Ignite Creation Date:
2026-03-26 @ 3:20 PM
Ignite Modification Date:
2026-03-30 @ 12:26 AM
Study NCT ID:
NCT07462520
Status:
COMPLETED
Last Update Posted:
2026-03-12
First Post:
2026-03-05
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of Blood Flow Restriction vs. High-Load Resistance Training on Arm Strength
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE', 'maskingDescription': 'This was an open-label study. No masking was applied to participants, investigators, or outcome assessors.'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Participants were prospectively assigned to one of two parallel groups: a low-load blood flow restriction training group or a high-load resistance training group. Both groups completed a 7-week intervention, and outcomes were assessed pre- and post-intervention.'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 22}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2024-02-05', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-03', 'completionDateStruct': {'date': '2024-04-01', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2026-03-10', 'studyFirstSubmitDate': '2026-03-05', 'studyFirstSubmitQcDate': '2026-03-05', 'lastUpdatePostDateStruct': {'date': '2026-03-12', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-03-10', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-03-25', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Arm Muscle Strength', 'timeFrame': 'Baseline and after 7 weeks of training', 'description': 'Isokinetic peak torque of elbow flexor and extensor muscles measured using an isokinetic dynamometer.'}], 'secondaryOutcomes': [{'measure': 'Isokinetic Contraction Parameters', 'timeFrame': 'Baseline and after 7 weeks of training', 'description': 'Isokinetic peak torque (Nm) of elbow flexor and extensor muscles measured using an isokinetic dynamometer.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Blood flow restriction', 'Resistance exercise', 'Isokinetic contraction', 'Muscle strength', 'Peak Torque'], 'conditions': ['Muscle Strength', 'Resistance Training', 'Blood Flow Restriction']}, 'descriptionModule': {'briefSummary': 'This study investigated the effects of low-load resistance training combined with blood flow restriction (BFRT) compared to traditional high-load resistance training on arm muscle strength and isokinetic contraction parameters in healthy young adults. Participants were prospectively assigned to either a low-load BFRT group or a high-load resistance training group for a 7-week intervention period. Muscle strength and isokinetic peak torque were assessed before and after the intervention. The primary objective was to determine whether low-load BFRT produces comparable improvements in muscle strength and isokinetic performance to high-load resistance training.', 'detailedDescription': 'his interventional study was designed to compare the effects of low-load blood flow restriction resistance training (LL-BFRT) and high-load resistance training (HL-RT) on arm muscle strength and isokinetic contraction parameters in healthy individuals.\n\nA total of 22 healthy young adults were prospectively assigned to either a low-load BFRT group or a high-load resistance training group. The intervention lasted 7 weeks. The low-load BFRT group performed resistance exercises at 30% of one-repetition maximum (1RM) combined with individualized blood flow restriction pressure, while the high-load group trained at 70% of 1RM without blood flow restriction.\n\nPrimary outcome measures included isokinetic peak torque values of the elbow flexors and extensors. Secondary outcomes included muscle strength assessments. All participants completed pre-intervention and post-intervention evaluations.\n\nThe study aimed to determine whether low-load BFRT can induce strength and performance adaptations comparable to traditional high-load resistance training, offering an alternative training strategy when high mechanical loads are not desirable.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT'], 'maximumAge': '40 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Healthy individuals between the ages of 18 and 40\n* Individuals not taking any dietary supplements\n* Individuals not taking a substance containing anabolic ingredients\n* Individuals subjected to a resistance training program for at least 6 months\n* Individuals not performing aerobic training for more than 30 minutes per day\n* Individuals training with a personal trainer\n\nExclusion Criteria:\n\n* Individuals with a skeletal muscle injury in the last 6 months\n* Individuals who have undergone a surgical operation\n* Individuals with chronic high blood pressure and cardiovascular disease\n* Individuals who miss three consecutive training sessions\n* Individuals with chronic cardiovascular disease'}, 'identificationModule': {'nctId': 'NCT07462520', 'acronym': 'BFRT-ARM', 'briefTitle': 'Effects of Blood Flow Restriction vs. High-Load Resistance Training on Arm Strength', 'organization': {'class': 'OTHER', 'fullName': 'Gazi University'}, 'officialTitle': 'The Effect of Blood Flow Restriction Resistance Exercise on Arm Muscle Strength and Isokinetic Contraction Parameters', 'orgStudyIdInfo': {'id': 'E-77082166-302.08.01-506408'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Low-Load Blood Flow Restriction Training(LL-BFRT)', 'description': 'Participants performed resistance exercises at 30% of one-repetition maximum combined with individualized blood flow restriction pressure for 7 weeks.', 'interventionNames': ['Procedure: Low Load Blood Flow Restriction Training']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'High-Load Resistance Training(HL-RT)', 'description': 'Participants performed resistance exercises at 70% of one-repetition maximum without blood flow restriction for 7 weeks.', 'interventionNames': ['Procedure: High Load Resistance Training']}], 'interventions': [{'name': 'Low Load Blood Flow Restriction Training', 'type': 'PROCEDURE', 'description': 'Low-load resistance training performed at 30% of one-repetition maximum with individualized blood flow restriction pressure.', 'armGroupLabels': ['Low-Load Blood Flow Restriction Training(LL-BFRT)']}, {'name': 'High Load Resistance Training', 'type': 'PROCEDURE', 'description': 'Traditional resistance training performed at 70% of one-repetition maximum without blood flow restriction.', 'armGroupLabels': ['High-Load Resistance Training(HL-RT)']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Ankara', 'country': 'Turkey (Türkiye)', 'facility': 'Gazi University', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Gazi University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Lecturer Phd.', 'investigatorFullName': 'Hüsnü Kocaman', 'investigatorAffiliation': 'Gazi University'}}}}