Ignite Creation Date:
2026-03-26 @ 3:17 PM
Ignite Modification Date:
2026-03-29 @ 11:58 PM
Study NCT ID:
NCT07438535
Status:
RECRUITING
Last Update Posted:
2026-02-27
First Post:
2026-02-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
High-Load, Low-Load, and Passive Blood Flow Restriction in Competitive Sprinters
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 18}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-12-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-02', 'completionDateStruct': {'date': '2026-09-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2026-02-23', 'studyFirstSubmitDate': '2026-02-23', 'studyFirstSubmitQcDate': '2026-02-23', 'lastUpdatePostDateStruct': {'date': '2026-02-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-02-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-08-01', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Lower Limb Muscle Strength (1RM Test)', 'timeFrame': 'Baseline (Week 0) and Post-Intervention (Week 6)', 'description': 'Maximum voluntary strength of lower limb muscles will be assessed using one repetition maximum (1RM) testing protocol for resistance training exercises.'}], 'secondaryOutcomes': [{'measure': 'Vertical Jump Height', 'timeFrame': 'Baseline (Week 0) and Post-Intervention (Week 6)', 'description': 'Explosive lower limb power will be assessed using vertical jump performance test measured in centimeters.'}, {'measure': '10-Meter Sprint Time', 'timeFrame': 'Baseline (Week 0) and Post-Intervention (Week 6)', 'description': 'Sprint performance over short distance will be measured using timing gates in seconds.'}, {'measure': '30-Meter Sprint Time', 'timeFrame': 'Baseline (Week 0) and Post-Intervention (Week 6)', 'description': 'Sprint acceleration and performance will be measured using electronic timing system in seconds.'}, {'measure': '100-Meter Sprint Time', 'timeFrame': 'Baseline (Week 0) and Post-Intervention (Week 6)', 'description': 'Overall sprint performance will be assessed using timing system in seconds.'}, {'measure': 'Participant-reported exertion during training sessions using Borg CR-10 Scale.', 'timeFrame': 'Throughout Intervention Period (Week 1-6)', 'description': 'Participant-reported exertion during training sessions using Borg CR-10 Scale.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Blood Flow Restriction', 'Competitive Sprinters', 'High-Load', 'Low-Load', 'Passive Blood Flow Restriction'], 'conditions': ['Blood Flow Restriction']}, 'referencesModule': {'references': [{'pmid': '38476581', 'type': 'BACKGROUND', 'citation': 'Herrera E, Osorio-Fuentealba C. Impact of warm-up methods on strength-speed for sprinters in athletics: a mini review. Front Sports Act Living. 2024 Feb 27;6:1360414. doi: 10.3389/fspor.2024.1360414. eCollection 2024.'}, {'pmid': '29745735', 'type': 'BACKGROUND', 'citation': 'Richard P, Billaut F. Time-Trial Performance in Elite Speed Skaters After Remote Ischemic Preconditioning. Int J Sports Physiol Perform. 2018 Nov 1;13(10):1308-1316. doi: 10.1123/ijspp.2018-0111.'}, {'pmid': '31453935', 'type': 'BACKGROUND', 'citation': 'Chen YT, Hsieh YY, Ho JY, Lin JC. Effects of Running Exercise Combined With Blood Flow Restriction on Strength and Sprint Performance. J Strength Cond Res. 2021 Nov 1;35(11):3090-3096. doi: 10.1519/JSC.0000000000003313.'}, {'pmid': '27325532', 'type': 'BACKGROUND', 'citation': 'Salvador AF, Schubert KR, Cruz RS, Corvino RB, Pereira KL, Caputo F, de Oliveira MF. Bilateral muscle strength symmetry and performance are improved following walk training with restricted blood flow in an elite paralympic sprint runner: Case study. Phys Ther Sport. 2016 Jul;20:1-6. doi: 10.1016/j.ptsp.2015.10.004. Epub 2015 Oct 21.'}, {'pmid': '37035675', 'type': 'BACKGROUND', 'citation': 'Zhang J, Zhou R, Zhao N, Li Y, Liu H, Zhang W, Guo W. Acute effects of blood flow restriction with whole-body vibration on sprint, muscle activation and metabolic accumulation in male sprinters. Front Physiol. 2023 Mar 16;14:1149400. doi: 10.3389/fphys.2023.1149400. eCollection 2023.'}]}, 'descriptionModule': {'briefSummary': 'This randomized clinical trial will include competitive male and female sprinters aged 16-30 years, recruited through purposive sampling. Participants will be randomly assigned to one of three groups: (A) HL-BFR (70-85% 1RM with BFR during sets), (B) LL-BFR (20-30% 1RM with BFR), or (C) Passive BFR (BFR applied between sets). The intervention will consist of a 6-week sprint-specific resistance training program performed thrice weekly, incorporating resisted sprints, barbell step-ups, hip thrusts, Nordic curls, and bounding exercises. Strength will be measured using 1RM testing, explosive power through countermovement and standing broad jumps, and sprint performance via 10m, 30m, and 100m timed sprints. Subjective exertion will be tracked using the sRPE scale.\n\nThe study aims to determine whether HL-BFR, LL-BFR, or passive BFR produces superior improvements in sprint performance and neuromuscular strength. It is hypothesized that HL-BFR may yield greater adaptations due to combined mechanical and metabolic stress, though LL-BFR and passive BFR may offer practical, low-impact alternatives.', 'detailedDescription': 'Blood Flow Restriction (BFR) training characterized by applying external pressure to occlude venous return during exercise has gained prominence in both rehabilitation and athletic conditioning due to its ability to stimulate muscle hypertrophy and strength gains with lighter mechanical loads. The physiological basis includes metabolic accumulation, cellular swelling, and increased motor unit recruitment, mimicking high-intensity training effects even with low loads .\n\nElite sprint performance demands a finely tuned combination of explosive strength, neuromuscular power, and sprint-specific endurance across different phases of the race (acceleration, maximal velocity, deceleration). While high-load resistance training (≥ 70% 1RM) has long been the gold standard for developing muscular strength and power , blood flow restriction (BFR) training-particularly in low-load protocols (20-40% 1RM)-has emerged as a low-stress alternative capable of eliciting comparable hypertrophy and strength gains.\n\nA growing body of literature now highlights the capacity of both high- and low-load BFR training to improve explosive performance metrics, such as vertical jump, sprint speed, and rate of force development. A systematic review found that athletes undergoing BFR training experienced small to moderate yet significant improvements in jumps (SMD ≈ 0.36), sprints (SMD ≈ 0.54), and power output (SMD ≈ 0.72), surpassing traditional resistance training outcomes.\n\nHigh-load resistance training (≥ 70 % 1RM) is the established standard for enhancing neuromuscular strength and power. Recent investigations have examined adding BFR to high-load protocols (high-load BFR), aiming to amplify metabolic stress and post-activation performance enhancement. Though the evidence is mixed-a systematic review of ≥ 60 % 1RM BFR protocols concluded that only some studies showed additional strength or hypertrophy benefits compared to non-BFR controls emerging data suggest that high-load BFR may offer acute increases in lifting velocity and small improvements in jump and sprint outcomes.\n\nAmong BFR strategies, low-load BFR (LL-BFR)-typically at 20-40% of one-repetition maximum (1RM)-has the most robust evidence base. Systematic reviews demonstrate that LL-BFR training can induce similar muscle hypertrophy and near-equivalent strength improvements compared to traditional high-load training . These benefits, coupled with lower mechanical stress, have made LL-BFR a preferred method in both clinical and performance settings. Meta-analyses report that while maximum strength gains are slightly lower than high-load training, power, jump, and sprint performance show no significant differences between low-load BFR and high-load resistance training.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '30 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Age between 16-30 years\n* Competitive sprinters with at least 2 years of sprint-specific training\n* Healthy individuals without cardiovascular, metabolic, musculoskeletal, or neurological disorders\n* Willingness to participate in a 6-week training program\n\nExclusion Criteria:\n\n* Pregnancy or lactation\n* Cardiovascular, vascular, pulmonary, renal or metabolic disorders\n* Uncontrolled hypertension\n* Recent significant weight loss\n* Use of performance-enhancing drugs within past 2 months\n* Any medical condition preventing safe participation'}, 'identificationModule': {'nctId': 'NCT07438535', 'briefTitle': 'High-Load, Low-Load, and Passive Blood Flow Restriction in Competitive Sprinters', 'organization': {'class': 'OTHER', 'fullName': 'Riphah International University'}, 'officialTitle': 'Comparative Effects of High-Load, Low-Load, and Passive Blood Flow Restriction Training on Strength and Sprint Performance in Competitive Sprinters', 'orgStudyIdInfo': {'id': 'Mubarak Janjua REC/25/0417'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'High-Load Blood Flow Restriction Training (HL-BFR)', 'description': 'Participants will perform resistance training at 70-85% of one-repetition maximum (1RM) combined with blood flow restriction applied using pneumatic cuffs during exercise sets for a period of 6 weeks (3 sessions per week).', 'interventionNames': ['Other: High-Load Blood Flow Restriction Training (HL-BFR)']}, {'type': 'EXPERIMENTAL', 'label': 'Low-Load Blood Flow Restriction Training (LL-BFR)', 'description': 'Participants will perform resistance training at 20-30% of one-repetition maximum (1RM) combined with blood flow restriction applied using pneumatic cuffs during exercise sets for a period of 6 weeks (3 sessions per week).', 'interventionNames': ['Other: Low-Load Blood Flow Restriction Training (LL-BFR)']}, {'type': 'EXPERIMENTAL', 'label': 'Passive Blood Flow Restriction Training (PBFR)', 'description': 'Participants will perform resistance training at 70-85% of one-repetition maximum (1RM) while blood flow restriction will be applied only during rest intervals between exercise sets for a period of 6 weeks (3 sessions per week).', 'interventionNames': ['Other: Passive Blood Flow Restriction Training (PBFR)']}], 'interventions': [{'name': 'High-Load Blood Flow Restriction Training (HL-BFR)', 'type': 'OTHER', 'description': 'In the High-Load BFR group, participants will perform resistance exercises at 70-85% of one-repetition maximum (1RM) with BFR applied during exercise sets.', 'armGroupLabels': ['High-Load Blood Flow Restriction Training (HL-BFR)']}, {'name': 'Low-Load Blood Flow Restriction Training (LL-BFR)', 'type': 'OTHER', 'description': 'In the Low-Load BFR group, participants will perform resistance exercises at 20-30% of one-repetition maximum (1RM) with BFR applied during exercise sets.', 'armGroupLabels': ['Low-Load Blood Flow Restriction Training (LL-BFR)']}, {'name': 'Passive Blood Flow Restriction Training (PBFR)', 'type': 'OTHER', 'description': 'In the Passive BFR group, participants will perform resistance exercises at 70-85% of one-repetition maximum (1RM) with BFR applied only during rest intervals between sets.', 'armGroupLabels': ['Passive Blood Flow Restriction Training (PBFR)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '547000', 'city': 'Lahore', 'state': 'Punjab Province', 'status': 'RECRUITING', 'country': 'Pakistan', 'contacts': [{'name': 'Danish Hassan, PhD', 'role': 'CONTACT', 'email': 'danish.hassan009@gmail.com', 'phone': '03457946009'}, {'name': 'Muhammad Mubarak Janjua, MSPT*', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Punjab Sports Board', 'geoPoint': {'lat': 31.558, 'lon': 74.35071}}], 'centralContacts': [{'name': 'Danish Hassan, PhD', 'role': 'CONTACT', 'email': 'danish.hassan009@gmail.com', 'phone': '+92 345 7946009'}], 'overallOfficials': [{'name': 'Muhammad Mubarak Janjua, MS PT', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Riphah International University'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Riphah International University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}