Ignite Creation Date:
2025-12-24 @ 4:06 PM
Ignite Modification Date:
2025-12-26 @ 10:04 PM
Study NCT ID:
NCT00017966
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2001-06-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Brain Excitability During Self-Paced Voluntary Movements
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D009069', 'term': 'Movement Disorders'}], 'ancestors': [{'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'enrollmentInfo': {'count': 30}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2001-06'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2002-06', 'completionDateStruct': {'date': '2002-06'}, 'lastUpdateSubmitDate': '2008-03-03', 'studyFirstSubmitDate': '2001-06-23', 'studyFirstSubmitQcDate': '2001-06-23', 'lastUpdatePostDateStruct': {'date': '2008-03-04', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2001-06-25', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['Transcranial Magnetic Stimulation', 'Motor Cortex', 'Cerebral Inhibition', 'Corpus Callosum', 'Evoked Potential', 'Healthy Volunteer', 'Normal Control'], 'conditions': ['Movement Disorder', 'Healthy']}, 'referencesModule': {'references': [{'pmid': '5456209', 'type': 'BACKGROUND', 'citation': 'Blakemore C, Carpenter RH, Georgeson MA. Lateral inhibition between orientation detectors in the human visual system. Nature. 1970 Oct 3;228(5266):37-9. doi: 10.1038/228037a0. No abstract available.'}, {'pmid': '6018049', 'type': 'BACKGROUND', 'citation': 'Prince DA, Wilder BJ. Control mechanisms in cortical epileptogenic foci. "Surround" inhibition. Arch Neurol. 1967 Feb;16(2):194-202. doi: 10.1001/archneur.1967.00470200082007. No abstract available.'}, {'pmid': '9250378', 'type': 'BACKGROUND', 'citation': 'Krnjevic K. Role of GABA in cerebral cortex. Can J Physiol Pharmacol. 1997 May;75(5):439-51. No abstract available.'}]}, 'descriptionModule': {'briefSummary': "This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease. Normal healthy volunteers 18 years of age and older may be eligible to participate.\n\nIn transcranial magnetic stimulation, an insulated wire coil is placed on the subject's scalp or skin. Brief electrical currents are passed through the coil, creating magnetic pulses that stimulate the brain. During the stimulation, participants will be asked to tense certain muscles slightly or perform other simple actions. The electrical activity of the muscle will be recorded on a computer through electrodes applied to the skin over the muscle. In most cases, the study will last less than 3 hours.", 'detailedDescription': 'The purpose of this study is to investigate the influence of volitional movement on excitability of ipsilateral as well as contralateral motor cortical neurons controlling homologous and surrounding muscles. Transcallosal and surrounding inhibitions are well known phenomenon to suppress unwanted movements during voluntary action, which is often disturbed in various movement disorders. Transcranial magnetic stimulation (TMS) has been used to investigate these inhibitory mechanisms, but the inhibitory influence during and after voluntary movement has not been well elucidated yet. In normal volunteers, we plan to determine if voluntary movements of one finger influence the cortical excitability responsible for surrounding as well as contralateral homologous muscles, using voluntary movement-triggered TMS. The primary outcome measures would be any changes in motor evoked potential (MEP) size and intracortical inhibition (ICI) parameters.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'healthyVolunteers': True, 'eligibilityCriteria': 'Normal adult volunteers 18 or more years old.\n\nSubjects must not have medico-surgical illness.\n\nSubjects must not have neurological illness.\n\nSubjects must not have psychiatric illness.\n\nSubjects must not be taking any medication with potential influence on nervous system function.\n\nSubjects must not have a pacemaker.\n\nSubject must not have an implanted medical pump.\n\nSubjects must not have a metal plate or a metal object in the skull or eye.\n\nSubjects must not have a history of seizure disorder.'}, 'identificationModule': {'nctId': 'NCT00017966', 'briefTitle': 'Brain Excitability During Self-Paced Voluntary Movements', 'organization': {'class': 'NIH', 'fullName': 'National Institutes of Health Clinical Center (CC)'}, 'officialTitle': 'Cortical Excitability During Self-Paced Voluntary Movements', 'orgStudyIdInfo': {'id': '010199'}, 'secondaryIdInfos': [{'id': '01-N-0199'}]}, 'contactsLocationsModule': {'locations': [{'zip': '20892', 'city': 'Bethesda', 'state': 'Maryland', 'country': 'United States', 'facility': 'National Institute of Neurological Disorders and Stroke (NINDS)', 'geoPoint': {'lat': 38.98067, 'lon': -77.10026}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Institute of Neurological Disorders and Stroke (NINDS)', 'class': 'NIH'}}}}