Ignite Creation Date:
2026-03-26 @ 3:15 PM
Ignite Modification Date:
2026-03-31 @ 2:09 AM
Study NCT ID:
NCT07443592
Status:
NOT_YET_RECRUITING
Last Update Posted:
2026-03-02
First Post:
2026-02-25
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Treatment for Ph-negative ALL for Adults up to 65 Years
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'conditionBrowseModule': {'meshes': [{'id': 'D054198', 'term': 'Precursor Cell Lymphoblastic Leukemia-Lymphoma'}, {'id': 'D018365', 'term': 'Neoplasm, Residual'}], 'ancestors': [{'id': 'D007945', 'term': 'Leukemia, Lymphoid'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D008206', 'term': 'Lymphatic Diseases'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}, {'id': 'D009385', 'term': 'Neoplastic Processes'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C510808', 'term': 'blinatumomab'}, {'id': 'D014180', 'term': 'Transplantation'}], 'ancestors': [{'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 330}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2026-03-06', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-02', 'completionDateStruct': {'date': '2033-06-01', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2026-02-25', 'studyFirstSubmitDate': '2026-02-25', 'studyFirstSubmitQcDate': '2026-02-25', 'lastUpdatePostDateStruct': {'date': '2026-03-02', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-03-02', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2031-03-06', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Overall survival comparison versus previous trial', 'timeFrame': '5 years', 'description': 'Comparison of time from diagnosis to death or last follow-up between the present LAL-2025 trial and the previous LAL19 trial for adult Ph-negative'}], 'secondaryOutcomes': [{'measure': 'Complete remission (CR) rate', 'timeFrame': '4 or 8 weeks after treatment onset', 'description': 'Proportion of participants who achieve CR with or 2 induction therapy lines'}, {'measure': 'MRD status after induction and consolidation', 'timeFrame': 'After induction (4-8 weeks) and consolidation (16-20 weeks)', 'description': 'Proportion of participants who achieve and maintain the negative MRD status (\\<10-4)'}, {'measure': 'MRD variation between induction and after cycle 1 blinatumomab', 'timeFrame': 'After induction (4-8 weeks) and after cycle 1 blinatumomab (8-12 weeks)', 'description': 'Proportion of B-cell precursor ALL participants who achieve and maintain the negative MRD status (\\<10-4) at week 4 or 8 (end of induction 1 or 2) and after week 8 or 12 (after blinatumomab cycle1)'}, {'measure': 'Frequency of allogeneic stem cell transplantation (alloSCT) dut to high-risk genetics', 'timeFrame': '5 years', 'description': 'Proportion of participants that are allocated to alloSCT exclusively due to the presence to high-risk genetic alterations defined in the trial'}, {'measure': 'Effect of blinatumomab within each B-cell precursor ALL genetic subtype', 'timeFrame': '5 years', 'description': 'Proportion of paarticipants with negative MRD status within each B-cell precursor ALL genetic subtype according to the World Health Organization (WHO) and the International Consensus Classification of Acute Leukemia (ICC)'}]}, 'oversightModule': {'isUsExport': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['ALL', 'adult', 'Philadephia-negative', 'minimal residual disease', 'genetics', 'immunotherapy', 'transplantation'], 'conditions': ['Acute Lymphoblastic Leukemia']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://www.fundacionpethema.es', 'label': 'Webpage of the sponsor of the study'}]}, 'descriptionModule': {'briefSummary': 'The goal of this trial is to provide a protocol for treatment for adults with Ph-negative acute lymphoblastic leukemia (ALL) and to learn if this provides higher probability of survival than the previous one. The main question is to know if the incorporation of blinatumomab for B-cell precursor ALL, substituting some chemotherapy blocks, offers better probability of survival than the previous trial, which did not use immunotherapy. In addition, T-cell precursor ALL participants will receive different treatment approaches depending on the stage of maturation of the tumor.', 'detailedDescription': 'Participants will be uniformly treated with four drug-induction: vincristine (VCR), prednisone (PDN), pegylated asparaginase (PegASP), daunorubicin (DNR).\n\nResistant participants will receive a second induction with inotuzumab for B-cell precursor ALL or with FLAG-Ida (fludarabine, cytarabine, idarubicin and granulocyte colony stimulating factor) for T-cell precursor ALL.\n\nB-cell precursor ALL participants with adequate MRD clearance after cycle 1 of blinatumomab will receive 3 blocks of early consolidation. If adequate MRD clearance and good genetic background, the patients will proceed to delayed intensification, reinduction and maintenance. The remaining patients will receive early or delayed alloHSCT.\n\nT-cell precursor ALL participants with adequate MRD clearance after the first cycle of consolidation will receive 2 blocks of early consolidation and reinduction. If adequate MRD clearance and good genetic background, the patients will proceed to delayed intensification and maintenance. The remaining patients will receive early or delayed alloHSCT.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* De novo ALL.\n* Age 18-65 years.\n* No prior treatment, except:\n\nUrgent leukapheresis, Urgent treatment of hyperleukocytosis with hydroxyurea, Urgent cranial irradiation (one dose) for CNS leukostasis, Urgent mediastinal irradiation for superior vena cava syndrome.\n\n* Adequate general condition (ECOG score 0-2), or \\>2 if due to ALL.\n* Negative pregnancy test for women of childbearing age.\n\nExclusion Criteria:\n\n* Age \\> 65 years.\n* ALL type L3 or with mature B phenotype (sIg+) or with the cytogenetic alterations characteristic of mature B-cell ALL (t(8;14), t(2;8), t(8;22)).\n* Ph-positive B-cell ALL (BCR::ABL1).\n* Lymphoid blast crisis of chronic myeloid leukemia.\n* Patients with a history of coronary artery disease, valvular heart disease, or hypertensive heart disease, which contraindicates the use of anthracyclines.\n* Patients with active chronic liver disease.\n* Patients with severe chronic respiratory failure.\n* Renal insufficiency not due to ALL.\n* Severe neurological disorders, not due to ALL, that contraindicate the use of these treatments (especially blinatumomab).\n* History of clinically significant pancreatitis, at the investigator's discretion (taking into account the date of the pancreatitis, its previous severity, and sequelae).\n* Pregnancy or breastfeeding.\n* Psychiatric or mental illness that prevents providing informed consent for sample submission or adequately participating in the study.\n* Impaired general health (ECOG scores 3 and 4) not attributable to ALL."}, 'identificationModule': {'nctId': 'NCT07443592', 'acronym': 'LAL-2025', 'briefTitle': 'Treatment for Ph-negative ALL for Adults up to 65 Years', 'organization': {'class': 'OTHER', 'fullName': 'PETHEMA Foundation'}, 'officialTitle': 'Protocol for the Treatment of BCR::ABL1-negative Acute Lymphoblastic Leukemia in Adults up to 65 Years', 'orgStudyIdInfo': {'id': 'PETHEMA LAL-2025'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'OTHER', 'label': 'Chemotherapy (+ blinatumomab for B-cell precursor ALL)', 'description': 'Pediatric-inspired chemotherapy', 'interventionNames': ['Drug: Pediatric-type of chemotherapy (+blinatumomab for B-cell precursor ALL)']}, {'type': 'OTHER', 'label': 'Transplantation', 'description': 'allogeneic stem cell transplantation', 'interventionNames': ['Procedure: Transplantation']}], 'interventions': [{'name': 'Pediatric-type of chemotherapy (+blinatumomab for B-cell precursor ALL)', 'type': 'DRUG', 'description': 'Pediatric type chemotherapy (induction, early and delayed consolidation, reinduction, maintenance). Induction (VCR,PDN,PegASP,DNR). Early and delayed consolidation (high-dose Methotrexate, high-dose Cytarabine, PegASP). Reinduction (VCR, PDN, PegASP, DNR). Maintenance (Methotrexate, Mercaptopurine). Blinatumomab cycles in consolidation therapy for participants with B-cell precursor ALL.', 'armGroupLabels': ['Chemotherapy (+ blinatumomab for B-cell precursor ALL)']}, {'name': 'Transplantation', 'type': 'PROCEDURE', 'description': 'allogeneic stem cell transplantation', 'armGroupLabels': ['Transplantation']}]}, 'contactsLocationsModule': {'locations': [{'city': 'A Coruña', 'country': 'Spain', 'contacts': [{'name': 'Victor Noriega, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital de A Coruña', 'geoPoint': {'lat': 43.37135, 'lon': -8.396}}, {'city': 'Alava', 'country': 'Spain', 'contacts': [{'name': 'Pilar Romero, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de Araba', 'geoPoint': {'lat': 43.36057, 'lon': -6.19946}}, {'city': 'Albacete', 'country': 'Spain', 'contacts': [{'name': 'Jesús Lorenzo Algarra, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital General Universitario de Albacete', 'geoPoint': {'lat': 38.99424, 'lon': -1.85643}}, {'city': 'Alicante', 'country': 'Spain', 'contacts': [{'name': 'Carmen Botella, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital General Universitario Dr. Balmis', 'geoPoint': {'lat': 38.34517, 'lon': -0.48149}}, {'city': 'Almería', 'country': 'Spain', 'contacts': [{'name': 'María José García, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Torrecárdenas', 'geoPoint': {'lat': 36.83814, 'lon': -2.45974}}, {'city': 'Arrecife', 'country': 'Spain', 'contacts': [{'name': 'Azueg Hong, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital General de Lanzarote', 'geoPoint': {'lat': 28.96302, 'lon': -13.54769}}, {'city': 'Ávila', 'country': 'Spain', 'contacts': [{'name': 'María Paz Martínez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Nuestra Señora de Sonsoles / Complejo Asistencial de Ávila', 'geoPoint': {'lat': 40.65724, 'lon': -4.69951}}, {'city': 'Badajoz', 'country': 'Spain', 'contacts': [{'name': 'María Soledad Casado, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de Badajoz', 'geoPoint': {'lat': 38.87789, 'lon': -6.97061}}, {'city': 'Badalona', 'country': 'Spain', 'contacts': [{'name': 'Anna Torrent, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'ICO-Hospital Germans Trias i Pujol', 'geoPoint': {'lat': 41.45004, 'lon': 2.24741}}, {'city': 'Barcelona', 'country': 'Spain', 'contacts': [{'name': 'Núria Martínez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Clínic de Barcelona', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'city': 'Barcelona', 'country': 'Spain', 'contacts': [{'name': 'Irene García, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital de Sant Pau', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'city': 'Barcelona', 'country': 'Spain', 'contacts': [{'name': 'Lucía Gómez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital del Mar', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'city': 'Barcelona', 'country': 'Spain', 'contacts': [{'name': 'Yva Rodríguez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital QuirónSalud', 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'city': 'Barcelona', 'country': 'Spain', 'contacts': [{'name': 'Pere Barba, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Hospital Vall d'Hebrón", 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'city': 'Bilbao', 'country': 'Spain', 'contacts': [{'name': 'Cristina Barrenetxea, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Basurtuko Ospitalea', 'geoPoint': {'lat': 43.26271, 'lon': -2.92528}}, {'city': 'Burgos', 'country': 'Spain', 'contacts': [{'name': 'Jorge Labrador, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de Burgos', 'geoPoint': {'lat': 42.34106, 'lon': -3.70184}}, {'city': 'Cadiz', 'country': 'Spain', 'contacts': [{'name': 'José Ángel Raposo, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Puerta del Mar', 'geoPoint': {'lat': 36.52672, 'lon': -6.2891}}, {'city': 'Cartagena', 'country': 'Spain', 'contacts': [{'name': 'Antonio Martínez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Santa Lucía', 'geoPoint': {'lat': 37.60197, 'lon': -0.98397}}, {'city': 'Castelló', 'country': 'Spain', 'contacts': [{'name': 'Raimundo García, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital General de Castellón', 'geoPoint': {'lat': 41.01149, 'lon': 0.84856}}, {'city': 'Cáceres', 'country': 'Spain', 'contacts': [{'name': 'Juan Bergua, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital San Pedro Alcántara', 'geoPoint': {'lat': 39.47649, 'lon': -6.37224}}, {'city': 'Ciudad Real', 'country': 'Spain', 'contacts': [{'name': 'Raúl Vanegas, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital General de Ciudad Real', 'geoPoint': {'lat': 38.98626, 'lon': -3.92907}}, {'city': 'Córdoba', 'country': 'Spain', 'contacts': [{'name': 'Josefina Serrano, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Reina Sofía', 'geoPoint': {'lat': 37.89155, 'lon': -4.77275}}, {'city': 'Cruces', 'country': 'Spain', 'contacts': [{'name': 'Javier Arzuaga, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de Cruces', 'geoPoint': {'lat': 42.79471, 'lon': -8.17208}}, {'city': 'Cuenca', 'country': 'Spain', 'contacts': [{'name': 'María José Busto, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Virgen de la Luz', 'geoPoint': {'lat': 40.06667, 'lon': -2.13333}}, {'city': 'Donostia / San Sebastian', 'country': 'Spain', 'contacts': [{'name': 'Teresa Artola, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de Donostia', 'geoPoint': {'lat': 43.31283, 'lon': -1.97499}}, {'city': 'Fuenlabrada', 'country': 'Spain', 'contacts': [{'name': 'Pilar Bravo, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital de Fuenlabrada', 'geoPoint': {'lat': 40.28419, 'lon': -3.79415}}, {'city': 'Galdakao', 'country': 'Spain', 'contacts': [{'name': 'Matxalen Olivares, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de Galdakao', 'geoPoint': {'lat': 43.23073, 'lon': -2.8429}}, {'city': 'Getafe', 'country': 'Spain', 'contacts': [{'name': 'Cristian Escolano, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital de Getafe', 'geoPoint': {'lat': 40.30571, 'lon': -3.73295}}, {'city': 'Girona', 'country': 'Spain', 'contacts': [{'name': 'Marta Sitges, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'ICO-Hospital Josep Trueta', 'geoPoint': {'lat': 41.98311, 'lon': 2.82493}}, {'city': 'Huelva', 'country': 'Spain', 'contacts': [{'name': 'María Solé, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Area Hospitalaria Juan Ramón Jimenez', 'geoPoint': {'lat': 37.26638, 'lon': -6.94004}}, {'city': 'Jaén', 'country': 'Spain', 'contacts': [{'name': 'Juan Antonio López, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Consorcio Hospitalario de Jaén', 'geoPoint': {'lat': 37.76922, 'lon': -3.79028}}, {'city': 'Jerez de la Frontera', 'country': 'Spain', 'contacts': [{'name': 'Lourdes Hermosín, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Jerez de la Frontera', 'geoPoint': {'lat': 36.68645, 'lon': -6.13606}}, {'city': "L'Hospitalet de Llobregat", 'country': 'Spain', 'contacts': [{'name': 'Clara Maluquer, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'ICO-Hospital Duran i Reynals', 'geoPoint': {'lat': 41.35967, 'lon': 2.10028}}, {'city': 'Las Palmas de Gran Canaria', 'country': 'Spain', 'contacts': [{'name': 'Carlos Rodríguez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'C. H. U. de Gran Canaria Dr. Negrín', 'geoPoint': {'lat': 28.10178, 'lon': -15.41573}}, {'city': 'Las Palmas de Gran Canaria', 'country': 'Spain', 'contacts': [{'name': 'Rosa Fernández, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Complejo Hospitalario Universitario Insular Materno Infantil de Canarias', 'geoPoint': {'lat': 28.10178, 'lon': -15.41573}}, {'city': 'Leganés', 'country': 'Spain', 'contacts': [{'name': 'Lorena Abalo, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Severo Ochoa', 'geoPoint': {'lat': 40.32718, 'lon': -3.7635}}, {'city': 'León', 'country': 'Spain', 'contacts': [{'name': 'Nora Suárez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario de León', 'geoPoint': {'lat': 42.60003, 'lon': -5.57032}}, {'city': 'Lleida', 'country': 'Spain', 'contacts': [{'name': 'Antoni Garcia, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Arnau de Vilanova', 'geoPoint': {'lat': 41.61674, 'lon': 0.62218}}, {'city': 'Logroño', 'country': 'Spain', 'contacts': [{'name': 'Andrea Campeny, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital San Pedro', 'geoPoint': {'lat': 42.46615, 'lon': -2.45115}}, {'city': 'Lugo', 'country': 'Spain', 'contacts': [{'name': 'Aitor Abuín, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Lucus Augusti', 'geoPoint': {'lat': 43.00992, 'lon': -7.55602}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Ignacio Alberto Gómez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'C. H. Gregorio Marañón', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Carlos Grande, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Clínica Universidad Navarra', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Marta Mateo, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Clínico San Carlos', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Pilar Martínez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Doce de Octubre', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'María Ángeles Foncillas, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Infanta Leonor', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Javier Ortín, dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital La Princesa', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Daniel García, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital La Zarzuela', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Paula Gili, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Príncipe de Asturias', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Pilar Herrera, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Ramón y Cajal', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Aranzazu Alonso, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Ruber Juan Bravo', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Laura Llorente, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Sanchinarro', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Laura Solán, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Fundación Jiménez Díaz', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Concha Alaez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario HLA Moncloa', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Alícia Roldán, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Infanta Sofía', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Irene Sánchez, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario La Paz', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Virginia Pradillo, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Universitario Quirónsalud', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Madrid', 'country': 'Spain', 'contacts': [{'name': 'Alejandro Bobes, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'MD Anderson Cancer Center', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'city': 'Majadahonda', 'country': 'Spain', 'contacts': [{'name': 'Ana Bocanegra, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hospital Puerta de Hierro', 'geoPoint': {'lat': 40.47353, 'lon': -3.87182}}, {'city': 'Málaga', 'country': 'Spain', 'contacts': [{'name': 'María Paz Queipo, Dr', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': '. 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