Ignite Creation Date:
2025-12-24 @ 3:51 PM
Ignite Modification Date:
2026-02-23 @ 1:12 AM
Study NCT ID:
NCT03433092
Status:
COMPLETED
Last Update Posted:
2018-02-22
First Post:
2018-02-07
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}], 'ancestors': [{'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'OTHER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 40641}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2017-11-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2018-02', 'completionDateStruct': {'date': '2017-12-28', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2018-02-15', 'studyFirstSubmitDate': '2018-02-07', 'studyFirstSubmitQcDate': '2018-02-07', 'lastUpdatePostDateStruct': {'date': '2018-02-22', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2018-02-14', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2017-11-20', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Gastrointestinal Tract Cancer Incident Measure', 'timeFrame': 'Through study completion, an average of 5 years.', 'description': 'The gastrointestinal tract cancer incident would be recorded during the follow-up years.'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Serum carotenoids', 'Gastrointestinal tract cancer', 'Meta-analysis'], 'conditions': ['Gastrointestinal Tract Cancer']}, 'referencesModule': {'references': [{'pmid': '28605127', 'type': 'RESULT', 'citation': 'Huang J, Lu MS, Fang YJ, Xu M, Huang WQ, Pan ZZ, Chen YM, Zhang CX. Serum carotenoids and colorectal cancer risk: A case-control study in Guangdong, China. Mol Nutr Food Res. 2017 Oct;61(10). doi: 10.1002/mnfr.201700267. Epub 2017 Jul 31.'}]}, 'descriptionModule': {'briefSummary': 'Previous studies have suggested that serum carotenoids may be associated with risk of gastrointestinal tract cancer (GIT cancer), but the results were inconsistent. Thus, the investigators conducted a meta-analysis to evaluate the associations between serum carotenoids and risk of GIT cancer.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'The study population include people from primary care clinic or community sample.', 'eligibilityCriteria': 'Inclusion Criteria:\n\n* The study had both case and control groups\n* Serum carotenoids levels, relative risk (RR) or OR and corresponding 95% CI were reported\n* Patients in case group were diagnosed with GIT cancer\n\nExclusion Criteria:\n\n·Animal studies'}, 'identificationModule': {'nctId': 'NCT03433092', 'briefTitle': 'Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies', 'organization': {'class': 'OTHER', 'fullName': 'West China Hospital'}, 'officialTitle': 'Serum Carotenoids and Risk of Gastrointestinal Tract Cancer: Meta-analysis of Ten Studies', 'orgStudyIdInfo': {'id': '2759067085'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Jing Huang et. al, 2017', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'Max Leenders et. al,2014', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'Yusuke Okuyama et. al,2014', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'GC Kabat et. al,2012', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'Christina Persson et. al,2008', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'M Jenab et. al,2006', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'Kenji Wakai et. al,2005', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'Christian C. Abnet et. al,2003', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'N Malila et. al,2002', 'interventionNames': ['Other: serum carotenoids']}, {'label': 'G Pappalardo et. al,1997', 'interventionNames': ['Other: serum carotenoids']}], 'interventions': [{'name': 'serum carotenoids', 'type': 'OTHER', 'description': 'In each study, the serum concentrations of carotenoids were detected by high performance liquid chromatography', 'armGroupLabels': ['Christian C. Abnet et. al,2003', 'Christina Persson et. al,2008', 'G Pappalardo et. al,1997', 'GC Kabat et. al,2012', 'Jing Huang et. al, 2017', 'Kenji Wakai et. al,2005', 'M Jenab et. al,2006', 'Max Leenders et. al,2014', 'N Malila et. al,2002', 'Yusuke Okuyama et. al,2014']}]}, 'contactsLocationsModule': {'locations': [{'zip': '610041', 'city': 'Chengdu', 'state': 'Sichuan', 'country': 'China', 'facility': 'West China Hospital, Sichuan University', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Yong Zhou', 'class': 'OTHER'}, 'collaborators': [{'name': 'Sichuan Provincial Science and Technology Support Project (2016SZ0047)', 'class': 'UNKNOWN'}], 'responsibleParty': {'type': 'SPONSOR_INVESTIGATOR', 'investigatorTitle': 'West China Hospital', 'investigatorFullName': 'Yong Zhou', 'investigatorAffiliation': 'West China Hospital'}}}}