Ignite Creation Date:
2025-12-24 @ 4:16 PM
Ignite Modification Date:
2025-12-27 @ 5:10 PM
Study NCT ID:
NCT00671866
Status:
UNKNOWN
Last Update Posted:
2008-05-05
First Post:
2008-04-30
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D010523', 'term': 'Peripheral Nervous System Diseases'}], 'ancestors': [{'id': 'D009468', 'term': 'Neuromuscular Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'CROSS_SECTIONAL', 'observationalModel': 'COHORT'}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'NOT_YET_RECRUITING', 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-04', 'lastUpdateSubmitDate': '2008-05-04', 'studyFirstSubmitDate': '2008-04-30', 'studyFirstSubmitQcDate': '2008-05-04', 'lastUpdatePostDateStruct': {'date': '2008-05-05', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2008-05-05', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['OP', 'Pesticides', 'Long-Term Low Level Exposure', 'Occupational Health', 'Neurobehavioral Effects'], 'conditions': ['Peripheral Neuropathy']}, 'descriptionModule': {'briefSummary': 'During 1987-1991, WHO supported studies of exposures and short term neurobehavioral effects in a cohort (n=200) with occupational and community exposures to pesticide drift containing organophosphates from orchards and cotton fields in the Hula Valley. We aim (1) to re-examine neurobehavioral outcomes in members of the original cohort and (2) to examine cognitive effects in children with residential exposures. In adults, we will carry out assays of alkyl phosphates, PON1 (paraoxonase-1), NTE (Neuropathy Target Esterase), neurobehavioral tests of cognitive and performance skills, nerve conduction measurements and mood status. We will carry out Psycho-Didactic tests in children. The findings will advance knowledge on delayed term health effects of lengthy everyday exposure to OP pesticides and guide regulatory policy.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Residents of Kibbutzim', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Participants of the former study twenty years ago'}, 'identificationModule': {'nctId': 'NCT00671866', 'briefTitle': 'Neurotoxic Health Hazards of Long-Term Low-Level Exposure to Organophosphate (OP) Compounds in in Hula Valley', 'organization': {'class': 'OTHER', 'fullName': 'Shaare Zedek Medical Center'}, 'orgStudyIdInfo': {'id': 'y.finkelstein.ctil.'}}, 'armsInterventionsModule': {'armGroups': [{'label': '1', 'description': 'Agricultural Workers'}, {'label': '2', 'description': 'Non - Agricultural Workers'}, {'label': '3', 'description': 'Kibbitz Residents working else where'}]}, 'contactsLocationsModule': {'locations': [{'zip': '91031', 'city': 'Jerusalem', 'country': 'Israel', 'contacts': [{'name': 'Yoram Finkelstein, MD PhD', 'role': 'CONTACT', 'email': 'yoramf@ekmd.huji.ac.il', 'phone': '972-2-6555655'}, {'name': 'Yoram Finkelstein, MD PhD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Neurology and Toxicology Unit and Service, Shaare Zedek Med Ctr', 'geoPoint': {'lat': 31.76904, 'lon': 35.21633}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Shaare Zedek Medical Center', 'class': 'OTHER'}}}}