Ignite Creation Date:
2026-03-26 @ 3:15 PM
Ignite Modification Date:
2026-03-31 @ 2:03 AM
Study NCT ID:
NCT07320092
Status:
RECRUITING
Last Update Posted:
2026-03-24
First Post:
2025-12-22
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Supine vs Prone Position and Atelectasis Assessed by Lung Ultrasound
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2026-03-25'}, 'conditionBrowseModule': {'meshes': [{'id': 'D001261', 'term': 'Pulmonary Atelectasis'}, {'id': 'D008192', 'term': 'Deception'}], 'ancestors': [{'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D012919', 'term': 'Social Behavior'}, {'id': 'D001519', 'term': 'Behavior'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 80}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2025-09-15', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2026-03', 'completionDateStruct': {'date': '2026-04-15', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2026-03-23', 'studyFirstSubmitDate': '2025-12-22', 'studyFirstSubmitQcDate': '2026-01-05', 'lastUpdatePostDateStruct': {'date': '2026-03-24', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2026-01-06', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-03-30', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Difference in lung ultrasound-detected atelectasis between supine and prone surgical positions', 'timeFrame': 'Perioperative (After induction of general anesthesia and before extubation)', 'description': 'Lung aeration will be evaluated using the Lung Ultrasound Score (LUS), a semiquantitative scoring system assessing aeration loss in 12 lung regions.\n\nIn the supine position, lung ultrasound assessment will be performed along:\n\nthe parasternal line (intercostal spaces 1-4 and 4-8), the anterior axillary line (intercostal spaces 1-6 and 6-12), and the posterior axillary line (intercostal spaces 1-6 and 6-12).\n\nIn the prone position, lung ultrasound assessment will be performed along:\n\nthe paravertebral line (intercostal spaces 1-6 and 6-12), the posterior axillary line (intercostal spaces 1-6 and 6-12), and the anterior axillary line (intercostal spaces 1-6 and 6-12). Each lung region will be scored from 0 to 3, resulting in a total LUS ranging from 0 to 36, where higher scores indicate greater loss of aeration and more severe atelectasis.\n\nAssessments will be performed after induction of general anesthesia and before extubation.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Lung Ultrasound', 'Atelectasis', 'Supine Position', 'Prone Position', 'General Anesthesia', 'Perioperative Care'], 'conditions': ['Postoperative Atelectasis']}, 'referencesModule': {'references': [{'pmid': '20851923', 'type': 'BACKGROUND', 'citation': 'Bouhemad B, Brisson H, Le-Guen M, Arbelot C, Lu Q, Rouby JJ. Bedside ultrasound assessment of positive end-expiratory pressure-induced lung recruitment. Am J Respir Crit Care Med. 2011 Feb 1;183(3):341-7. doi: 10.1164/rccm.201003-0369OC. Epub 2010 Sep 17.'}, {'type': 'BACKGROUND', 'citation': 'Tusman G, Böhm SH, Warner DO, Sprung J. Atelectasis and perioperative pulmonary complications in general anesthesia. Br J Anaesth. 2012;108(2):229-240. PMID: 22156255.'}, {'pmid': '24662376', 'type': 'BACKGROUND', 'citation': 'Acosta CM, Maidana GA, Jacovitti D, Belaunzaran A, Cereceda S, Rae E, Molina A, Gonorazky S, Bohm SH, Tusman G. Accuracy of transthoracic lung ultrasound for diagnosing anesthesia-induced atelectasis in children. Anesthesiology. 2014 Jun;120(6):1370-9. doi: 10.1097/ALN.0000000000000231.'}, {'pmid': '27669555', 'type': 'BACKGROUND', 'citation': 'Monastesse A, Girard F, Massicotte N, Chartrand-Lefebvre C, Girard M. Lung Ultrasonography for the Assessment of Perioperative Atelectasis: A Pilot Feasibility Study. Anesth Analg. 2017 Feb;124(2):494-504. doi: 10.1213/ANE.0000000000001603.'}, {'pmid': '24401163', 'type': 'BACKGROUND', 'citation': 'Lichtenstein DA. Lung ultrasound in the critically ill. Ann Intensive Care. 2014 Jan 9;4(1):1. doi: 10.1186/2110-5820-4-1.'}]}, 'descriptionModule': {'briefSummary': 'Atelectasis frequently develops during and after general anesthesia due to factors such as anesthesia-induced diaphragmatic dysfunction, reduced functional residual capacity, altered ventilation-perfusion matching, and surgical positioning. The development of atelectasis has been associated with postoperative hypoxemia and other pulmonary complications.\n\nLung ultrasound (LUS) has emerged as a reliable, radiation-free bedside imaging modality for the detection and monitoring of atelectasis. LUS allows assessment of lung aeration through standardized ultrasound patterns and scoring systems, enabling dynamic evaluation in the perioperative period.\n\nThis is a prospective, observational cohort study designed to compare the incidence and severity of atelectasis in patients undergoing surgery in the supine position versus the prone position under general anesthesia. Adult patients undergoing elective surgical procedures will be enrolled. No experimental intervention will be applied, and all anesthetic and surgical management will follow routine clinical practice.\n\nLung ultrasound examinations will be performed at predefined time points after induction of anesthesia and before extubation. A standardized lung ultrasound protocol and scoring system will be used to assess lung aeration loss and detect the presence of atelectasis.\n\nThe primary outcome of the study is the difference in atelectasis detected by lung ultrasound between supine and prone surgical positions. The secondary outcome is the change in lung ultrasound scores over time.\n\nThis study aims to clarify the effects of supine and prone positions on perioperative atelectasis and to support the clinical use of lung ultrasound as a noninvasive monitoring tool in perioperative and anesthetic practice..'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'The study population consists of adult patients aged 18 years and older who are scheduled to undergo elective surgical procedures under general anesthesia. Patients will be evaluated according to surgical positioning (supine or prone) during routine perioperative care.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Adult patients aged 18 years or older.\n* Patients scheduled for elective surgery under general anesthesia.\n* Patients undergoing surgery in the supine or prone position.\n* Patients able to provide informed consent.\n\nExclusion Criteria:\n\n* Emergency surgical procedures.\n* Pre-existing severe pulmonary disease affecting lung ultrasound assessment.\n* Hemodynamic instability requiring urgent intervention.\n* Contraindications to lung ultrasound examination.'}, 'identificationModule': {'nctId': 'NCT07320092', 'acronym': 'LUS-ATELEC', 'briefTitle': 'Supine vs Prone Position and Atelectasis Assessed by Lung Ultrasound', 'organization': {'class': 'OTHER', 'fullName': 'Istanbul University - Cerrahpasa'}, 'officialTitle': 'Comparison of the Incidence of Atelectasis Assessed by Lung Ultrasound in Patients Undergoing Surgery in Supine and Prone Positions', 'orgStudyIdInfo': {'id': 'E-74555795-050.04-1231752'}, 'secondaryIdInfos': [{'id': '2025/24', 'type': 'OTHER', 'domain': 'Istanbul University-Cerrahpasa'}]}, 'armsInterventionsModule': {'armGroups': [{'label': 'Supine Position', 'description': 'Patients undergoing surgery in the supine position under general anesthesia.'}, {'label': 'Prone Position', 'description': 'Patients undergoing surgery in the prone position under general anesthesia.'}]}, 'contactsLocationsModule': {'locations': [{'zip': '34320', 'city': 'Istanbul', 'state': 'Istanbul', 'status': 'RECRUITING', 'country': 'Turkey (Türkiye)', 'contacts': [{'name': 'Department of Anesthesiology and Reanimation', 'role': 'CONTACT', 'email': 'chinara.namazova@iuc.edu.tr', 'phone': '+90 (212) 404 03 00'}], 'facility': 'Istanbul University-Cerrahpasa, Cerrahpasa Faculty of Medicine', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}], 'centralContacts': [{'name': 'CHINARA NAMAZOVA, MD, Research Assistant', 'role': 'CONTACT', 'email': 'chinara.namazova@iuc.edu.tr', 'phone': '+90 554 174 87 91'}], 'overallOfficials': [{'name': 'ÖZLEM KORKMAZ DİLMEN, PROFESSOR', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Istanbul University - Cerrahpasa'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO', 'description': 'Individual participant data will not be shared, as this is a single-center observational study conducted for a postgraduate thesis.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Istanbul University - Cerrahpasa', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Research Assistant', 'investigatorFullName': 'CHINARA NAMAZOVA', 'investigatorAffiliation': 'Istanbul University - Cerrahpasa'}}}}