Ignite Creation Date:
2026-03-26 @ 3:20 PM
Ignite Modification Date:
2026-03-31 @ 11:50 AM
Study NCT ID:
NCT07361302
Status:
RECRUITING
Last Update Posted:
2026-03-17
First Post:
2026-01-14
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000083242', 'term': 'Ischemic Stroke'}], 'ancestors': [{'id': 'D020521', 'term': 'Stroke'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000077785', 'term': 'Tenecteplase'}], 'ancestors': [{'id': 'D010959', 'term': 'Tissue Plasminogen Activator'}, {'id': 'D012697', 'term': 'Serine Endopeptidases'}, {'id': 'D010450', 'term': 'Endopeptidases'}, {'id': 'D010447', 'term': 'Peptide Hydrolases'}, {'id': 'D006867', 'term': 'Hydrolases'}, {'id': 'D004798', 'term': 'Enzymes'}, {'id': 'D045762', 'term': 'Enzymes and Coenzymes'}, {'id': 'D057057', 'term': 'Serine Proteases'}, {'id': 'D010960', 'term': 'Plasminogen Activators'}, {'id': 'D001779', 'term': 'Blood Coagulation Factors'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 1325}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2026-02-17', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-03', 'completionDateStruct': {'date': '2027-10-02', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2026-03-16', 'studyFirstSubmitDate': '2026-01-14', 'studyFirstSubmitQcDate': '2026-01-14', 'lastUpdatePostDateStruct': {'date': '2026-03-17', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-01-23', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-10-02', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'modified Rankin Scale (mRS) score of 0-1 at Day 90', 'timeFrame': 'at day 90', 'description': 'The Modified Rankin Scale, MRS, is a tool used to evaluate disability after a stroke. The score ranges from 0 to 6, with higher values indicating greater severity of the disability.'}], 'secondaryOutcomes': [{'measure': 'mRS (ordinal) at Day 90', 'timeFrame': 'at day 90'}, {'measure': 'Early neurological improvement (reduction in acute - 24-hour National Institute of Health Stroke Scale (NIHSS) score of ≥8 or value of 0/1)', 'timeFrame': 'at baseline/randomisation, 24 hours after randomization', 'description': 'NIHSS is a tool used by healthcare providers to objectively quantify the impairment caused by a stroke. It is composed of 11 items. The score ranges from 0 to a maximum of 42. For each item a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment.'}, {'measure': 'mRS 0-2 at Day 90', 'timeFrame': 'at Day 90'}, {'measure': 'Symptomatic intracranial haemorrhage (sICH) as defined by Safety Implementation of Thrombolysis in Stroke: Monitoring Study (SITS-MOST) criteria at 36 h', 'timeFrame': 'after 36 hours'}, {'measure': 'sICH as defined by European Cooperative Acute Stroke Study (ECASS) III criteria at 36 h', 'timeFrame': 'after 36 hours'}, {'measure': 'Death from any cause within 90 days', 'timeFrame': 'up to 90 days'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Acute Ischemic Stroke']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'https://www.clinicalstudies.boehringer-ingelheim.com/msw/datatransparency', 'label': 'Related Info'}]}, 'descriptionModule': {'briefSummary': "This study is open to adults who had an acute stroke caused by a clot blocking a blood vessel in the brain (acute ischemic stroke). This study is for people who had an acute stroke or woke up with a stroke and were last seen well more than 4.5 hours before joining the study. Participants need to have imaging that shows there is brain tissue that can still be saved. They also should not be planned to receive a procedure to remove the blood clot.\n\nThe purpose of this study is to find out whether a medicine called tenecteplase helps people recover from an acute stroke. Tenecteplase is already used to treat people within 4.5 hours after they had a stroke. This study tests if tenecteplase also helps if it is given more than 4.5 hours after the stroke.\n\nParticipants are put into 2 groups randomly, which means by chance. One group gets tenecteplase as a single injection into a vein. The other group receives standard medical practice. Participants have an equal chance of receiving tenecteplase or the standard treatment.\n\nParticipants are in the study for about 3 months. In the beginning, participants stay in the hospital for about 1 week. During the study, participants have 7 clinical examinations or visits. The last 2 of these visits will likely be done from home, allowing participants to complete certain assessments remotely. Doctors regularly test participants' recovery using a scale that measures the level of disability or dependence in daily activities. The results are compared between the 2 groups to see whether the treatment works. The doctors also check participants' health and take note of any unwanted effects."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion criteria:\n\n1. Male or female ≥18 years old and at least at the legal age of consent in countries where it is greater than 18 years\n2. Signed and dated written informed consent in accordance with ICH-GCP and local legislation prior to admission to the trial\n3. Acute ischaemic stroke (including wake-up stroke) affecting the supratentorial circulation (anterior cerebral artery (ACA), middle cerebral artery (MCA), and posterior cerebral arteries (PCA)) last known well \\>4.5 h before time of presumed randomisation\n4. Pre-stroke modified Rankin scale (mRS) ≤1\n5. Imaging eligibility by magnetic resonance imaging (MRI)computed tomography (CT)\n\nExclusion criteria:\n\n1. Intention to proceed to mechanical thrombectomy (MT) at the same site (hospital) of randomisation\n2. Occlusion of the internal carotid artery (ICA)\n3. High-risk patients (increased risk of thrombolysis related hemorrhage)\n4. Any intracranial hemorrhage detected on non-contrast computed tomography (NCCT) or MRI scans\n5. Contra-indication to contrast brain imaging with CT and MRI\n6. Severe stroke as assessed clinically (National Institute of Health Stroke Scale (NIHSS) \\> 25)\n7. Non-disabling minor stroke symptoms (NIHSS ≤5), or rapidly improving symptoms at the discretion of the investigator\n8. Imaging or clinical findings not indicative of acute ischemic stroke or suggesting stroke older than 72 h\n9. Patients scheduled to receive intravenous (i.v.) thrombolysis as standard of care Further exclusion criteria apply.'}, 'identificationModule': {'nctId': 'NCT07361302', 'briefTitle': 'A Study to Test if Tenecteplase Helps People to Recover From an Acute Stroke When Given More Than 4.5 Hours After the Person Was Last Seen Well', 'organization': {'class': 'INDUSTRY', 'fullName': 'Boehringer Ingelheim'}, 'officialTitle': 'TENACITY - A Phase III, Prospective, Randomized, Open-label, Blinded Endpoint Assessment (PROBE) to Assess Efficacy and Safety of i.v. Tenecteplase vs Standard of Care in Patients With Acute Ischemic Stroke (Including Wake-up Stroke), Last Known Well >4.5 h With Imaging Evidence of Salvageable Ischemic Tissue', 'orgStudyIdInfo': {'id': '1123-0060'}, 'secondaryIdInfos': [{'id': '2025-522542-40-00', 'type': 'CTIS'}, {'id': 'U1111-1323-6001', 'type': 'REGISTRY', 'domain': 'WHO - International Clinical Trials Registry Platform (ICTRP)'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Tenecteplase treatment arm', 'interventionNames': ['Drug: Tenecteplase']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Standard of care treatment arm', 'interventionNames': ['Drug: Standard of care treatment']}], 'interventions': [{'name': 'Tenecteplase', 'type': 'DRUG', 'description': 'Tenecteplase', 'armGroupLabels': ['Tenecteplase treatment arm']}, {'name': 'Standard of care treatment', 'type': 'DRUG', 'description': 'Standard of care treatment', 'armGroupLabels': ['Standard of care treatment arm']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'C1180AAX', 'city': 'Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'Sanatorio Güemes', 'geoPoint': {'lat': -34.61315, 'lon': -58.37723}}, {'zip': '1199', 'city': 'Ciudad Autonoma Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'Hospital Italiano de Buenos Aires'}, {'zip': '1431', 'city': 'Ciudad Autonoma Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'CEMIC'}, {'zip': 'C1221ADC', 'city': 'Ciudad Autonoma Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'Hospital General de Agudos Dr. J. M. Ramos Mejia'}, {'zip': 'C1426EOB', 'city': 'Ciudad Autonoma Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'Clínica La Sagrada Familia'}, {'zip': 'C1428AQK', 'city': 'Ciudad Autonoma Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'Fundacion para la Lucha contra las Enfermedades Neurologicas de la Infancia - FLENI'}, {'zip': 'C1437JCP', 'city': 'Ciudad Autonoma Buenos Aires', 'status': 'NOT_YET_RECRUITING', 'country': 'Argentina', 'contacts': [{'name': 'Boehringer Ingelheim', 'role': 'CONTACT', 'email': 'argentina@bitrialsupport.com', 'phone': '08002667801'}], 'facility': 'Complejo Medico de la Policia Federal Argentina Churruca Visca'}, {'zip': '5000', 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