Ignite Creation Date:
2026-03-26 @ 3:15 PM
Ignite Modification Date:
2026-03-30 @ 2:23 AM
Study NCT ID:
NCT07453550
Status:
NOT_YET_RECRUITING
Last Update Posted:
2026-03-06
First Post:
2026-02-15
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The Effects of Brief Periods of Exercise on Blood Pressure
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'conditionBrowseModule': {'meshes': [{'id': 'D006973', 'term': 'Hypertension'}, {'id': 'D058246', 'term': 'Prehypertension'}], 'ancestors': [{'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'For the acute study, a cross-over design will be used to allow each participant to go through both conditions. For the long-term study, a randomized controlled study design will be used.'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 45}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2026-02', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-02', 'completionDateStruct': {'date': '2027-06', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2026-03-02', 'studyFirstSubmitDate': '2026-02-15', 'studyFirstSubmitQcDate': '2026-03-02', 'lastUpdatePostDateStruct': {'date': '2026-03-06', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-03-06', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': '24 h blood pressure', 'timeFrame': 'From the enrollment to the end of the study at six weeks', 'description': 'The average, peak and variations of 24 h SBP and DBP, daytime SBP and DBP, night time SBP and DBP will be measured before and after the intervention.'}], 'secondaryOutcomes': [{'measure': 'endothelial function', 'timeFrame': 'at baseline (Day 1) and Week 6', 'description': 'endothelial function measured by flow mediated dilation'}, {'measure': 'arterial stiffness', 'timeFrame': 'at baseline (Day 1) and week 6', 'description': 'arterial stiffness measured by pulse wave velocity'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['isometric exericse'], 'conditions': ['Hypertension (HTN)', 'Pre Hypertension']}, 'descriptionModule': {'briefSummary': "High blood pressure is a common medical condition that affects the body's arteries. It's also called hypertension. Untreated hypertension increases the risk of heart attack, stroke and other serious health problems. Exercise is a promising tool in hypertension management. Regular participation in exercise improves vascular health, heart and lung function, and multisystem health. However, the direct evidence of the treatment effects of a brief period of exercise on blood pressure in individuals with hypertension is limited. A brief period of exercise refers to an exercise protocol that only lasts for a very short period of time, such as 5-10 minutes.", 'detailedDescription': 'The study will investigate both acute and long-term effects of a brief exercise on blood pressure. For the acute effect, participants will conduct a single bout of resistance exercise (leg press) with or without blood flow restriction technique. The blood pressure changes from pre- to post-exercise will be monitored. The long-term effect of exercise on blood pressure will be examined through a six to eight weeks home-based intervention program. Participants will conduct two forms of exercise, one is a clustered wall-sit exercise and the other is a scattered wall-sit exercise.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '55 Years', 'minimumAge': '18 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* 18-55 yrs.\n* 24 hour average BP \\>110/70 mmHg, but \\< 160 systolic blood pressure\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Currently taking anti-hypertensive medication smokers and alcohol drinkers Inability to undertake exercise intervention (resistance and isometric exercise)\n\nCurrent medical history of any of the following:\n\nhyperaldosteronism Diabetes mellitus (Type 1 or type 2) Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease If female, pregnancy or currently breast feeding Enrolled in another Clinical Trial of an Interventional Medicinal Product or Medical Device or other interventional study Medical condition that, in the opinion of the investigator, would make the participant unsuitable for the study On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel\n\nPrevious medication history of any of the following:\n\nhyperaldosteronism Heart disease Stroke or transient ischemic attack Peripheral neuropathy Aortic aneurysm and/or peripheral arterial disease thromboembolism Infection within limb within 3 months On long term warfarin Allergies to blood pressure cuff materials or ultrasound gel'}, 'identificationModule': {'nctId': 'NCT07453550', 'briefTitle': 'The Effects of Brief Periods of Exercise on Blood Pressure', 'organization': {'class': 'OTHER', 'fullName': 'University of Hartford'}, 'officialTitle': 'The Effects of Brief Periods of Exercise on Blood Pressure', 'orgStudyIdInfo': {'id': '25-12-505'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'NO_INTERVENTION', 'label': 'Non-Ex control group'}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Clustered Ex Condition', 'interventionNames': ['Behavioral: wall-squat-tradition']}, {'type': 'EXPERIMENTAL', 'label': 'Scattered Ex Condition', 'interventionNames': ['Behavioral: wall-squat']}], 'interventions': [{'name': 'wall-squat', 'type': 'BEHAVIORAL', 'description': 'the experimental group will complete the four sets of wall-squats at four different times across the day: morning, noon, afternoon, night.', 'armGroupLabels': ['Scattered Ex Condition']}, {'name': 'wall-squat-tradition', 'type': 'BEHAVIORAL', 'description': 'The other exercise group will do 4 sets of wall squat in a continuous way.', 'armGroupLabels': ['Clustered Ex Condition']}]}, 'ipdSharingStatementModule': {'infoTypes': ['STUDY_PROTOCOL', 'SAP', 'CSR'], 'timeFrame': 'The IPD information will be available 1-1-2027 for six months.', 'ipdSharing': 'YES', 'description': 'The data and protocol can be shared with other researchers by request after publication.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Hartford', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Assistant Professor', 'investigatorFullName': 'Jinghui Yang', 'investigatorAffiliation': 'University of Hartford'}}}}