Ignite Creation Date:
2025-12-24 @ 3:01 PM
Ignite Modification Date:
2026-02-20 @ 6:05 PM
Study NCT ID:
NCT00685659
Status:
COMPLETED
Last Update Posted:
2017-08-07
First Post:
2008-05-23
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Effectiveness of Extended Treatments for Drug Dependence
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D019970', 'term': 'Cocaine-Related Disorders'}], 'ancestors': [{'id': 'D019966', 'term': 'Substance-Related Disorders'}, {'id': 'D064419', 'term': 'Chemically-Induced Disorders'}, {'id': 'D001523', 'term': 'Mental Disorders'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'jimrache@mail.med.upenn.edu', 'phone': '215-746-7704', 'title': 'James R. McKay, Ph.D.', 'organization': 'University of Pennsylvania'}, 'certainAgreement': {'piSponsorEmployee': True, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months', 'otherNumAtRisk': 108, 'deathsNumAtRisk': 108, 'otherNumAffected': 0, 'seriousNumAtRisk': 108, 'deathsNumAffected': 2, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included', 'otherNumAtRisk': 106, 'deathsNumAtRisk': 106, 'otherNumAffected': 0, 'seriousNumAtRisk': 106, 'deathsNumAffected': 1, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included', 'otherNumAtRisk': 107, 'deathsNumAtRisk': 107, 'otherNumAffected': 0, 'seriousNumAtRisk': 107, 'deathsNumAffected': 1, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Abstinence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '96', 'groupId': 'OG000'}, {'value': '97', 'groupId': 'OG001'}, {'value': '96', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '45', 'groupId': 'OG000'}, {'value': '57', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '3 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents that number of people we reached for three month follow up evaluation.'}, {'type': 'PRIMARY', 'title': 'Abstinence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '95', 'groupId': 'OG000'}, {'value': '95', 'groupId': 'OG001'}, {'value': '95', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '43', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '6 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents that number of participants we reached for 6 month follow up evaluation.'}, {'type': 'PRIMARY', 'title': 'Abstinence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '91', 'groupId': 'OG000'}, {'value': '91', 'groupId': 'OG001'}, {'value': '91', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '43', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '39', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '9 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants we were able to reach for the 9 month follow up evaluation.'}, {'type': 'PRIMARY', 'title': 'Abstinence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '89', 'groupId': 'OG000'}, {'value': '90', 'groupId': 'OG001'}, {'value': '90', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '33', 'groupId': 'OG000'}, {'value': '39', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '12 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants we were able to reach at the 12 month follow up for evaluation.'}, {'type': 'PRIMARY', 'title': 'Abstinence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '77', 'groupId': 'OG000'}, {'value': '79', 'groupId': 'OG001'}, {'value': '83', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '30', 'groupId': 'OG000'}, {'value': '27', 'groupId': 'OG001'}, {'value': '34', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '18 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants we were able to reach for the 18 month follow up.'}, {'type': 'PRIMARY', 'title': 'Abstinence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '59', 'groupId': 'OG000'}, {'value': '64', 'groupId': 'OG001'}, {'value': '68', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '20', 'groupId': 'OG000'}, {'value': '28', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '24 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.', 'unitOfMeasure': 'participants', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants we were able to reach for 24 month follow up.'}, {'type': 'PRIMARY', 'title': 'Cocaine Urine Toxicology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '89', 'groupId': 'OG000'}, {'value': '76', 'groupId': 'OG001'}, {'value': '83', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '0.31', 'groupId': 'OG000'}, {'value': '0.22', 'groupId': 'OG001'}, {'value': '0.20', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '3 month follow up', 'description': 'Positive cocaine test of urine', 'unitOfMeasure': 'proportion of participants positive', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants for whom we had UDS results in month 3.'}, {'type': 'PRIMARY', 'title': 'Cocaine Urine Toxicology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '82', 'groupId': 'OG000'}, {'value': '76', 'groupId': 'OG001'}, {'value': '83', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '0.26', 'groupId': 'OG000'}, {'value': '0.24', 'groupId': 'OG001'}, {'value': '0.28', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '6 month follow up', 'description': 'Positive cocaine test of urine', 'unitOfMeasure': 'proportion of participants positive', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants for whom we had UDS results in month 6.'}, {'type': 'PRIMARY', 'title': 'Cocaine Urine Toxicology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '74', 'groupId': 'OG000'}, {'value': '69', 'groupId': 'OG001'}, {'value': '78', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '0.30', 'groupId': 'OG000'}, {'value': '0.25', 'groupId': 'OG001'}, {'value': '0.29', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '9 month follow up', 'description': 'Positive cocaine test of urine', 'unitOfMeasure': 'proportion of participants positive', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants for whom we had UDS results in month 9.'}, {'type': 'PRIMARY', 'title': 'Cocaine Urine Toxicology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '76', 'groupId': 'OG000'}, {'value': '73', 'groupId': 'OG001'}, {'value': '77', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '0.37', 'groupId': 'OG000'}, {'value': '0.27', 'groupId': 'OG001'}, {'value': '0.27', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '12 month follow up', 'description': 'Positive cocaine test of urine', 'unitOfMeasure': 'proportion of participants positive', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants for whom we had UDS results in month 12.'}, {'type': 'PRIMARY', 'title': 'Cocaine Urine Toxicology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '67', 'groupId': 'OG000'}, {'value': '72', 'groupId': 'OG001'}, {'value': '80', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '0.33', 'groupId': 'OG000'}, {'value': '0.29', 'groupId': 'OG001'}, {'value': '0.24', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '18 month follow up', 'description': 'Positive cocaine test of urine', 'unitOfMeasure': 'proportion of participants positive', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants for whom we had UDS results in month 18.'}, {'type': 'PRIMARY', 'title': 'Cocaine Urine Toxicology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '69', 'groupId': 'OG000'}, {'value': '80', 'groupId': 'OG001'}, {'value': '75', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '038', 'groupId': 'OG000'}, {'value': '0.26', 'groupId': 'OG001'}, {'value': '0.35', 'groupId': 'OG002'}]}]}], 'paramType': 'NUMBER', 'timeFrame': '24 month follow up', 'description': 'Positive cocaine test of urine', 'unitOfMeasure': 'proportion of participants positive', 'reportingStatus': 'POSTED', 'populationDescription': 'The N analyzed represents the number of participants for whom we had UDS results in month 24.'}, {'type': 'PRIMARY', 'title': 'Comparison Across Groups in Societal Costs', 'denoms': [{'units': 'Participants', 'counts': [{'value': '108', 'groupId': 'OG000'}, {'value': '106', 'groupId': 'OG001'}, {'value': '107', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '-1545', 'spread': '23195', 'groupId': 'OG000'}, {'value': '1564', 'spread': '10997', 'groupId': 'OG001'}, {'value': '-191', 'spread': '20514', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months', 'description': 'Total savings/spending calculated as the monetary value of days of illegal activity, days experiencing medical problems, days experiencing psychiatric problems, and days in jail captured with the ASI. Presented in 2008 dollars.', 'unitOfMeasure': 'US Dollars', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Net Saving/Spending Comparisons Across Groups From Provider Perspective', 'denoms': [{'units': 'Participants', 'counts': [{'value': '108', 'groupId': 'OG000'}, {'value': '106', 'groupId': 'OG001'}, {'value': '107', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '-1545', 'spread': '23195', 'groupId': 'OG000'}, {'value': '1222', 'spread': '11000', 'groupId': 'OG001'}, {'value': '-750', 'spread': '20477', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months', 'description': 'Savings minus intervention costs. Presented in 2008 dollars.', 'unitOfMeasure': 'US Dollars', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Net Comparisons of Savings and Spendings Across Groups From Societal Perspective', 'denoms': [{'units': 'Participants', 'counts': [{'value': '108', 'groupId': 'OG000'}, {'value': '106', 'groupId': 'OG001'}, {'value': '107', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '-1545', 'spread': '23195', 'groupId': 'OG000'}, {'value': '838', 'spread': '11018', 'groupId': 'OG001'}, {'value': '-1497', 'spread': '20414', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months', 'description': 'Savings minus intervention costs. Presented in 2008 dollars.', 'unitOfMeasure': 'US Dollars', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Participation in Protocol', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '69', 'groupId': 'OG001'}, {'value': '82', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '38.8', 'spread': '31.9', 'groupId': 'OG001'}, {'value': '67.1', 'spread': '30.7', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months', 'description': 'Percent available sessions completed', 'unitOfMeasure': 'percentage of sessions', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "Participants in TAU did not receive telephone counseling so were not included in these analyses. N's for TMAC and TMAC Plus represent participants who completed orientation."}, {'type': 'SECONDARY', 'title': 'HIV Sex Risk Score', 'denoms': [{'units': 'Participants', 'counts': [{'value': '79', 'groupId': 'OG000'}, {'value': '74', 'groupId': 'OG001'}, {'value': '77', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '2.9', 'spread': '2.65', 'groupId': 'OG000'}, {'value': '2.8', 'spread': '2.10', 'groupId': 'OG001'}, {'value': '2.7', 'spread': '2.23', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '12 months', 'description': 'Risk score from RAB: Risk Assessment Battery. The RAB is a 41 - item self report developed to study the transmission of HIV. The Risk Assessment Battery generates a drug-risk score and a sex-risk score. For this study, the sex-risk score was used as the outcome measure of sexual behavior that is associated with HIV transmission. The sex-risk score ranges from 0 to 18, with 0 denoting no sex-risk and 18 denoting highest sex-risk. Previous research among drug using populations have found a sex-risk score mean of 6.2.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at 12 months for whom we have a completed RAB (Risk Assessment Battery)."}, {'type': 'SECONDARY', 'title': 'HIV Sex Risk Score', 'denoms': [{'units': 'Participants', 'counts': [{'value': '70', 'groupId': 'OG000'}, {'value': '78', 'groupId': 'OG001'}, {'value': '77', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '2.7', 'spread': '2.45', 'groupId': 'OG000'}, {'value': '3', 'spread': '2.74', 'groupId': 'OG001'}, {'value': '2.7', 'spread': '2.56', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months', 'description': 'Risk score from RAB: Risk Assessment Battery. The RAB is a 41 - item self report developed to study the transmission of HIV. The Risk Assessment Battery generates a drug-risk score and a sex-risk score. For this study, the sex-risk score was used as the outcome measure of sexual behavior that is associated with HIV transmission. The sex-risk score ranges from 0 to 18, with 0 denoting no sex-risk and 18 denoting highest sex-risk. Previous research among drug using populations have found a sex-risk score mean of 6.2.', 'unitOfMeasure': 'units on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at 24 months for whom we have a completed RAB (Risk Assessment Battery)."}, {'type': 'PRIMARY', 'title': 'Percent Days Cocaine Use', 'denoms': [{'units': 'Participants', 'counts': [{'value': '99', 'groupId': 'OG000'}, {'value': '97', 'groupId': 'OG001'}, {'value': '97', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '4.50', 'spread': '1.53', 'groupId': 'OG000'}, {'value': '4.25', 'spread': '1.56', 'groupId': 'OG001'}, {'value': '5.91', 'spread': '1.80', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '3 months (approximately study days 1 - 90)', 'description': 'Percent of days during the follow up that there was any cocaine use', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Cocaine Use', 'denoms': [{'units': 'Participants', 'counts': [{'value': '98', 'groupId': 'OG000'}, {'value': '91', 'groupId': 'OG001'}, {'value': '94', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '6.60', 'spread': '1.98', 'groupId': 'OG000'}, {'value': '7.01', 'spread': '2.14', 'groupId': 'OG001'}, {'value': '11.66', 'spread': '2.47', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '6 months (approproximately study days 91 - 180)', 'description': 'Percent of days during the follow up that there was any cocaine use', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Cocaine Use', 'denoms': [{'units': 'Participants', 'counts': [{'value': '93', 'groupId': 'OG000'}, {'value': '87', 'groupId': 'OG001'}, {'value': '91', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '6.96', 'spread': '2.19', 'groupId': 'OG000'}, {'value': '8.23', 'spread': '2.22', 'groupId': 'OG001'}, {'value': '5.43', 'spread': '1.81', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '9 months (approximately study days 181 - 270)', 'description': 'Percent of days during the follow up that there was any cocaine use', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Cocaine Use', 'denoms': [{'units': 'Participants', 'counts': [{'value': '91', 'groupId': 'OG000'}, {'value': '87', 'groupId': 'OG001'}, {'value': '91', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '5.58', 'spread': '1.82', 'groupId': 'OG000'}, {'value': '8.88', 'spread': '2.38', 'groupId': 'OG001'}, {'value': '7.89', 'spread': '2.37', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '12 months (approximately study days 271 - 365)', 'description': 'Percent of days during the follow up that there was any cocaine use', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Cocaine Use', 'denoms': [{'units': 'Participants', 'counts': [{'value': '81', 'groupId': 'OG000'}, {'value': '82', 'groupId': 'OG001'}, {'value': '84', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '5.13', 'spread': '1.66', 'groupId': 'OG000'}, {'value': '6.97', 'spread': '1.98', 'groupId': 'OG001'}, {'value': '5.18', 'spread': '1.48', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '18 months (approximately study days 366 - 546)', 'description': 'Percent of days during the follow up that there was any cocaine use', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Cocaine Use', 'denoms': [{'units': 'Participants', 'counts': [{'value': '77', 'groupId': 'OG000'}, {'value': '82', 'groupId': 'OG001'}, {'value': '80', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '9.80', 'spread': '2.69', 'groupId': 'OG000'}, {'value': '6.14', 'spread': '2.06', 'groupId': 'OG001'}, {'value': '6.01', 'spread': '1.77', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months (approximately study days 547 - 730)', 'description': 'Percent of days during the follow up that there was any cocaine use', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Abstinent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '99', 'groupId': 'OG000'}, {'value': '97', 'groupId': 'OG001'}, {'value': '97', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '94.01', 'spread': '1.66', 'groupId': 'OG000'}, {'value': '89.85', 'spread': '2.45', 'groupId': 'OG001'}, {'value': '92.70', 'spread': '1.85', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '3 months (approximately study days 1 - 90)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Abstinent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '98', 'groupId': 'OG000'}, {'value': '91', 'groupId': 'OG001'}, {'value': '94', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '90.20', 'spread': '2.23', 'groupId': 'OG000'}, {'value': '89.44', 'spread': '2.41', 'groupId': 'OG001'}, {'value': '85.61', 'spread': '2.75', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '6 months (approximately study days 91 - 180)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Abstinent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '93', 'groupId': 'OG000'}, {'value': '87', 'groupId': 'OG001'}, {'value': '91', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '88.16', 'spread': '2.75', 'groupId': 'OG000'}, {'value': '87.94', 'spread': '2.64', 'groupId': 'OG001'}, {'value': '91.79', 'spread': '2.08', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '9 months (approximately study days 181 - 270)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Abstinent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '91', 'groupId': 'OG000'}, {'value': '87', 'groupId': 'OG001'}, {'value': '91', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '88.91', 'spread': '2.55', 'groupId': 'OG000'}, {'value': '87.53', 'spread': '2.68', 'groupId': 'OG001'}, {'value': '89.60', 'spread': '2.50', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '12 months (approximately study days 271 - 365)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Abstinent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '81', 'groupId': 'OG000'}, {'value': '82', 'groupId': 'OG001'}, {'value': '84', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '86.40', 'spread': '3.03', 'groupId': 'OG000'}, {'value': '88.58', 'spread': '2.55', 'groupId': 'OG001'}, {'value': '90.56', 'spread': '1.96', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '18 months (approximately days 366 - 546)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}, {'type': 'PRIMARY', 'title': 'Percent Days Abstinent', 'denoms': [{'units': 'Participants', 'counts': [{'value': '77', 'groupId': 'OG000'}, {'value': '82', 'groupId': 'OG001'}, {'value': '80', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'OG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'OG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'classes': [{'categories': [{'measurements': [{'value': '84.00', 'spread': '3.45', 'groupId': 'OG000'}, {'value': '88.88', 'spread': '2.69', 'groupId': 'OG001'}, {'value': '89.66', 'spread': '2.42', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': '24 months (approximately study days 547 - 730)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine', 'unitOfMeasure': 'percentage of days', 'dispersionType': 'Standard Error', 'reportingStatus': 'POSTED', 'populationDescription': "N's represent the participants at three months for whom complete Time Line Follow Back data was available."}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'FG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'FG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '108'}, {'groupId': 'FG001', 'numSubjects': '106'}, {'groupId': 'FG002', 'numSubjects': '107'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '77'}, {'groupId': 'FG001', 'numSubjects': '81'}, {'groupId': 'FG002', 'numSubjects': '92'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '31'}, {'groupId': 'FG001', 'numSubjects': '25'}, {'groupId': 'FG002', 'numSubjects': '15'}]}]}], 'recruitmentDetails': 'We enrolled 332, but 11 of those were pilot participants assigned to receive the Telephone Monitoring and Counseling plus vouchers. They were not randomly assigned participants and their data was not included in the final analyses.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '108', 'groupId': 'BG000'}, {'value': '106', 'groupId': 'BG001'}, {'value': '107', 'groupId': 'BG002'}, {'value': '321', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': 'Treatment as Usual', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)\n\nIntensive Outpatient Treatment: 9 hours of group counseling per week for 2-3 months'}, {'id': 'BG001', 'title': 'TMAC', 'description': 'Adaptive telephone-based counseling\n\nAdaptive telephone-based counseling: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included'}, {'id': 'BG002', 'title': 'TMAC Plus', 'description': 'Adaptive telephone-based counseling, plus incentives\n\nAdaptive telephone-based counseling plus incentives: In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '42.9', 'spread': '8.0', 'groupId': 'BG000'}, {'value': '43.3', 'spread': '7.8', 'groupId': 'BG001'}, {'value': '43.4', 'spread': '6.48', 'groupId': 'BG002'}, {'value': '43.2', 'spread': '7.43', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '26', 'groupId': 'BG000'}, {'value': '26', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}, {'value': '76', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '82', 'groupId': 'BG000'}, {'value': '80', 'groupId': 'BG001'}, {'value': '83', 'groupId': 'BG002'}, {'value': '245', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '12', 'groupId': 'BG003'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '105', 'groupId': 'BG000'}, {'value': '99', 'groupId': 'BG001'}, {'value': '104', 'groupId': 'BG002'}, {'value': '308', 'groupId': 'BG003'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Asian', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Black or African American', 'measurements': [{'value': '97', 'groupId': 'BG000'}, {'value': '89', 'groupId': 'BG001'}, {'value': '98', 'groupId': 'BG002'}, {'value': '284', 'groupId': 'BG003'}]}, {'title': 'White', 'measurements': [{'value': '8', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '6', 'groupId': 'BG002'}, {'value': '24', 'groupId': 'BG003'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}, {'value': '13', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'United States', 'categories': [{'measurements': [{'value': '108', 'groupId': 'BG000'}, {'value': '106', 'groupId': 'BG001'}, {'value': '107', 'groupId': 'BG002'}, {'value': '321', 'groupId': 'BG003'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 332}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2007-05'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2017-06', 'completionDateStruct': {'date': '2011-12', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2017-06-28', 'studyFirstSubmitDate': '2008-05-23', 'resultsFirstSubmitDate': '2016-02-15', 'studyFirstSubmitQcDate': '2008-05-23', 'lastUpdatePostDateStruct': {'date': '2017-08-07', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2016-10-20', 'studyFirstPostDateStruct': {'date': '2008-05-28', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2016-12-14', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-12', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Abstinence', 'timeFrame': '3 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.'}, {'measure': 'Abstinence', 'timeFrame': '6 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.'}, {'measure': 'Abstinence', 'timeFrame': '9 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.'}, {'measure': 'Abstinence', 'timeFrame': '12 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.'}, {'measure': 'Abstinence', 'timeFrame': '18 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.'}, {'measure': 'Abstinence', 'timeFrame': '24 month follow up', 'description': 'Abstinence as reported on Addiction Severity Index, Timeline Follow up, and as tested on the urine drug screen. Measure was created as such: if on ASI the participant reported no use, and on the TLFB the participant reported no use, and on the urine drug screen there was no substances detected, then the participant is considered abstinent. If there is use indicated on any one or all of those items (ASI, TLFB, UDS) then the participant is not abstinent.'}, {'measure': 'Cocaine Urine Toxicology', 'timeFrame': '3 month follow up', 'description': 'Positive cocaine test of urine'}, {'measure': 'Cocaine Urine Toxicology', 'timeFrame': '6 month follow up', 'description': 'Positive cocaine test of urine'}, {'measure': 'Cocaine Urine Toxicology', 'timeFrame': '9 month follow up', 'description': 'Positive cocaine test of urine'}, {'measure': 'Cocaine Urine Toxicology', 'timeFrame': '12 month follow up', 'description': 'Positive cocaine test of urine'}, {'measure': 'Cocaine Urine Toxicology', 'timeFrame': '18 month follow up', 'description': 'Positive cocaine test of urine'}, {'measure': 'Cocaine Urine Toxicology', 'timeFrame': '24 month follow up', 'description': 'Positive cocaine test of urine'}, {'measure': 'Comparison Across Groups in Societal Costs', 'timeFrame': '24 months', 'description': 'Total savings/spending calculated as the monetary value of days of illegal activity, days experiencing medical problems, days experiencing psychiatric problems, and days in jail captured with the ASI. Presented in 2008 dollars.'}, {'measure': 'Net Saving/Spending Comparisons Across Groups From Provider Perspective', 'timeFrame': '24 months', 'description': 'Savings minus intervention costs. Presented in 2008 dollars.'}, {'measure': 'Net Comparisons of Savings and Spendings Across Groups From Societal Perspective', 'timeFrame': '24 months', 'description': 'Savings minus intervention costs. Presented in 2008 dollars.'}, {'measure': 'Percent Days Cocaine Use', 'timeFrame': '3 months (approximately study days 1 - 90)', 'description': 'Percent of days during the follow up that there was any cocaine use'}, {'measure': 'Percent Days Cocaine Use', 'timeFrame': '6 months (approproximately study days 91 - 180)', 'description': 'Percent of days during the follow up that there was any cocaine use'}, {'measure': 'Percent Days Cocaine Use', 'timeFrame': '9 months (approximately study days 181 - 270)', 'description': 'Percent of days during the follow up that there was any cocaine use'}, {'measure': 'Percent Days Cocaine Use', 'timeFrame': '12 months (approximately study days 271 - 365)', 'description': 'Percent of days during the follow up that there was any cocaine use'}, {'measure': 'Percent Days Cocaine Use', 'timeFrame': '18 months (approximately study days 366 - 546)', 'description': 'Percent of days during the follow up that there was any cocaine use'}, {'measure': 'Percent Days Cocaine Use', 'timeFrame': '24 months (approximately study days 547 - 730)', 'description': 'Percent of days during the follow up that there was any cocaine use'}, {'measure': 'Percent Days Abstinent', 'timeFrame': '3 months (approximately study days 1 - 90)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine'}, {'measure': 'Percent Days Abstinent', 'timeFrame': '6 months (approximately study days 91 - 180)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine'}, {'measure': 'Percent Days Abstinent', 'timeFrame': '9 months (approximately study days 181 - 270)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine'}, {'measure': 'Percent Days Abstinent', 'timeFrame': '12 months (approximately study days 271 - 365)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine'}, {'measure': 'Percent Days Abstinent', 'timeFrame': '18 months (approximately days 366 - 546)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine'}, {'measure': 'Percent Days Abstinent', 'timeFrame': '24 months (approximately study days 547 - 730)', 'description': 'Percent of days during the follow up that participant was abstinent from Alcohol and Cocaine'}], 'secondaryOutcomes': [{'measure': 'Participation in Protocol', 'timeFrame': '24 months', 'description': 'Percent available sessions completed'}, {'measure': 'HIV Sex Risk Score', 'timeFrame': '12 months', 'description': 'Risk score from RAB: Risk Assessment Battery. The RAB is a 41 - item self report developed to study the transmission of HIV. The Risk Assessment Battery generates a drug-risk score and a sex-risk score. For this study, the sex-risk score was used as the outcome measure of sexual behavior that is associated with HIV transmission. The sex-risk score ranges from 0 to 18, with 0 denoting no sex-risk and 18 denoting highest sex-risk. Previous research among drug using populations have found a sex-risk score mean of 6.2.'}, {'measure': 'HIV Sex Risk Score', 'timeFrame': '24 months', 'description': 'Risk score from RAB: Risk Assessment Battery. The RAB is a 41 - item self report developed to study the transmission of HIV. The Risk Assessment Battery generates a drug-risk score and a sex-risk score. For this study, the sex-risk score was used as the outcome measure of sexual behavior that is associated with HIV transmission. The sex-risk score ranges from 0 to 18, with 0 denoting no sex-risk and 18 denoting highest sex-risk. Previous research among drug using populations have found a sex-risk score mean of 6.2.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['cocaine dependence', 'treatment', 'continuing care', 'outcomes', 'incentives', 'adaptive'], 'conditions': ['Cocaine Dependence']}, 'referencesModule': {'references': [{'pmid': '24041231', 'type': 'RESULT', 'citation': 'McKay JR, Van Horn DH, Lynch KG, Ivey M, Cary MS, Drapkin ML, Coviello DM, Plebani JG. An adaptive approach for identifying cocaine dependent patients who benefit from extended continuing care. J Consult Clin Psychol. 2013 Dec;81(6):1063-73. doi: 10.1037/a0034265. Epub 2013 Sep 16.'}, {'pmid': '24355401', 'type': 'RESULT', 'citation': 'McKay JR, Van Horn DH, Lynch KG, Ivey M, Cary MS, Drapkin M, Coviello D. Who benefits from extended continuing care for cocaine dependence? Addict Behav. 2014 Mar;39(3):660-8. doi: 10.1016/j.addbeh.2013.11.019. Epub 2013 Dec 1.'}, {'pmid': '23561331', 'type': 'RESULT', 'citation': 'McKay JR, Van Horn D, Rennert L, Drapkin M, Ivey M, Koppenhaver J. Factors in sustained recovery from cocaine dependence. J Subst Abuse Treat. 2013 Aug;45(2):163-72. doi: 10.1016/j.jsat.2013.02.007. Epub 2013 Apr 2.'}, {'pmid': '21041041', 'type': 'RESULT', 'citation': 'Van Horn DH, Drapkin M, Ivey M, Thomas T, Domis SW, Abdalla O, Herd D, McKay JR. Voucher incentives increase treatment participation in telephone-based continuing care for cocaine dependence. Drug Alcohol Depend. 2011 Apr 1;114(2-3):225-8. doi: 10.1016/j.drugalcdep.2010.09.007. Epub 2010 Nov 1.'}, {'pmid': '27224980', 'type': 'RESULT', 'citation': 'Wimberly AS, Ivey M, Rennert L, McKay JR. Effect of Continuing Care for Cocaine Dependence on HIV Sex-Risk Behaviors. AIDS Behav. 2017 Apr;21(4):1082-1090. doi: 10.1007/s10461-016-1434-6.'}, {'pmid': '26621551', 'type': 'RESULT', 'citation': 'McCollister K, Yang X, McKay JR. Cost-effectiveness analysis of a continuing care intervention for cocaine-dependent adults. Drug Alcohol Depend. 2016 Jan 1;158:38-44. doi: 10.1016/j.drugalcdep.2015.10.032. Epub 2015 Nov 12.'}]}, 'descriptionModule': {'briefSummary': 'This study tests the effectiveness of two 24 month, telephone-based adaptive continuing care interventions for patients with cocaine dependence. The two interventions are predicted to produce better drug use outcomes than standard care. Furthermore, the intervention that also includes monetary incentives for continued participation is hypothesized to produce better retention and drug use outcomes than the intervention without incentives. Economic analyses will determine the cost-effectiveness and benefit-cost of the interventions relative to standard care, and to each other.', 'detailedDescription': 'There is considerable evidence that treatment for drug use disorders can lead to substantial improvements in substance use and psychosocial problem severity. However, a significant percentage of patients relapse to problematic levels of substance use after primary treatment, and require additional treatment episodes. Patients are therefore frequently referred to continuing care programs to prevent relapse and decrease the probability of additional rehabilitation treatments. However, current models of continuing care may not be adequate for the long-term management of a chronic, relapsing disorder such as substance dependence. One possible approach for improving the management of drug dependence is adaptive treatment regimes, which combine low intensity monitoring and counseling when patients are doing well with stepped care protocols to increase the intensity of treatment when warranted by deteriorations in status and functioning. However, addiction management protocols may require incentives and other features to make long-term participation more appealing.\n\nCocaine dependent patients who have completed 2 weeks of intensive outpatient treatment (IOP) will be randomly assigned to one of the following interventions: (1) continued participation in IOP without additional intervention (TAU); (2) TAU plus an adaptive protocol that includes monitoring, feedback, and brief counseling via telephone on a tapered schedule out to 24 months, and more intensive face-to-face treatment when warranted (TMAC); or (3) TAU and the adaptive protocol, plus incentives for sustained participation (TMAC-Plus). Patients will be followed up at 3, 6, 9, 12, 18, and 24 months post intake into the study. Follow-up assessments will include measures of drug use, treatment process and potential mediating factors, psychosocial problem severity, utilization of health and social services, and costs.\n\nThe two adaptive extended interventions (TMAC and TMAC-Plus) are predicted to produce better drug use outcomes than TAU. TMAC-Plus is hypothesized to produce better retention and drug use outcomes than TMAC. Economic analyses will determine the cost-effectiveness and benefit-cost of TMAC and TMF-Plus relative to TAU, and to each other. Other analyses will test mediation hypotheses, examine potential moderator effects, and test the impact of disease management on HIV risk behaviors.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* qualify for a DSM-IV lifetime diagnosis of cocaine dependence and cocaine use in 6 months prior to treatment;\n* initial engagement in IOP, as indicated by attendance at 4 or more sessions in the first two weeks of treatment;\n* 18 to 75 years of age;\n* willingness to be randomized and participate in research.\n* metropolitan area residents;\n* able to provide the name, verified telephone number, and address of at least one contact who can provide locator information on the patient during follow-up.\n\nExclusion Criteria:\n\n* current psychotic disorder or evidence of dementia severe enough to prevent participation in outpatient treatment;\n* acute medical problem requiring immediate inpatient treatment;\n* current participation in methadone or other forms of DA treatment, other than IOP'}, 'identificationModule': {'nctId': 'NCT00685659', 'acronym': 'ETDD', 'briefTitle': 'Effectiveness of Extended Treatments for Drug Dependence', 'organization': {'class': 'OTHER', 'fullName': 'University of Pennsylvania'}, 'officialTitle': 'Effectiveness of Extended Treatments for Drug Dependence', 'orgStudyIdInfo': {'id': 'R01DA020623', 'link': 'https://reporter.nih.gov/quickSearch/R01DA020623', 'type': 'NIH'}, 'secondaryIdInfos': [{'id': 'R01DA020623', 'link': 'https://reporter.nih.gov/quickSearch/R01DA020623', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'TAU only', 'description': 'Control condition that consists of treatment as usual, which is Intensive Outpatient Treatment (about 3 months long)', 'interventionNames': ['Other: Intensive Outpatient Treatment']}, {'type': 'EXPERIMENTAL', 'label': 'TMAC only', 'description': 'Adaptive telephone-based counseling', 'interventionNames': ['Other: Adaptive telephone-based counseling']}, {'type': 'EXPERIMENTAL', 'label': 'TMAC plus', 'description': 'Adaptive telephone-based counseling, plus incentives', 'interventionNames': ['Other: Adaptive telephone-based counseling plus incentives']}], 'interventions': [{'name': 'Intensive Outpatient Treatment', 'type': 'OTHER', 'description': '9 hours of group counseling per week for 2-3 months', 'armGroupLabels': ['TAU only']}, {'name': 'Adaptive telephone-based counseling', 'type': 'OTHER', 'description': 'In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm is included', 'armGroupLabels': ['TMAC only']}, {'name': 'Adaptive telephone-based counseling plus incentives', 'type': 'OTHER', 'description': 'In addition to IOP, patients receive telephone counseling calls, in which risk level is assessed and coping skills intervention delivered to address risk areas. Adaptive stepped care algorithm and monetary incentives for participation are included', 'armGroupLabels': ['TMAC plus']}]}, 'contactsLocationsModule': {'locations': [{'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Presbyterian Hospital', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '19123', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'NorthEast Treatment Centers', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}], 'overallOfficials': [{'name': 'James R McKay, Ph.D.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University of Pennsylvania'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University of Pennsylvania', 'class': 'OTHER'}, 'collaborators': [{'name': 'National Institute on Drug Abuse (NIDA)', 'class': 'NIH'}], 'responsibleParty': {'type': 'SPONSOR'}}}}