Ignite Creation Date:
2025-12-24 @ 3:57 PM
Ignite Modification Date:
2026-01-02 @ 8:30 PM
Study NCT ID:
NCT00632892
Status:
COMPLETED
Last Update Posted:
2008-03-11
First Post:
2008-03-03
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D007674', 'term': 'Kidney Diseases'}], 'ancestors': [{'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITHOUT_DNA', 'description': "The urine samples are collected just before and 30 minutes after IVP.The samples are immediately frozen at -80'C until analyzed."}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_ONLY'}, 'enrollmentInfo': {'count': 80}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2007-12'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2008-02', 'lastUpdateSubmitDate': '2008-03-10', 'studyFirstSubmitDate': '2008-03-03', 'studyFirstSubmitQcDate': '2008-03-10', 'lastUpdatePostDateStruct': {'date': '2008-03-11', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2008-03-11', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2008-01', 'type': 'ACTUAL'}}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['oxidative stress markers in urine', 'urine norepinephrine', 'renal tubular enzyme markers'], 'conditions': ['Kidney Diseases']}, 'descriptionModule': {'briefSummary': 'Clinically, iodinated contrast-medium (CM) is widely used in angiography and computerized tomography. CM-induced nephropathy (CMIN) is one major complication after application of CM. Therefore, how to prevent CMIN is always one of the hot topics concerned by nephrologists, cardiologists, and radiologists.\n\nThe present study is aimed to determine the norepinephrine concentration, oxidative markers, and tubular damage markers in the urine samples of patients undergoing intravenous pyelography (IVP).\n\nThe working hypothesis is high-osmolarity contrast media (HOCM) causes more oxidative stress and greater tubular damage than iso-osmolarity contrast media (IOCM).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': '1. Adult patients (\\> 18 years old)\n2. Undergoing IVP with an appropriate medical indication\n3. Signing informed consent', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Adult patients (\\> 18 years old)\n2. Undergoing IVP with an appropriate medical indication\n3. Signing informed consent\n\nExclusion Criteria:\n\n1\\. Without signing informed consent'}, 'identificationModule': {'nctId': 'NCT00632892', 'briefTitle': 'The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity', 'organization': {'class': 'OTHER', 'fullName': 'Far Eastern Memorial Hospital'}, 'officialTitle': 'The Correlation Between Oxidative Stress and Indinated Contrast-Media Nephrotoxicity', 'orgStudyIdInfo': {'id': '96013'}}, 'contactsLocationsModule': {'locations': [{'zip': '220', 'city': 'Pan Chiao, Taipei', 'country': 'Taiwan', 'facility': 'Far Eastern Memorial Hospital'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Far Eastern Memorial Hospital', 'class': 'OTHER'}}}}