Ignite Creation Date:
2025-12-24 @ 4:04 PM
Ignite Modification Date:
2025-12-26 @ 10:06 AM
Study NCT ID:
NCT06283966
Status:
RECRUITING
Last Update Posted:
2025-12-11
First Post:
2024-02-21
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D029424', 'term': 'Pulmonary Disease, Chronic Obstructive'}], 'ancestors': [{'id': 'D008173', 'term': 'Lung Diseases, Obstructive'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D002908', 'term': 'Chronic Disease'}, {'id': 'D020969', 'term': 'Disease Attributes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'This is a Phase III randomized, double-blind, parallel group, multi-center event-driven study comparing BGF MDI 320/14.4/9.6 μg BID with GFF MDI 14.4/9.6 μg BID in participants with COPD who are at risk of a cardiopulmonary event.'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 5000}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2024-02-21', 'type': 'ACTUAL'}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2028-03-07', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-05', 'studyFirstSubmitDate': '2024-02-21', 'studyFirstSubmitQcDate': '2024-02-21', 'lastUpdatePostDateStruct': {'date': '2025-12-11', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2024-02-28', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-03-07', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Serious Adverse Events (SAEs) and Adverse Events leading to discontinuation (DAEs), Adverse Events of Special Interest (AESIs) of pneumonia leading to hospitalization or death', 'timeFrame': 'Up to 3 years', 'description': 'To assess the safety and tolerability of BGF MDI and GFF MDI'}], 'primaryOutcomes': [{'measure': 'Time to first severe cardiac or COPD event', 'timeFrame': 'Up to 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on cardiopulmonary outcomes.'}], 'secondaryOutcomes': [{'measure': 'Time to first severe COPD exacerbation event', 'timeFrame': 'Up to 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on severe COPD exacerbations.'}, {'measure': 'Time to first severe cardiac event', 'timeFrame': 'Up to 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on severe cardiac outcomes.'}, {'measure': 'Time to cardiopulmonary death', 'timeFrame': 'Up to 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on cardiopulmonary deaths.'}, {'measure': 'Moderate/severe COPD exacerbation rate', 'timeFrame': 'Over time, up 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on moderate/severe COPD exacerbations.'}, {'measure': 'Time to Myocardial Infarction (MI) hospitalization or cardiac death', 'timeFrame': 'Up to 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on the time to MI hospitalization (or cardiac death).'}, {'measure': 'Time to Heart Failure (HF) acute healthcare visit/hospitalization or cardiac death', 'timeFrame': 'Up to 3 years', 'description': 'Evaluate the effect of combination triple therapy (BGF MDI 320/14.4/9.6 μg) compared with dual bronchodilator therapy (GFF MDI 14.4/9.6 μg) on the time to HF acute healthcare visit/hospitalization (or cardiac death).'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['COPD (Chronic Obstructive Pulmonary Disease)']}, 'descriptionModule': {'briefSummary': 'This study will evaluate the effect of triple ICS/LAMA/LABA therapy with BGF MDI 320/14.4/9.6 μg on cardiopulmonary outcomes relative to LAMA/LABA therapy with GFF MDI 14.4/9.6 μg in a population with COPD and elevated cardiopulmonary risk.', 'detailedDescription': 'This is a Phase III randomized, double-blind, parallel group, multi-center event-driven study comparing BGF MDI 320/14.4/9.6 μg BID with GFF MDI 14.4/9.6 μg BID in participants with COPD who are at risk of a cardiopulmonary event.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '40 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Male or female participants must be 40 to 80 years of age inclusive, at the time of signing\n\n the ICF.\n2. Demonstrate acceptable MDI administration technique at Visit 1 (V1) and Visit 2 (V2)\n3. A diagnosis of COPD confirmed by a post-bronchodilator FEV1/FVC ratio \\< 70%\n\n at V1.\n4. Current or former smokers with a history of at least 10 pack-years of cigarette smoking;\n\n defined as (number of cigarettes per day/20) x number of years smoked. Previous smokers are defined as those who have stopped smoking for at least 6\n\n months prior to V1.\n5. A baseline peripheral blood eosinophil count of ≥ 100 cells/mm3 assessed at Visit 1 by\n\n the central laboratory\n6. A CAT score of ≥ 10 at Visit 1.\n7. Participant must fulfill at least 1 of the 4 CV disease/risk factor criteria below \\[(a), (b),\n\n (c), or (d)\\]:\n 1. : Established CV Disease\n 2. : Combination of CV risk factors:\n\n * Hypertension\n * Diabetes Mellitus\n * Chronic Kidney Disease\n * Dyslipidemia\n * Obesity\n 3. : High risk of CV disease determined using an established CV risk assessment\n\n tool.\n 4. : CT coronary Artery Calcification\n8. Willing and, in the opinion of the investigator, able to adjust current COPD therapy, as\n\n required by the protocol.\n9. Willing to visit at the study site or participate in virtual visits as required per the protocol\n\n to complete all study assessments.\n10. A female is eligible to enter and participate in the study if the female is of:\n\n * Non-childbearing potential: either permanently sterilized or who are post-menopausal.\n * Childbearing potential: has a negative serum pregnancy test at V1 and must use one\n\n highly effective form of birth control.\n11. Capable of giving signed informed consent, which includes compliance with the requirements and restrictions listed in the ICF and in the protocol.\n\nExclusion Criteria:\n\n1. Active diagnosis of asthma within the past 5 years (previous diagnosis as a child or adolescent are eligible), asthma-COPD overlap, or any other chronic respiratory disease other than COPD such as alpha-1 antitrypsin deficiency, active tuberculosis, lung fibrosis, sarcoidosis, interstitial lung disease, and pulmonary hypertension.\n2. End-stage renal disease requiring renal replacement therapy\n3. History of heart or lung transplant or actively listed for heart or lung transplant.\n4. Implanted left ventricular assist device or implant anticipated in \\< 3 months.\n5. History of lung cancer and/or treatment for lung cancer within the 5 years prior to Visit 1.\n6. Unstable or life-threatening cardiac disease - participants with any of the following at Visit 1 would be excluded:\n\n 1. An MI or unstable angina in the last 8 weeks\n 2. Unstable or life-threatening cardiac arrhythmia requiring intervention in the last 8 weeks.\n\n NOTE: Any participant who experiences unstable or life-threatening cardiac disease during the run-in period will be excluded but can be rescreened 8 weeks after the resolution of the event.\n7. Pneumonia and/or moderate or severe COPD exacerbation that has not resolved at least 8 weeks prior to Visit 1\n8. Any life-threatening condition, including malignancy, with a life expectancy \\< 5 years, other than CV disease or COPD, that might prevent the participant from completing the study.\n9. Use of maintenance ICS treatment within the past 12 months.\n10. Unable to abstain from protocol-defined prohibited medications\n11. Participation in another clinical study with a study intervention administered in the last 30 days or 5 half-lives, whichever is longer prior to Visit 1 (any other investigational product that is not identified in protocol is prohibited for use during the duration of the study).\n12. Participants with a known hypersensitivity to LAMA, LABA or ICS or any component of the MDI.\n13. Involvement in the planning and/or conduct of the study (applies to both AstraZeneca staff and/or staff at the study site).\n14. Judgment by the investigator that the participant should not participate in the study if the participant is unlikely to comply with study procedures, restrictions, and requirements.\n15. Previous randomization in the present study.\n16. For females only - currently pregnant (confirmed with positive pregnancy test) or breastfeeding'}, 'identificationModule': {'nctId': 'NCT06283966', 'acronym': 'THARROS', 'briefTitle': 'A Study Evaluating the Efficacy of Budesonide, Glycopyrronium and Formoterol Fumarate Metered Dosed Inhaler on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease', 'organization': {'class': 'INDUSTRY', 'fullName': 'AstraZeneca'}, 'officialTitle': 'A Randomized, Double-blind, Parallel Group, Multi-center, Phase III Study to Assess the Efficacy of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler Relative to Glycopyrronium and Formoterol Fumarate MDI on Cardiopulmonary Outcomes in Chronic Obstructive Pulmonary Disease (THARROS)', 'orgStudyIdInfo': {'id': 'D5989C00001'}, 'secondaryIdInfos': [{'id': '2023-507407-59-00', 'type': 'REGISTRY', 'domain': 'CTIS'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'BGF arm', 'description': 'BGF MDI 320/14.4/9.6 μg BID', 'interventionNames': ['Drug: BGF MDI 320/14.4/9.6 μg']}, {'type': 'EXPERIMENTAL', 'label': 'GFF arm', 'description': 'GFF MDI 14.4/9.6 μg BID', 'interventionNames': ['Drug: GFF MDI 14.4/9.6 μg']}], 'interventions': [{'name': 'BGF MDI 320/14.4/9.6 μg', 'type': 'DRUG', 'description': 'Budesonide, glycopyrronium, and formoterol fumarate pressurized inhalation suspension', 'armGroupLabels': ['BGF arm']}, {'name': 'GFF MDI 14.4/9.6 μg', 'type': 'DRUG', 'description': 'Glycopyrronium and formoterol fumarate pressurized inhalation suspension', 'armGroupLabels': ['GFF arm']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35611', 'city': 'Athens', 'state': 'Alabama', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.80243, 'lon': -86.97219}}, {'zip': '35058', 'city': 'Cullman', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.17482, 'lon': -86.84361}}, {'zip': '36532', 'city': 'Fairhope', 'state': 'Alabama', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 30.52297, 'lon': -87.90333}}, {'zip': '35801', 'city': 'Huntsville', 'state': 'Alabama', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.7304, 'lon': -86.58594}}, {'zip': '36608', 'city': 'Mobile', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 30.69436, 'lon': -88.04305}}, {'zip': '35660', 'city': 'Sheffield', 'state': 'Alabama', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.76509, 'lon': -87.69864}}, {'zip': '85296', 'city': 'Gilbert', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.35283, 'lon': -111.78903}}, {'zip': '85308', 'city': 'Glendale', 'state': 'Arizona', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.53865, 'lon': -112.18599}}, {'zip': '85206', 'city': 'Mesa', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.42227, 'lon': -111.82264}}, {'zip': '85213', 'city': 'Mesa', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.42227, 'lon': -111.82264}}, {'zip': '85006', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85281', 'city': 'Tempe', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.41477, 'lon': -111.90931}}, {'zip': '85283', 'city': 'Tempe', 'state': 'Arizona', 'status': 'TERMINATED', 'country': 'United States', 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{'zip': '90717', 'city': 'Lomita', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.79224, 'lon': -118.31507}}, {'zip': '90815', 'city': 'Long Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90720', 'city': 'Los Alamitos', 'state': 'California', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.80307, 'lon': -118.07256}}, {'zip': '92660', 'city': 'Newport Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '92663', 'city': 'Newport Beach', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.61891, 'lon': -117.92895}}, {'zip': '91602', 'city': 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'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 34.18667, 'lon': -118.44897}}, {'zip': '92081', 'city': 'Vista', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.20004, 'lon': -117.24254}}, {'zip': '92683', 'city': 'Westminster', 'state': 'California', 'status': 'SUSPENDED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 33.75918, 'lon': -118.00673}}, {'zip': '80012', 'city': 'Aurora', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '80228', 'city': 'Denver', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 39.73915, 'lon': -104.9847}}, {'zip': '80110', 'city': 'Englewood', 'state': 'Colorado', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 39.64777, 'lon': -104.98776}}, {'zip': '20016', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33435', 'city': 'Boynton Beach', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.52535, 'lon': -80.06643}}, {'zip': '34209', 'city': 'Bradenton', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 27.49893, 'lon': -82.57482}}, {'zip': '33990', 'city': 'Cape Coral', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.56285, 'lon': -81.94953}}, {'zip': '33756', 'city': 'Clearwater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '33765', 'city': 'Clearwater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 27.96585, 'lon': -82.8001}}, {'zip': '34429', 'city': 'Crystal River', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 28.90248, 'lon': -82.5926}}, {'zip': '33189', 'city': 'Cutler Bay', 'state': 'Florida', 'status': 'SUSPENDED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.5783, 'lon': -80.3377}}, {'zip': '32132', 'city': 'Edgewater', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 28.98888, 'lon': -80.90228}}, {'zip': '33308', 'city': 'Fort Lauderdale', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.12231, 'lon': -80.14338}}, {'zip': '33912', 'city': 'Fort Myers', 'state': 'Florida', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '33012', 'city': 'Hialeah', 'state': 'Florida', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33013', 'city': 'Hialeah', 'state': 'Florida', 'status': 'TERMINATED', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33024', 'city': 'Hollywood', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '33032', 'city': 'Homestead', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Research Site', 'geoPoint': {'lat': 25.46872, 'lon': -80.47756}}, {'zip': '34741', 'city': 'Kissimmee', 'state': 'Florida', 'status': 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