control to the OFC for a 30 second ramped up and down at the beginning and end of the 20 min period for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: Active-control stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment', 'otherNumAtRisk': 4, 'deathsNumAtRisk': 4, 'otherNumAffected': 0, 'seriousNumAtRisk': 4, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Beta-Gamma Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment', 'otherNumAtRisk': 5, 'deathsNumAtRisk': 5, 'otherNumAffected': 0, 'seriousNumAtRisk': 5, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Eye Fatigue/Pain', 'notes': 'Individual reported eye pain/fatigue after completing 10 sessions of stimulation. The individual was suffering from a common cold at the time. Symptoms resolved on their own after a few days.', 'stats': [{'groupId': 'EG000', 'numAtRisk': 5, 'numEvents': 1, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 4, 'numEvents': 0, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 5, 'numEvents': 0, 'numAffected': 0}], 'organSystem': 'Eye disorders', 'assessmentType': 'NON_SYSTEMATIC_ASSESSMENT'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Young Mania Rating Scale (YMRS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5.5', 'groupId': 'OG000', 'lowerLimit': '0.5', 'upperLimit': '6'}, {'value': '11.8', 'groupId': 'OG001', 'lowerLimit': '9.575', 'upperLimit': '13.25'}, {'value': '7.5', 'groupId': 'OG002', 'lowerLimit': '5.5', 'upperLimit': '8'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '3', 'groupId': 'OG000', 'lowerLimit': '2', 'upperLimit': '3.5'}, {'value': '8', 'groupId': 'OG001', 'lowerLimit': '4.75', 'upperLimit': '11.125'}, {'value': '3', 'groupId': 'OG002', 'lowerLimit': '1.5', 'upperLimit': '13'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'Measuring total Mania scores; 11 items used to access severity of mania (total score 0-60); higher scores represent higher severity of symptoms', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'PRIMARY', 'title': 'Young Mania Rating Scale (YMRS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5.5', 'groupId': 'OG000', 'lowerLimit': '0.5', 'upperLimit': '6'}, {'value': '11.8', 'groupId': 'OG001', 'lowerLimit': '9.575', 'upperLimit': '13.25'}, {'value': '7.5', 'groupId': 'OG002', 'lowerLimit': '5.5', 'upperLimit': '8'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '1.5', 'groupId': 'OG000', 'lowerLimit': '1.5', 'upperLimit': '4'}, {'value': '11', 'groupId': 'OG001', 'lowerLimit': '8', 'upperLimit': '14.25'}, {'value': '4', 'groupId': 'OG002', 'lowerLimit': '1.5', 'upperLimit': '5.5'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'Measuring total Mania scores; 11 items used to access severity of mania (total score 0-60); higher scores represent higher severity of symptoms', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': '\'Mice" R package used for 1 individual 1 Month data. Total score reported.'}, {'type': 'PRIMARY', 'title': 'Young Mania Rating Scale (YMRS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5.5', 'groupId': 'OG000', 'lowerLimit': '0.5', 'upperLimit': '6'}, {'value': '11.8', 'groupId': 'OG001', 'lowerLimit': '9.575', 'upperLimit': '13.25'}, {'value': '7.5', 'groupId': 'OG002', 'lowerLimit': '5.5', 'upperLimit': '8'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '2.6', 'groupId': 'OG000', 'lowerLimit': '1.5', 'upperLimit': '3.5'}, {'value': '7.5', 'groupId': 'OG001', 'lowerLimit': '5', 'upperLimit': '9.625'}, {'value': '2', 'groupId': 'OG002', 'lowerLimit': '0.5', 'upperLimit': '7'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'Measuring total Mania scores; 11 items used to access severity of mania (total score 0-60); higher scores represent higher severity of symptoms', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}, {'type': 'PRIMARY', 'title': 'Altman Self-Rating Mania Scale (ASRM)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5', 'groupId': 'OG000', 'lowerLimit': '4', 'upperLimit': '5'}, {'value': '7', 'groupId': 'OG001', 'lowerLimit': '3.75', 'upperLimit': '9.5'}, {'value': '3', 'groupId': 'OG002', 'lowerLimit': '3', 'upperLimit': '5'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '7', 'groupId': 'OG000', 'lowerLimit': '4', 'upperLimit': '8'}, {'value': '2', 'groupId': 'OG001', 'lowerLimit': '1', 'upperLimit': '4.25'}, {'value': '5', 'groupId': 'OG002', 'lowerLimit': '5', 'upperLimit': '7'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'PRIMARY', 'title': 'Altman Self-Rating Mania Scale (ASRM)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5', 'groupId': 'OG000', 'lowerLimit': '4', 'upperLimit': '5'}, {'value': '7', 'groupId': 'OG001', 'lowerLimit': '3.75', 'upperLimit': '9.5'}, {'value': '3', 'groupId': 'OG002', 'lowerLimit': '3', 'upperLimit': '5'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '2', 'groupId': 'OG000', 'lowerLimit': '1', 'upperLimit': '3'}, {'value': '4', 'groupId': 'OG001', 'lowerLimit': '2.25', 'upperLimit': '6.25'}, {'value': '5', 'groupId': 'OG002', 'lowerLimit': '5', 'upperLimit': '6'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data. Total score reported."}, {'type': 'PRIMARY', 'title': 'Altman Self-Rating Mania Scale (ASRM)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '5', 'groupId': 'OG000', 'lowerLimit': '4', 'upperLimit': '5'}, {'value': '7', 'groupId': 'OG001', 'lowerLimit': '3.75', 'upperLimit': '9.5'}, {'value': '3', 'groupId': 'OG002', 'lowerLimit': '3', 'upperLimit': '5'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '2', 'groupId': 'OG000', 'lowerLimit': '2', 'upperLimit': '4'}, {'value': '3.6', 'groupId': 'OG001', 'lowerLimit': '2.25', 'upperLimit': '4.5'}, {'value': '6', 'groupId': 'OG002', 'lowerLimit': '5', 'upperLimit': '7.2'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}, {'type': 'PRIMARY', 'title': 'Psychiatric Hospitalizations for Mania Post Study Entry', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '0', 'groupId': 'OG001'}, {'value': '0', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'Cumulative count of hospitalizations for mania from baseline to end of study', 'description': 'Psychiatric hospitalization for mania. Count of hospitalizations from baseline to end of study period assessed at Day 5, 1 Month \\& 3 Month.', 'unitOfMeasure': 'number of hospitalizations', 'reportingStatus': 'POSTED', 'populationDescription': 'Cumulative count of hospitalizations for mania from baseline to end of study'}, {'type': 'SECONDARY', 'title': 'Balloon Analogue Risk Task (BART)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '16', 'groupId': 'OG000', 'lowerLimit': '10', 'upperLimit': '17'}, {'value': '13.5', 'groupId': 'OG001', 'lowerLimit': '11.5', 'upperLimit': '15.25'}, {'value': '13', 'groupId': 'OG002', 'lowerLimit': '11', 'upperLimit': '19'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '17', 'groupId': 'OG000', 'lowerLimit': '16', 'upperLimit': '17'}, {'value': '13.5', 'groupId': 'OG001', 'lowerLimit': '7.75', 'upperLimit': '20'}, {'value': '18', 'groupId': 'OG002', 'lowerLimit': '14', 'upperLimit': '25'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The BART is a computerized task the measures risk-taking behavior. Participants are tasked with inflating the virtual balloon. The number of pumps a participant chooses to make on each balloon is used as a measure of their risk-taking behavior. More pumps generally indicate a higher tolerance for risk. The balloon bursts at a given point if the participant overfills it. Number of popped balloons reported for a given trial.', 'unitOfMeasure': 'popped balloons', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Balloon Analogue Risk Task (BART)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '16', 'groupId': 'OG000', 'lowerLimit': '10', 'upperLimit': '17'}, {'value': '13.5', 'groupId': 'OG001', 'lowerLimit': '11.5', 'upperLimit': '15.25'}, {'value': '13', 'groupId': 'OG002', 'lowerLimit': '11', 'upperLimit': '19'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '15', 'groupId': 'OG000', 'lowerLimit': '15', 'upperLimit': '16'}, {'value': '14.1', 'groupId': 'OG001', 'lowerLimit': '10.5', 'upperLimit': '18.65'}, {'value': '27', 'groupId': 'OG002', 'lowerLimit': '17', 'upperLimit': '28'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The BART is a computerized task the measures risk-taking behavior. Participants are tasked with inflating the virtual balloon. The number of pumps a participant chooses to make on each balloon is used as a measure of their risk-taking behavior. More pumps generally indicate a higher tolerance for risk. The balloon bursts at a given point if the participant overfills it. Number of popped balloons reported for a given trial.', 'unitOfMeasure': 'popped balloons', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data"}, {'type': 'SECONDARY', 'title': 'Balloon Analogue Risk Task (BART)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '16', 'groupId': 'OG000', 'lowerLimit': '10', 'upperLimit': '17'}, {'value': '13.5', 'groupId': 'OG001', 'lowerLimit': '11.5', 'upperLimit': '15.25'}, {'value': '13', 'groupId': 'OG002', 'lowerLimit': '11', 'upperLimit': '19'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '12.2', 'groupId': 'OG000', 'lowerLimit': '11', 'upperLimit': '14'}, {'value': '14.7', 'groupId': 'OG001', 'lowerLimit': '11.75', 'upperLimit': '18.3'}, {'value': '18', 'groupId': 'OG002', 'lowerLimit': '14', 'upperLimit': '22'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The BART is a computerized task the measures risk-taking behavior. Participants are tasked with inflating the virtual balloon. The number of pumps a participant chooses to make on each balloon is used as a measure of their risk-taking behavior. More pumps generally indicate a higher tolerance for risk. The balloon bursts at a given point if the participant overfills it. Number of popped balloons reported for a given trial.', 'unitOfMeasure': 'popped balloons', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R packaged used to impute 5 individuals' 3 Month data"}, {'type': 'SECONDARY', 'title': 'The Go/No Go Task', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '876.9768638', 'groupId': 'OG000', 'lowerLimit': '675.4974359', 'upperLimit': '923.1895604'}, {'value': '954.3716154', 'groupId': 'OG001', 'lowerLimit': '894.5683204', 'upperLimit': '964.7482317'}, {'value': '859.6685714', 'groupId': 'OG002', 'lowerLimit': '857.6372796', 'upperLimit': '1139.709184'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '927.1679389', 'groupId': 'OG000', 'lowerLimit': '925.6649616', 'upperLimit': '1011.031746'}, {'value': '878.0193364', 'groupId': 'OG001', 'lowerLimit': '871.9321033', 'upperLimit': '915.1828861'}, {'value': '917.7871795', 'groupId': 'OG002', 'lowerLimit': '805.0713097', 'upperLimit': '994.2446809'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The Go/No Go Task is a computerized task that measures impulsiveness. Participants presented with Go (to respond) and no Go (when not to respond) instructions. Two trials are performed. The first trial consist of two distinct auditory stimuli (both Go stimuli) where the participant is asked to respond with a different number of mouse clicks to the stimuli respectively. The second trial, has a no Go stimuli (where the participant is suppose to withhold a response) and a go stimuli. Reaction time for correct trials only for the entire task are reported in milliseconds.', 'unitOfMeasure': 'reaction time (ms) on task', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'The Go/No Go Task', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '876.9768638', 'groupId': 'OG000', 'lowerLimit': '675.4974359', 'upperLimit': '923.1895604'}, {'value': '954.3716154', 'groupId': 'OG001', 'lowerLimit': '894.5683204', 'upperLimit': '964.7482317'}, {'value': '859.6685714', 'groupId': 'OG002', 'lowerLimit': '857.6372796', 'upperLimit': '1139.709184'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '923.5850515', 'groupId': 'OG000', 'lowerLimit': '914.8220551', 'upperLimit': '939.1815857'}, {'value': '919.8986144', 'groupId': 'OG001', 'lowerLimit': '910.2266457', 'upperLimit': '942.2465073'}, {'value': '880.3450882', 'groupId': 'OG002', 'lowerLimit': '838.5765306', 'upperLimit': '993.5419847'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The Go/No Go Task is a computerized task that measures impulsiveness. Participants presented with Go (to respond) and no Go (when not to respond) instructions. Two trials are performed. The first trial consist of two distinct auditory stimuli (both Go stimuli) where the participant is asked to respond with a different number of mouse clicks to the stimuli respectively. The second trial, has a no Go stimuli (where the participant is suppose to withhold a response) and a go stimuli. Reaction time for correct trials only for the entire task are reported in milliseconds.', 'unitOfMeasure': 'reaction time (ms) on task', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used for 1 individual's 1 Month data"}, {'type': 'SECONDARY', 'title': 'The Go/No Go Task', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '876.9768638', 'groupId': 'OG000', 'lowerLimit': '675.4974359', 'upperLimit': '923.1895604'}, {'value': '954.3716154', 'groupId': 'OG001', 'lowerLimit': '894.5683204', 'upperLimit': '964.7482317'}, {'value': '859.6685714', 'groupId': 'OG002', 'lowerLimit': '857.6372796', 'upperLimit': '1139.709184'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '931.8461538', 'groupId': 'OG000', 'lowerLimit': '902.5325077', 'upperLimit': '953.3693886'}, {'value': '925.0182573', 'groupId': 'OG001', 'lowerLimit': '897.7525324', 'upperLimit': '951.0867497'}, {'value': '845.64', 'groupId': 'OG002', 'lowerLimit': '803.9641944', 'upperLimit': '930.8737113'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The Go/No Go Task is a computerized task that measures impulsiveness. Participants presented with Go (to respond) and no Go (when not to respond) instructions. Two trials are performed. The first trial consist of two distinct auditory stimuli (both Go stimuli) where the participant is asked to respond with a different number of mouse clicks to the stimuli respectively. The second trial, has a no Go stimuli (where the participant is suppose to withhold a response) and a go stimuli. Reaction time for correct trials only for the entire task are reported in milliseconds.', 'unitOfMeasure': 'reaction time (ms) on task', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data"}, {'type': 'SECONDARY', 'title': 'Electroencephalography (EEG) Resting State', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline Delta/Theta', 'categories': [{'measurements': [{'value': '-9.261', 'groupId': 'OG000', 'lowerLimit': '-9.654', 'upperLimit': '-8.720'}, {'value': '-7.555', 'groupId': 'OG001', 'lowerLimit': '-8.544', 'upperLimit': '-4.817'}, {'value': '-6.410', 'groupId': 'OG002', 'lowerLimit': '-9.009', 'upperLimit': '-5.245'}]}]}, {'title': 'Baseline Alpha', 'categories': [{'measurements': [{'value': '-13.336', 'groupId': 'OG000', 'lowerLimit': '-13.435', 'upperLimit': '-12.118'}, {'value': '-8.834', 'groupId': 'OG001', 'lowerLimit': '-9.639', 'upperLimit': '-6.513'}, {'value': '-11.185', 'groupId': 'OG002', 'lowerLimit': '-12.112', 'upperLimit': '-6.792'}]}]}, {'title': 'Baseline Beta', 'categories': [{'measurements': [{'value': '-17.191', 'groupId': 'OG000', 'lowerLimit': '-18.932', 'upperLimit': '-17.076'}, {'value': '-11.636', 'groupId': 'OG001', 'lowerLimit': '-13.139', 'upperLimit': '-10.309'}, {'value': '-17.344', 'groupId': 'OG002', 'lowerLimit': '-18.287', 'upperLimit': '-16.151'}]}]}, {'title': 'Baseline Gamma', 'categories': [{'measurements': [{'value': '-21.651', 'groupId': 'OG000', 'lowerLimit': '-23.656', 'upperLimit': '-20.064'}, {'value': '-17.087', 'groupId': 'OG001', 'lowerLimit': '-18.618', 'upperLimit': '-15.387'}, {'value': '-24.011', 'groupId': 'OG002', 'lowerLimit': '-24.143', 'upperLimit': '-20.892'}]}]}, {'title': 'Day 5 Delta/Theta', 'categories': [{'measurements': [{'value': '-8.844', 'groupId': 'OG000', 'lowerLimit': '-10.331', 'upperLimit': '-8.711'}, {'value': '-3.373', 'groupId': 'OG001', 'lowerLimit': '-4.858', 'upperLimit': '-1.851'}, {'value': '-3.567', 'groupId': 'OG002', 'lowerLimit': '-8.164', 'upperLimit': '-3.369'}]}]}, {'title': 'Day 5 Alpha', 'categories': [{'measurements': [{'value': '-12.946', 'groupId': 'OG000', 'lowerLimit': '-14.470', 'upperLimit': '-11.370'}, {'value': '-8.241', 'groupId': 'OG001', 'lowerLimit': '-9.049', 'upperLimit': '-6.130'}, {'value': '-8.445', 'groupId': 'OG002', 'lowerLimit': '-12.857', 'upperLimit': '-6.938'}]}]}, {'title': 'Day 5 Beta', 'categories': [{'measurements': [{'value': '-17.898', 'groupId': 'OG000', 'lowerLimit': '-17.968', 'upperLimit': '-16.311'}, {'value': '-12.266', 'groupId': 'OG001', 'lowerLimit': '-13.787', 'upperLimit': '-10.604'}, {'value': '-16.360', 'groupId': 'OG002', 'lowerLimit': '-16.494', 'upperLimit': '-16.166'}]}]}, {'title': 'Day 5 Gamma', 'categories': [{'measurements': [{'value': '-20.695', 'groupId': 'OG000', 'lowerLimit': '-22.511', 'upperLimit': '-20.690'}, {'value': '-16.232', 'groupId': 'OG001', 'lowerLimit': '-18.035', 'upperLimit': '-15.364'}, {'value': '-22.996', 'groupId': 'OG002', 'lowerLimit': '-24.261', 'upperLimit': '-22.019'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'Measuring neural activity at rest consisting of 5 minutes of eyes-open resting-state EEG (rsEEG) was recorded. Fast Fourier transformations were conducted on data, resulting in 4 frequency bands: delta/theta, alpha, beta, and gamma.', 'unitOfMeasure': 'peak amplitude measured in microvolts', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Delta/Theta represents the range of 2-7Hz'}, {'type': 'SECONDARY', 'title': 'Electroencephalography (EEG) Resting State', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline Delta/Theta', 'categories': [{'measurements': [{'value': '-9.261', 'groupId': 'OG000', 'lowerLimit': '-9.654', 'upperLimit': '-8.720'}, {'value': '-7.555', 'groupId': 'OG001', 'lowerLimit': '-8.544', 'upperLimit': '-4.817'}, {'value': '-6.410', 'groupId': 'OG002', 'lowerLimit': '-9.009', 'upperLimit': '-5.245'}]}]}, {'title': 'Baseline Alpha', 'categories': [{'measurements': [{'value': '-13.336', 'groupId': 'OG000', 'lowerLimit': '-13.435', 'upperLimit': '-12.118'}, {'value': '-8.834', 'groupId': 'OG001', 'lowerLimit': '-9.639', 'upperLimit': '-6.513'}, {'value': '-11.185', 'groupId': 'OG002', 'lowerLimit': '-12.112', 'upperLimit': '-6.792'}]}]}, {'title': 'Baseline Beta', 'categories': [{'measurements': [{'value': '-17.191', 'groupId': 'OG000', 'lowerLimit': '-18.932', 'upperLimit': '-17.076'}, {'value': '-11.636', 'groupId': 'OG001', 'lowerLimit': '-13.139', 'upperLimit': '-10.309'}, {'value': '-17.344', 'groupId': 'OG002', 'lowerLimit': '-18.287', 'upperLimit': '-16.151'}]}]}, {'title': 'Baseline Gamma', 'categories': [{'measurements': [{'value': '-21.651', 'groupId': 'OG000', 'lowerLimit': '-23.656', 'upperLimit': '-20.064'}, {'value': '-17.087', 'groupId': 'OG001', 'lowerLimit': '-18.618', 'upperLimit': '-15.387'}, {'value': '-24.011', 'groupId': 'OG002', 'lowerLimit': '-24.143', 'upperLimit': '-20.892'}]}]}, {'title': '1 Month Delta/Theta', 'categories': [{'measurements': [{'value': '-9.775', 'groupId': 'OG000', 'lowerLimit': '-10.242', 'upperLimit': '-8.359'}, {'value': '-8.373', 'groupId': 'OG001', 'lowerLimit': '-9.455', 'upperLimit': '-7.109'}, {'value': '-4.015', 'groupId': 'OG002', 'lowerLimit': '-8.554', 'upperLimit': '-3.696'}]}]}, {'title': '1 Month Alpha', 'categories': [{'measurements': [{'value': '-14.921', 'groupId': 'OG000', 'lowerLimit': '-15.199', 'upperLimit': '-11.276'}, {'value': '-11.520', 'groupId': 'OG001', 'lowerLimit': '-12.060', 'upperLimit': '-10.555'}, {'value': '-10.646', 'groupId': 'OG002', 'lowerLimit': '-12.675', 'upperLimit': '-7.025'}]}]}, {'title': '1 Month Beta', 'categories': [{'measurements': [{'value': '-16.627', 'groupId': 'OG000', 'lowerLimit': '-17.518', 'upperLimit': '-16.425'}, {'value': '-13.489', 'groupId': 'OG001', 'lowerLimit': '-14.057', 'upperLimit': '-13.213'}, {'value': '-17.502', 'groupId': 'OG002', 'lowerLimit': '-18.891', 'upperLimit': '-16.455'}]}]}, {'title': '1 Month Gamma', 'categories': [{'measurements': [{'value': '-19.358', 'groupId': 'OG000', 'lowerLimit': '-19.363', 'upperLimit': '-19.102'}, {'value': '-19.739', 'groupId': 'OG001', 'lowerLimit': '-21.221', 'upperLimit': '-18.424'}, {'value': '-22.594', 'groupId': 'OG002', 'lowerLimit': '-24.795', 'upperLimit': '-21.966'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'Measuring neural activity at rest consisting of 5 minutes of eyes-open resting-state EEG (rsEEG) was recorded. Fast Fourier transformations were conducted on data, resulting in 4 frequency bands: delta/theta, alpha, beta, and gamma.', 'unitOfMeasure': 'peak amplitude measured in microvolts', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month Data. Delta/Theta represents the range of 2-7Hz."}, {'type': 'SECONDARY', 'title': 'Electroencephalography (EEG) Resting State', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline Delta/Theta', 'categories': [{'measurements': [{'value': '-9.261', 'groupId': 'OG000', 'lowerLimit': '-9.654', 'upperLimit': '-8.720'}, {'value': '-7.555', 'groupId': 'OG001', 'lowerLimit': '-8.544', 'upperLimit': '-4.817'}, {'value': '-6.410', 'groupId': 'OG002', 'lowerLimit': '-9.009', 'upperLimit': '-5.245'}]}]}, {'title': 'Baseline Alpha', 'categories': [{'measurements': [{'value': '-13.336', 'groupId': 'OG000', 'lowerLimit': '-13.435', 'upperLimit': '-12.118'}, {'value': '-8.834', 'groupId': 'OG001', 'lowerLimit': '-9.639', 'upperLimit': '-6.513'}, {'value': '-11.185', 'groupId': 'OG002', 'lowerLimit': '-12.112', 'upperLimit': '-6.792'}]}]}, {'title': 'Baseline Beta', 'categories': [{'measurements': [{'value': '-17.191', 'groupId': 'OG000', 'lowerLimit': '-18.932', 'upperLimit': '-17.076'}, {'value': '-11.636', 'groupId': 'OG001', 'lowerLimit': '-13.139', 'upperLimit': '-10.309'}, {'value': '-17.344', 'groupId': 'OG002', 'lowerLimit': '-18.287', 'upperLimit': '-16.151'}]}]}, {'title': 'Baseline Gamma', 'categories': [{'measurements': [{'value': '-21.651', 'groupId': 'OG000', 'lowerLimit': '-23.656', 'upperLimit': '-20.064'}, {'value': '-17.087', 'groupId': 'OG001', 'lowerLimit': '-18.618', 'upperLimit': '-15.387'}, {'value': '-24.011', 'groupId': 'OG002', 'lowerLimit': '-24.143', 'upperLimit': '-20.892'}]}]}, {'title': '3 Month Delta/Theta', 'categories': [{'measurements': [{'value': '-8.764', 'groupId': 'OG000', 'lowerLimit': '-9.704', 'upperLimit': '-8.220'}, {'value': '-7.362', 'groupId': 'OG001', 'lowerLimit': '-8.040', 'upperLimit': '-6.876'}, {'value': '-3.686', 'groupId': 'OG002', 'lowerLimit': '-8.560', 'upperLimit': '-3.538'}]}]}, {'title': '3 Month Alpha', 'categories': [{'measurements': [{'value': '-14.041', 'groupId': 'OG000', 'lowerLimit': '-14.599', 'upperLimit': '-12.839'}, {'value': '-10.615', 'groupId': 'OG001', 'lowerLimit': '-10.914', 'upperLimit': '-9.682'}, {'value': '-7.918', 'groupId': 'OG002', 'lowerLimit': '-11.435', 'upperLimit': '-7.331'}]}]}, {'title': '3 Month Beta', 'categories': [{'measurements': [{'value': '-17.323', 'groupId': 'OG000', 'lowerLimit': '-18.195', 'upperLimit': '-17.186'}, {'value': '-13.074', 'groupId': 'OG001', 'lowerLimit': '-13.410', 'upperLimit': '-12.645'}, {'value': '-17.643', 'groupId': 'OG002', 'lowerLimit': '-18.436', 'upperLimit': '-16.060'}]}]}, {'title': '3 Month Gamma', 'categories': [{'measurements': [{'value': '-21.479', 'groupId': 'OG000', 'lowerLimit': '-21.743', 'upperLimit': '-20.864'}, {'value': '-19.348', 'groupId': 'OG001', 'lowerLimit': '-20.173', 'upperLimit': '-17.743'}, {'value': '-23.863', 'groupId': 'OG002', 'lowerLimit': '-24.238', 'upperLimit': '-23.257'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'Measuring neural activity at rest consisting of 5 minutes of eyes-open resting-state EEG (rsEEG) was recorded. Fast Fourier transformations were conducted on data, resulting in 4 frequency bands: delta/theta, alpha, beta, and gamma.', 'unitOfMeasure': 'peak amplitude measured in microvolts', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Delta/Theta represents the range of 2-7Hz."}, {'type': 'SECONDARY', 'title': 'Reinforcement Learning Task', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '26', 'groupId': 'OG000', 'lowerLimit': '23.5', 'upperLimit': '29'}, {'value': '25.25', 'groupId': 'OG001', 'lowerLimit': '20', 'upperLimit': '30.875'}, {'value': '32', 'groupId': 'OG002', 'lowerLimit': '31', 'upperLimit': '32'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '28.5', 'groupId': 'OG000', 'lowerLimit': '25', 'upperLimit': '30.5'}, {'value': '33.75', 'groupId': 'OG001', 'lowerLimit': '30.5', 'upperLimit': '35'}, {'value': '22', 'groupId': 'OG002', 'lowerLimit': '22', 'upperLimit': '35'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The reinforcement learning task is a monetary based learning tasks that included reward and punishment trails. The task presents multiple trials of stimuli where the participant chooses 1 of 2 stimuli presented at a time (one of which is associated with punishment represented by loss of monetary reward while the other is associated with gain of monetary reward). EEG is record during the task and signal is captured during the participants choose and the feedback received. Reported is the peak beta/gamma range response derived from the EEG during reward feedback. This measurement is used from the baseline assessment to inform the personalized beta-gamma range stimulation for the Personalized Beta-Gamma tACS group.', 'unitOfMeasure': 'peak frequency measured in hertz', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Reinforcement Learning Task', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '26', 'groupId': 'OG000', 'lowerLimit': '23.5', 'upperLimit': '29'}, {'value': '25.25', 'groupId': 'OG001', 'lowerLimit': '20', 'upperLimit': '30.875'}, {'value': '32', 'groupId': 'OG002', 'lowerLimit': '31', 'upperLimit': '32'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '25', 'groupId': 'OG000', 'lowerLimit': '21.5', 'upperLimit': '30.5'}, {'value': '28.75', 'groupId': 'OG001', 'lowerLimit': '28.5', 'upperLimit': '29.875'}, {'value': '27.5', 'groupId': 'OG002', 'lowerLimit': '22.5', 'upperLimit': '28.5'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The reinforcement learning task is a monetary based learning tasks that included reward and punishment trails. The task presents multiple trials of stimuli where the participant chooses 1 of 2 stimuli presented at a time (one of which is associated with punishment represented by loss of monetary reward while the other is associated with gain of monetary reward). EEG is record during the task and signal is captured during the participants choose and the feedback received. Reported is the peak beta/gamma range response derived from the EEG during reward feedback. This measurement is used from the baseline assessment to inform the personalized beta-gamma range stimulation for the Personalized Beta-Gamma tACS group.', 'unitOfMeasure': 'peak frequency measured in hertz', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data"}, {'type': 'SECONDARY', 'title': 'Reinforcement Learning Task', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '26', 'groupId': 'OG000', 'lowerLimit': '23.5', 'upperLimit': '29'}, {'value': '25.25', 'groupId': 'OG001', 'lowerLimit': '20', 'upperLimit': '30.875'}, {'value': '32', 'groupId': 'OG002', 'lowerLimit': '31', 'upperLimit': '32'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '25.5', 'groupId': 'OG000', 'lowerLimit': '23.7', 'upperLimit': '25.6'}, {'value': '29.25', 'groupId': 'OG001', 'lowerLimit': '28.625', 'upperLimit': '29.5'}, {'value': '27.5', 'groupId': 'OG002', 'lowerLimit': '27', 'upperLimit': '30'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The reinforcement learning task is a monetary based learning tasks that included reward and punishment trails. The task presents multiple trials of stimuli where the participant chooses 1 of 2 stimuli presented at a time (one of which is associated with punishment represented by loss of monetary reward while the other is associated with gain of monetary reward). EEG is record during the task and signal is captured during the participants choose and the feedback received. Reported is the peak beta/gamma range response derived from the EEG during reward feedback. This measurement is used from the baseline assessment to inform the personalized beta-gamma range stimulation for the Personalized Beta-Gamma tACS group.', 'unitOfMeasure': 'peak frequency measured in hertz', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used for imputing 5 individuals 3 Month data"}, {'type': 'SECONDARY', 'title': 'Social Functioning Scale (SFS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '161', 'groupId': 'OG000', 'lowerLimit': '133', 'upperLimit': '166'}, {'value': '125.5', 'groupId': 'OG001', 'lowerLimit': '120', 'upperLimit': '129.25'}, {'value': '142', 'groupId': 'OG002', 'lowerLimit': '129', 'upperLimit': '152'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '159', 'groupId': 'OG000', 'lowerLimit': '138.4', 'upperLimit': '159.4'}, {'value': '125.7', 'groupId': 'OG001', 'lowerLimit': '123.95', 'upperLimit': '128.05'}, {'value': '144', 'groupId': 'OG002', 'lowerLimit': '124.2', 'upperLimit': '145.4'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The SFS a self-report questionnaire initially designed for people diagnosed with Schizophrenia; consists of 79 items designed to reflect the social skills and performances in different areas of life. Subscores are summed together for a total score. Total score of SFS ranges between 0-223 points. Higher scores mean better social functioning.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'SECONDARY', 'title': 'Social Functioning Scale (SFS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '161', 'groupId': 'OG000', 'lowerLimit': '133', 'upperLimit': '166'}, {'value': '125.5', 'groupId': 'OG001', 'lowerLimit': '120', 'upperLimit': '129.25'}, {'value': '142', 'groupId': 'OG002', 'lowerLimit': '129', 'upperLimit': '152'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '160', 'groupId': 'OG000', 'lowerLimit': '133', 'upperLimit': '171'}, {'value': '130.5', 'groupId': 'OG001', 'lowerLimit': '122', 'upperLimit': '139'}, {'value': '134', 'groupId': 'OG002', 'lowerLimit': '131', 'upperLimit': '145'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The SFS a self-report questionnaire initially designed for people diagnosed with Schizophrenia; consists of 79 items designed to reflect the social skills and performances in different areas of life. Subscores are summed together for a total score. Total score of SFS ranges between 0-223 points. Higher scores mean better social functioning.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Social Functioning Scale (SFS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '161', 'groupId': 'OG000', 'lowerLimit': '133', 'upperLimit': '166'}, {'value': '125.5', 'groupId': 'OG001', 'lowerLimit': '120', 'upperLimit': '129.25'}, {'value': '142', 'groupId': 'OG002', 'lowerLimit': '129', 'upperLimit': '152'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '156.6', 'groupId': 'OG000', 'lowerLimit': '134', 'upperLimit': '164'}, {'value': '127.2', 'groupId': 'OG001', 'lowerLimit': '116.75', 'upperLimit': '135.75'}, {'value': '150', 'groupId': 'OG002', 'lowerLimit': '135', 'upperLimit': '170'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The SFS a self-report questionnaire initially designed for people diagnosed with Schizophrenia; consists of 79 items designed to reflect the social skills and performances in different areas of life. Subscores are summed together for a total score. Total score of SFS ranges between 0-223 points. Higher scores mean better social functioning.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Global Assessment of Functioning (GAF)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '65', 'groupId': 'OG000', 'lowerLimit': '60', 'upperLimit': '65'}, {'value': '46', 'groupId': 'OG001', 'lowerLimit': '40.75', 'upperLimit': '53.25'}, {'value': '59', 'groupId': 'OG002', 'lowerLimit': '51', 'upperLimit': '60'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '61', 'groupId': 'OG000', 'lowerLimit': '61', 'upperLimit': '61'}, {'value': '50.5', 'groupId': 'OG001', 'lowerLimit': '48.75', 'upperLimit': '52'}, {'value': '60', 'groupId': 'OG002', 'lowerLimit': '57', 'upperLimit': '60'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The GAF measures how symptoms affect individuals day-to-day life; scored from 0 to 100', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Global Assessment of Functioning (GAF)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '65', 'groupId': 'OG000', 'lowerLimit': '60', 'upperLimit': '65'}, {'value': '46', 'groupId': 'OG001', 'lowerLimit': '40.75', 'upperLimit': '53.25'}, {'value': '59', 'groupId': 'OG002', 'lowerLimit': '51', 'upperLimit': '60'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '67', 'groupId': 'OG000', 'lowerLimit': '65', 'upperLimit': '70'}, {'value': '51', 'groupId': 'OG001', 'lowerLimit': '50.75', 'upperLimit': '51.25'}, {'value': '55', 'groupId': 'OG002', 'lowerLimit': '55', 'upperLimit': '60'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The GAF measures how symptoms affect individuals day-to-day life; scored from 0 to 100', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data"}, {'type': 'SECONDARY', 'title': 'Global Assessment of Functioning (GAF)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '65', 'groupId': 'OG000', 'lowerLimit': '60', 'upperLimit': '65'}, {'value': '46', 'groupId': 'OG001', 'lowerLimit': '40.75', 'upperLimit': '53.25'}, {'value': '59', 'groupId': 'OG002', 'lowerLimit': '51', 'upperLimit': '60'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '65', 'groupId': 'OG000', 'lowerLimit': '65', 'upperLimit': '67'}, {'value': '52.1', 'groupId': 'OG001', 'lowerLimit': '50.55', 'upperLimit': '53.65'}, {'value': '61', 'groupId': 'OG002', 'lowerLimit': '60', 'upperLimit': '61'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The GAF measures how symptoms affect individuals day-to-day life; scored from 0 to 100', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data"}, {'type': 'SECONDARY', 'title': 'Positive and Negative Syndrome Scale (PANSS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '49', 'groupId': 'OG000', 'lowerLimit': '49', 'upperLimit': '55'}, {'value': '71', 'groupId': 'OG001', 'lowerLimit': '60.75', 'upperLimit': '78.5'}, {'value': '68', 'groupId': 'OG002', 'lowerLimit': '61', 'upperLimit': '69'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '52', 'groupId': 'OG000', 'lowerLimit': '48', 'upperLimit': '56'}, {'value': '74.5', 'groupId': 'OG001', 'lowerLimit': '69', 'upperLimit': '77'}, {'value': '56', 'groupId': 'OG002', 'lowerLimit': '49', 'upperLimit': '68'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': '30 items included in the PANSS measuring positive, negative and general symptoms; 7 related to positive symptoms, 7 for negative symptoms, and 16 for general psychopathology Scale. Ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale. Scores summed for Total Score on scale (30 to 210). Higher scores mean worse clinical symptoms. Total score reported.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'SECONDARY', 'title': 'Positive and Negative Syndrome Scale (PANSS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '49', 'groupId': 'OG000', 'lowerLimit': '49', 'upperLimit': '55'}, {'value': '71', 'groupId': 'OG001', 'lowerLimit': '60.75', 'upperLimit': '78.5'}, {'value': '68', 'groupId': 'OG002', 'lowerLimit': '61', 'upperLimit': '69'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '50', 'groupId': 'OG000', 'lowerLimit': '42', 'upperLimit': '54'}, {'value': '75', 'groupId': 'OG001', 'lowerLimit': '73.5', 'upperLimit': '78'}, {'value': '55', 'groupId': 'OG002', 'lowerLimit': '52', 'upperLimit': '55'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': '30 items included in the PANSS measuring positive, negative and general symptoms; 7 related to positive symptoms, 7 for negative symptoms, and 16 for general psychopathology Scale. Ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale. Scores summed for Total Score on scale (30 to 210). Higher scores mean worse clinical symptoms. Total score reported.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individuals 1 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Positive and Negative Syndrome Scale (PANSS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '49', 'groupId': 'OG000', 'lowerLimit': '49', 'upperLimit': '55'}, {'value': '71', 'groupId': 'OG001', 'lowerLimit': '60.75', 'upperLimit': '78.5'}, {'value': '68', 'groupId': 'OG002', 'lowerLimit': '61', 'upperLimit': '69'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '54.8', 'groupId': 'OG000', 'lowerLimit': '48.6', 'upperLimit': '55'}, {'value': '73.3', 'groupId': 'OG001', 'lowerLimit': '72.25', 'upperLimit': '77.45'}, {'value': '52', 'groupId': 'OG002', 'lowerLimit': '51', 'upperLimit': '54.6'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': '30 items included in the PANSS measuring positive, negative and general symptoms; 7 related to positive symptoms, 7 for negative symptoms, and 16 for general psychopathology Scale. Ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale. Scores summed for Total Score on scale (30 to 210). Higher scores mean worse clinical symptoms. Total score reported.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Montgomery-Åsberg Depression Rating Scale (MADRS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '8', 'groupId': 'OG000', 'lowerLimit': '8', 'upperLimit': '11'}, {'value': '17.5', 'groupId': 'OG001', 'lowerLimit': '11.5', 'upperLimit': '23.75'}, {'value': '10', 'groupId': 'OG002', 'lowerLimit': '8', 'upperLimit': '29'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '7', 'groupId': 'OG000', 'lowerLimit': '6', 'upperLimit': '13'}, {'value': '14.5', 'groupId': 'OG001', 'lowerLimit': '12', 'upperLimit': '16'}, {'value': '7', 'groupId': 'OG002', 'lowerLimit': '7', 'upperLimit': '10'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The MADRS is designed to measure depression and severity of symptoms; 0 to 6 indicates no depression, 7 to 19 indicates mild depression, 20 to 34 indicates moderate depression, 35 and greater indicates severe depression. Total score reported (0 to 60).', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'SECONDARY', 'title': 'Montgomery-Åsberg Depression Rating Scale (MADRS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '8', 'groupId': 'OG000', 'lowerLimit': '8', 'upperLimit': '11'}, {'value': '17.5', 'groupId': 'OG001', 'lowerLimit': '11.5', 'upperLimit': '23.75'}, {'value': '10', 'groupId': 'OG002', 'lowerLimit': '8', 'upperLimit': '29'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '7', 'groupId': 'OG000', 'lowerLimit': '6', 'upperLimit': '13'}, {'value': '16', 'groupId': 'OG001', 'lowerLimit': '15.75', 'upperLimit': '17.5'}, {'value': '8', 'groupId': 'OG002', 'lowerLimit': '5', 'upperLimit': '8'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The MADRS is designed to measure depression and severity of symptoms; 0 to 6 indicates no depression, 7 to 19 indicates mild depression, 20 to 34 indicates moderate depression, 35 and greater indicates severe depression. Total score reported (0 to 60).', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Montgomery-Åsberg Depression Rating Scale (MADRS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '8', 'groupId': 'OG000', 'lowerLimit': '8', 'upperLimit': '11'}, {'value': '17.5', 'groupId': 'OG001', 'lowerLimit': '11.5', 'upperLimit': '23.75'}, {'value': '10', 'groupId': 'OG002', 'lowerLimit': '8', 'upperLimit': '29'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '8', 'groupId': 'OG000', 'lowerLimit': '5', 'upperLimit': '8'}, {'value': '19.2', 'groupId': 'OG001', 'lowerLimit': '16.25', 'upperLimit': '26'}, {'value': '6', 'groupId': 'OG002', 'lowerLimit': '6', 'upperLimit': '9'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The MADRS is designed to measure depression and severity of symptoms; 0 to 6 indicates no depression, 7 to 19 indicates mild depression, 20 to 34 indicates moderate depression, 35 and greater indicates severe depression. Total score reported (0 to 60).', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Barratt Impulsiveness Scale-11 (BIS-11)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '37', 'groupId': 'OG000', 'lowerLimit': '36', 'upperLimit': '41'}, {'value': '35', 'groupId': 'OG001', 'lowerLimit': '29', 'upperLimit': '41.75'}, {'value': '42', 'groupId': 'OG002', 'lowerLimit': '40', 'upperLimit': '42'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '38', 'groupId': 'OG000', 'lowerLimit': '36', 'upperLimit': '41'}, {'value': '38.5', 'groupId': 'OG001', 'lowerLimit': '35.5', 'upperLimit': '43'}, {'value': '41', 'groupId': 'OG002', 'lowerLimit': '32', 'upperLimit': '44'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The BIS-11 is designed to assess the personality/behavioral impulsiveness. The BIS-11 has 30 items and is scored appropriately. Scored to yield a total score, three second-order factors, and six first-order factors. Each question has a 4-point scale ranging from 1 (rarely/never) to 4 (almost always/always). Higher scores mean more impulsive behavior. Total score reported (30-120).', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'SECONDARY', 'title': 'Barratt Impulsiveness Scale-11 (BIS-11)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '37', 'groupId': 'OG000', 'lowerLimit': '36', 'upperLimit': '41'}, {'value': '35', 'groupId': 'OG001', 'lowerLimit': '29', 'upperLimit': '41.75'}, {'value': '42', 'groupId': 'OG002', 'lowerLimit': '40', 'upperLimit': '42'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '35', 'groupId': 'OG000', 'lowerLimit': '34', 'upperLimit': '40'}, {'value': '38', 'groupId': 'OG001', 'lowerLimit': '27.5', 'upperLimit': '47.25'}, {'value': '40', 'groupId': 'OG002', 'lowerLimit': '36', 'upperLimit': '42'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The BIS-11 is designed to assess the personality/behavioral impulsiveness. The BIS-11 has 30 items and is scored appropriately. Scored to yield a total score, three second-order factors, and six first-order factors. Each question has a 4-point scale ranging from 1 (rarely/never) to 4 (almost always/always). Higher scores mean more impulsive behavior. Total score reported (30-120).', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Barratt Impulsiveness Scale-11 (BIS-11)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '37', 'groupId': 'OG000', 'lowerLimit': '36', 'upperLimit': '41'}, {'value': '35', 'groupId': 'OG001', 'lowerLimit': '29', 'upperLimit': '41.75'}, {'value': '42', 'groupId': 'OG002', 'lowerLimit': '40', 'upperLimit': '42'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '35.2', 'groupId': 'OG000', 'lowerLimit': '31', 'upperLimit': '35.6'}, {'value': '38', 'groupId': 'OG001', 'lowerLimit': '37', 'upperLimit': '38.15'}, {'value': '36', 'groupId': 'OG002', 'lowerLimit': '35.2', 'upperLimit': '36'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The BIS-11 is designed to assess the personality/behavioral impulsiveness. The BIS-11 has 30 items and is scored appropriately. Scored to yield a total score, three second-order factors, and six first-order factors. Each question has a 4-point scale ranging from 1 (rarely/never) to 4 (almost always/always). Higher scores mean more impulsive behavior. Total score reported (30-120).', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Brief Assessment of Cognition (BACS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '0.44', 'groupId': 'OG000', 'lowerLimit': '-0.79', 'upperLimit': '0.71'}, {'value': '-0.66', 'groupId': 'OG001', 'lowerLimit': '-1.065', 'upperLimit': '0.0025'}, {'value': '0.25', 'groupId': 'OG002', 'lowerLimit': '-0.35', 'upperLimit': '0.76'}]}]}, {'title': 'Day 5', 'categories': [{'measurements': [{'value': '0.43', 'groupId': 'OG000', 'lowerLimit': '-0.26', 'upperLimit': '0.71'}, {'value': '-0.74', 'groupId': 'OG001', 'lowerLimit': '-0.97', 'upperLimit': '-0.3525'}, {'value': '0.3', 'groupId': 'OG002', 'lowerLimit': '0.21', 'upperLimit': '0.77'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The BACS is designed to assess several domains of cognition; Verbal Memory; Processing Speed; Working Memory; Verbal Fluency; Motor Function; Executive Functioning. Higher scores indicate better cognitive functioning. Total score reported after being transformed into z score based on normative scoring provide by test makers.', 'unitOfMeasure': 'score on a test', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Total score reported.'}, {'type': 'SECONDARY', 'title': 'Brief Assessment of Cognition (BACS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '0.44', 'groupId': 'OG000', 'lowerLimit': '-0.79', 'upperLimit': '0.71'}, {'value': '-0.66', 'groupId': 'OG001', 'lowerLimit': '-1.065', 'upperLimit': '0.0025'}, {'value': '0.25', 'groupId': 'OG002', 'lowerLimit': '-0.35', 'upperLimit': '0.76'}]}]}, {'title': '1 Month', 'categories': [{'measurements': [{'value': '0.01', 'groupId': 'OG000', 'lowerLimit': '-0.07', 'upperLimit': '0.51'}, {'value': '-1.26', 'groupId': 'OG001', 'lowerLimit': '-1.3975', 'upperLimit': '-0.9485'}, {'value': '0.74', 'groupId': 'OG002', 'lowerLimit': '-0.09', 'upperLimit': '0.9'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The BACS is designed to assess several domains of cognition; Verbal Memory; Processing Speed; Working Memory; Verbal Fluency; Motor Function; Executive Functioning. Higher scores indicate better cognitive functioning. Total score reported after being transformed into z score based on normative scoring provide by test makers.', 'unitOfMeasure': 'score on a test', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 1 individual's 1 Month data. Total score reported."}, {'type': 'SECONDARY', 'title': 'Brief Assessment of Cognition (BACS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'OG000'}, {'value': '4', 'groupId': 'OG001'}, {'value': '5', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'OG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'OG002', 'title': 'Personalized Beta-Gamma tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'classes': [{'title': 'Baseline', 'categories': [{'measurements': [{'value': '0.44', 'groupId': 'OG000', 'lowerLimit': '-0.79', 'upperLimit': '0.71'}, {'value': '-0.66', 'groupId': 'OG001', 'lowerLimit': '-1.065', 'upperLimit': '0.0025'}, {'value': '0.25', 'groupId': 'OG002', 'lowerLimit': '-0.35', 'upperLimit': '0.76'}]}]}, {'title': '3 Month', 'categories': [{'measurements': [{'value': '0.18', 'groupId': 'OG000', 'lowerLimit': '-0.146', 'upperLimit': '0.44'}, {'value': '-0.602', 'groupId': 'OG001', 'lowerLimit': '-0.7055', 'upperLimit': '-0.456'}, {'value': '0.97', 'groupId': 'OG002', 'lowerLimit': '0.384', 'upperLimit': '1.58'}]}]}], 'paramType': 'MEDIAN', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The BACS is designed to assess several domains of cognition; Verbal Memory; Processing Speed; Working Memory; Verbal Fluency; Motor Function; Executive Functioning. Higher scores indicate better cognitive functioning. Total score reported after being transformed into z score based on normative scoring provide by test makers.', 'unitOfMeasure': 'score on a test', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': "'Mice' R package used to impute 5 individuals 3 Month data. Total score reported."}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'FG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: 10hz HD-tACS stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment.'}, {'id': 'FG002', 'title': 'Personalized Beta-Gamma HD-tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Beta-Gamma Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '5'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '5'}]}, {'type': 'Day 5', 'achievements': [{'groupId': 'FG000', 'numSubjects': '5'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '5'}]}, {'type': '1 Month', 'achievements': [{'groupId': 'FG000', 'numSubjects': '5'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '5'}]}, {'type': '3 Month', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '2'}, {'groupId': 'FG002', 'numSubjects': '4'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '2'}, {'groupId': 'FG002', 'numSubjects': '4'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '2'}, {'groupId': 'FG001', 'numSubjects': '2'}, {'groupId': 'FG002', 'numSubjects': '1'}]}]}], 'preAssignmentDetails': 'Individuals were randomized into 1 of 3 protocol arms (tDCS, 10hz tACS or personalized tACS)'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '5', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}, {'value': '14', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Electrical-Current Stimulation: Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment'}, {'id': 'BG001', 'title': 'HD-tACS (Alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of passive sham control to the OFC for a 30 second ramped up and down at the beginning and end of the 20 min period for 5 days (10 total sessions).\n\nHigh-Definition Transcranial Alternate-Current Stimulation: Active-control stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment'}, {'id': 'BG002', 'title': 'Personalized Beta-Gamma HD-tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).\n\nHigh-Definition Personalized Transcranial (Beta-Gamma) Electrical Stimulation: Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}, {'value': '14', 'groupId': 'BG003'}]}, {'title': '>=65 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '35.2', 'spread': '10.402', 'groupId': 'BG000'}, {'value': '38.25', 'spread': '12.685', 'groupId': 'BG001'}, {'value': '30.2', 'spread': '11.476', 'groupId': 'BG002'}, {'value': '34.29', 'spread': '11.07', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}, {'value': '7', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '7', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '12', 'groupId': 'BG003'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}, {'value': '14', 'groupId': 'BG003'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}, {'title': 'Altman Self-Rating Mania Scale (ASRM)', 'classes': [{'categories': [{'measurements': [{'value': '5', 'groupId': 'BG000', 'lowerLimit': '4', 'upperLimit': '5'}, {'value': '7', 'groupId': 'BG001', 'lowerLimit': '3.75', 'upperLimit': '9.5'}, {'value': '3', 'groupId': 'BG002', 'lowerLimit': '3', 'upperLimit': '5'}, {'value': '5', 'groupId': 'BG003', 'lowerLimit': '3', 'upperLimit': '7.25'}]}]}], 'paramType': 'MEDIAN', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'INTER_QUARTILE_RANGE'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2025-06-23', 'size': 543760, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2025-06-24T12:04', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 14}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2022-12-16', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-10', 'completionDateStruct': {'date': '2025-06-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-10-22', 'studyFirstSubmitDate': '2022-06-17', 'resultsFirstSubmitDate': '2025-06-24', 'studyFirstSubmitQcDate': '2022-06-30', 'lastUpdatePostDateStruct': {'date': '2025-11-06', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2025-10-22', 'studyFirstPostDateStruct': {'date': '2022-07-06', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2025-11-06', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2025-06-01', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Young Mania Rating Scale (YMRS)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'Measuring total Mania scores; 11 items used to access severity of mania (total score 0-60); higher scores represent higher severity of symptoms'}, {'measure': 'Young Mania Rating Scale (YMRS)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'Measuring total Mania scores; 11 items used to access severity of mania (total score 0-60); higher scores represent higher severity of symptoms'}, {'measure': 'Young Mania Rating Scale (YMRS)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'Measuring total Mania scores; 11 items used to access severity of mania (total score 0-60); higher scores represent higher severity of symptoms'}, {'measure': 'Altman Self-Rating Mania Scale (ASRM)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.'}, {'measure': 'Altman Self-Rating Mania Scale (ASRM)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.'}, {'measure': 'Altman Self-Rating Mania Scale (ASRM)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The ASRM is a 5-item self rating mania scale, assessing the presence and severity of manic symptoms. The scores for all five items are added together, resulting in a total score that can range from 0 to 20. A score of 6 or higher indicates a high probability of a manic or hypomanic condition.'}, {'measure': 'Psychiatric Hospitalizations for Mania Post Study Entry', 'timeFrame': 'Cumulative count of hospitalizations for mania from baseline to end of study', 'description': 'Psychiatric hospitalization for mania. Count of hospitalizations from baseline to end of study period assessed at Day 5, 1 Month \\& 3 Month.'}], 'secondaryOutcomes': [{'measure': 'Balloon Analogue Risk Task (BART)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The BART is a computerized task the measures risk-taking behavior. Participants are tasked with inflating the virtual balloon. The number of pumps a participant chooses to make on each balloon is used as a measure of their risk-taking behavior. More pumps generally indicate a higher tolerance for risk. The balloon bursts at a given point if the participant overfills it. Number of popped balloons reported for a given trial.'}, {'measure': 'Balloon Analogue Risk Task (BART)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The BART is a computerized task the measures risk-taking behavior. Participants are tasked with inflating the virtual balloon. The number of pumps a participant chooses to make on each balloon is used as a measure of their risk-taking behavior. More pumps generally indicate a higher tolerance for risk. The balloon bursts at a given point if the participant overfills it. Number of popped balloons reported for a given trial.'}, {'measure': 'Balloon Analogue Risk Task (BART)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The BART is a computerized task the measures risk-taking behavior. Participants are tasked with inflating the virtual balloon. The number of pumps a participant chooses to make on each balloon is used as a measure of their risk-taking behavior. More pumps generally indicate a higher tolerance for risk. The balloon bursts at a given point if the participant overfills it. Number of popped balloons reported for a given trial.'}, {'measure': 'The Go/No Go Task', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The Go/No Go Task is a computerized task that measures impulsiveness. Participants presented with Go (to respond) and no Go (when not to respond) instructions. Two trials are performed. The first trial consist of two distinct auditory stimuli (both Go stimuli) where the participant is asked to respond with a different number of mouse clicks to the stimuli respectively. The second trial, has a no Go stimuli (where the participant is suppose to withhold a response) and a go stimuli. Reaction time for correct trials only for the entire task are reported in milliseconds.'}, {'measure': 'The Go/No Go Task', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The Go/No Go Task is a computerized task that measures impulsiveness. Participants presented with Go (to respond) and no Go (when not to respond) instructions. Two trials are performed. The first trial consist of two distinct auditory stimuli (both Go stimuli) where the participant is asked to respond with a different number of mouse clicks to the stimuli respectively. The second trial, has a no Go stimuli (where the participant is suppose to withhold a response) and a go stimuli. Reaction time for correct trials only for the entire task are reported in milliseconds.'}, {'measure': 'The Go/No Go Task', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The Go/No Go Task is a computerized task that measures impulsiveness. Participants presented with Go (to respond) and no Go (when not to respond) instructions. Two trials are performed. The first trial consist of two distinct auditory stimuli (both Go stimuli) where the participant is asked to respond with a different number of mouse clicks to the stimuli respectively. The second trial, has a no Go stimuli (where the participant is suppose to withhold a response) and a go stimuli. Reaction time for correct trials only for the entire task are reported in milliseconds.'}, {'measure': 'Electroencephalography (EEG) Resting State', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'Measuring neural activity at rest consisting of 5 minutes of eyes-open resting-state EEG (rsEEG) was recorded. Fast Fourier transformations were conducted on data, resulting in 4 frequency bands: delta/theta, alpha, beta, and gamma.'}, {'measure': 'Electroencephalography (EEG) Resting State', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'Measuring neural activity at rest consisting of 5 minutes of eyes-open resting-state EEG (rsEEG) was recorded. Fast Fourier transformations were conducted on data, resulting in 4 frequency bands: delta/theta, alpha, beta, and gamma.'}, {'measure': 'Electroencephalography (EEG) Resting State', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'Measuring neural activity at rest consisting of 5 minutes of eyes-open resting-state EEG (rsEEG) was recorded. Fast Fourier transformations were conducted on data, resulting in 4 frequency bands: delta/theta, alpha, beta, and gamma.'}, {'measure': 'Reinforcement Learning Task', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The reinforcement learning task is a monetary based learning tasks that included reward and punishment trails. The task presents multiple trials of stimuli where the participant chooses 1 of 2 stimuli presented at a time (one of which is associated with punishment represented by loss of monetary reward while the other is associated with gain of monetary reward). EEG is record during the task and signal is captured during the participants choose and the feedback received. Reported is the peak beta/gamma range response derived from the EEG during reward feedback. This measurement is used from the baseline assessment to inform the personalized beta-gamma range stimulation for the Personalized Beta-Gamma tACS group.'}, {'measure': 'Reinforcement Learning Task', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The reinforcement learning task is a monetary based learning tasks that included reward and punishment trails. The task presents multiple trials of stimuli where the participant chooses 1 of 2 stimuli presented at a time (one of which is associated with punishment represented by loss of monetary reward while the other is associated with gain of monetary reward). EEG is record during the task and signal is captured during the participants choose and the feedback received. Reported is the peak beta/gamma range response derived from the EEG during reward feedback. This measurement is used from the baseline assessment to inform the personalized beta-gamma range stimulation for the Personalized Beta-Gamma tACS group.'}, {'measure': 'Reinforcement Learning Task', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The reinforcement learning task is a monetary based learning tasks that included reward and punishment trails. The task presents multiple trials of stimuli where the participant chooses 1 of 2 stimuli presented at a time (one of which is associated with punishment represented by loss of monetary reward while the other is associated with gain of monetary reward). EEG is record during the task and signal is captured during the participants choose and the feedback received. Reported is the peak beta/gamma range response derived from the EEG during reward feedback. This measurement is used from the baseline assessment to inform the personalized beta-gamma range stimulation for the Personalized Beta-Gamma tACS group.'}, {'measure': 'Social Functioning Scale (SFS)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The SFS a self-report questionnaire initially designed for people diagnosed with Schizophrenia; consists of 79 items designed to reflect the social skills and performances in different areas of life. Subscores are summed together for a total score. Total score of SFS ranges between 0-223 points. Higher scores mean better social functioning.'}, {'measure': 'Social Functioning Scale (SFS)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The SFS a self-report questionnaire initially designed for people diagnosed with Schizophrenia; consists of 79 items designed to reflect the social skills and performances in different areas of life. Subscores are summed together for a total score. Total score of SFS ranges between 0-223 points. Higher scores mean better social functioning.'}, {'measure': 'Social Functioning Scale (SFS)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The SFS a self-report questionnaire initially designed for people diagnosed with Schizophrenia; consists of 79 items designed to reflect the social skills and performances in different areas of life. Subscores are summed together for a total score. Total score of SFS ranges between 0-223 points. Higher scores mean better social functioning.'}, {'measure': 'Global Assessment of Functioning (GAF)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The GAF measures how symptoms affect individuals day-to-day life; scored from 0 to 100'}, {'measure': 'Global Assessment of Functioning (GAF)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The GAF measures how symptoms affect individuals day-to-day life; scored from 0 to 100'}, {'measure': 'Global Assessment of Functioning (GAF)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The GAF measures how symptoms affect individuals day-to-day life; scored from 0 to 100'}, {'measure': 'Positive and Negative Syndrome Scale (PANSS)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': '30 items included in the PANSS measuring positive, negative and general symptoms; 7 related to positive symptoms, 7 for negative symptoms, and 16 for general psychopathology Scale. Ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale. Scores summed for Total Score on scale (30 to 210). Higher scores mean worse clinical symptoms. Total score reported.'}, {'measure': 'Positive and Negative Syndrome Scale (PANSS)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': '30 items included in the PANSS measuring positive, negative and general symptoms; 7 related to positive symptoms, 7 for negative symptoms, and 16 for general psychopathology Scale. Ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale. Scores summed for Total Score on scale (30 to 210). Higher scores mean worse clinical symptoms. Total score reported.'}, {'measure': 'Positive and Negative Syndrome Scale (PANSS)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': '30 items included in the PANSS measuring positive, negative and general symptoms; 7 related to positive symptoms, 7 for negative symptoms, and 16 for general psychopathology Scale. Ranges are 7 to 49 for the Positive and Negative Scales, and 16 to 112 for the General Psychopathology Scale. Scores summed for Total Score on scale (30 to 210). Higher scores mean worse clinical symptoms. Total score reported.'}, {'measure': 'Montgomery-Åsberg Depression Rating Scale (MADRS)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The MADRS is designed to measure depression and severity of symptoms; 0 to 6 indicates no depression, 7 to 19 indicates mild depression, 20 to 34 indicates moderate depression, 35 and greater indicates severe depression. Total score reported (0 to 60).'}, {'measure': 'Montgomery-Åsberg Depression Rating Scale (MADRS)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The MADRS is designed to measure depression and severity of symptoms; 0 to 6 indicates no depression, 7 to 19 indicates mild depression, 20 to 34 indicates moderate depression, 35 and greater indicates severe depression. Total score reported (0 to 60).'}, {'measure': 'Montgomery-Åsberg Depression Rating Scale (MADRS)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The MADRS is designed to measure depression and severity of symptoms; 0 to 6 indicates no depression, 7 to 19 indicates mild depression, 20 to 34 indicates moderate depression, 35 and greater indicates severe depression. Total score reported (0 to 60).'}, {'measure': 'Barratt Impulsiveness Scale-11 (BIS-11)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The BIS-11 is designed to assess the personality/behavioral impulsiveness. The BIS-11 has 30 items and is scored appropriately. Scored to yield a total score, three second-order factors, and six first-order factors. Each question has a 4-point scale ranging from 1 (rarely/never) to 4 (almost always/always). Higher scores mean more impulsive behavior. Total score reported (30-120).'}, {'measure': 'Barratt Impulsiveness Scale-11 (BIS-11)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The BIS-11 is designed to assess the personality/behavioral impulsiveness. The BIS-11 has 30 items and is scored appropriately. Scored to yield a total score, three second-order factors, and six first-order factors. Each question has a 4-point scale ranging from 1 (rarely/never) to 4 (almost always/always). Higher scores mean more impulsive behavior. Total score reported (30-120).'}, {'measure': 'Barratt Impulsiveness Scale-11 (BIS-11)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The BIS-11 is designed to assess the personality/behavioral impulsiveness. The BIS-11 has 30 items and is scored appropriately. Scored to yield a total score, three second-order factors, and six first-order factors. Each question has a 4-point scale ranging from 1 (rarely/never) to 4 (almost always/always). Higher scores mean more impulsive behavior. Total score reported (30-120).'}, {'measure': 'Brief Assessment of Cognition (BACS)', 'timeFrame': 'Change from baseline to 5 Day follow-up', 'description': 'The BACS is designed to assess several domains of cognition; Verbal Memory; Processing Speed; Working Memory; Verbal Fluency; Motor Function; Executive Functioning. Higher scores indicate better cognitive functioning. Total score reported after being transformed into z score based on normative scoring provide by test makers.'}, {'measure': 'Brief Assessment of Cognition (BACS)', 'timeFrame': 'Change from baseline to 1-month follow-up', 'description': 'The BACS is designed to assess several domains of cognition; Verbal Memory; Processing Speed; Working Memory; Verbal Fluency; Motor Function; Executive Functioning. Higher scores indicate better cognitive functioning. Total score reported after being transformed into z score based on normative scoring provide by test makers.'}, {'measure': 'Brief Assessment of Cognition (BACS)', 'timeFrame': 'Change from baseline to 3-month follow-up', 'description': 'The BACS is designed to assess several domains of cognition; Verbal Memory; Processing Speed; Working Memory; Verbal Fluency; Motor Function; Executive Functioning. Higher scores indicate better cognitive functioning. Total score reported after being transformed into z score based on normative scoring provide by test makers.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isUnapprovedDevice': True, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'keywords': ['Brain Stimulation', 'Mania'], 'conditions': ['Bipolar Disorder', 'Schizo Affective Disorder']}, 'descriptionModule': {'briefSummary': 'Mania is a core symptom of bipolar disorder involving periods of euphoria. Decreased inhibitory control, increased risk-taking behaviors, and aberrant reward processing are some of the more recognized symptoms of bipolar disorder and are included in the diagnostic criteria for mania. Current drug therapies for mania are frequently intolerable, ineffective, and carry significant risk for side effects. Presently there are no neurobiologically informed therapies that treat or prevent mania. However, using a newly validated technique termed lesion network mapping, researchers demonstrated that focal brain lesions having a causal role in the development of mania in people without a psychiatric history can occur in different brain locations, such as the right orbitofrontal cortex (OFC), right dorsolateral prefrontal cortex (DLPFC), and right inferior temporal gyrus (ITG). This lesion network evidence converges with existing cross-sectional and longitudinal observations in bipolar mania that have identified specific disruptions in network communication between the amygdala and ventro-lateral prefrontal cortex. The OFC is associated with inhibitory control, risk-taking behavior, and reward learning which are major components of bipolar mania. Thus, the association between OFC with mania symptoms, inhibitory control, risk-taking behavior, and reward processing suggests that this region could be targeted using non-invasive brain stimulation.', 'detailedDescription': "Mania is a core symptom of bipolar disorder involving periods of euphoria, delusions, and overactivity. Mania occurs in multiple medical and psychiatric illnesses and can be refractory to existing treatments. Two recent studies using brain lesion mapping of psychiatrically healthy individuals presenting with mania identified causal locations in the brain, including the orbitofrontal cortex (OFC), dorsolateral prefrontal cortex (DLPFC), and inferior temporal gyrus (ITG), that were associated with new onset mania symptoms. Moreover, these identified brain regions have also been implicated in bipolar mania with specific disruption in network communication between the amygdala and ventro-lateral prefrontal cortex. The OFC is of particular interest because it is a brain structure that is associated with inhibitory control, risk-taking behavior and reward, which are major behavioral components of mania. Thus, the association between OFC with mania symptoms, inhibitory control, risk-taking behavior and reward suggests that this region could be targeted using noninvasive brain stimulation. While several studies have non-invasively targeted the DLPFC for mania, no study to date has non-invasively stimulated the OFC with either transcranial direct current stimulation (tDCS) or alternating current (tACS) in bipolar disorder and examined its effects on mania, inhibitory control, or risk-taking behavior. However, a study in healthy volunteers showed that cathodal stimulation to the OFC enhanced inhibitory control and decreased risk-taking behavior. Recently, researches have showed that targeting the OFC with tACS, personalized to the individual's intrinsic beta-gamma frequency of the reward network, that individuals showed rapid, reversible, frequency-specific modulation of reward-guided choice behavior and learning. Here we aim to answer the question of whether noninvasive brain stimulation when optimally targeted and personalized to an individual's beta-gamma frequency to the OFC can improve emotional cognitive processing and mania symptoms compared to tDCS or sham targeting. The knowledge gained from this study will provide a marker for clinical response and allow personalized treatment for patients with bipolar disorder."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Aged 18-65 years of age\n2. Proficient in English\n3. Able to give informed consent\n4. Meet diagnostic criteria for bipolar disorder or schizoaffective disorder, bipolar type as verified by the SCID\n5. History of mania ( \\>1 lifetime episode)\n6. Experiencing mild to moderate symptoms of mania\n7. No changes to mood stabilizing medications for a period of 2 weeks prior to participation\n8. Has not recently participated in tES/TMS treatments\n\nExclusion Criteria:\n\n1. Substance abuse or dependence (w/in past 6 months)\n2. Those who are pregnant/breastfeeding\n3. History of head injury with \\> 15 minutes of loss of consciousness/mal sequelae\n4. DSM-V intellectual disability\n5. Having a non-removable ferromagnetic metal within the body (particularly in the head)\n6. History of seizures'}, 'identificationModule': {'nctId': 'NCT05445466', 'briefTitle': 'Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical Stimulation', 'organization': {'class': 'OTHER', 'fullName': 'Beth Israel Deaconess Medical Center'}, 'officialTitle': 'Causal Lesion Network Guided Treatment of Bipolar Mania With Transcranial Electrical Stimulation', 'orgStudyIdInfo': {'id': '2022P000295'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'HD-tDCS', 'description': 'HD-tDCS; Two, twenty-minute sessions of tDCS to the OFC for 5 days (10 total sessions)', 'interventionNames': ['Device: High-Definition Transcranial Electrical-Current Stimulation']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'HD-tACS (alpha, 10 Hz)', 'description': '10 Hz HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).', 'interventionNames': ['Device: High-Definition Transcranial Alternate-Current Stimulation']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Personalized Beta-Gamma HD-tACS', 'description': 'Personalized HD-tACS; Two, twenty-minute sessions of tACS to the OFC for 5 days (10 total sessions).', 'interventionNames': ['Device: High-Definition Personalized Beta-Gamma Electrical Stimulation']}], 'interventions': [{'name': 'High-Definition Transcranial Electrical-Current Stimulation', 'type': 'DEVICE', 'otherNames': ['Soterix Medical', 'GTEN 200'], 'description': 'Non-frequency dependent transcranial electrical stimulation condition for 5 days of twice a day treatment', 'armGroupLabels': ['HD-tDCS']}, {'name': 'High-Definition Transcranial Alternate-Current Stimulation', 'type': 'DEVICE', 'otherNames': ['Soterix Medical', 'GTEN 200'], 'description': 'Active-control stimulation condition will target alpha (10 Hz) for 5 days of twice a day treatment', 'armGroupLabels': ['HD-tACS (alpha, 10 Hz)']}, {'name': 'High-Definition Personalized Beta-Gamma Electrical Stimulation', 'type': 'DEVICE', 'otherNames': ['Soterix Medical', 'GTEN 200'], 'description': 'Personalized beta-gamma electrical stimulation for 5 days of twice a day treatment', 'armGroupLabels': ['Personalized Beta-Gamma HD-tACS']}]}, 'contactsLocationsModule': {'locations': [{'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Beth Israel Deaconess Medical Center', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}], 'overallOfficials': [{'name': 'Paulo Lizano, MD,PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Beth Israel Deaconess Medical Center'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Beth Israel Deaconess Medical Center', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Assistant Professor', 'investigatorFullName': 'Paulo Lizano', 'investigatorAffiliation': 'Beth Israel Deaconess Medical Center'}}}}