Ignite Creation Date:
2026-03-26 @ 3:17 PM
Ignite Modification Date:
2026-03-30 @ 10:29 PM
Study NCT ID:
NCT07436169
Status:
COMPLETED
Last Update Posted:
2026-02-27
First Post:
2026-02-21
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
2D:4D Finger Ratio and Breast Cancer in Women
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}, {'id': 'C536137', 'term': 'Medullary cystic kidney disease 1'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 132}, 'targetDuration': '1 Day', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2024-04-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-03', 'completionDateStruct': {'date': '2025-08-07', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2026-02-21', 'studyFirstSubmitDate': '2026-02-21', 'studyFirstSubmitQcDate': '2026-02-21', 'lastUpdatePostDateStruct': {'date': '2026-02-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-02-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-07-02', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'only description measurement', 'timeFrame': "1 patientt's measurements have taken nearly 20 minutes", 'description': 'The lengths of the second (index) and fourth (ring) digits were measured on both hands of all participants to calculate the 2D:4D digit ratio. Measurements were obtained using a digital caliper with a precision of 0.01 mm. Each digit was measured from the midpoint of the basal crease (proximal flexion crease) to the tip of the finger, with the hand placed flat and fully extended on a stable surface.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['breast cancer', '2D:4D Ratio', 'CEA', 'Anatomy', 'CA 15-3', 'Anthropometry'], 'conditions': ['Breast Cancer', 'Anthropometric Measurements', 'Females']}, 'referencesModule': {'references': [{'type': 'RESULT', 'citation': '1. Li C, Li H, Zhong H, Li X. Association of 25-hydroxyvitamin D level with survival outcomes in female breast cancer patients: A meta-analysis. The Journal of Steroid Biochemistry and Molecular Biology. 01 Eylül 2021;212:105947. 2. Bidard FC, Hajage D, Bachelot T, Delaloge S, Brain E, Campone M, vd. Assessment of circulating tumor cells and serum markers for progression-free survival prediction in metastatic breast cancer: a prospective observational study. Breast Cancer Res. 13 Şubat 2012;14(1):R29. 3. Falzarano R, Viggiani V, Michienzi S, Longo F, Tudini S, Frati L, vd. Evaluation of a CLEIA automated assay system for the detection of a panel of tumor markers. Tumour Biol. Ekim 2013;34(5):3093-100. 4. Hasan D. Diagnostic impact of CEA and CA 15-3 on chemotherapy monitoring of breast cancer patients. J Circ Biomark. 2022;11:57-63. 5. Manning J, Kilduff L, Cook C, Crewther B, Fink B. Digit ratio (2D: 4D): a biomarker for prenatal sex steroids and adult sex steroids in challenge situations. Frontiers in endocrinology. 2014;5:9. 6. Manning JT, Churchill AJG, Peters M. The Effects of Sex, Ethnicity, and Sexual Orientation on Self-Measured Digit Ratio (2D:4D). Arch Sex Behav. Nisan 2007;36(2):223-33. 7. Bağci Uzun G, İnceoğlu F. Association of 2D:4D finger length ratio of People Working in different professions with personality traits. Heliyon. Haziran 2024;10(11):e32332. 8. Fonseca C de AD, Martelli DRB, Maia CMF, Dias VO, Carvalho AA, Júnior HM. Digital biomarker 2D:4D as a predictor of cancer: A systematic review. Early Hum Dev. Ocak 2022;164:105521. 9. Swift-Gallant A, Aung T, Salia S, Breedlove SM, Puts D. Sexual orientation is associated with 2D:4D finger length ratios in both sexes: an updated and expanded meta-analysis. Front Psychol. 2025;16:1559158. 10. Muller DC, Baglietto L, Manning JT, McLean C, Hopper JL, English DR, vd. Second to fourth digit ratio (2D:4D), breast cancer risk factors, and breast cancer risk: a prospective cohort study. Br J Canc'}]}, 'descriptionModule': {'briefSummary': 'This prospective study aims to evaluate the 2D:4D finger ratio in women diagnosed with breast cancer compared to healthy controls and to examine its potential association with tumor markers, including carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA 15-3).\n\nA total of 132 women are included in the study, comprising 79 patients with breast cancer and 53 healthy controls. Participants are recruited from a breast clinic setting. Finger lengths are measured to calculate 2D:4D ratios, and serum CEA and CA 15-3 levels are recorded. Statistical analyses are performed to assess correlations between finger morphometry and tumor marker levels.\n\nThe study seeks to explore whether finger length patterns and 2D:4D ratios are associated with breast cancer status and selected tumor markers, and to evaluate their potential relevance as non-invasive indicators related to hormonal exposure history.', 'detailedDescription': 'Breast cancer is one of the most common malignancies among women worldwide. Prenatal hormonal exposure has been proposed as a potential factor influencing the development of hormone-related cancers. The second-to-fourth digit (2D:4D) ratio is considered an indirect marker of prenatal androgen and estrogen exposure and has been investigated in relation to various health conditions.\n\nThis prospective study is designed to evaluate differences in 2D:4D finger ratios between women diagnosed with breast cancer and healthy controls and to examine potential associations between digit ratios and tumor markers, including carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA 15-3).\n\nA total of 132 women are included in the study, consisting of 79 breast cancer patients and 53 healthy controls recruited from a breast clinic setting. Finger lengths of both hands are measured to calculate 2D:4D ratios. Serum CEA and CA 15-3 levels are recorded as part of routine clinical evaluation.\n\nStatistical analyses are conducted to assess correlations between finger measurements, digit ratios, and tumor marker levels. The study aims to explore whether finger morphometry may provide additional insight into hormonal exposure patterns and their potential relevance in breast cancer assessment.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '70 Years', 'minimumAge': '19 Years', 'genderBased': True, 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Women aged 18 years and older who attended the breast clinic during the study period, including patients with histopathologically confirmed breast cancer and age-matched healthy controls.', 'genderDescription': 'self female patients have conducted in the study', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Women aged 18 years and older with histopathologically confirmed primary breast cancer who were evaluated and/or treated at the breast clinic during the study period and who provided written informed consent were included in the study.\n\nExclusion Criteria:\n\n* Individuals with hand deformities, a history of finger fractures, or finger deformities were excluded from the study during finger measurements'}, 'identificationModule': {'nctId': 'NCT07436169', 'briefTitle': '2D:4D Finger Ratio and Breast Cancer in Women', 'organization': {'class': 'OTHER', 'fullName': 'Malatya Turgut Ozal University'}, 'officialTitle': 'Evaluation Of The Relationship Between Finger 2d-4d Ratios And Cancer In Breast Cancer Patients. A Randomized Controlled Trial', 'orgStudyIdInfo': {'id': 'B.270'}, 'secondaryIdInfos': [{'id': 'B.270', 'type': 'OTHER_GRANT', 'domain': 'Malatya Turgut Ozal University Ethical Commitee'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Breast Cancer Patients', 'description': 'Women aged 18 years and older with histopathologically confirmed breast cancer.'}, {'label': 'Healthy Controls', 'description': 'Age-matched women without a history of breast cancer or other malignancies.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '44100', 'city': 'Malatya', 'state': 'Central', 'country': 'Turkey (Türkiye)', 'facility': 'Malatya Turgut Ozal University', 'geoPoint': {'lat': 38.35018, 'lon': 38.31667}}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'Individual participant data will not be publicly shared to protect patient confidentiality and in accordance with institutional ethics committee policies. De-identified aggregate data may be available upon reasonable request.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Malatya Turgut Ozal University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Ph.D', 'investigatorFullName': 'Muhammed Furkan ARPACI', 'investigatorAffiliation': 'Malatya Turgut Ozal University'}}}}