Ignite Creation Date:
2026-03-26 @ 3:19 PM
Ignite Modification Date:
2026-03-30 @ 3:51 AM
Study NCT ID:
NCT07458594
Status:
COMPLETED
Last Update Posted:
2026-03-09
First Post:
2026-03-04
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Combined Caffeine and Rhodiola Rosea on Aerial Duel Performance in Soccer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'interventionBrowseModule': {'meshes': [{'id': 'D002110', 'term': 'Caffeine'}], 'ancestors': [{'id': 'D014970', 'term': 'Xanthines'}, {'id': 'D000470', 'term': 'Alkaloids'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D011688', 'term': 'Purinones'}, {'id': 'D011687', 'term': 'Purines'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR'], 'maskingDescription': 'Participants, outcome assessors, and data analysts are blinded to group allocation. Supplement distribution and group coding are managed by an independent researcher not involved in data collection or statistical analysis. All capsules are identical in appearance to maintain blinding throughout the study period.'}, 'primaryPurpose': 'OTHER', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'This is a 4-week, randomized, double-blind, placebo-controlled, parallel-group trial with four arms (placebo, Rhodiola rosea, caffeine, and Rhodiola rosea plus caffeine; n=24 per arm). Participants complete identical pre- and post-intervention testing sessions. Rhodiola rosea is administered daily throughout the intervention period, while caffeine is administered acutely prior to the test sessions; matching placebo capsules are used to maintain blinding across all groups.'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 96}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2025-10-30', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-03', 'completionDateStruct': {'date': '2026-01-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2026-03-04', 'studyFirstSubmitDate': '2026-03-04', 'studyFirstSubmitQcDate': '2026-03-04', 'lastUpdatePostDateStruct': {'date': '2026-03-09', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-03-09', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-12-27', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Early takeoff impulse (Impulse₀-₂₀₀)', 'timeFrame': 'Baseline (Day 0) and Post-intervention (Day 30), measured under both non-fatigued and fatigued conditions.', 'description': 'Calculated as the integration of vertical force over the first 200 ms of the countermovement jump (CMJ) takeoff phase, relative to body mass (N·s·kg-¹). This measures the capacity for rapid force production.'}], 'secondaryOutcomes': [{'measure': 'Heading contact height', 'timeFrame': 'Baseline (Pre-test) and 4 weeks (Post-test), including measurements under both non-fatigued and fatigued conditions at each time point.', 'description': 'Participants perform a header and touch a football suspended on a vertical jump tester with their forehead. The highest touch height from three trials is recorded to reflect aerial reach capacity.'}, {'measure': 'Heading Ball Velocity', 'timeFrame': 'Baseline (Pre-test) and 4 weeks (Post-test), including measurements under both non-fatigued and fatigued conditions at each time point.', 'description': 'The maximum velocity of the ball after heading is measured using a speed device. A ball machine is used to ensure consistent delivery direction and speed. This measures momentum transfer efficiency and technical execution.'}, {'measure': 'Aerial Duel Success Rate', 'timeFrame': 'Baseline (Pre-test) and 4 weeks (Post-test), including measurements under both non-fatigued and fatigued conditions at each time point.', 'description': 'Calculated as the percentage of successful duels out of a fixed number of trials in a standardized head-to-head setting. Success is defined as effectively contacting the ball first and directing it toward a target area.'}, {'measure': 'Neck Isometric Strength', 'timeFrame': 'Baseline (Pre-test) and 4 weeks (Post-test).', 'description': 'Maximum isometric force measured in neck flexion and extension using a handheld dynamometer. Values are normalized to body mass ($N \\\\cdot kg\\^{-1}$) to assess the stability of the head-trunk system.'}, {'measure': 'Rate of Perceived Exertion (RPE)', 'timeFrame': 'Immediately after the fatigue-induction protocol and post-fatigue testing at Baseline and 4 weeks.', 'description': 'Subjective effort level reported by participants on a scale of 1 to 10 (1 = nearly no effort, 10 = extreme effort) immediately following the fatigue protocol and post-fatigue tests.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Caffeine', 'Rhodiola rosea', 'Combined Supplementation', 'Soccer Performance', 'Neuromuscular Fatigue', 'Countermovement Jump (CMJ)', 'Early Impulse (Impulse₀-₂₀₀)', 'Aerial Duel'], 'conditions': ['Aerial Duel Performance in Soccer Players']}, 'descriptionModule': {'briefSummary': 'This study will examine whether caffeine (CAF) and Rhodiola rosea (RHO) supplementation, taken alone or in combination, can improve explosive performance and soccer-specific aerial duel performance in trained male soccer players. In a randomized, double-blind, placebo-controlled, parallel design, participants will be assigned to placebo, RHO, CAF, or RHO+CAF for 4 weeks. Performance outcomes will be assessed before and after the intervention using countermovement jump measures (including early take-off impulse) and standardized heading tests (heading reach height, ball exit velocity, and heading duel success rate), with additional measures of neck isometric strength and perceived exertion.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT'], 'maximumAge': '30 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Healthy male soccer players from the Beijing Sport University team.\n\nSystematic soccer-specific training background and stable competitive level.\n\nSuitable for high-intensity physical testing based on the Physical Activity Readiness Questionnaire (PAR-Q).\n\nExclusion Criteria:\n\n* History of neuromuscular or musculoskeletal system diseases.\n\nIntake of caffeine (coffee/tea), other supplements, ergogenic aids, or alcohol within the last 3 months.\n\nCurrent use of antidepressants or central nervous system stimulants.\n\nSmokers.'}, 'identificationModule': {'nctId': 'NCT07458594', 'acronym': 'CCRP-AD', 'briefTitle': 'Combined Caffeine and Rhodiola Rosea on Aerial Duel Performance in Soccer', 'organization': {'class': 'OTHER', 'fullName': 'Beijing Sport University'}, 'officialTitle': 'Effects of Combined Caffeine and Rhodiola Rosea Supplementation on Aerial Duel Performance Under Fatigue in Soccer Players', 'orgStudyIdInfo': {'id': '2025602H'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo Control Group (CTR)', 'description': 'Participants receive empty capsules (containing starch or rice flour) identical to the active supplements for 30 days.', 'interventionNames': ['Dietary Supplement: Placebo']}, {'type': 'EXPERIMENTAL', 'label': 'Rhodiola Rosea Group (RHO)', 'description': 'Daily supplementation of 2.4g Rhodiola rosea extract (approx. 12mg salidroside) for 30 days, taken in two doses before breakfast and lunch.', 'interventionNames': ['Dietary Supplement: Rhodiola rosea extract']}, {'type': 'EXPERIMENTAL', 'label': 'Caffeine Group (CAF)', 'description': 'A single dose of 3 mg/kg body mass of anhydrous caffeine administered 30 minutes before exercise testing.', 'interventionNames': ['Dietary Supplement: Caffeine']}, {'type': 'EXPERIMENTAL', 'label': 'Combined Rhodiola and Caffeine Group (RHO + CAF)', 'description': 'Combined daily supplementation of 2.4g Rhodiola rosea for 30 days and a single 3 mg/kg dose of caffeine before testing.', 'interventionNames': ['Dietary Supplement: Caffeine', 'Dietary Supplement: Rhodiola rosea extract']}], 'interventions': [{'name': 'Caffeine', 'type': 'DIETARY_SUPPLEMENT', 'description': 'Anhydrous caffeine capsules administered at a dose of 3 mg/kg body weight. Taken as a single dose 30 minutes prior to the physical performance tests.', 'armGroupLabels': ['Caffeine Group (CAF)', 'Combined Rhodiola and Caffeine Group (RHO + CAF)']}, {'name': 'Rhodiola rosea extract', 'type': 'DIETARY_SUPPLEMENT', 'description': 'Standardized Rhodiola rosea extract capsules. Daily total dosage of 2.4 g (containing approx. 12 mg salidroside), taken twice daily (before breakfast and lunch) for 30 days.', 'armGroupLabels': ['Combined Rhodiola and Caffeine Group (RHO + CAF)', 'Rhodiola Rosea Group (RHO)']}, {'name': 'Placebo', 'type': 'DIETARY_SUPPLEMENT', 'description': 'Appearance-matched capsules containing inert ingredients (starch or rice flour).', 'armGroupLabels': ['Placebo Control Group (CTR)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '100084', 'city': 'Beijing', 'state': 'Beijing Municipality', 'country': 'China', 'facility': 'China Football Institute, Beijing Sport University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Beijing', 'country': 'China', 'facility': 'Beijing Sport University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'Individual participant data will not be shared due to participant confidentiality and institutional data protectionpolicies.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Beijing Sport University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Graduate Student', 'investigatorFullName': 'Yue Dou', 'investigatorAffiliation': 'Beijing Sport University'}}}}