Ignite Creation Date:
2025-12-24 @ 4:25 PM
Ignite Modification Date:
2026-01-02 @ 11:23 AM
Study NCT ID:
NCT05550766
Status:
UNKNOWN
Last Update Posted:
2022-09-22
First Post:
2022-09-20
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'submissionTracking': {'submissionInfos': [{'resetDate': '2024-10-25', 'releaseDate': '2024-08-07'}], 'estimatedResultsFirstSubmitDate': '2024-08-07'}}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 50}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2022-12', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-09', 'completionDateStruct': {'date': '2023-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2022-09-20', 'studyFirstSubmitDate': '2022-09-20', 'studyFirstSubmitQcDate': '2022-09-20', 'lastUpdatePostDateStruct': {'date': '2022-09-22', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2022-09-22', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2023-09', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma', 'timeFrame': 'One or two days after staining sections with the marker.', 'description': 'immuohistochemical expression of RXR-α in Squamous and Basal Cell Carcinoma'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Non-melanoma Skin Cancer']}, 'descriptionModule': {'briefSummary': 'Vitamin D has a crucial role in cancer control and prevention.vitamin D receptor (VDR) and its heterodimer Retinoid X receptor (RXR) are equally important in the cell. This ligand (vitamin D) and receptors (VDR-RXR) complex together triggers downstream DNA damage response in the cell.\n\nRetinoid receptors are a superfamily of nuclear receptors. The preferred receptor that attaches to VDR is RXR, with its subunits α, β and γ. RXR α is more frequent in the skin than other tissues, while β occurs in internal organs and γ is frequently related to neural disorders.\n\nthe investigator hopes to assess prognosis of SCC \\& BCC by using RXR-α biomarker \\& attempts to use it in the treatment.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Blocks obtained from cutaneous basal and squamous cell carcinoma tissue from 50 patients.', 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Squamous cell carcinoma and basal cell carcinoma.\n2. Incisional \\& excisional biopsies.\n3. All the studied cases include sufficient materials for the immunohistochemical study 4. Complete clinical data\n\nExclusion Criteria:\n\n1. Patients with a history of preoperative chemotherapy and/or radiotherapy.\n2. Insufficient or tiny tissue biopsies.'}, 'identificationModule': {'nctId': 'NCT05550766', 'briefTitle': 'Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma', 'organization': {'class': 'OTHER', 'fullName': 'Sohag University'}, 'officialTitle': 'Prognostic Value of RXR-α in Cutaneous Squamous and Basal Cell Carcinoma: An Immunohistochemical Study.', 'orgStudyIdInfo': {'id': 'Soh-Med-22-09-05'}}, 'contactsLocationsModule': {'centralContacts': [{'name': 'Fatma M.Hamdan', 'role': 'CONTACT', 'email': 'fatma.mohammad@med.sohag.edu.eg', 'phone': '01000419587'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'UNDECIDED'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Sohag University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'demonstrator at pathology department', 'investigatorFullName': 'Fatma Mohammed Hamdan', 'investigatorAffiliation': 'Sohag University'}}}, 'annotationSection': {'annotationModule': {'unpostedAnnotation': {'unpostedEvents': [{'date': '2024-08-07', 'type': 'RELEASE'}, {'date': '2024-10-25', 'type': 'RESET'}], 'unpostedResponsibleParty': 'Fatma Mohammed Hamdan, demonstrator at pathology department, Sohag University'}}}}