Ignite Creation Date:
2025-12-24 @ 3:51 PM
Ignite Modification Date:
2025-12-26 @ 2:43 PM
Study NCT ID:
NCT04712292
Status:
UNKNOWN
Last Update Posted:
2022-02-28
First Post:
2021-01-13
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003110', 'term': 'Colonic Neoplasms'}, {'id': 'D015179', 'term': 'Colorectal Neoplasms'}, {'id': 'D004194', 'term': 'Disease'}, {'id': 'D000086382', 'term': 'COVID-19'}], 'ancestors': [{'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D011024', 'term': 'Pneumonia, Viral'}, {'id': 'D011014', 'term': 'Pneumonia'}, {'id': 'D012141', 'term': 'Respiratory Tract Infections'}, {'id': 'D007239', 'term': 'Infections'}, {'id': 'D014777', 'term': 'Virus Diseases'}, {'id': 'D018352', 'term': 'Coronavirus Infections'}, {'id': 'D003333', 'term': 'Coronaviridae Infections'}, {'id': 'D030341', 'term': 'Nidovirales Infections'}, {'id': 'D012327', 'term': 'RNA Virus Infections'}, {'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 15000}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2020-09-08', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2022-02', 'completionDateStruct': {'date': '2022-04-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2022-02-10', 'studyFirstSubmitDate': '2021-01-13', 'studyFirstSubmitQcDate': '2021-01-14', 'lastUpdatePostDateStruct': {'date': '2022-02-28', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2021-01-15', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-02-15', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Oncologic stage', 'timeFrame': '30 days from the surgery', 'description': 'The stage will be reported at the histological examination according to TNM classification'}, {'measure': 'Palliative surgery', 'timeFrame': 'at time 0 (surgery)', 'description': 'Rate of palliative surgery (defined as any procedure which did not have the aim of radically removing the primary cancer, either planned preoperatively in order to reduce the symptoms, or which became necessary during surgery due to unexpected findings'}, {'measure': 'Rate of radical surgery', 'timeFrame': '30 days from surgery', 'description': 'Surgery is defined radical according to the absence of cancer (R0) at the surgical margins on the histological specimen'}], 'secondaryOutcomes': [{'measure': 'Aggressive cancer biology', 'timeFrame': '30 days from the surgery', 'description': 'Biology was considered aggressive if any of the following characteristics were found at the histological examination: signet ring cells, mucinous tumor, tumor budding, lymphovascular invasion, perineurial invasion, lymphangitis.'}, {'measure': 'Rate of clinical T4 cancer at the preoperative staging', 'timeFrame': 'At time 0 (surgery)', 'description': 'Clinical T4 cancer are defined as those with high suspicious of local invasion of adjacent organs or structures, not necessary confirmed as T4 at the histological examination'}, {'measure': 'Liver metastases', 'timeFrame': 'At the preoperative staging or at surgery (time 0)', 'description': 'Rate of single/multiple liver metastases'}, {'measure': 'Lung metastases', 'timeFrame': 'At the preoperative staging or at surgery (time 0)', 'description': 'Rate of single/multiple lung metastases'}, {'measure': 'Associated symptoms', 'timeFrame': 'Before surgery', 'description': 'Rate of patients who had a diagnosis of cancer without any associated symptoms - as sign of effectiveness of the screening'}, {'measure': 'Emergency surgery', 'timeFrame': 'surgery (time 0)', 'description': 'rate of operations requiring surgery within 48 hours from the unpredicted admission to hospital'}, {'measure': 'Postoperative complications', 'timeFrame': '30 days from surgery', 'description': 'Rate of 30-day complications graded according to the Clavien-Dindo Classification'}, {'measure': 'Mortality', 'timeFrame': '30 days from surgery', 'description': 'Rate of 30-day deaths'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['colorectal cancer', 'diagnosis', 'screening', 'COVID-19', 'surgery', 'outcomes'], 'conditions': ['Colorectal Neoplasms Malignant']}, 'referencesModule': {'references': [{'pmid': '33097915', 'type': 'RESULT', 'citation': 'Greenwood E, Swanton C. Consequences of COVID-19 for cancer care - a CRUK perspective. Nat Rev Clin Oncol. 2021 Jan;18(1):3-4. doi: 10.1038/s41571-020-00446-0.'}, {'pmid': '32986516', 'type': 'RESULT', 'citation': 'Jazieh AR, Akbulut H, Curigliano G, Rogado A, Alsharm AA, Razis ED, Mula-Hussain L, Errihani H, Khattak A, De Guzman RB, Mathias C, Alkaiyat MOF, Jradi H, Rolfo C; International Research Network on COVID-19 Impact on Cancer Care. Impact of the COVID-19 Pandemic on Cancer Care: A Global Collaborative Study. JCO Glob Oncol. 2020 Sep;6:1428-1438. doi: 10.1200/GO.20.00351.'}, {'pmid': '32675512', 'type': 'RESULT', 'citation': 'Torzilli G, Vigano L, Galvanin J, Castoro C, Quagliuolo V, Spinelli A, Zerbi A, Donadon M, Montorsi M; COVID-SURGE-ITA group. A Snapshot of Elective Oncological Surgery in Italy During COVID-19 Emergency: Pearls, Pitfalls, and Perspectives. Ann Surg. 2020 Aug;272(2):e112-e117. doi: 10.1097/SLA.0000000000004081.'}, {'pmid': '33339569', 'type': 'RESULT', 'citation': 'Mitchell EP. Declines in Cancer Screening During COVID-19 Pandemic. J Natl Med Assoc. 2020 Dec;112(6):563-564. doi: 10.1016/j.jnma.2020.12.004. No abstract available.'}, {'pmid': '32203977', 'type': 'RESULT', 'citation': 'Onder G, Rezza G, Brusaferro S. Case-Fatality Rate and Characteristics of Patients Dying in Relation to COVID-19 in Italy. JAMA. 2020 May 12;323(18):1775-1776. doi: 10.1001/jama.2020.4683. No abstract available.'}]}, 'descriptionModule': {'briefSummary': 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread worldwide.\n\nSince then, the COVID-19 pandemic has caused a detrimental effect of the national health care system, causing a drastic reduction of the screening programs for colorectal cancer and requiring the redistribution of the hospital resources from elective surgery to the care of patients with SARS-Cov\\_2 infection requiring admission.', 'detailedDescription': 'Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has been identified as the cause of the Coronavirus disease 19 (COVID-19), which was initially reported in December 2019 in China and has since rapidly spread worldwide. Italy witnessed a rapid and uncontrolled spread of the infection after March 2020, and a worrisome increasing number of related deaths.\n\nThe need for increased capacity for COVID-19 patients required elective activities to be drastically reduced or canceled. The unprecedented stress on the healthcare system has caused the reduction of the elective surgery and the cancer screening programs during the last 2 years. Studies predicting harmful impact of the COVID-19 pandemic on cancer care have been already published. However, it has not been proved whether the potential delay of screening, diagnosis and treatment could have a measurable effect on patients undergoing surgery for colorectal cancer in the COVID-19 era.\n\nThe aim of the study is therefore to compare the 30-day perioperative and oncologic outcomes between patients undergoing surgery for cancer of the colon and rectum between January 2020 and December 2021 (study group) and those who had surgery for colorectal cancer between January 2018 and December 2019 (Control Group), in order to identify:\n\n* any change in the distribution of the histological stage (primary aim)\n* any change in the rate of palliative surgery (primary aim)\n* any change in the rate of non-radical surgery (R1 or R2 resection) ( primary aim)\n* any change in the rate of 30-day postoperative complications (secondary outcome)\n\nAnonimyzed data will be retrospectively collected on a RedCap platform hosted on the servers of the Alma Mater Studiorum University of Bologna. The variables included demographic characteristics, comorbidities, details of the disease at the diagnosis, details of the neoadjuvant therapy, perioperative variables and 30-day postoperative follow-up variables.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'The study will include all adult patients undergoing elective or urgent surgery for proven or suspected colorectal within the study periods', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Any patient undergoing radical surgery for histologically confirmed diagnosis of cancer located in the colon, the rectum or the anus; or\n* any patient undergoing surgery with oncologic intents, for instance: radicalization of endoscopically removed cancerous polyp; radical surgery to remove large, at-risk polyp which are not removable by endoscopy; or\n* any patient undergoing planned or unpredicted palliative surgery for a primary cancer localized in the colon, rectum or anus; or\n* any patient undergoing a staging procedure (i.e. staging laparoscopy, surgical exploration), which did not result in any radical surgery due to advanced disease, metastasis, etc.\n\nand\n\n* age \\> 18 years\n* elective or urgent surgery\n\nExclusion Criteria:\n\n* Colorectal cancer recurring after previous surgery;\n* Cancer originating from other organs than the colon, the rectum and the anus;\n* Lack of significant histological details (expect when the cancer was not removed)\n* lack of 30-day follow-up'}, 'identificationModule': {'nctId': 'NCT04712292', 'acronym': 'COVID-CRC', 'briefTitle': 'Effects of COVID-19 Pandemic on the Outcomes of Colorectal Cancer', 'organization': {'class': 'OTHER', 'fullName': 'University of Bologna'}, 'officialTitle': 'Effects of the COVID-19 Pandemic on the Diagnosis, Treatment and Outcomes of Patients Affected by Colorectal Cancer Requiring Surgery: Results From a National Multicentre Cohort Study', 'orgStudyIdInfo': {'id': '854/2020/Oss/AOUBo'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Study group', 'description': 'Patients undergoing surgery for confirmed or suspected colorectal cancer between January 2020 and December 2021', 'interventionNames': ['Procedure: Surgical procedure for confirmed or suspected colorectal cancer']}, {'label': 'Control group', 'description': 'Patients undergoing surgery for confirmed or suspected colorectal cancer between January 2018 and December 2019', 'interventionNames': ['Procedure: Surgical procedure for confirmed or suspected colorectal cancer']}], 'interventions': [{'name': 'Surgical procedure for confirmed or suspected colorectal cancer', 'type': 'PROCEDURE', 'description': 'Surgical procedure for cancer may include:\n\n* any radical surgery (right or left hemicolectomy, rectal resection, abdomino-perineal resection, total colectomy, proctocolectomy, and others depending on the tumor site and other tumor characteristics),\n* surgery for radicalization of cancer polyps previously removed endoscopically\n* surgery for excision of large polyps which are not removable endoscopically\n* staging surgery (laparoscopy or laparotomy), in case of advanced-non operable cancer\n* palliative surgery (defined as any surgery with no curative intent)', 'armGroupLabels': ['Control group', 'Study group']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Rho', 'state': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Gianluca Sampietro, MD', 'role': 'CONTACT', 'email': 'gianluca.sampietro@unimi.it'}], 'facility': 'Rho Memorial Hospital', 'geoPoint': {'lat': 45.53245, 'lon': 9.0402}}, {'zip': '40100', 'city': 'Rozzano', 'state': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonino Spinelli, MD', 'role': 'CONTACT', 'email': 'antonino.spinelli@humanitas.it'}], 'facility': 'Humanitas Research Center', 'geoPoint': {'lat': 45.38193, 'lon': 9.1559}}, {'city': 'Bari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Gennaro Martines, MD', 'role': 'CONTACT', 'email': 'gerrymartines@virgilio.it'}], 'facility': 'AOU Policlinico di Bari "M. Rubino"', 'geoPoint': {'lat': 41.12066, 'lon': 16.86982}}, {'city': 'Bari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Leonardo Vincenti, MD', 'role': 'CONTACT', 'email': 'dr.leonardo.vincenti@gmail.com'}], 'facility': 'Policlinico di Bari', 'geoPoint': {'lat': 41.12066, 'lon': 16.86982}}, {'city': 'Bergamo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giovanni Dapri, MD', 'role': 'CONTACT', 'email': 'giovanni@dapri.net'}], 'facility': 'Humanitas Gavazzeni Hospital', 'geoPoint': {'lat': 45.69601, 'lon': 9.66721}}, {'city': 'Bergamo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Stefano Olmi, MD', 'role': 'CONTACT', 'email': 'stefano.olmi@gmail.com'}], 'facility': 'Policlinico San Marco', 'geoPoint': {'lat': 45.69601, 'lon': 9.66721}}, {'zip': '40100', 'city': 'Bologna', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Elio Jovine, MD', 'role': 'CONTACT', 'email': 'elio.jovine@ausl.bologna.it'}], 'facility': 'Maggiore Hospital', 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'city': 'Brescia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': "Moh'd Abu Hilal, MD", 'role': 'CONTACT', 'email': 'mohd.abuhilal@poliambulanza.it'}], 'facility': 'Fondazione Poliambulanza', 'geoPoint': {'lat': 45.53558, 'lon': 10.21472}}, {'city': 'Brescia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Nazario Portolani, MD', 'role': 'CONTACT', 'email': 'nazario.portolani@unibs.it'}], 'facility': 'Spedali Civili', 'geoPoint': {'lat': 45.53558, 'lon': 10.21472}}, {'city': 'Brescia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giusto Pignata, MD', 'role': 'CONTACT', 'email': 'giusto.pignata@gmail.com'}], 'facility': 'Spedali Civili', 'geoPoint': {'lat': 45.53558, 'lon': 10.21472}}, {'city': 'Cagliari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Nicola Cillara, MD', 'role': 'CONTACT', 'email': 'ncillara@gmail.com'}], 'facility': 'Santissima Trinità Hospital', 'geoPoint': {'lat': 39.23054, 'lon': 9.11917}}, {'city': 'Carate Brianza', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Letizia Laface, MD', 'role': 'CONTACT', 'email': 'lafaceletizia@gmail.com'}], 'facility': 'Vittorio Emanuele III Hospital', 'geoPoint': {'lat': 45.67574, 'lon': 9.23723}}, {'city': 'Civitavecchia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Pasquale Lepiane, MD', 'role': 'CONTACT', 'email': 'pasquale.lepiane@aslroma4.it'}], 'facility': 'San Paolo Hospital', 'geoPoint': {'lat': 42.09325, 'lon': 11.79674}}, {'city': 'Faenza', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giampaolo Ugolini, MD', 'role': 'CONTACT', 'email': 'g.ugolini@unibo.it'}], 'facility': 'AUSL Romagna Ravenna-Faenza', 'geoPoint': {'lat': 44.29007, 'lon': 11.87948}}, {'city': 'Florence', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giuseppe Canonico, MD', 'role': 'CONTACT', 'email': 'giuseppe.canonico@uslcentro.toscana.it'}], 'facility': 'San Giovanni di Dio Hospital', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'city': 'Gardone Val Trompia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Maurizio Ronconi, MD', 'role': 'CONTACT', 'email': 'maurizio.ronconi@asst-spedalicivili.it'}], 'facility': 'Gardone Val Trompia Hospital', 'geoPoint': {'lat': 45.69137, 'lon': 10.18635}}, {'zip': '20100', 'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Piergiorgio Danelli, MD', 'role': 'CONTACT', 'email': 'piergiorgio.danelli@unimi.it'}], 'facility': 'ASST FBF Sacco Hospital', 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'zip': '20100', 'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Riccardo Rosati, MD', 'role': 'CONTACT', 'email': 'rosati.riccardo@hsr.it'}], 'facility': 'San Raffaele Hospital', 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Enrico Opocher, MD', 'role': 'CONTACT', 'email': 'enrico.opocher@unimi.it'}], 'facility': 'ASST Santi Paolo e Carlo Hospital', 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Luigi Boni, MD', 'role': 'CONTACT', 'email': 'luigi.boni@unimi.it'}], 'facility': "Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico - Milano", 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Maurizio Cosimelli, MD', 'role': 'CONTACT', 'email': 'mcosimelli@libero.it'}], 'facility': 'Istituto Nazionale dei Tumori', 'geoPoint': {'lat': 45.46427, 'lon': 9.18951}}, {'city': 'Mirano', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Corrado Da Lio, MD', 'role': 'CONTACT', 'email': 'corrado.dalio@aulss3.veneto.it'}], 'facility': 'Mirano Hospital', 'geoPoint': {'lat': 45.49458, 'lon': 12.10775}}, {'city': 'Napoli', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonio Castaldi, MD', 'role': 'CONTACT', 'email': 'antonio.castaldi@icloud.com'}], 'facility': 'AORN Cardarelli', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'city': 'Napoli', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Gianluca Pellino, MD', 'role': 'CONTACT', 'email': 'gianluca.pellino@unicampania.it'}], 'facility': 'Università della Campania Luigi Vanvitelli', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'city': 'Padua', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Salvatore Pucciarelli, MD', 'role': 'CONTACT', 'email': 'puc@unipd.it'}], 'facility': 'Padova University Hospital', 'geoPoint': {'lat': 45.40797, 'lon': 11.88586}}, {'city': 'Padua', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Pierluigi Pilati, MD', 'role': 'CONTACT', 'email': 'pierluigi.pilati@iov.veneto.it'}], 'facility': 'Veneto Institute of Oncology IOV-IRCCS', 'geoPoint': {'lat': 45.40797, 'lon': 11.88586}}, {'city': 'Palermo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Marco V Marino, MD', 'role': 'CONTACT', 'email': 'Marco.Vito.marino@gmail.com'}], 'facility': 'Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello', 'geoPoint': {'lat': 38.1166, 'lon': 13.3636}}, {'city': 'Parma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Mario Giuffrida, MD', 'role': 'CONTACT', 'email': 'mario.giuffrida4@gmail.com'}], 'facility': 'AOU Parma', 'geoPoint': {'lat': 44.79935, 'lon': 10.32618}}, {'city': 'Pavia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Andrea Pietrabissa, MD', 'role': 'CONTACT', 'email': 'andrea.pietrabissa@gmail.com'}], 'facility': 'San Matteo Hospital', 'geoPoint': {'lat': 45.19205, 'lon': 9.15917}}, {'city': 'Peschiera del Garda', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Harmony Impellizzeri, MD', 'role': 'CONTACT', 'email': 'harmony85@hotmail.it'}], 'facility': 'Pederzoli Hospital', 'geoPoint': {'lat': 45.43912, 'lon': 10.68614}}, {'city': 'Pordenone', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Stefano MM Basso, MD', 'role': 'CONTACT', 'email': 'drsteba@gmail.com'}], 'facility': 'Azienda Sanitaria Fiuli Occidentale', 'geoPoint': {'lat': 45.95689, 'lon': 12.66051}}, {'city': 'Riccione', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Andrea Lucchi, MD', 'role': 'CONTACT', 'email': 'andrea.lucchi@auslromagna.it'}], 'facility': 'Ceccarini Hospital', 'geoPoint': {'lat': 43.99942, 'lon': 12.65689}}, {'city': 'Rimini', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Gianluca Garulli, MD', 'role': 'CONTACT', 'email': 'gianluca.garulli@auslromagna.it'}], 'facility': 'Infermi Hospital', 'geoPoint': {'lat': 44.05755, 'lon': 12.56528}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Gabriella T Capolupo, MD', 'role': 'CONTACT', 'email': 'g.capolupo@unicampus.it'}], 'facility': 'Campus Biomedico', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giuseppe Sica, MD', 'role': 'CONTACT', 'email': 'sigisica@gmail.com'}], 'facility': 'Fondazione Policlinico Roma Tor Vergata', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Carlo Ratto, MD', 'role': 'CONTACT', 'email': 'carloratto@tiscali.it'}], 'facility': 'Fondazione Policlinico Universitario Agostino Gemelli IRCCS', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Biagio Picardi, MD', 'role': 'CONTACT', 'email': 'biagiopicardi@gmail.com'}], 'facility': 'San Filippo Neri Hospital', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Massimo Carlini, MD', 'role': 'CONTACT', 'email': 'massimo.carlini@aslroma2.it'}], 'facility': "Sant'Eugenio Hospital", 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Michela Campanelli, MD', 'role': 'CONTACT', 'email': 'michelacampanelli@live.it'}], 'facility': 'UOSD Tor Vergata', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Sassari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alberto Porcu, MD', 'role': 'CONTACT', 'email': 'alberto.porcu.1@gmail.com'}], 'facility': 'AOU Sassari', 'geoPoint': {'lat': 40.72586, 'lon': 8.55552}}, {'city': 'Treviso', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Ugo Grossi, MD', 'role': 'CONTACT', 'email': 'ugo.grossi@aulss2.veneto.it'}], 'facility': 'Regional Hospital Treviso', 'geoPoint': {'lat': 45.66673, 'lon': 12.2416}}, {'city': 'Trieste', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Nicolò De Manzini, MD', 'role': 'CONTACT', 'email': 'ndemanzini@units.it'}], 'facility': 'University Hospital of Trieste', 'geoPoint': {'lat': 45.64953, 'lon': 13.77678}}, {'city': 'Turin', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Mario Morino, MD', 'role': 'CONTACT', 'email': 'mario.morino@unito.it'}], 'facility': 'AOU Città della Salute e della Scienza', 'geoPoint': {'lat': 45.07049, 'lon': 7.68682}}, {'city': 'Turin', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alessandro Ferrero, MD', 'role': 'CONTACT', 'email': 'aferrero@mauriziano.it'}], 'facility': 'Mauriziano Hospital', 'geoPoint': {'lat': 45.07049, 'lon': 7.68682}}, {'city': 'Vimercate', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alice Frontali, MD', 'role': 'CONTACT', 'email': 'frontalice@gmail.com'}], 'facility': 'ASST Vimercate', 'geoPoint': {'lat': 45.61545, 'lon': 9.36801}}], 'centralContacts': 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