Ignite Creation Date:
2025-12-24 @ 11:47 AM
Ignite Modification Date:
2025-12-29 @ 11:01 AM
Study NCT ID:
NCT00148161
Status:
UNKNOWN
Last Update Posted:
2007-04-27
First Post:
2005-09-06
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D013342', 'term': 'Stuttering'}], 'ancestors': [{'id': 'D013064', 'term': 'Speech Disorders'}, {'id': 'D007806', 'term': 'Language Disorders'}, {'id': 'D003147', 'term': 'Communication Disorders'}, {'id': 'D019954', 'term': 'Neurobehavioral Manifestations'}, {'id': 'D009461', 'term': 'Neurologic Manifestations'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'OTHER', 'observationalModel': 'DEFINED_POPULATION'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 20}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2004-11'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2006-09', 'lastUpdateSubmitDate': '2007-04-26', 'studyFirstSubmitDate': '2005-09-06', 'studyFirstSubmitQcDate': '2005-09-06', 'lastUpdatePostDateStruct': {'date': '2007-04-27', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2005-09-07', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['Magnetoencephalography', 'Auditory cortex', 'Stuttering', 'Non stuttering'], 'conditions': ['Stuttering']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://biomag.uni-muenster.de', 'label': 'Homepage of the Institute for Biomagnetism and Biosignalanalysis'}]}, 'descriptionModule': {'briefSummary': 'The goal of the study is to examine the cortical activity during speech perception and speech production in idiopathic stutterers compared to fluent speakers. Therefore, the noninvasive method of magnetoencephalography (MEG) is used. A better understanding for the complexity of speech perception and its pathology should be developed.\n\nFundamental properties of stuttering are repetitions, prolongations, and blocks. In most cases stuttering emerges between 2 and 5 years of age. The auditory feedback should become less important during development, as soon as information about mispronounced words does not occur anymore. During speech development this control function should be adopted by other systems. In stutterers the dominance of the acoustic control should remain.\n\nBrain imaging studies with positron emission tomography (PET) or magnetic resonance imaging (MRI) show defects in the network of motor system, in the lateralization of speech areas, and functions of the auditory cortex. Magnetoencephalographic studies describe a similar variety as cause of stuttering. There may be defects in the auditory feedback, a modification of the lateralization of speech areas, or an alteration of co-action of motor planning and auditory system.\n\nThe benefit of magnetoencephalography is a very good temporal resolution in the range of milliseconds combined with good spatial resolution. Therefore, it is well suited to examine the dynamics of cortical processing during stuttering. In this study evoked components of the auditory systems related to complex sounds, vocals, consonant-vocal combinations, and single words are analyzed. Differences of these components in the auditory cortices of stutterers and fluent speakers are hypothesized as well in temporal structure as in localization and lateralization.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Subjects with idiopathic stuttering (for the group of stutterers)\n* Fluently speaking subjects (for the control group)\n* Right handed\n* Normal hearing\n\nExclusion Criteria:\n\n* Neurological diseases\n* Psychiatric diseases\n* Medication with neurological effective drugs\n* Implants with magnetic impact'}, 'identificationModule': {'nctId': 'NCT00148161', 'briefTitle': 'Activity of the Auditory Cortex During Speech Perception and Speech Production in Stuttering', 'organization': {'class': 'OTHER', 'fullName': 'University Hospital Muenster'}, 'officialTitle': 'Evoked and Induced Auditory Cortical Activity During Speech Perception and Speech Production in Stuttering', 'orgStudyIdInfo': {'id': 'phonpaed001'}}, 'contactsLocationsModule': {'locations': [{'zip': '48149', 'city': 'Münster', 'status': 'RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Christo Pantev, Prof. Dr.', 'role': 'CONTACT', 'email': 'pantev@uni-muenster.de', 'phone': '+49(0)251 83', 'phoneExt': '56865'}, {'name': 'Christo Pantev, Prof. Dr.', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Institute for Biomagnetism and Biosignalanalysis', 'geoPoint': {'lat': 51.96236, 'lon': 7.62571}}, {'zip': '48161', 'city': 'Münster', 'status': 'RECRUITING', 'country': 'Germany', 'contacts': [{'name': 'Antoinette G Dinnesen, Prof. Dr.', 'role': 'CONTACT', 'email': 'a.g.dinnesen@uni-muenster.de', 'phone': '+49(0)251 83', 'phoneExt': '56859'}, {'name': 'Antoinette G Dinnesen, Prof. Dr.', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Arne Knief, Dr.', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Michael Schneider', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Department of Phoniatrics and Pediatric Audiology, University Hospital Münster', 'geoPoint': {'lat': 51.96236, 'lon': 7.62571}}], 'centralContacts': [{'name': 'Antoinette G Dinnesen, Prof. Dr.', 'role': 'CONTACT', 'email': 'a.g.dinnesen@uni-muenster.de', 'phone': '+49(0)251 83', 'phoneExt': '56859'}, {'name': 'Arne Knief, Dr.', 'role': 'CONTACT', 'email': 'knief@uni-muenster.de', 'phone': '+49(0)251 83', 'phoneExt': '56886'}], 'overallOfficials': [{'name': 'Antoinette G Dinnesen, Prof. Dr.', 'role': 'STUDY_DIRECTOR', 'affiliation': 'Department of Phoniatrics and Pediatric Audiology, University Hospital Münster'}, {'name': 'Arne Knief, Dr.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Department of Phoniatrics and Pediatric Audiology, University Hospital Münster'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University Hospital Muenster', 'class': 'OTHER'}}}}