Ignite Creation Date:
2026-03-26 @ 3:16 PM
Ignite Modification Date:
2026-03-30 @ 1:05 AM
Study NCT ID:
NCT07441057
Status:
RECRUITING
Last Update Posted:
2026-02-27
First Post:
2026-02-23
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Effects of CHRIST on Upper Limb Function in Children With Pediatric Stroke
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'conditionBrowseModule': {'meshes': [{'id': 'D020521', 'term': 'Stroke'}], 'ancestors': [{'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 15}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2026-02-04', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-02', 'completionDateStruct': {'date': '2026-08-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2026-02-23', 'studyFirstSubmitDate': '2026-02-23', 'studyFirstSubmitQcDate': '2026-02-23', 'lastUpdatePostDateStruct': {'date': '2026-02-27', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-02-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-07-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'ABILHAND-Kids', 'timeFrame': 'Baseline and after 10 weeks', 'description': 'The ABILHAND-Kids is specifically developed to evaluate upper limb function in children and adolescents with neurological impairments, making them highly sensitive to changes in motor performance'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Stroke']}, 'referencesModule': {'references': [{'pmid': '18420156', 'type': 'BACKGROUND', 'citation': 'Amlie-Lefond C, Sebire G, Fullerton HJ. Recent developments in childhood arterial ischaemic stroke. Lancet Neurol. 2008 May;7(5):425-35. doi: 10.1016/S1474-4422(08)70086-3.'}, {'pmid': '22506234', 'type': 'BACKGROUND', 'citation': 'Kim DA, Lee JA, Hwang PW, Lee MJ, Kim HK, Park JJ, You JH, Lee DR, Lee NG. The Effect of Comprehensive Hand Repetitive Intensive Strength Training (CHRIST) Using Motion Analysis in Children with Cerebral Palsy. Ann Rehabil Med. 2012 Feb;36(1):39-46. doi: 10.5535/arm.2012.36.1.39. Epub 2012 Feb 29.'}, {'pmid': '35888850', 'type': 'BACKGROUND', 'citation': 'Kabir R, Sunny MSH, Ahmed HU, Rahman MH. Hand Rehabilitation Devices: A Comprehensive Systematic Review. Micromachines (Basel). 2022 Jun 29;13(7):1033. doi: 10.3390/mi13071033.'}]}, 'descriptionModule': {'briefSummary': "Pediatric stroke poses significant challenges due to its impact on a child's developing brain. Both ischemic and hemorrhagic strokes in children can result in long-term motor, sensory, and cognitive impairments, particularly affecting upper limb function.\n\nComprehensive Hand Repetitive Intensive Strength Training is a structured intervention model that integrates high-repetition, strength-based, and goal-oriented exercises targeting upper limb coordination and use. This study aims to explore the efficacy of CHRIST in improving upper limb function using the ABILHAND-Kids questionnaire to assess changes in manual ability. The study aims to generate pediatric-specific evidence for intensive hand-focused rehabilitation strategies."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD'], 'maximumAge': '12 Years', 'minimumAge': '7 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Children aged 7 to 12 years diagnosed with pediatric ischemic or hemorrhagic stroke(21).\n\n * Clinical evidence of upper limb motor impairment following stroke.\n * Parent/guardian consent and child assent obtained.\n\nExclusion Criteria:\n\n* Severe cognitive or behavioral impairments interfering with therapy.\n\n * Uncontrolled seizures or medical conditions contraindicating exercise.\n * Previous participation in intensive upper limb therapy within the last 3 months.\n * Orthopedic conditions (e.g., fractures, contractures) that limit upper limb movement.'}, 'identificationModule': {'nctId': 'NCT07441057', 'briefTitle': 'Effects of CHRIST on Upper Limb Function in Children With Pediatric Stroke', 'organization': {'class': 'OTHER', 'fullName': 'Riphah International University'}, 'officialTitle': 'Effects of Comprehensive Hand Repetitive Intense Strength Training on Upper Limb Function in Children With Pediatric Stroke', 'orgStudyIdInfo': {'id': 'Zurriat Fatima'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'CHRIST will be given to childrenwith pediatric stroke', 'interventionNames': ['Other: CHRIST']}], 'interventions': [{'name': 'CHRIST', 'type': 'OTHER', 'description': 'A session of 40 minutes, which includes 3 sets (10 minutes exercise with 3 minutes rest period per set), three times a week, over a 10 weeks period. The speed of the treadmill for the upper limbs will be 0.3-1.2 km/h.', 'armGroupLabels': ['CHRIST will be given to childrenwith pediatric stroke']}]}, 'contactsLocationsModule': {'locations': [{'zip': '5400', 'city': 'Mandi Bahāuddīn', 'state': 'Punjab Province', 'status': 'RECRUITING', 'country': 'Pakistan', 'contacts': [{'name': 'Mashar Hayat, MS', 'role': 'CONTACT', 'email': 'docmashar@gmail.com', 'phone': '03338264018'}], 'facility': 'Clinical settings having pediatric stroke patients.'}], 'centralContacts': [{'name': 'Imran Amjad, Phd', 'role': 'CONTACT', 'email': 'imran.amjad@riphah.edu.pk', 'phone': '03324390125'}], 'overallOfficials': [{'name': 'Mashar Hayat, MS', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Riphah International University, Lahore'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Riphah International University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}