Ignite Creation Date:
2025-12-24 @ 2:53 PM
Ignite Modification Date:
2025-12-26 @ 1:49 PM
Study NCT ID:
NCT01296659
Status:
WITHDRAWN
Last Update Posted:
2012-07-12
First Post:
2011-02-03
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Study of Oral Ridaforolimus in Combination With Standard Chemotherapy for Soft Tissue Sarcoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D012509', 'term': 'Sarcoma'}], 'ancestors': [{'id': 'D018204', 'term': 'Neoplasms, Connective and Soft Tissue'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C515074', 'term': 'ridaforolimus'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NON_RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 0}}, 'statusModule': {'whyStopped': 'Principal Investigator left institution.', 'overallStatus': 'WITHDRAWN', 'startDateStruct': {'date': '2011-02'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2012-07', 'completionDateStruct': {'date': '2011-08', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2012-07-11', 'studyFirstSubmitDate': '2011-02-03', 'studyFirstSubmitQcDate': '2011-02-14', 'lastUpdatePostDateStruct': {'date': '2012-07-12', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2011-02-15', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Define maximum tolerated dose (MTD)', 'timeFrame': '12-18 months', 'description': 'Defining the maximum tolerated dose (MTD) and recommended Phase II dose for the combination ridaforolimus and SOC chemotherapy'}], 'secondaryOutcomes': [{'measure': 'Number of Grade 2 or higher side effects with the combined therapy.', 'timeFrame': '12-18 months', 'description': 'Any evidence of antitumor activity--as measured by response rate (RECIST).'}, {'measure': 'Pharmacokinetics', 'timeFrame': '12-18 months', 'description': 'Ridaforolimus pharmacokinetics when given in combination with SOC chemotherapy. Limited PK for SOC chemotherapy when combined with ridaforlimus. We will measure change in concentration of Ridaforolimus when combined with chemotherapy.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['sarcoma', 'Ridaforolimus', 'soft tissue sarcoma', 'unresectable sarcoma'], 'conditions': ['Soft Tissue Sarcoma']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://www.ctrc.net', 'label': "Cancer Therapy \\& Research Center's Website"}]}, 'descriptionModule': {'briefSummary': 'Ridaforolimus has been tested in almost 2 dozen studies; however, it has not previously been tested in combination with the standard of care chemotherapy for sarcoma as this study will. We will be looking to see if Ridaforolimus given with SOC chemo (AIM or TG) is well tolerated and to determine a Phase 2 dose.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Advanced or metastatic soft tissue sarcoma with histological or cytological proven disease. No more than 2 lines of chemotherapy in the metastatic setting in the dose escalation phase, and no more than one line of prior therapy in the expansion phase.\n* ECOG performance status of ≤ 1\n* A minimum life expectancy \\> 3 months\n* At least 4 weeks must have elapsed between prior investigational therapy, chemotherapy or radiotherapy and the first dose of ridaforolimus\n* Adequate hematological, hepatic and renal function (hemoglobin ≥ 9g/dl, absolute neutrophil count \\[ANC\\] ≥ 1.5 x 109/L; platelets ≥ 100 x 109/L; bilirubin ≤ ULN; alkaline phosphatase ≤ 2.5 x ULN; AST, ALT ≤ 2.5 x ULN; albumin ≥ 2.5mg/dL; creatinine ≤ 1.5 x ULN)\n* Serum cholesterol ≤ 350 mg/dL and triglycerides ≤400 mg/dL\n* Signed informed consent\n* Women of childbearing potential must have a negative serum pregnancy test within 7 days prior to start of therapy and must use an approved contraceptive method as appropriate from the time of screening until 30 days after the last dose of study drug.\n\nExclusion Criteria:\n\n* Uncontrolled brain metastases, spinal cord compression, or carcinomatous meningitis.\n* Clinically significant unexplained bleeding within 28 days prior to entering the trial\n* Uncontrolled systemic vascular hypertension\n* Clinically significant cardiovascular disease\n* Newly diagnosed (within 3 months of enrollment) or poorly controlled type 1 or 2 diabetes\n* Have received \\>350 mg/m2 total dose of Doxorubicin\n* Active infection requiring prescribed intervention\n* Other concurrent illness\n* Major surgery within 28 days before trial entry, or incompletely healed surgical incision; minor surgery or procedures within 7 days\n* Previous anthracycline lifetime exposure more than 350 mg/m2 would exclude patient form AIM Arm enrollment\n* Pregnant or breastfeeding\n* Known allergy to macrolide antibiotics\n* Concurrent treatment with medications that induce or inhibit cytochrome P450 (CYP3A).\n* Known history of HIV sero-positivity'}, 'identificationModule': {'nctId': 'NCT01296659', 'briefTitle': 'Study of Oral Ridaforolimus in Combination With Standard Chemotherapy for Soft Tissue Sarcoma', 'organization': {'class': 'OTHER', 'fullName': 'The University of Texas Health Science Center at San Antonio'}, 'officialTitle': 'Phase Ib Study of Oral Ridaforolimus in Combination With Standard Chemotherapy for Patients With Advanced Unresectable Soft Tissue Sarcoma', 'orgStudyIdInfo': {'id': 'IDD 10-09'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'AIM Arm', 'description': 'Ridaforolimus combined with doxorubicin/ifosfamide/mesma (AIM)', 'interventionNames': ['Drug: ridaforolimus']}, {'type': 'EXPERIMENTAL', 'label': 'TG Arm', 'description': 'Ridaforolimus combined with docetaxel and gemcitabine (TG)', 'interventionNames': ['Drug: ridaforolimus']}], 'interventions': [{'name': 'ridaforolimus', 'type': 'DRUG', 'otherNames': ['deforolimus'], 'description': 'Ridaforolimus administered orally 5 days per week in combination with standard chemotherapy', 'armGroupLabels': ['AIM Arm', 'TG Arm']}]}, 'contactsLocationsModule': {'locations': [{'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'country': 'United States', 'facility': 'Cancer Therapy & Research Center at UTHSCSA', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}], 'overallOfficials': [{'name': 'Monica Mita, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'The University of Texas Health Science Center at San Antonio'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'The University of Texas Health Science Center at San Antonio', 'class': 'OTHER'}, 'collaborators': [{'name': 'Merck Sharp & Dohme LLC', 'class': 'INDUSTRY'}], 'responsibleParty': {'type': 'SPONSOR'}}}}