Ignite Creation Date:
2025-12-24 @ 3:31 PM
Ignite Modification Date:
2026-01-05 @ 12:11 AM
Study NCT ID:
NCT03036592
Status:
COMPLETED
Last Update Posted:
2025-04-16
First Post:
2017-01-26
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
MTNR1B SNP*Food Timing Interaction on Glucose Control
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'garaulet@um.es', 'phone': '868884030', 'title': 'Prof. Marta Garaulet Aza', 'organization': 'University of Murcia'}, 'certainAgreement': {'piSponsorEmployee': True}, 'limitationsAndCaveats': {'description': '* Typically, the Participant Flow list Arms/Groups "per sequence" (i.e., "MTNR1B CC Early OGTT first, then Late OGTT", MTNR1B CC Late OGTT first, then Early OGTT", etc.). However, as shown (Diabetes Care, PUBMED: 35015083), the study was conducted to compare the conditions of "early" and "late", within each genotyping-group without considering the order.\n* The individual\'s genotypes were not known until the end of the study, then we could not assign the groups until we finished the study.'}}, 'adverseEventsModule': {'timeFrame': 'During 9 days (1 day of intervention-1 week of washout-1 day of intervention), through study completion', 'eventGroups': [{'id': 'EG000', 'title': 'Early OGTT (First) in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.', 'otherNumAtRisk': 221, 'deathsNumAtRisk': 221, 'otherNumAffected': 0, 'seriousNumAtRisk': 221, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Early OGTT (First) in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.', 'otherNumAtRisk': 193, 'deathsNumAtRisk': 193, 'otherNumAffected': 0, 'seriousNumAtRisk': 193, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Early OGTT (First) in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.', 'otherNumAtRisk': 36, 'deathsNumAtRisk': 36, 'otherNumAffected': 0, 'seriousNumAtRisk': 36, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'Late OGTT (First) in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.', 'otherNumAtRisk': 202, 'deathsNumAtRisk': 202, 'otherNumAffected': 0, 'seriousNumAtRisk': 202, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG004', 'title': 'Late OGTT (First) in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.', 'otherNumAtRisk': 149, 'deathsNumAtRisk': 149, 'otherNumAffected': 0, 'seriousNumAtRisk': 149, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG005', 'title': 'Late OGTT (First) in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.', 'otherNumAtRisk': 44, 'deathsNumAtRisk': 44, 'otherNumAffected': 0, 'seriousNumAtRisk': 44, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG006', 'title': 'Late OGTT (Second) in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.', 'otherNumAtRisk': 221, 'deathsNumAtRisk': 221, 'otherNumAffected': 0, 'seriousNumAtRisk': 221, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG007', 'title': 'Late OGTT (Second) in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a', 'otherNumAtRisk': 193, 'deathsNumAtRisk': 193, 'otherNumAffected': 0, 'seriousNumAtRisk': 193, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG008', 'title': 'Late OGTT (Second) in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.', 'otherNumAtRisk': 36, 'deathsNumAtRisk': 36, 'otherNumAffected': 0, 'seriousNumAtRisk': 36, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG009', 'title': 'Early OGTT (Second) in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.', 'otherNumAtRisk': 202, 'deathsNumAtRisk': 202, 'otherNumAffected': 0, 'seriousNumAtRisk': 202, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG010', 'title': 'Early OGTT (Second) in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.', 'otherNumAtRisk': 149, 'deathsNumAtRisk': 149, 'otherNumAffected': 0, 'seriousNumAtRisk': 149, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG011', 'title': 'Early OGTT (Second) in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.', 'otherNumAtRisk': 44, 'deathsNumAtRisk': 44, 'otherNumAffected': 0, 'seriousNumAtRisk': 44, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Area Under the Curve (AUC) Glucose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'AUC_Glucose_EE (Early Eating)', 'categories': [{'measurements': [{'value': '278.84', 'spread': '49.12', 'groupId': 'OG000'}, {'value': '268.92', 'spread': '48.69', 'groupId': 'OG001'}, {'value': '260.66', 'spread': '45.30', 'groupId': 'OG002'}, {'value': '282.21', 'spread': '54.89', 'groupId': 'OG003'}, {'value': '274.91', 'spread': '55.55', 'groupId': 'OG004'}, {'value': '282.19', 'spread': '56.56', 'groupId': 'OG005'}]}]}, {'title': 'AUC_Glucose_LE (Late Eating)', 'categories': [{'measurements': [{'value': '291.58', 'spread': '49.73', 'groupId': 'OG000'}, {'value': '300.51', 'spread': '54.60', 'groupId': 'OG001'}, {'value': '300.61', 'spread': '61.35', 'groupId': 'OG002'}, {'value': '300.70', 'spread': '56.88', 'groupId': 'OG003'}, {'value': '299.09', 'spread': '57.74', 'groupId': 'OG004'}, {'value': '320.32', 'spread': '63.95', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Along 120 minutes in visits 1 and 2', 'description': 'Glucose levels are measured along 120 minutes corresponding to at early and late condition in each visit. The Area Under the Curve was calculated as the sum of the area of several trapezoids. This trapezoids was obtained at times 0-30 min, 30-60 min, 60-90 min, 90-120 min. The values are the difference between the late and the early condition.', 'unitOfMeasure': 'mg*h/dL', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Disposition Index (DI)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'DI_EE', 'categories': [{'measurements': [{'value': '3.44', 'spread': '3.03', 'groupId': 'OG000'}, {'value': '4.59', 'spread': '6.42', 'groupId': 'OG001'}, {'value': '5.04', 'spread': '6.14', 'groupId': 'OG002'}, {'value': '3.54', 'spread': '3.04', 'groupId': 'OG003'}, {'value': '3.83', 'spread': '3.84', 'groupId': 'OG004'}, {'value': '3.96', 'spread': '3.61', 'groupId': 'OG005'}]}]}, {'title': 'DI_LE', 'categories': [{'measurements': [{'value': '3.33', 'spread': '3.66', 'groupId': 'OG000'}, {'value': '2.97', 'spread': '2.55', 'groupId': 'OG001'}, {'value': '2.78', 'spread': '1.67', 'groupId': 'OG002'}, {'value': '3.19', 'spread': '3.34', 'groupId': 'OG003'}, {'value': '3.19', 'spread': '2.50', 'groupId': 'OG004'}, {'value': '3.04', 'spread': '4.46', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Along 120 minutes in visits 1 and 2', 'description': 'Disposition Index (DI) is the product of insulin sensitivity times by the amount of insulin secreted in response to blood glucose levels. Disposition index is used as a measure of beta cell function and the ability of the body to dispose of a glucose load. This index was determined by this formula:\n\nDI= CIR × ISI, where CIR is the measure Corrected Insulin Response, and ISI is Insulin Sensitivity Index. The values are the difference between the late and the early condition.\n\nHigher DI indicates an increased beta cell function and increased ability of the body to dispose of a glucose load.', 'unitOfMeasure': 'Index', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Corrected Insulin Response (CIR)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'CIR_EE', 'categories': [{'measurements': [{'value': '0.57', 'spread': '0.60', 'groupId': 'OG000'}, {'value': '0.70', 'spread': '1.10', 'groupId': 'OG001'}, {'value': '0.94', 'spread': '1.41', 'groupId': 'OG002'}, {'value': '0.58', 'spread': '0.52', 'groupId': 'OG003'}, {'value': '0.59', 'spread': '0.45', 'groupId': 'OG004'}, {'value': '0.53', 'spread': '0.38', 'groupId': 'OG005'}]}]}, {'title': 'CIR_LE', 'categories': [{'measurements': [{'value': '0.50', 'spread': '0.46', 'groupId': 'OG000'}, {'value': '0.44', 'spread': '0.38', 'groupId': 'OG001'}, {'value': '0.46', 'spread': '0.23', 'groupId': 'OG002'}, {'value': '0.53', 'spread': '0.60', 'groupId': 'OG003'}, {'value': '0.51', 'spread': '0.45', 'groupId': 'OG004'}, {'value': '0.36', 'spread': '0.28', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'At minute 30 during the visit 1 and 2.', 'description': 'The measure of Corrected Insulin Response (CIR) uses the insulin and glucose levels at minute 30, integrating these values in the formula:\n\nCIR= l30/(G30 × (G30 - 70)).The values are the difference between the late and the early conditions.\n\nCIR is an index that assesses the insulin secretion capacity of B cells. A low CIR implies hyposecretion in response to glucose levels.', 'unitOfMeasure': 'Index', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Insulin Sensitivity Index (ISI)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.\n\nEarly OGTT: Test glucose tolerance using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)\n\nLate OGTT: Test glucose tolerance using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'ISI_EE', 'categories': [{'measurements': [{'value': '7.36', 'spread': '5.40', 'groupId': 'OG000'}, {'value': '7.26', 'spread': '4.38', 'groupId': 'OG001'}, {'value': '6.42', 'spread': '3.43', 'groupId': 'OG002'}, {'value': '7.19', 'spread': '5.02', 'groupId': 'OG003'}, {'value': '7.40', 'spread': '5.13', 'groupId': 'OG004'}, {'value': '7.61', 'spread': '3.91', 'groupId': 'OG005'}]}]}, {'title': 'ISI_LE', 'categories': [{'measurements': [{'value': '8.11', 'spread': '6.98', 'groupId': 'OG000'}, {'value': '8.11', 'spread': '6.34', 'groupId': 'OG001'}, {'value': '7.32', 'spread': '4.20', 'groupId': 'OG002'}, {'value': '6.99', 'spread': '4.91', 'groupId': 'OG003'}, {'value': '7.59', 'spread': '5.22', 'groupId': 'OG004'}, {'value': '8.00', 'spread': '6.66', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Along 120min in visits 1 and 2', 'description': "Insulin Sensitivity Index is a measurement which integrates fasting glucose and insulin concentrations (0 min) and the mean of the glucose and insulin levels from 0 to 120 minutes (0, 30, 60, 90 and 120 min), from an OGTT, to measure insulin sensitivity. This formula allows its use in clinical settings as well as in large epidemiological studies. The values are the difference between the late and the early condition.\n\nElevated ISI values typically indicate a favorable outcome. This index reflects the body's responsiveness to insulin, a hormone crucial for regulating blood sugar levels. Higher sensitivity to insulin suggests that cells efficiently utilize insulin's signals, promoting better blood sugar management. Lower ISI may lead to challenges in maintaining stable blood glucose levels and is often associated with conditions such as type 2 diabetes and metabolic syndrome.", 'unitOfMeasure': 'Index', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Fasting Glucose', 'denoms': [{'units': 'Participants', 'counts': [{'value': '212', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'Fasting glucose_EE', 'categories': [{'measurements': [{'value': '85.25', 'spread': '7.73', 'groupId': 'OG000'}, {'value': '84.36', 'spread': '7.25', 'groupId': 'OG001'}, {'value': '84.05', 'spread': '5.75', 'groupId': 'OG002'}, {'value': '84.37', 'spread': '6.84', 'groupId': 'OG003'}, {'value': '84.69', 'spread': '7.71', 'groupId': 'OG004'}, {'value': '83.01', 'spread': '4.90', 'groupId': 'OG005'}]}]}, {'title': 'Fasting glucose_LE', 'categories': [{'measurements': [{'value': '84.09', 'spread': '7.15', 'groupId': 'OG000'}, {'value': '84.92', 'spread': '7.07', 'groupId': 'OG001'}, {'value': '85.70', 'spread': '6.90', 'groupId': 'OG002'}, {'value': '84.70', 'spread': '7.74', 'groupId': 'OG003'}, {'value': '85.53', 'spread': '6.8', 'groupId': 'OG004'}, {'value': '83.87', 'spread': '7.51', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'At minute 0 in visit 1 and 2.', 'description': 'Fasting glucose (or basal glucose) is a simple measurement of glucose concentrations at minute 0 to see how glucose levels rise immediately after an OGTT. The values are the difference between the late and the early condition.', 'unitOfMeasure': 'mg/dL', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Fasting Insulin', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'Fasting insulin_EE', 'categories': [{'measurements': [{'value': '6.70', 'spread': '4.51', 'groupId': 'OG000'}, {'value': '6.30', 'spread': '4.28', 'groupId': 'OG001'}, {'value': '6.88', 'spread': '3.73', 'groupId': 'OG002'}, {'value': '6.67', 'spread': '4.73', 'groupId': 'OG003'}, {'value': '6.16', 'spread': '3.58', 'groupId': 'OG004'}, {'value': '5.63', 'spread': '3.69', 'groupId': 'OG005'}]}]}, {'title': 'Fasting insulin_LE', 'categories': [{'measurements': [{'value': '6.13', 'spread': '4.48', 'groupId': 'OG000'}, {'value': '5.70', 'spread': '3.65', 'groupId': 'OG001'}, {'value': '5.71', 'spread': '2.73', 'groupId': 'OG002'}, {'value': '6.50', 'spread': '4.56', 'groupId': 'OG003'}, {'value': '6.09', 'spread': '3.83', 'groupId': 'OG004'}, {'value': '5.52', 'spread': '3.32', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'At minute 0 in visit 1 and 2', 'description': 'Fasting insulin (or basal insulin) is a simple measurement of insulin concentrations at minute 0 to see how insulin levels rise immediately after an OGTT.The values are the difference between the late and the early condition.', 'unitOfMeasure': 'µU/mL', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Serum Melatonin', 'denoms': [{'units': 'Participants', 'counts': [{'value': '158', 'groupId': 'OG000'}, {'value': '136', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}, {'value': '136', 'groupId': 'OG003'}, {'value': '104', 'groupId': 'OG004'}, {'value': '31', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'Melatonin_t0_EE', 'categories': [{'measurements': [{'value': '20.86', 'spread': '12.32', 'groupId': 'OG000'}, {'value': '19.50', 'spread': '9.82', 'groupId': 'OG001'}, {'value': '20.25', 'spread': '10.70', 'groupId': 'OG002'}, {'value': '19.20', 'spread': '10.39', 'groupId': 'OG003'}, {'value': '19.01', 'spread': '10.87', 'groupId': 'OG004'}, {'value': '23.13', 'spread': '14.92', 'groupId': 'OG005'}]}]}, {'title': 'Melatonin_t120_EE', 'categories': [{'measurements': [{'value': '25.81', 'spread': '17.69', 'groupId': 'OG000'}, {'value': '26.85', 'spread': '22.10', 'groupId': 'OG001'}, {'value': '25.72', 'spread': '19.65', 'groupId': 'OG002'}, {'value': '25.40', 'spread': '18.03', 'groupId': 'OG003'}, {'value': '21.83', 'spread': '13.47', 'groupId': 'OG004'}, {'value': '29.61', 'spread': '26.63', 'groupId': 'OG005'}]}]}, {'title': 'Melatonin_t0_LE', 'categories': [{'measurements': [{'value': '52.69', 'spread': '40.34', 'groupId': 'OG000'}, {'value': '53.16', 'spread': '43.69', 'groupId': 'OG001'}, {'value': '54.24', 'spread': '35.21', 'groupId': 'OG002'}, {'value': '49.32', 'spread': '34.39', 'groupId': 'OG003'}, {'value': '47.16', 'spread': '41.14', 'groupId': 'OG004'}, {'value': '55.33', 'spread': '32.39', 'groupId': 'OG005'}]}]}, {'title': 'Melatonin_t120_LE', 'categories': [{'measurements': [{'value': '79.36', 'spread': '52.24', 'groupId': 'OG000'}, {'value': '83.92', 'spread': '60.28', 'groupId': 'OG001'}, {'value': '93.83', 'spread': '63.71', 'groupId': 'OG002'}, {'value': '81.07', 'spread': '55.86', 'groupId': 'OG003'}, {'value': '74.06', 'spread': '55.72', 'groupId': 'OG004'}, {'value': '83.80', 'spread': '44.87', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'At baseline and 120 minutes in visit 1 and 2', 'description': 'Measurement of serum melatonin is made at time 0 and at time 120 in both the early and late conditions of everyone.', 'unitOfMeasure': 'pg/mL', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Dim Light Melatonin Onset (DLMO) at Early Condition Only', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '40', 'groupId': 'OG001'}, {'value': '12', 'groupId': 'OG002'}, {'value': '42', 'groupId': 'OG003'}, {'value': '29', 'groupId': 'OG004'}, {'value': '8', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '22.42', 'spread': '1.33', 'groupId': 'OG000'}, {'value': '22.03', 'spread': '1.06', 'groupId': 'OG001'}, {'value': '22.41', 'spread': '0.92', 'groupId': 'OG002'}, {'value': '22.50', 'spread': '1.38', 'groupId': 'OG003'}, {'value': '22.08', 'spread': '1.13', 'groupId': 'OG004'}, {'value': '22.39', 'spread': '1.40', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Melatonin measured every half hour for 5 hours at Early condition in all participants', 'description': 'This measurement shows the decimal time of the onset of melatonin in dim light conditions. In the case of DLMO, we only performed this measure at the early condition in order to get the analysis of melatonin during 5 hours (4 hours before the habitual bedtime and 1 hour later), as it is described in literature (DOI: 10.1002/oby.23749).', 'unitOfMeasure': 'decimal hours', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'We only performed this measure at the early condition in each arm'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Temperature Record (Mean Value 10hours Daytime)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '32.94', 'spread': '0.98', 'groupId': 'OG000'}, {'value': '32.95', 'spread': '1.09', 'groupId': 'OG001'}, {'value': '33.24', 'spread': '0.94', 'groupId': 'OG002'}, {'value': '33.05', 'spread': '0.98', 'groupId': 'OG003'}, {'value': '32.91', 'spread': '0.93', 'groupId': 'OG004'}, {'value': '33.02', 'spread': '0.95', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Measured using a temperature sensor which records the temperature during 7 days. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'centigrade degrees', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Activity Record (Mean Value 10hours Daytime)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.\n\nEarly OGTT: Test glucose tolerance using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)\n\nLate OGTT: Test glucose tolerance using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '42.69', 'spread': '8.51', 'groupId': 'OG000'}, {'value': '51.61', 'spread': '85.33', 'groupId': 'OG001'}, {'value': '42.62', 'spread': '6.46', 'groupId': 'OG002'}, {'value': '41.73', 'spread': '9.12', 'groupId': 'OG003'}, {'value': '43.83', 'spread': '8.06', 'groupId': 'OG004'}, {'value': '44.30', 'spread': '8.31', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'During the seven days of the study, individuals wore a wristwatch in their non-dominant hand, that integrates two sensors: a temperature sensor, and an accelerometer sensor that records physical activity and body position data (G Acceleration Data Logger UA-004-64; Onset Computer, Bourne, MA, USA). Activity was expressed as the change in degrees per minute (Δ°/min). We calculated the average activity value during the 10 consecutive hours of maximum values. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'changes in degrees/min (Δ°/min)', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Light Exposure (Mean Value 10hours Daytime)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '0.82', 'spread': '0.24', 'groupId': 'OG000'}, {'value': '0.83', 'spread': '0.24', 'groupId': 'OG001'}, {'value': '0.77', 'spread': '0.27', 'groupId': 'OG002'}, {'value': '0.81', 'spread': '0.25', 'groupId': 'OG003'}, {'value': '0.81', 'spread': '0.25', 'groupId': 'OG004'}, {'value': '0.88', 'spread': '0.32', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between the visits 1 and 2', 'description': 'Measured using a light sensor during 7 days. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'Lux log', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Sleep Duration', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '7.43', 'spread': '0.75', 'groupId': 'OG000'}, {'value': '7.52', 'spread': '0.79', 'groupId': 'OG001'}, {'value': '7.58', 'spread': '0.70', 'groupId': 'OG002'}, {'value': '7.56', 'spread': '0.82', 'groupId': 'OG003'}, {'value': '7.46', 'spread': '0.88', 'groupId': 'OG004'}, {'value': '7.51', 'spread': '0.69', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Sleep duration will be computed from self-reported. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'decimal hours', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Total Energy Intake', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '1563.64', 'spread': '529.39', 'groupId': 'OG000'}, {'value': '1548.29', 'spread': '552.64', 'groupId': 'OG001'}, {'value': '1666.25', 'spread': '633.62', 'groupId': 'OG002'}, {'value': '1555.96', 'spread': '625.39', 'groupId': 'OG003'}, {'value': '1619.23', 'spread': '695.37', 'groupId': 'OG004'}, {'value': '1753.18', 'spread': '719.78', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Total energy intake in kcal/day will be computed with a 7-day dietary log. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'Kcal/day', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Dietary Composition', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'Fat', 'categories': [{'measurements': [{'value': '34.85', 'spread': '7.01', 'groupId': 'OG000'}, {'value': '33.95', 'spread': '7.37', 'groupId': 'OG001'}, {'value': '36.04', 'spread': '8.25', 'groupId': 'OG002'}, {'value': '33.94', 'spread': '7.83', 'groupId': 'OG003'}, {'value': '34.90', 'spread': '8.04', 'groupId': 'OG004'}, {'value': '35.85', 'spread': '8.49', 'groupId': 'OG005'}]}]}, {'title': 'Proteins', 'categories': [{'measurements': [{'value': '17.52', 'spread': '3.41', 'groupId': 'OG000'}, {'value': '18.26', 'spread': '3.94', 'groupId': 'OG001'}, {'value': '18.02', 'spread': '3.92', 'groupId': 'OG002'}, {'value': '18.18', 'spread': '3.95', 'groupId': 'OG003'}, {'value': '18.24', 'spread': '3.48', 'groupId': 'OG004'}, {'value': '17.57', 'spread': '3.65', 'groupId': 'OG005'}]}]}, {'title': 'Carbohydrates', 'categories': [{'measurements': [{'value': '47.17', 'spread': '7.66', 'groupId': 'OG000'}, {'value': '47.75', 'spread': '7.42', 'groupId': 'OG001'}, {'value': '46.85', 'spread': '7.38', 'groupId': 'OG002'}, {'value': '47.82', 'spread': '8.33', 'groupId': 'OG003'}, {'value': '46.64', 'spread': '8.49', 'groupId': 'OG004'}, {'value': '46.68', 'spread': '7.58', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Macronutrient and micronutrient intake will be computed from 7-days of self-reported 24-hr dietary recalls.\n\nPercentage Kcal respect to the Total Energy Intake. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'percentage', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Dietary Intake Timing', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'title': 'Start breakfast', 'categories': [{'measurements': [{'value': '8.72', 'spread': '0.98', 'groupId': 'OG000'}, {'value': '8.68', 'spread': '0.87', 'groupId': 'OG001'}, {'value': '8.80', 'spread': '0.92', 'groupId': 'OG002'}, {'value': '8.74', 'spread': '0.92', 'groupId': 'OG003'}, {'value': '8.68', 'spread': '0.83', 'groupId': 'OG004'}, {'value': '8.66', 'spread': '0.96', 'groupId': 'OG005'}]}]}, {'title': 'Start lunch', 'categories': [{'measurements': [{'value': '14.66', 'spread': '0.49', 'groupId': 'OG000'}, {'value': '14.72', 'spread': '0.53', 'groupId': 'OG001'}, {'value': '14.60', 'spread': '0.42', 'groupId': 'OG002'}, {'value': '14.70', 'spread': '0.52', 'groupId': 'OG003'}, {'value': '14.71', 'spread': '0.48', 'groupId': 'OG004'}, {'value': '14.50', 'spread': '0.38', 'groupId': 'OG005'}]}]}, {'title': 'Start dinner', 'categories': [{'measurements': [{'value': '21.66', 'spread': '0.53', 'groupId': 'OG000'}, {'value': '21.61', 'spread': '0.65', 'groupId': 'OG001'}, {'value': '21.64', 'spread': '0.49', 'groupId': 'OG002'}, {'value': '21.61', 'spread': '0.56', 'groupId': 'OG003'}, {'value': '21.67', 'spread': '0.54', 'groupId': 'OG004'}, {'value': '21.54', 'spread': '0.56', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Food timing will be self-reported and averaged across 7-days of 24-hour dietary recalls. We only determined it during the washout period (neither early nor late conditions).', 'unitOfMeasure': 'decimal hours', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Physical Activity', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '4066.98', 'spread': '5898.97', 'groupId': 'OG000'}, {'value': '4548.62', 'spread': '5060.76', 'groupId': 'OG001'}, {'value': '4560.41', 'spread': '5779.47', 'groupId': 'OG002'}, {'value': '4646.63', 'spread': '4877.34', 'groupId': 'OG003'}, {'value': '4429.64', 'spread': '5284.58', 'groupId': 'OG004'}, {'value': '4608.31', 'spread': '4765.35', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the International Physical Activity Questionnaire (IPAQ). This international questionnaire measures physical activity through the amount of energy expended carrying out physical activity i.e., Metabolic Units (MET) minutes a week. The higher the MET, the more amount of physical activity the individual performs. This allows us to classify low, moderate, or vigorous activity. 7 or more days of any combination of walking, moderate-intensity or vigorous intensity activities achieving a minimum of at least 3000 MET minutes a week. We only determined it during the washout period (neither early nor late conditions).\n\nFormula for computation of Met-minutes:\n\n* Walking MET-minutes/week = 3.3 \\* walking minutes \\* walking "days"\n* Moderate MET-minutes/week = 4.0 \\* moderate-intensity activity minutes \\* moderate days\n* Vigorous MET-minutes/week = 8.0 \\* vigorous-intensity activity minutes \\* vigorous-intensity days', 'unitOfMeasure': 'Metabolic Units (MET)-minutes/week', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Chronotype', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '51.15', 'spread': '9.42', 'groupId': 'OG000'}, {'value': '51.75', 'spread': '8.90', 'groupId': 'OG001'}, {'value': '49.83', 'spread': '10.70', 'groupId': 'OG002'}, {'value': '51.35', 'spread': '10.15', 'groupId': 'OG003'}, {'value': '51.65', 'spread': '10.32', 'groupId': 'OG004'}, {'value': '51.11', 'spread': '8.97', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the week of washout', 'description': "Assessed using the Morningness-Eveningness Questionnaire (MEQ). Its main purpose is to measure whether a person's circadian rhythm produces peak alertness in the morning, in the evening, or in between. It is a score that indicates the degree to which the individual favors the morning over the night. We only determined it during the washout period (neither early nor late conditions).\n\nValues:\n\nMin: 17 Max: 86\n\nExplanation:\n\n17-30: extreme eveningness 31-41: eveningness 42-58: neither 59-69: morningness 70-86: extreme morningness", 'unitOfMeasure': 'score', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Emotional Eating', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '11.10', 'spread': '6.26', 'groupId': 'OG000'}, {'value': '10.64', 'spread': '5.74', 'groupId': 'OG001'}, {'value': '11.16', 'spread': '6.32', 'groupId': 'OG002'}, {'value': '10.98', 'spread': '6.16', 'groupId': 'OG003'}, {'value': '10.81', 'spread': '6.28', 'groupId': 'OG004'}, {'value': '10.54', 'spread': '5.79', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Emotional Eating Questionnaire (EEQ). This questionnaire classifies individuals based on the relationship between food intake and emotions.\n\nScore between 0 and 30. We only determined it during the washout period (neither early nor late conditions).\n\nExplanation:\n\n0-5: nothing emotional 5-10: less emotional 10-20: emotional 20-30: Very emotional', 'unitOfMeasure': 'score', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Sleep Quality', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '6.05', 'spread': '3.05', 'groupId': 'OG000'}, {'value': '6.15', 'spread': '3.15', 'groupId': 'OG001'}, {'value': '6.75', 'spread': '3.25', 'groupId': 'OG002'}, {'value': '7.00', 'spread': '3.74', 'groupId': 'OG003'}, {'value': '6.84', 'spread': '3.36', 'groupId': 'OG004'}, {'value': '6.49', 'spread': '3.29', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Pittsburgh Sleep Quality Index (PSQI). This questionnaire is used to quantitatively assess the quality of sleep. 7 scores are obtained that inform us about various aspects of sleep quality. We only determined it during the washout period (neither early nor late conditions).\n\nScore between 0 and 21. Total score of the questionnaire is divided into 7 items. Those items have a score from 0 (no problem) to 3 (severe problem).\n\n0-5: sleep quality optimum 6-21: sleep disorders', 'unitOfMeasure': 'score', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Insomnia', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '6.44', 'spread': '4.83', 'groupId': 'OG000'}, {'value': '6.63', 'spread': '4.99', 'groupId': 'OG001'}, {'value': '7.86', 'spread': '5.48', 'groupId': 'OG002'}, {'value': '7.04', 'spread': '5.39', 'groupId': 'OG003'}, {'value': '6.86', 'spread': '5.48', 'groupId': 'OG004'}, {'value': '7.29', 'spread': '5.97', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Insomnia Severity Index (ISI). This questionnaire has 5 items and is used to assess the possible existence of sleep problems. According to the score obtained, a classification is made from no insomnia to severe clinical insomnia. We only determined it during the washout period (neither early nor late conditions).\n\nScore ranges between 0 and 28\n\nExplanation:\n\n0-7: no insomnia 8-14: subclinical insomnia 15-21: moderate insomnia 22-28: severe insomnia The higher the score, the more harmful', 'unitOfMeasure': 'score', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Depression', 'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}, {'value': '202', 'groupId': 'OG003'}, {'value': '149', 'groupId': 'OG004'}, {'value': '44', 'groupId': 'OG005'}]}], 'groups': [{'id': 'OG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'OG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'OG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}], 'classes': [{'categories': [{'measurements': [{'value': '4.50', 'spread': '3.89', 'groupId': 'OG000'}, {'value': '4.61', 'spread': '4.17', 'groupId': 'OG001'}, {'value': '4.77', 'spread': '4.83', 'groupId': 'OG002'}, {'value': '4.98', 'spread': '4.52', 'groupId': 'OG003'}, {'value': '4.57', 'spread': '3.63', 'groupId': 'OG004'}, {'value': '5.31', 'spread': '4.41', 'groupId': 'OG005'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Patient Health Questionnaire (PHQ-9). This instrument aims to help the diagnosis of depression through the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), and to determine the severity of the disorder. It is made up of 9 items that refer to the last two weeks. The score ranges between 0 and 27. We only determined it during the washout period (neither early nor late conditions).\n\n0-4: no depression 5-9: mild depression 10-14: moderate depression 15-19: moderate-severe depression 20-27: severe depression\n\nExplanation:\n\n0-4: no depression 5-9: mild depression 10-14: moderate depression 15-19: moderate-severe depression 20-27: severe depression The higher the score, the more harmful', 'unitOfMeasure': 'score', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.\n\nEarly OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)\n\nLate OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)'}, {'id': 'FG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.\n\nEarly OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)\n\nLate OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)'}, {'id': 'FG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.\n\nEarly OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)\n\nLate OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)'}, {'id': 'FG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.\n\nLate OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)\n\nEarly OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)'}, {'id': 'FG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.\n\nLate OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)\n\nEarly OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)'}, {'id': 'FG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.\n\nLate OGTT: Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)'}], 'periods': [{'title': 'First Visit (1day)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '221'}, {'groupId': 'FG001', 'numSubjects': '193'}, {'groupId': 'FG002', 'numSubjects': '36'}, {'groupId': 'FG003', 'numSubjects': '202'}, {'groupId': 'FG004', 'numSubjects': '149'}, {'groupId': 'FG005', 'numSubjects': '44'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '221'}, {'groupId': 'FG001', 'numSubjects': '193'}, {'groupId': 'FG002', 'numSubjects': '36'}, {'groupId': 'FG003', 'numSubjects': '202'}, {'groupId': 'FG004', 'numSubjects': '149'}, {'groupId': 'FG005', 'numSubjects': '44'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}]}, {'title': 'Washout (1week)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '221'}, {'groupId': 'FG001', 'numSubjects': '193'}, {'groupId': 'FG002', 'numSubjects': '36'}, {'groupId': 'FG003', 'numSubjects': '202'}, {'groupId': 'FG004', 'numSubjects': '149'}, {'groupId': 'FG005', 'numSubjects': '44'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '221'}, {'groupId': 'FG001', 'numSubjects': '193'}, {'groupId': 'FG002', 'numSubjects': '36'}, {'groupId': 'FG003', 'numSubjects': '202'}, {'groupId': 'FG004', 'numSubjects': '149'}, {'groupId': 'FG005', 'numSubjects': '44'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}]}, {'title': 'Second Visit (1day)', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '221'}, {'groupId': 'FG001', 'numSubjects': '193'}, {'groupId': 'FG002', 'numSubjects': '36'}, {'groupId': 'FG003', 'numSubjects': '202'}, {'groupId': 'FG004', 'numSubjects': '149'}, {'groupId': 'FG005', 'numSubjects': '44'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '221'}, {'groupId': 'FG001', 'numSubjects': '193'}, {'groupId': 'FG002', 'numSubjects': '36'}, {'groupId': 'FG003', 'numSubjects': '202'}, {'groupId': 'FG004', 'numSubjects': '149'}, {'groupId': 'FG005', 'numSubjects': '44'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}, {'groupId': 'FG004', 'numSubjects': '0'}, {'groupId': 'FG005', 'numSubjects': '0'}]}]}], 'recruitmentDetails': '1457 patients were recruited from January 2017 to March 2020.', 'preAssignmentDetails': '845 of 1457 participants were included in this study. Of those not included, 200 declined to participate, 176 did not meet inclusion criteria, 192 lost to follow-up and 44 did not have the complete data. Nevertheless, because the genotype was not known until finishing recruitment, we cannot add the information in each arm of the started, etc.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '221', 'groupId': 'BG000'}, {'value': '193', 'groupId': 'BG001'}, {'value': '36', 'groupId': 'BG002'}, {'value': '202', 'groupId': 'BG003'}, {'value': '149', 'groupId': 'BG004'}, {'value': '44', 'groupId': 'BG005'}, {'value': '845', 'groupId': 'BG006'}]}], 'groups': [{'id': 'BG000', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'BG001', 'title': 'Early OGTT, Then Late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'BG002', 'title': 'Early OGTT, Then Late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early condition. After a washout period of 1 week, OGTT was performed in Late condition in a randomized cross-over study design.'}, {'id': 'BG003', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'BG004', 'title': 'Late OGTT, Then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'BG005', 'title': 'Late OGTT, Then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Late condition. After a washout period of 1 week, OGTT was performed in Early condition in a randomized cross-over study design.'}, {'id': 'BG006', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '36', 'spread': '13', 'groupId': 'BG000'}, {'value': '39', 'spread': '14', 'groupId': 'BG001'}, {'value': '36', 'spread': '15', 'groupId': 'BG002'}, {'value': '38', 'spread': '14', 'groupId': 'BG003'}, {'value': '39', 'spread': '15', 'groupId': 'BG004'}, {'value': '37', 'spread': '16', 'groupId': 'BG005'}, {'value': '38', 'spread': '14', 'groupId': 'BG006'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '152', 'groupId': 'BG000'}, {'value': '136', 'groupId': 'BG001'}, {'value': '30', 'groupId': 'BG002'}, {'value': '143', 'groupId': 'BG003'}, {'value': '107', 'groupId': 'BG004'}, {'value': '32', 'groupId': 'BG005'}, {'value': '600', 'groupId': 'BG006'}]}, {'title': 'Male', 'measurements': [{'value': '69', 'groupId': 'BG000'}, {'value': '57', 'groupId': 'BG001'}, {'value': '6', 'groupId': 'BG002'}, {'value': '59', 'groupId': 'BG003'}, {'value': '42', 'groupId': 'BG004'}, {'value': '12', 'groupId': 'BG005'}, {'value': '245', 'groupId': 'BG006'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}]}, {'title': 'Asian', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}]}, {'title': 'Black or African American', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}]}, {'title': 'White', 'measurements': [{'value': '221', 'groupId': 'BG000'}, {'value': '193', 'groupId': 'BG001'}, {'value': '36', 'groupId': 'BG002'}, {'value': '202', 'groupId': 'BG003'}, {'value': '149', 'groupId': 'BG004'}, {'value': '44', 'groupId': 'BG005'}, {'value': '845', 'groupId': 'BG006'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}, {'value': '0', 'groupId': 'BG005'}, {'value': '0', 'groupId': 'BG006'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2016-09-01', 'size': 264269, 'label': 'Study Protocol', 'hasIcf': False, 'hasSap': False, 'filename': 'Prot_002.pdf', 'typeAbbrev': 'Prot', 'uploadDate': '2021-01-08T06:33', 'hasProtocol': True}, {'date': '2016-09-01', 'size': 165675, 'label': 'Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'SAP_003.pdf', 'typeAbbrev': 'SAP', 'uploadDate': '2021-01-08T06:32', 'hasProtocol': False}, {'date': '2016-09-01', 'size': 186091, 'label': 'Informed Consent Form', 'hasIcf': True, 'hasSap': False, 'filename': 'ICF_004.pdf', 'typeAbbrev': 'ICF', 'uploadDate': '2021-01-08T06:33', 'hasProtocol': False}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'CROSSOVER'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 889}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2017-01-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-03', 'completionDateStruct': {'date': '2020-03-13', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-03-27', 'studyFirstSubmitDate': '2017-01-26', 'resultsFirstSubmitDate': '2020-12-08', 'studyFirstSubmitQcDate': '2017-01-26', 'lastUpdatePostDateStruct': {'date': '2025-04-16', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2025-03-27', 'studyFirstPostDateStruct': {'date': '2017-01-30', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2025-04-16', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2020-03-13', 'type': 'ACTUAL'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Temperature Record (Mean Value 10hours Daytime)', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Measured using a temperature sensor which records the temperature during 7 days. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Activity Record (Mean Value 10hours Daytime)', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'During the seven days of the study, individuals wore a wristwatch in their non-dominant hand, that integrates two sensors: a temperature sensor, and an accelerometer sensor that records physical activity and body position data (G Acceleration Data Logger UA-004-64; Onset Computer, Bourne, MA, USA). Activity was expressed as the change in degrees per minute (Δ°/min). We calculated the average activity value during the 10 consecutive hours of maximum values. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Light Exposure (Mean Value 10hours Daytime)', 'timeFrame': 'For 1 week between the visits 1 and 2', 'description': 'Measured using a light sensor during 7 days. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Sleep Duration', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Sleep duration will be computed from self-reported. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Total Energy Intake', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Total energy intake in kcal/day will be computed with a 7-day dietary log. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Dietary Composition', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Macronutrient and micronutrient intake will be computed from 7-days of self-reported 24-hr dietary recalls.\n\nPercentage Kcal respect to the Total Energy Intake. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Dietary Intake Timing', 'timeFrame': 'For 1 week between visit 1 and 2', 'description': 'Food timing will be self-reported and averaged across 7-days of 24-hour dietary recalls. We only determined it during the washout period (neither early nor late conditions).'}, {'measure': 'Physical Activity', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the International Physical Activity Questionnaire (IPAQ). This international questionnaire measures physical activity through the amount of energy expended carrying out physical activity i.e., Metabolic Units (MET) minutes a week. The higher the MET, the more amount of physical activity the individual performs. This allows us to classify low, moderate, or vigorous activity. 7 or more days of any combination of walking, moderate-intensity or vigorous intensity activities achieving a minimum of at least 3000 MET minutes a week. We only determined it during the washout period (neither early nor late conditions).\n\nFormula for computation of Met-minutes:\n\n* Walking MET-minutes/week = 3.3 \\* walking minutes \\* walking "days"\n* Moderate MET-minutes/week = 4.0 \\* moderate-intensity activity minutes \\* moderate days\n* Vigorous MET-minutes/week = 8.0 \\* vigorous-intensity activity minutes \\* vigorous-intensity days'}, {'measure': 'Chronotype', 'timeFrame': 'During the week of washout', 'description': "Assessed using the Morningness-Eveningness Questionnaire (MEQ). Its main purpose is to measure whether a person's circadian rhythm produces peak alertness in the morning, in the evening, or in between. It is a score that indicates the degree to which the individual favors the morning over the night. We only determined it during the washout period (neither early nor late conditions).\n\nValues:\n\nMin: 17 Max: 86\n\nExplanation:\n\n17-30: extreme eveningness 31-41: eveningness 42-58: neither 59-69: morningness 70-86: extreme morningness"}, {'measure': 'Emotional Eating', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Emotional Eating Questionnaire (EEQ). This questionnaire classifies individuals based on the relationship between food intake and emotions.\n\nScore between 0 and 30. We only determined it during the washout period (neither early nor late conditions).\n\nExplanation:\n\n0-5: nothing emotional 5-10: less emotional 10-20: emotional 20-30: Very emotional'}, {'measure': 'Sleep Quality', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Pittsburgh Sleep Quality Index (PSQI). This questionnaire is used to quantitatively assess the quality of sleep. 7 scores are obtained that inform us about various aspects of sleep quality. We only determined it during the washout period (neither early nor late conditions).\n\nScore between 0 and 21. Total score of the questionnaire is divided into 7 items. Those items have a score from 0 (no problem) to 3 (severe problem).\n\n0-5: sleep quality optimum 6-21: sleep disorders'}, {'measure': 'Insomnia', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Insomnia Severity Index (ISI). This questionnaire has 5 items and is used to assess the possible existence of sleep problems. According to the score obtained, a classification is made from no insomnia to severe clinical insomnia. We only determined it during the washout period (neither early nor late conditions).\n\nScore ranges between 0 and 28\n\nExplanation:\n\n0-7: no insomnia 8-14: subclinical insomnia 15-21: moderate insomnia 22-28: severe insomnia The higher the score, the more harmful'}, {'measure': 'Depression', 'timeFrame': 'During the week of washout', 'description': 'Assessed using the Patient Health Questionnaire (PHQ-9). This instrument aims to help the diagnosis of depression through the diagnostic criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV), and to determine the severity of the disorder. It is made up of 9 items that refer to the last two weeks. The score ranges between 0 and 27. We only determined it during the washout period (neither early nor late conditions).\n\n0-4: no depression 5-9: mild depression 10-14: moderate depression 15-19: moderate-severe depression 20-27: severe depression\n\nExplanation:\n\n0-4: no depression 5-9: mild depression 10-14: moderate depression 15-19: moderate-severe depression 20-27: severe depression The higher the score, the more harmful'}], 'primaryOutcomes': [{'measure': 'Area Under the Curve (AUC) Glucose', 'timeFrame': 'Along 120 minutes in visits 1 and 2', 'description': 'Glucose levels are measured along 120 minutes corresponding to at early and late condition in each visit. The Area Under the Curve was calculated as the sum of the area of several trapezoids. This trapezoids was obtained at times 0-30 min, 30-60 min, 60-90 min, 90-120 min. The values are the difference between the late and the early condition.'}, {'measure': 'Disposition Index (DI)', 'timeFrame': 'Along 120 minutes in visits 1 and 2', 'description': 'Disposition Index (DI) is the product of insulin sensitivity times by the amount of insulin secreted in response to blood glucose levels. Disposition index is used as a measure of beta cell function and the ability of the body to dispose of a glucose load. This index was determined by this formula:\n\nDI= CIR × ISI, where CIR is the measure Corrected Insulin Response, and ISI is Insulin Sensitivity Index. The values are the difference between the late and the early condition.\n\nHigher DI indicates an increased beta cell function and increased ability of the body to dispose of a glucose load.'}], 'secondaryOutcomes': [{'measure': 'Corrected Insulin Response (CIR)', 'timeFrame': 'At minute 30 during the visit 1 and 2.', 'description': 'The measure of Corrected Insulin Response (CIR) uses the insulin and glucose levels at minute 30, integrating these values in the formula:\n\nCIR= l30/(G30 × (G30 - 70)).The values are the difference between the late and the early conditions.\n\nCIR is an index that assesses the insulin secretion capacity of B cells. A low CIR implies hyposecretion in response to glucose levels.'}, {'measure': 'Insulin Sensitivity Index (ISI)', 'timeFrame': 'Along 120min in visits 1 and 2', 'description': "Insulin Sensitivity Index is a measurement which integrates fasting glucose and insulin concentrations (0 min) and the mean of the glucose and insulin levels from 0 to 120 minutes (0, 30, 60, 90 and 120 min), from an OGTT, to measure insulin sensitivity. This formula allows its use in clinical settings as well as in large epidemiological studies. The values are the difference between the late and the early condition.\n\nElevated ISI values typically indicate a favorable outcome. This index reflects the body's responsiveness to insulin, a hormone crucial for regulating blood sugar levels. Higher sensitivity to insulin suggests that cells efficiently utilize insulin's signals, promoting better blood sugar management. Lower ISI may lead to challenges in maintaining stable blood glucose levels and is often associated with conditions such as type 2 diabetes and metabolic syndrome."}, {'measure': 'Fasting Glucose', 'timeFrame': 'At minute 0 in visit 1 and 2.', 'description': 'Fasting glucose (or basal glucose) is a simple measurement of glucose concentrations at minute 0 to see how glucose levels rise immediately after an OGTT. The values are the difference between the late and the early condition.'}, {'measure': 'Fasting Insulin', 'timeFrame': 'At minute 0 in visit 1 and 2', 'description': 'Fasting insulin (or basal insulin) is a simple measurement of insulin concentrations at minute 0 to see how insulin levels rise immediately after an OGTT.The values are the difference between the late and the early condition.'}, {'measure': 'Serum Melatonin', 'timeFrame': 'At baseline and 120 minutes in visit 1 and 2', 'description': 'Measurement of serum melatonin is made at time 0 and at time 120 in both the early and late conditions of everyone.'}, {'measure': 'Dim Light Melatonin Onset (DLMO) at Early Condition Only', 'timeFrame': 'Melatonin measured every half hour for 5 hours at Early condition in all participants', 'description': 'This measurement shows the decimal time of the onset of melatonin in dim light conditions. In the case of DLMO, we only performed this measure at the early condition in order to get the analysis of melatonin during 5 hours (4 hours before the habitual bedtime and 1 hour later), as it is described in literature (DOI: 10.1002/oby.23749).'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Glucose tolerance test, MTNR1B, nutrigenomics, food timing'], 'conditions': ['Non-Diabetic Disorder of Endocrine Pancreas']}, 'referencesModule': {'references': [{'pmid': '35015083', 'type': 'DERIVED', 'citation': 'Garaulet M, Lopez-Minguez J, Dashti HS, Vetter C, Hernandez-Martinez AM, Perez-Ayala M, Baraza JC, Wang W, Florez JC, Scheer FAJL, Saxena R. Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes Care. 2022 Mar 1;45(3):512-519. doi: 10.2337/dc21-1314.'}]}, 'descriptionModule': {'briefSummary': 'The purpose of this investigation is to assess the role of melatonin receptor 1B (MTNR1B) single nucleotide polymorphism (SNP)\\*food timing interaction on glucose control in the deleterious effect in a vulnerable population with regular exposure to concurrent high melatonin and food intake as late night eaters (those having dinner within 2.5 h before their usual bed time). With the results from this study, we expect to advance our understanding of the role of endogenous melatonin on glucose metabolism in late night eaters and carriers of the MTNR1B risk allele, with potential implications on the guidelines to mitigate risk of type 2 diabetes in late night eaters and carriers of the MTNR1B risk allele.', 'detailedDescription': 'Late-night dinner eating is associated with increased risk for type-2-diabetes. The underlying mechanism is unclear. One explanatory hypothesis is that the concurrence of elevated circulating melatonin and high glucose concentrations (characterizing late-eating) leads to impaired glucose-tolerance. However, to date, no study has tested the influence of physiological melatonin concentrations on glucose tolerance. The discovery of melatonin receptor MTNR1B as a diabetes risk gene provides evidence for a role of physiological levels of melatonin in glucose control.\n\nThe aim of the current study is to test the hypothesis that the concurrence of meal timing with elevated endogenous melatonin concentrations results in impaired glucose control and that this effect is stronger in homozygous MTNR1B risk carriers than in non-carriers. To do so we will test glucose tolerance using identical mixed meals under two glucose oral tolerance test (OGTT) conditions: a) delayed OGTT or Late Eating (LE): starting1 hour before their usual bed time, b) advanced OGTT or Early Eating (EE): starting 4 hours before habitual bed time, in a randomized, cross-over study design.\n\nThese findings could support a clinical application for the screening of this SNP and the possibility of implementing tailored and cost-effective behavioral interventions to prevent type 2 diabetes in vulnerable populations.\n\nThese goals will be achieved through a specific approach:\n\n• Interventional (randomized, cross-over controlled trials) (Aim 1): To study the potential interaction between meal timing (dinner) and genetic variants MTNR1B for glucose tolerance (n=1000).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Body Mass Index: \\> 18.5 o \\< 40 kg/m2\n* Age: between 18 and 65 year of age\n* European ancestry\n* Day workers\n\nExclusion Criteria:\n\n* Receiving treatment with thermogenic, lipogenic, or drugs\n* Diabetes mellitus, chronic renal failure, hepatic diseases, or cancer diagnosis\n* Bulimia diagnosis, prone to binge eating\n* Undergoing treatment with Type 2 diabetes mellitus (high blood sugar) medications such as Metformin or other non-Metformin oral anti-diabetic drugs such as sulfonylureas, meglitinides, or glitazones\n* Undergoing treatment with Corticosteroids/steroids, Growth hormone, Anticoagulant medicines, or blood thinners, Beta blockers for hypertension, Medications for sleep, Fluvoxamine, Opioids or Amphetamines, Tranquilizers, nonsteroidal anti-inflammatory drugs.\n* Pregnant'}, 'identificationModule': {'nctId': 'NCT03036592', 'acronym': 'ONTIME-MT', 'briefTitle': 'MTNR1B SNP*Food Timing Interaction on Glucose Control', 'organization': {'class': 'OTHER', 'fullName': 'Universidad de Murcia'}, 'officialTitle': 'MTNR1B SNP*Food Timing Interaction on Glucose Control in a Late Eater Mediterranean Population', 'orgStudyIdInfo': {'id': '2017ES00001'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Early OGTT, then late OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in homozygous non-carriers (CC) for MTNR1B rs10830963 in Early and Late conditions', 'interventionNames': ['Behavioral: Early OGTT', 'Behavioral: Late OGTT']}, {'type': 'EXPERIMENTAL', 'label': 'Early OGTT, then late OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early and Late conditions', 'interventionNames': ['Behavioral: Early OGTT', 'Behavioral: Late OGTT']}, {'type': 'EXPERIMENTAL', 'label': 'Early OGTT, then late OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in homozygous (GG) risk allele carriers for MTNR1B rs10830963 in Early and Late conditions', 'interventionNames': ['Behavioral: Early OGTT', 'Behavioral: Late OGTT']}, {'type': 'EXPERIMENTAL', 'label': 'Late OGTT, then Early OGTT in MTNR1B CC', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early and Late conditions', 'interventionNames': ['Behavioral: Early OGTT', 'Behavioral: Late OGTT']}, {'type': 'EXPERIMENTAL', 'label': 'Late OGTT, then Early OGTT in MTNR1B CG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early and Late conditions', 'interventionNames': ['Behavioral: Early OGTT', 'Behavioral: Late OGTT']}, {'type': 'EXPERIMENTAL', 'label': 'Late OGTT, then Early OGTT in MTNR1B GG', 'description': 'Oral glucose tolerance test (OGTT) in heterozygous (CG) risk allele carriers for MTNR1B rs10830963 in Early and Late conditions', 'interventionNames': ['Behavioral: Early OGTT', 'Behavioral: Late OGTT']}], 'interventions': [{'name': 'Early OGTT', 'type': 'BEHAVIORAL', 'description': 'Oral glucose tolerance test using identical mixed 75 gr of glucose under early condition (4 hours before habitual bedtime)', 'armGroupLabels': ['Early OGTT, then late OGTT in MTNR1B CC', 'Early OGTT, then late OGTT in MTNR1B CG', 'Early OGTT, then late OGTT in MTNR1B GG', 'Late OGTT, then Early OGTT in MTNR1B CC', 'Late OGTT, then Early OGTT in MTNR1B CG', 'Late OGTT, then Early OGTT in MTNR1B GG']}, {'name': 'Late OGTT', 'type': 'BEHAVIORAL', 'description': 'Oral glucose tolerance test using identical mixed 75 gr of glucose under late condition (1 hour before habitual bedtime)', 'armGroupLabels': ['Early OGTT, then late OGTT in MTNR1B CC', 'Early OGTT, then late OGTT in MTNR1B CG', 'Early OGTT, then late OGTT in MTNR1B GG', 'Late OGTT, then Early OGTT in MTNR1B CC', 'Late OGTT, then Early OGTT in MTNR1B CG', 'Late OGTT, then Early OGTT in MTNR1B GG']}]}, 'contactsLocationsModule': {'locations': [{'zip': '30100', 'city': 'Murcia', 'country': 'Spain', 'facility': 'University of Murcia', 'geoPoint': {'lat': 37.98704, 'lon': -1.13004}}], 'overallOfficials': [{'name': 'Purificación Gomez Abellan, PHD', 'role': 'STUDY_CHAIR', 'affiliation': 'Universidad de Murcia'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Universidad de Murcia', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Full Professor', 'investigatorFullName': 'PROF. MARTA GARAULET AZA', 'investigatorAffiliation': 'Universidad de Murcia'}}}}