Ignite Creation Date:
2025-12-24 @ 3:42 PM
Ignite Modification Date:
2026-01-01 @ 10:40 PM
Study NCT ID:
NCT05147792
Status:
RECRUITING
Last Update Posted:
2025-12-23
First Post:
2021-11-24
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The CONFORM Pivotal Trial
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001281', 'term': 'Atrial Fibrillation'}, {'id': 'D020521', 'term': 'Stroke'}], 'ancestors': [{'id': 'D001145', 'term': 'Arrhythmias, Cardiac'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 1600}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2022-05-26', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-09', 'completionDateStruct': {'date': '2031-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-19', 'studyFirstSubmitDate': '2021-11-24', 'studyFirstSubmitQcDate': '2021-11-24', 'lastUpdatePostDateStruct': {'date': '2025-12-23', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2021-12-07', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2028-06', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Procedure-related complications, all-cause death, major bleeding', 'timeFrame': '12 months', 'description': 'The primary safety endpoint is a composite of 1) major procedure-related complications including a) cardiac perforation, b) pericardial effusion requiring drainage, c) ischemic stroke, d) device embolization, and e) major vascular complications, or 2) major bleeding, or 3) all-cause death'}, {'measure': 'Ischemic stroke and systemic embolism', 'timeFrame': '18 months', 'description': 'The primary effectiveness endpoint is a composite of ischemic stroke and systemic embolism through 18 months.'}], 'secondaryOutcomes': [{'measure': 'All Cause Mortality', 'timeFrame': '18 months', 'description': 'A secondary safety endpoint is all-cause mortality including cardiovascular through 18 months'}, {'measure': 'Myocardial Infarction', 'timeFrame': '7 days', 'description': 'A secondary safety endpoint is myocardial infarction evaluated through 7 days post-procedure'}, {'measure': 'Neurologic Events', 'timeFrame': '45 days', 'description': 'A secondary safety endpoint is neurologic events including stroke (ischemic and hemorrhagic) and TIA'}, {'measure': 'Closure Success', 'timeFrame': '12 months', 'description': 'A secondary performance and efficacy endpoint is closure success at 12 months based upon each of the following criteria: a) demonstration of peri-device leak \\</=5 mm, and b) demonstration of peri-device leak \\</=3 mm'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isUnapprovedDevice': True, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'conditions': ['Atrial Fibrillation', 'Stroke']}, 'descriptionModule': {'briefSummary': 'The CLAAS® device will be evaluated for safety and efficacy by establishing its performance is non-inferior to the commercially available WATCHMAN® and Amulet™ left atrial appendage closure devices in patients with non-valvular atrial fibrillation. Patients who are eligible for the trial will be randomized to receive either the CLAAS device or the WATCHMAN or Amulet™ devices and will be followed for 5 years after device implant.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Male or non-pregnant female aged ≥18 years\n2. Documented non-valvular AF (paroxysmal, persistent, or permanent)\n3. High risk of stroke or systemic embolism, defined as CHA2DS2-VASc score of ≥ 3\n4. Has an appropriate rationale to seek a non-pharmacologic alternative to long-term oral anticoagulation\n5. Deemed by the site investigator to be suitable for short term oral anticoagulation therapy but deemed less favorable for long-term oral anticoagulation therapy.\n6. Deemed appropriate for LAA closure by the site investigator and a clinician not a part of the procedural team using a shared decision-making process in accordance with standard of care\n7. Able to comply with the protocol-specified medication regimen and follow-up evaluations\n8. The subject (or legally authorized representative, where allowed) has been informed of the nature of the study, agrees to its provisions, and has provided written informed consent approved by the appropriate institutional review board (IRB)/Regional Ethics Board (REB)/Ethics Committee (EC).\n\nExclusion Criteria:\n\n1. Pregnant or nursing patients and those who plan pregnancy in the period up to one year following the index procedure. Female patients of childbearing potential must have a negative pregnancy test (per site standard test) within 7 days prior to index procedure.\n2. Anatomic conditions that would prevent performance of an LAA occlusion procedure (e.g., atrial septal defect (ASD) requiring closure, high-risk patent foramen ovale (PFO) requiring closure, a highly mobile inter-atrial septal aneurysm precluding a safe TSP, presence of a PFO/ASD closure device, history of surgical ASD repair or history of surgical LAAO closure)\n3. Atrial fibrillation that is defined by a single occurrence or that is transient or reversible (e.g., secondary thyroid disorders, acute alcohol intoxication, trauma, recent major surgical procedures)\n4. A medical condition (other than atrial fibrillation) that mandates long-term oral anticoagulation (e.g., history of unprovoked deep vein thrombosis or pulmonary embolism, or prosthetic mechanical heart valve)\n5. History of bleeding diathesis or coagulopathy, or patients in whom antiplatelet and/or anticoagulant therapy is contraindicated\n6. Documented active systemic infection\n7. Symptomatic carotid artery disease (defined as \\>50% stenosis with symptoms of ipsilateral transient or visual TIA evidenced by amaurosis fugax, ipsilateral hemispheric TIAs or ipsilateral stroke); if subject has a history of carotid stent or endarterectomy the subject is eligible if there is \\<50% stenosis noted at the site of prior treatment\n8. Recent (within 30 days of index procedure) or planned (within 60 days post-procedure) cardiac or major non-cardiac interventional or surgical procedure\n9. Recent (within 30 days of index procedure) stroke or transient ischemic attack\n10. Recent (within 30 days of index procedure) myocardial infarction\n11. Vascular access precluding delivery of implant with catheter-based system\n12. Severe heart failure (New York Heart Association Class IV)\n13. Prior cardiac transplant, history of mitral valve replacement or transcatheter mitral valve intervention, or any prosthetic mechanical valve implant\n14. Renal insufficiency, defined as estimated glomerular filtration rate (eGFR) \\<30 mL/min/1.73 m2 (by the Modification of Diet in Renal Disease equation)\n15. Platelet count \\<75,000 cells/mm3 or \\>700,000 cells/mm3, or white blood cell count \\<3,000 cells/mm3\n16. Known allergy, hypersensitivity or contraindication to aspirin, heparin, or device materials (e.g., nickel, titanium) that would preclude any P2Y12 inhibitor therapy, or the patient has contrast sensitivity that cannot be adequately pre-medicated\n17. Actively enrolled or plans to enroll in a concurrent clinical study in which the active treatment arm may confound the results of this trial\n18. Unable to undergo general anesthesia\n19. Known other medical illness or known history of substance abuse that may cause non-compliance with the protocol or protocol-specified medication regimen, confound the data interpretation, or is associated with a life expectancy of less than 5 years\n20. A condition which precludes adequate transesophageal echocardiographic assessment\n\nEcho exclusion criteria:\n\n1. Left atrial appendage anatomy which cannot accommodate a commercially available control device or the CLAAS Implant per manufacturer IFU (e.g., the anatomy and sizing must be appropriate for both the investigational (CLAAS) and a commercially available device in order to be enrolled in the trial)\n2. Intracardiac thrombus or dense spontaneous echo contrast consistent with thrombus, as visualized by TEE prior to implant\n3. Left ventricular ejection fraction (LVEF) \\<30%\n4. Moderate or large pericardial effusion \\>10 mm or symptomatic pericardial effusion, signs or symptoms of acute or chronic pericarditis, or evidence of tamponade physiology\n5. Atrial septal defect that warrants closure\n6. High risk patent foramen ovale (PFO), defined as an atrial septal aneurysm (excursion \\>15 mm or length \\> 15 mm) or large shunt (early \\[within 3 beats\\] and/or substantial passage of bubbles, e.g., \\>20)\n7. Moderate or severe mitral valve stenosis (mitral valve area \\<1.5 cm2)\n8. Complex atheroma with mobile plaque of the descending aorta and/or aortic arch\n9. Evidence of cardiac tumor'}, 'identificationModule': {'nctId': 'NCT05147792', 'briefTitle': 'The CONFORM Pivotal Trial', 'organization': {'class': 'INDUSTRY', 'fullName': 'Conformal Medical, Inc'}, 'officialTitle': 'An Evaluation of the Safety and Effectiveness of the Conformal CLAAS System for Left Atrial Appendage Occlusion', 'orgStudyIdInfo': {'id': '21-101'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'CLAAS', 'description': 'Transcatheter left atrial occluder', 'interventionNames': ['Device: CLAAS']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'WATCHMAN / Amulet', 'description': 'Transcatheter left atrial occluder', 'interventionNames': ['Device: WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder']}], 'interventions': [{'name': 'CLAAS', 'type': 'DEVICE', 'description': 'CLAAS', 'armGroupLabels': ['CLAAS']}, {'name': 'WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder', 'type': 'DEVICE', 'description': 'WATCHMAN left atrial appendage closure device / Amulet left atrial appendage occluder', 'armGroupLabels': ['WATCHMAN / Amulet']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35243', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kristy Raco', 'role': 'CONTACT', 'email': 'kristy.raco@grandviewhealth.com'}, {'name': 'Anil Rajendra, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Grandview Medical Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85006', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Karen Moylen', 'role': 'CONTACT', 'email': 'kmoylen@arizona.edu'}, {'name': 'Wilber Su, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Banner University Medical Center Phoenix', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85016', 'city': 'Phoenix', 'state': 'Arizona', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Abrazo Arizona Heart Hospital', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85258', 'city': 'Scottsdale', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ethan Ashley', 'role': 'CONTACT', 'email': 'eashley@honorhealth.com'}, {'name': 'Rahul Doshi, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'HonorHealth', 'geoPoint': {'lat': 33.50921, 'lon': -111.89903}}, {'zip': '85719', 'city': 'Tucson', 'state': 'Arizona', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Salma Blum', 'role': 'CONTACT', 'email': 'Salma.Blum@tmcaz.com'}, {'name': 'Thomas Waggoner, DO', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Pima Heart & Vascular', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '72401', 'city': 'Jonesboro', 'state': 'Arkansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kayla Rubino', 'role': 'CONTACT', 'email': 'krubino@dnairresearch.com'}, {'name': 'Devi Nair, M.D.', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "St. Bernard's Medical Center", 'geoPoint': {'lat': 35.8423, 'lon': -90.70428}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Samia Solh', 'role': 'CONTACT', 'email': 'Samia.Solh@huntingtonhealth.org', 'phone': '626-397-3883'}, {'name': 'Mayer Rashtian, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Huntington Hospital', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '90405', 'city': 'Santa Monica', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Alette Laughton', 'role': 'CONTACT', 'email': 'research@pacificheart.com'}, {'name': 'Shephal Doshi, M.D.', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Pacific Heart Institute', 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '93003', 'city': 'Ventura', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Marisa Grant', 'role': 'CONTACT', 'email': 'marisa@siteresearchmgmt.com'}, {'name': 'Jonathan Dukes, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Community Memorial Hospital Ventura', 'geoPoint': {'lat': 34.27834, 'lon': -119.29317}}, {'zip': '06606', 'city': 'Bridgeport', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jesse Cardona', 'role': 'CONTACT', 'email': 'Jesse.cardona@hhchealth.org'}, {'name': 'Edward Carreras, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Hartford Health Care St. Vincent's Medical Center", 'geoPoint': {'lat': 41.17923, 'lon': -73.18945}}, {'zip': '20010', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nebu Alexander', 'role': 'CONTACT', 'email': 'nebu.alexander@medstar.net'}, {'name': 'Sarfraz Durrani, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'MedStar Washington Hospital Center', 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '32204', 'city': 'Jacksonville', 'state': 'Florida', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': "Ascension St. Vincent's Jacksonville", 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '33770', 'city': 'Largo', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Holly Lynn Grospitch', 'role': 'CONTACT', 'email': 'HollyLynn.Grospitch@hcahealthcare.com'}, {'name': 'Saurabh Sanan, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Largo Medical Center', 'geoPoint': {'lat': 27.90979, 'lon': -82.78842}}, {'zip': '33176', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Maria Ardid', 'role': 'CONTACT', 'email': 'mariaar@baptisthealth.net'}, {'name': 'Ramon Quesada, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Baptist Hospital of Miami', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '32803', 'city': 'Orlando', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Chantie Garvey', 'role': 'CONTACT', 'email': 'chantie.garvey@adventhealth.com'}, {'name': 'Usman Siddiqui, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'AdventHealth Orlando', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '34239', 'city': 'Sarasota', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Kristen Sangmaster', 'role': 'CONTACT', 'email': 'kristen-sangmaster@smh.com', 'phone': '941-917-2165'}, {'name': 'Robert Eckart, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sarasota Memorial Health Care System', 'geoPoint': {'lat': 27.33643, 'lon': -82.53065}}, {'zip': '33613', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daniel Robledo', 'role': 'CONTACT', 'email': 'daniel.robledo@adventhealth.com'}, {'name': 'Giancarlo Speziani, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'AdventHealth Tampa', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '33620', 'city': 'Tampa', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jacky He', 'role': 'CONTACT', 'email': 'jackyhe@usf.edu'}, {'name': 'Bibhu Mohanty, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'USF - Tampa General Hospital', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30309', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Megan Kopp', 'role': 'CONTACT', 'email': 'Megan.Kopp@piedmont.org'}, {'name': 'Sandeep Goyal, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Piedmont Health Institute', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30342', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Teressa Burns', 'role': 'CONTACT', 'email': 'teressa.burns@emory.edu'}, {'name': 'David De Lurgio, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30342', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Katie Moore', 'role': 'CONTACT', 'email': 'katie.moore@northside.com'}, {'name': 'Alok Gambhir, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Northside Hospital, Inc', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30062', 'city': 'Marietta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer Cuvo', 'role': 'CONTACT', 'email': 'Jennifer.Cuvo@wellstar.org'}, {'name': 'Amar Patel, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'WellStar Kennestone Hospital', 'geoPoint': {'lat': 33.9526, 'lon': -84.54993}}, {'zip': '60540', 'city': 'Naperville', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sherri McCoy', 'role': 'CONTACT', 'email': 'Sherri.McCoy@cardio.com'}, {'name': 'Moeen Saleem, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Midwest Cardiovascular Institute', 'geoPoint': {'lat': 41.78586, 'lon': -88.14729}}, {'zip': '46260', 'city': 'Indianapolis', 'state': 'Indiana', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Ascension St. Vincent - Carmel, IN', 'geoPoint': {'lat': 39.76838, 'lon': -86.15804}}, {'zip': '52242', 'city': 'Iowa City', 'state': 'Iowa', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Trisha Elliott', 'role': 'CONTACT', 'email': 'trisha-elliott@uiowa.edu'}, {'name': 'Paari Dominic, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Iowa', 'geoPoint': {'lat': 41.66113, 'lon': -91.53017}}, {'zip': '66160', 'city': 'Kansas City', 'state': 'Kansas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Grace Millington', 'role': 'CONTACT', 'email': 'gmillington@kumc.edu'}, {'name': 'Madhu Reddy, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Kansas Medical Center', 'geoPoint': {'lat': 39.11417, 'lon': -94.62746}}, {'zip': '70360', 'city': 'Houma', 'state': 'Louisiana', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Vicky Parfait', 'role': 'CONTACT', 'email': 'vicky.parfait@cardio.com'}, {'name': 'Peter Fail, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Terrebone - Cardiovascular Institute of the South', 'geoPoint': {'lat': 29.59577, 'lon': -90.71953}}, {'zip': '21218', 'city': 'Baltimore', 'state': 'Maryland', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Keith Moyer', 'role': 'CONTACT', 'email': 'Keith.T.Moyer@medstar.net'}, {'name': 'John Wang, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Medstar Union Memorial Hospital', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'zip': '01805', 'city': 'Burlington', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jean Byrne', 'role': 'CONTACT', 'email': 'jean.byrne@lahey.org'}, {'name': 'Jonathan Silver, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Lahey Hospital & Medical Centeer', 'geoPoint': {'lat': 42.50482, 'lon': -71.19561}}, {'zip': '01199', 'city': 'Springfield', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Christine Callahan', 'role': 'CONTACT', 'email': 'Christine.Callahan@baystatehealth.org'}, {'name': 'Andrew Goldsweig, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Baystate Medical Center', 'geoPoint': {'lat': 42.10148, 'lon': -72.58981}}, {'zip': '48236', 'city': 'Detroit', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Heather Metcalfe', 'role': 'CONTACT', 'email': 'hmetcal1@hfhs.org'}, {'name': 'Amir Kaki, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Henry Ford St. John Hospital', 'geoPoint': {'lat': 42.33143, 'lon': -83.04575}}, {'zip': '49503', 'city': 'Grand Rapids', 'state': 'Michigan', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Corewell Health', 'geoPoint': {'lat': 42.96336, 'lon': -85.66809}}, {'zip': '48075', 'city': 'Southfield', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Candice Edillo', 'role': 'CONTACT', 'email': 'cedillo1@hfhs.org'}, {'name': 'Dipak Shah, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Henry Ford Providence Southfield Hospital', 'geoPoint': {'lat': 42.47337, 'lon': -83.22187}}, {'zip': '55109', 'city': 'Maplewood', 'state': 'Minnesota', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Beth Jorgenson', 'role': 'CONTACT', 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