Ignite Creation Date:
2025-12-25 @ 5:08 AM
Ignite Modification Date:
2026-02-20 @ 4:33 PM
Study NCT ID:
NCT02959827
Status:
COMPLETED
Last Update Posted:
2019-01-30
First Post:
2016-10-11
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D007037', 'term': 'Hypothyroidism'}], 'ancestors': [{'id': 'D013959', 'term': 'Thyroid Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'clinical-trials-contact@bayer.com', 'phone': '(+) 1-888-8422937', 'title': 'Therapeutic Area Head', 'organization': 'Bayer'}, 'certainAgreement': {'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'Incidence of hypothyroidism was assessed up to one year after iodine contrast exposure', 'description': 'This study is a retrospective study using data from the database in United States. The safety outcome focused on the incidence of hypothyroidism for up to one year after iodine contrast exposure. Please refer to the result of primary outcome measure. All-Cause Mortality, Serious, and Other (Not Including Serious) Adverse Events were not monitored/assessed during this retrospective observation study. Only retrospective safety outcome data were assessed, which are on the outcome measures module.', 'eventGroups': [{'id': 'EG000', 'title': 'Iodine Contrast Agent', 'description': 'Children under age 4, from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having a diagnostic procedure.', 'otherNumAtRisk': 0, 'deathsNumAtRisk': 0, 'otherNumAffected': 0, 'seriousNumAtRisk': 0, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Incidence Rate of Hypothyroidism Detected in Routine Clinical Practice', 'denoms': [{'units': 'Participants', 'counts': [{'value': '2320', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Iodine Contrast Agent', 'description': 'Children under age 4, from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having a diagnostic procedure.'}], 'classes': [{'categories': [{'measurements': [{'value': '15.9', 'groupId': 'OG000', 'lowerLimit': '11.2', 'upperLimit': '22.0'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'In the 365 days post exposure to an iodinated contrast agent', 'description': 'Incidence density rates (IDR) were calculated as the number of cases over the person time at risk where the numerator was the number of cases and the denominator was the person years at risk.', 'unitOfMeasure': 'events per 1,000 person years', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Baseline Characteristics (Age) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '2286', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases', 'description': 'Participants who met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Non-hypothyroidism Cases', 'description': 'Participants who did not meet the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': '<1 month', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}]}, {'title': '1 to 3 months', 'measurements': [{'value': '6', 'groupId': 'OG000'}, {'value': '168', 'groupId': 'OG001'}]}, {'title': '3 to 6 months', 'measurements': [{'value': '6', 'groupId': 'OG000'}, {'value': '168', 'groupId': 'OG001'}]}, {'title': '6 months to 1 year', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '253', 'groupId': 'OG001'}]}, {'title': '1 to 4 years', 'measurements': [{'value': '14', 'groupId': 'OG000'}, {'value': '1504', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Baseline Characteristics (Sex) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '2286', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases', 'description': 'Participants who met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Non-hypothyroidism Cases', 'description': 'Participants who did not meet the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': 'Male', 'measurements': [{'value': '24', 'groupId': 'OG000'}, {'value': '1264', 'groupId': 'OG001'}]}, {'title': 'Female', 'measurements': [{'value': '10', 'groupId': 'OG000'}, {'value': '1022', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Baseline Characteristics (Year of Hypothyroidism Diagnosis) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '2286', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases', 'description': 'Participants who met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Non-hypothyroidism Cases', 'description': 'Participants who did not meet the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': '2008', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '300', 'groupId': 'OG001'}]}, {'title': '2009', 'measurements': [{'value': '3', 'groupId': 'OG000'}, {'value': '320', 'groupId': 'OG001'}]}, {'title': '2010', 'measurements': [{'value': '9', 'groupId': 'OG000'}, {'value': '297', 'groupId': 'OG001'}]}, {'title': '2011', 'measurements': [{'value': '2', 'groupId': 'OG000'}, {'value': '260', 'groupId': 'OG001'}]}, {'title': '2012', 'measurements': [{'value': '2', 'groupId': 'OG000'}, {'value': '266', 'groupId': 'OG001'}]}, {'title': '2013', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '263', 'groupId': 'OG001'}]}, {'title': '2014', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '234', 'groupId': 'OG001'}]}, {'title': '2015', 'measurements': [{'value': '6', 'groupId': 'OG000'}, {'value': '241', 'groupId': 'OG001'}]}, {'title': 'through August 2016', 'measurements': [{'value': '0', 'groupId': 'OG000'}, {'value': '105', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Baseline Characteristics (Type of Iodine Contrast Exposure) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '2286', 'groupId': 'OG001'}]}, {'units': 'Iodine contrast exposure', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '2290', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases', 'description': 'Participants who met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Non-hypothyroidism Cases', 'description': 'Participants who did not meet the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': 'CT scan', 'measurements': [{'value': '18', 'groupId': 'OG000'}, {'value': '1762', 'groupId': 'OG001'}]}, {'title': 'Heart catheterization', 'measurements': [{'value': '16', 'groupId': 'OG000'}, {'value': '528', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_UNITS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Iodine contrast exposure', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'Iodine contrast exposure', 'denomUnitsSelected': 'Iodine contrast exposure'}, {'type': 'SECONDARY', 'title': 'Baseline Characteristics (Race/Ethnicity) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '2286', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases', 'description': 'Participants who met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Non-hypothyroidism Cases', 'description': 'Participants who did not meet the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': 'White', 'measurements': [{'value': '13', 'groupId': 'OG000'}, {'value': '787', 'groupId': 'OG001'}]}, {'title': 'African American', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '170', 'groupId': 'OG001'}]}, {'title': 'Hispanic', 'measurements': [{'value': '6', 'groupId': 'OG000'}, {'value': '720', 'groupId': 'OG001'}]}, {'title': 'Asian/Pacific islander', 'measurements': [{'value': '9', 'groupId': 'OG000'}, {'value': '416', 'groupId': 'OG001'}]}, {'title': 'Other or missing', 'measurements': [{'value': '2', 'groupId': 'OG000'}, {'value': '193', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Time From First Iodinated Contrast to First Hypothyroidism Event', 'denoms': [{'units': 'Participants', 'counts': [{'value': '18', 'groupId': 'OG000'}, {'value': '16', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases With CT Scan', 'description': 'Participants who had CT scan and met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Hypothyroidism Cases With Cardiac Catheterization', 'description': 'Participants who had cardiac catheterization and met the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': '<30 days', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '3', 'groupId': 'OG001'}]}, {'title': '30 - 59 days', 'measurements': [{'value': '4', 'groupId': 'OG000'}, {'value': '3', 'groupId': 'OG001'}]}, {'title': '60+ days', 'measurements': [{'value': '10', 'groupId': 'OG000'}, {'value': '10', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Classification of Subclinical/Manifest Hypothyroidism by Type of Exposure', 'denoms': [{'units': 'Participants', 'counts': [{'value': '18', 'groupId': 'OG000'}, {'value': '16', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases With CT Scan', 'description': 'Participants who had CT scan and met the criteria to be a case of hypothyroidism were identified.'}, {'id': 'OG001', 'title': 'Hypothyroidism Cases With Cardiac Catheterization', 'description': 'Participants who had cardiac catheterization and met the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': 'Subclinical hypothyroidism', 'measurements': [{'value': '15', 'groupId': 'OG000'}, {'value': '9', 'groupId': 'OG001'}]}, {'title': 'Manifest hypothyroidism', 'measurements': [{'value': '2', 'groupId': 'OG000'}, {'value': '1', 'groupId': 'OG001'}]}, {'title': 'Treatment or diagnosis with no TSH test', 'measurements': [{'value': '1', 'groupId': 'OG000'}, {'value': '6', 'groupId': 'OG001'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Classification of Hypothyroidism by Etiology', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Hypothyroidism Cases', 'description': 'Participants who met the criteria to be a case of hypothyroidism were identified.'}], 'classes': [{'categories': [{'title': 'Iodine induced cases', 'measurements': [{'value': '23', 'groupId': 'OG000'}]}, {'title': 'Other etiology cases', 'measurements': [{'value': '11', 'groupId': 'OG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent', 'unitOfMeasure': 'Participants', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Iodine Contrast Agent', 'description': 'Children under age 4, from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having a diagnostic procedure.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '2320'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '2320'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}]}]}], 'recruitmentDetails': 'This study was a retrospective cohort study, using the data from the years 2008 to June of 2016 in the database of Kaiser Permanente Northern California.', 'preAssignmentDetails': 'There were 2320 children identified in Kaiser Permanente Northern California who met our study population criteria: patients who had a procedure that used iodinated contrast agent and were under the age of 4, during the years 2008 to June of 2016.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '2320', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Iodine Contrast Agent', 'description': 'Children under age 4, from the US-based Kaiser Permanente Northern California database, who were exposed to iodinated contrast agent through having a diagnostic procedure.'}], 'measures': [{'title': 'Age, Customized', 'classes': [{'categories': [{'title': '<1 month', 'measurements': [{'value': '197', 'groupId': 'BG000'}]}, {'title': '1 to 3 months', 'measurements': [{'value': '174', 'groupId': 'BG000'}]}, {'title': '3 to 6 months', 'measurements': [{'value': '174', 'groupId': 'BG000'}]}, {'title': '6 months to 1 year', 'measurements': [{'value': '257', 'groupId': 'BG000'}]}, {'title': '1 to 4 years', 'measurements': [{'value': '1518', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '1032', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '1288', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race/Ethnicity, Customized', 'classes': [{'categories': [{'title': 'White', 'measurements': [{'value': '800', 'groupId': 'BG000'}]}, {'title': 'African American', 'measurements': [{'value': '174', 'groupId': 'BG000'}]}, {'title': 'Hispanic', 'measurements': [{'value': '726', 'groupId': 'BG000'}]}, {'title': 'Asian/Pacific islander', 'measurements': [{'value': '425', 'groupId': 'BG000'}]}, {'title': 'Other or missing', 'measurements': [{'value': '195', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2016-10-11', 'size': 715616, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2018-05-23T22:29', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 2320}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2016-10-15', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-01', 'completionDateStruct': {'date': '2017-06-15', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-01-29', 'studyFirstSubmitDate': '2016-10-11', 'resultsFirstSubmitDate': '2018-05-24', 'studyFirstSubmitQcDate': '2016-11-07', 'lastUpdatePostDateStruct': {'date': '2019-01-30', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2019-01-29', 'studyFirstPostDateStruct': {'date': '2016-11-09', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2019-01-30', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2017-06-15', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Incidence Rate of Hypothyroidism Detected in Routine Clinical Practice', 'timeFrame': 'In the 365 days post exposure to an iodinated contrast agent', 'description': 'Incidence density rates (IDR) were calculated as the number of cases over the person time at risk where the numerator was the number of cases and the denominator was the person years at risk.'}], 'secondaryOutcomes': [{'measure': 'Baseline Characteristics (Age) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Baseline Characteristics (Sex) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Baseline Characteristics (Year of Hypothyroidism Diagnosis) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Baseline Characteristics (Type of Iodine Contrast Exposure) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Baseline Characteristics (Race/Ethnicity) of the Cases With Hypothyroidism and of the Rest of the Cohort', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Time From First Iodinated Contrast to First Hypothyroidism Event', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Classification of Subclinical/Manifest Hypothyroidism by Type of Exposure', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}, {'measure': 'Classification of Hypothyroidism by Etiology', 'timeFrame': 'Up to 365 days after a diagnostic scan with iodinated contrast agent'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Hypothyroidism,', 'children,', 'iodinated contrast agents,', 'retrospective cohort,', 'database'], 'conditions': ['Hypothyroidism']}, 'descriptionModule': {'briefSummary': 'This study will estimate the incidence of hypothyroidism in a pediatric population of children under age 4, based on data from the US-based Kaiser Permanente Northern California database, which were exposed to iodinated contrast agent through having a diagnostic procedure.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD'], 'maximumAge': '3 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Children under age 4 in the Kaiser Permanente Northern California database, who had a diagnostic procedure with an iodinated contrast agent', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Children under age 4 in the Kaiser Permanente Northern California (KPNC) database, who had a diagnostic procedure with an iodinated contrast agent.\n* Participants should be member of the KPNC for at least 3 months before the iodinated contrast exposure, except where the child is under 3 months of age at time of initial exposure, and 2 weeks after the exposure.\n\nExclusion Criteria:\n\n* Diagnosis of hypothyroid any time prior to the iodine contrast exposure.\n* Lab values for low thyroid (TSH \\> 5 mU/L for children) any time before the exposure\n* Thyroid replacement therapy, Hashimoto thyroiditis, or congenital hypothyroidism any time prior to exposure.'}, 'identificationModule': {'nctId': 'NCT02959827', 'briefTitle': 'Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States', 'organization': {'class': 'INDUSTRY', 'fullName': 'Bayer'}, 'officialTitle': 'Iodinated Contrast Agents and Risk of Hypothyroidism in Young Children in the United States', 'orgStudyIdInfo': {'id': '19185'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Iodinated contrast agents', 'description': 'Children under age 4 in the Kaiser Permanente Northern California database, who had a diagnostic procedure with an iodinated contrast agent', 'interventionNames': ['Drug: Iodinated contrast agents']}], 'interventions': [{'name': 'Iodinated contrast agents', 'type': 'DRUG', 'description': 'Use of iodine contrast agents and doses following the decision of the treating physician.', 'armGroupLabels': ['Iodinated contrast agents']}]}, 'contactsLocationsModule': {'locations': [{'zip': '94612', 'city': 'Oakland', 'state': 'California', 'country': 'United States', 'facility': 'Oakland', 'geoPoint': {'lat': 37.80437, 'lon': -122.2708}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Bayer', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}