Ignite Creation Date:
2025-12-25 @ 5:04 AM
Ignite Modification Date:
2025-12-26 @ 4:06 AM
Study NCT ID:
NCT01143818
Status:
COMPLETED
Last Update Posted:
2011-10-17
First Post:
2010-06-09
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
ESPRIT Study in Hypogonadal Men
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D007006', 'term': 'Hypogonadism'}, {'id': 'D005058', 'term': 'Eunuchism'}], 'ancestors': [{'id': 'D006058', 'term': 'Gonadal Disorders'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D013739', 'term': 'Testosterone'}], 'ancestors': [{'id': 'D000737', 'term': 'Androstenols'}, {'id': 'D000736', 'term': 'Androstenes'}, {'id': 'D000731', 'term': 'Androstanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D045165', 'term': 'Testosterone Congeners'}, {'id': 'D012739', 'term': 'Gonadal Steroid Hormones'}, {'id': 'D042341', 'term': 'Gonadal Hormones'}, {'id': 'D006728', 'term': 'Hormones'}, {'id': 'D006730', 'term': 'Hormones, Hormone Substitutes, and Hormone Antagonists'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'phone': '800-633-9110', 'title': 'Global Medical Services', 'organization': 'Abbott'}, 'certainAgreement': {'otherDetails': 'Abbott requests that any investigator or institution that plans on presenting/publishing results disclosure, provide written notification of their request 60 days prior to their presentation/publication. Abbott requests that no presentation/publication will be instituted until 12 months after a study is completed, or after the first presentation/publication whichever occurs first. A delay may be proposed of a presentation/publication if Abbott needs to secure patent or proprietary protection.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'All reported adverse events are treatment-emergent and are defined as events that started or worsened at or after the first administration of AndroGel and ended before or at treatment completion. Only suspected adverse drug reactions were collected.', 'description': 'Treatment-emergent adverse events that were not serious occurred in 64 patients. None of the adverse events occured at a frequency threshold of \\>=5%. Therefore, no adverse events were reported.', 'eventGroups': [{'id': 'EG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.', 'otherNumAtRisk': 1049, 'otherNumAffected': 0, 'seriousNumAtRisk': 1049, 'seriousNumAffected': 3}], 'seriousEvents': [{'term': 'Angina pectoris', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1049, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'sourceVocabulary': 'MedDRA (11.0)'}, {'term': 'Atrial fibrillation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1049, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'sourceVocabulary': 'MedDRA (11.0)'}, {'term': 'Hypertension', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1049, 'numAffected': 1}], 'organSystem': 'Vascular disorders', 'sourceVocabulary': 'MedDRA (11.0)'}, {'term': 'Nausea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 1049, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders', 'sourceVocabulary': 'MedDRA (11.0)'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Percent Change From Baseline to Month 6 in Aging Male Symptoms (AMS) in Mean Total Score', 'denoms': [{'units': 'Participants', 'counts': [{'value': '712', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.'}], 'classes': [{'categories': [{'measurements': [{'value': '-29.0', 'spread': '22.6', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline to Month 6', 'description': 'The Aging Male Symptoms (AMS) test is self-administered and designed to assess symptoms of aging with a rating from none (0) to extremely severe (5) for 17 items from psychological (5 items), somatic (7 items), and sexual (5 items) categories. Total scores range from 17 (minimum) to 85 (maximum). The AMS total score was reported at baseline and at Month 6 and represented the sum of all the items. The percent change from baseline was calculated as the \\[(AMS value at Month 6 - AMS value at baseline)/baseline value\\] x 100.', 'unitOfMeasure': 'Percent Change', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The full analysis set included all participants in the safety analysis set who had an Aging Male Symptoms (AMS) score available at baseline and Month 6.'}, {'type': 'SECONDARY', 'title': 'Percent Change From Baseline to Month 6 in the International Index of Erectile Function (IIEF) Total Score', 'denoms': [{'units': 'Participants', 'counts': [{'value': '651', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.'}], 'classes': [{'categories': [{'measurements': [{'value': '115.7', 'spread': '226.3', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline to Month 6', 'description': 'The International Index of Erectile Function (IIEF) test is a validated 15 question assessment designed to measure changes in erectile function (6 items), orgasmic function (2 items), sexual desire (2 items), intercourse satisfaction (3 items), and overall satisfaction (2 items). The scores ranged from 0 to 5 on each item with a lower score indicating greater dysfunction. A total IIEF score of 0 (minimum) to 75 (maximum) was possible and represented the sum of all the items at baseline and Month 6. The percent change = \\[(IIEF value at Month 6-IIEF baseline value)/IIEF baseline value\\]x 100.', 'unitOfMeasure': 'Percent Change', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The full analysis set included all participants in the safety analysis set who had an IIEF score available at baseline and Month 6.'}, {'type': 'SECONDARY', 'title': 'Percent Change From Baseline to Month 6 in the Multidimensional Fatigue Inventory (MFI) Total Score', 'denoms': [{'units': 'Participants', 'counts': [{'value': '655', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.'}], 'classes': [{'categories': [{'measurements': [{'value': '-21.5', 'spread': '33.5', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline to Month 6', 'description': 'The MFI is a 20-item self-reported instrument designed to measure fatigue. Five scales measure different modes of fatigue: general fatigue (4 items), physical fatigue (4 items), mental fatigue (4 items), reduced motivation (4 items), and reduced activity items (4 items). The scores for each item range from 1 to 5. Each subscale includes 4 items with 5-point Likert scales and subscale scores range from 4 to 20 with a higher score indicating greater fatigue. The percent change=\\[(MFI value at Month 6-MFI value at baseline)/MFI baseline value\\] X 100.', 'unitOfMeasure': 'Percent Change', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The full analysis set included all participants in the safety analysis set who had an MFI score available at baseline and Month 6.'}, {'type': 'SECONDARY', 'title': 'Percent Change From Baseline to Month 6 in Body Mass Index (BMI)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '611', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.'}], 'classes': [{'categories': [{'measurements': [{'value': '-2.38', 'spread': '5.75', 'groupId': 'OG000'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Baseline to Month 6', 'description': 'The BMI was measured in kg/m\\^2 and was reported at baseline and at the Month 6. BMI = weight (kg)/\\[(height (m) x height (m)\\] and was measured to 1 decimal point precision.', 'unitOfMeasure': 'Percent Change', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The full analysis set included all participants in the safety analysis set who had BMI available at baseline and Month 6.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'comment': 'A total of 1053 participants were enrolled but only 1049 received study drug.', 'groupId': 'FG000', 'numSubjects': '1049'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '799'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '250'}]}]}], 'recruitmentDetails': 'Participants enrolled in this study were newly-diagnosed for hypogonadism and treatment naive to testosterone preparations. A total of 1053 participants were enrolled but only 1049 were treated with AndroGel.', 'preAssignmentDetails': 'AndroGel (testosterone gel) 1% was prescribed according to the regional Summary of Product Characteristics with a starting dose of 50 mg testosterone/day (packaged as 1 sachet of 50 mg). Testosterone was applied once daily.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '1049', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'AndroGel (Testosterone Gel) 1%', 'description': 'Topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose. All participants who received at least 1 dose of study drug are included in the safety analysis set.'}], 'measures': [{'title': 'Age Continuous', 'classes': [{'categories': [{'measurements': [{'value': '53', 'spread': '12', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '1049', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Canada', 'categories': [{'measurements': [{'value': '338', 'groupId': 'BG000'}]}]}, {'title': 'Russian Federation', 'categories': [{'measurements': [{'value': '267', 'groupId': 'BG000'}]}]}, {'title': 'Croatia', 'categories': [{'measurements': [{'value': '134', 'groupId': 'BG000'}]}]}, {'title': 'Germany', 'categories': [{'measurements': [{'value': '91', 'groupId': 'BG000'}]}]}, {'title': 'Slovenia', 'categories': [{'measurements': [{'value': '87', 'groupId': 'BG000'}]}]}, {'title': 'Saudi Arabia', 'categories': [{'measurements': [{'value': '68', 'groupId': 'BG000'}]}]}, {'title': 'Romania', 'categories': [{'measurements': [{'value': '54', 'groupId': 'BG000'}]}]}, {'title': 'United Arab Emirates', 'categories': [{'measurements': [{'value': '10', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'Participants'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'ECOLOGIC_OR_COMMUNITY'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 1053}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2007-12'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2011-10', 'completionDateStruct': {'date': '2010-08', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2011-10-12', 'studyFirstSubmitDate': '2010-06-09', 'resultsFirstSubmitDate': '2011-08-19', 'studyFirstSubmitQcDate': '2010-06-11', 'lastUpdatePostDateStruct': {'date': '2011-10-17', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2011-08-19', 'studyFirstPostDateStruct': {'date': '2010-06-14', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2011-09-26', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2010-08', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Percent Change From Baseline to Month 6 in Aging Male Symptoms (AMS) in Mean Total Score', 'timeFrame': 'Baseline to Month 6', 'description': 'The Aging Male Symptoms (AMS) test is self-administered and designed to assess symptoms of aging with a rating from none (0) to extremely severe (5) for 17 items from psychological (5 items), somatic (7 items), and sexual (5 items) categories. Total scores range from 17 (minimum) to 85 (maximum). The AMS total score was reported at baseline and at Month 6 and represented the sum of all the items. The percent change from baseline was calculated as the \\[(AMS value at Month 6 - AMS value at baseline)/baseline value\\] x 100.'}], 'secondaryOutcomes': [{'measure': 'Percent Change From Baseline to Month 6 in the International Index of Erectile Function (IIEF) Total Score', 'timeFrame': 'Baseline to Month 6', 'description': 'The International Index of Erectile Function (IIEF) test is a validated 15 question assessment designed to measure changes in erectile function (6 items), orgasmic function (2 items), sexual desire (2 items), intercourse satisfaction (3 items), and overall satisfaction (2 items). The scores ranged from 0 to 5 on each item with a lower score indicating greater dysfunction. A total IIEF score of 0 (minimum) to 75 (maximum) was possible and represented the sum of all the items at baseline and Month 6. The percent change = \\[(IIEF value at Month 6-IIEF baseline value)/IIEF baseline value\\]x 100.'}, {'measure': 'Percent Change From Baseline to Month 6 in the Multidimensional Fatigue Inventory (MFI) Total Score', 'timeFrame': 'Baseline to Month 6', 'description': 'The MFI is a 20-item self-reported instrument designed to measure fatigue. Five scales measure different modes of fatigue: general fatigue (4 items), physical fatigue (4 items), mental fatigue (4 items), reduced motivation (4 items), and reduced activity items (4 items). The scores for each item range from 1 to 5. Each subscale includes 4 items with 5-point Likert scales and subscale scores range from 4 to 20 with a higher score indicating greater fatigue. The percent change=\\[(MFI value at Month 6-MFI value at baseline)/MFI baseline value\\] X 100.'}, {'measure': 'Percent Change From Baseline to Month 6 in Body Mass Index (BMI)', 'timeFrame': 'Baseline to Month 6', 'description': 'The BMI was measured in kg/m\\^2 and was reported at baseline and at the Month 6. BMI = weight (kg)/\\[(height (m) x height (m)\\] and was measured to 1 decimal point precision.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ['Male hypogonadism'], 'conditions': ['Hypogonadism']}, 'referencesModule': {'seeAlsoLinks': [{'url': 'http://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?id=23151&CFID', 'label': 'Related Info'}]}, 'descriptionModule': {'briefSummary': 'Observational study with AndroGel®, Testosterone 1% gel therapy (ESPRIT) in hypogonadal men in the community over 6 months.', 'detailedDescription': 'The objective of this study was to evaluate the efficacy and safety of AndroGel (testosterone gel) 1% following administration in community dwelling men with hypogonadism. The percent change from baseline to Month 6 in aging male symptom (AMS) assessment was the primary endpoint. Secondary endpoints were changes from baseline to Month 6 in International Index of Erectile Dysfunction (IIEF), Multidimensional Fatigue Inventory (MFI), and body mass index (BMI) assessments.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Community', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria\n\n1. Male patients \\>= 18 years of age\n2. Hypogonadism not previously treated with testosterone\n3. Testosterone deficiency confirmed clinically and biochemically\n4. Being prescribed AndroGel® 1% in accordance with the local summary of product characteristics\n\nExclusion Criteria\n\n1. According to the contra-indications,\n2. Unwilling or unable to sign informed consent form'}, 'identificationModule': {'nctId': 'NCT01143818', 'briefTitle': 'ESPRIT Study in Hypogonadal Men', 'organization': {'class': 'INDUSTRY', 'fullName': 'Abbott'}, 'officialTitle': 'Energy, Sexual Desire and Body PropoRtions wIth AndroGel®, Testosterone 1% Gel Therapy (ESPRIT) in Hypogonadal Men', 'orgStudyIdInfo': {'id': 'S176.4.103'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'AndroGel (testosterone gel )1%', 'description': 'AndroGel is topical testosterone gel 1% (1 sachet of 5 g contains 50 mg of testosterone), 1 daily dose.', 'interventionNames': ['Drug: AndroGel (testosterone gel) 1%']}], 'interventions': [{'name': 'AndroGel (testosterone gel) 1%', 'type': 'DRUG', 'otherNames': ['Topical AndroGel', '1% AndroGel', 'AndroGel®'], 'description': 'AndroGel is topical testosterone gel 1% and is prescribed for once daily use.', 'armGroupLabels': ['AndroGel (testosterone gel )1%']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'V5G 1T4', 'city': 'Burnaby', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59749', 'geoPoint': {'lat': 49.26636, 'lon': -122.95263}}, {'zip': 'V3B 6S2', 'city': 'Coquitlam', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59765', 'geoPoint': {'lat': 49.2846, 'lon': -122.78217}}, {'zip': 'V2C 5Y2', 'city': 'Kamloops', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59742', 'geoPoint': {'lat': 50.66648, 'lon': -120.3192}}, {'zip': 'V1X 7N6', 'city': 'Kelowna', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59775', 'geoPoint': {'lat': 49.88307, 'lon': -119.48568}}, {'zip': 'V2A 5C8', 'city': 'Penticton', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59757', 'geoPoint': {'lat': 49.48062, 'lon': -119.58584}}, {'zip': 'V9A 7N6', 'city': 'Victoria', 'state': 'British Columbia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59754', 'geoPoint': {'lat': 48.4359, 'lon': -123.35155}}, {'zip': 'R2H 0R8', 'city': 'Winnipeg', 'state': 'Manitoba', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59763', 'geoPoint': {'lat': 49.8844, 'lon': -97.14704}}, {'zip': 'R3R 3C9', 'city': 'Winnipeg', 'state': 'Manitoba', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59762', 'geoPoint': {'lat': 49.8844, 'lon': -97.14704}}, {'zip': 'B2Y 4P5', 'city': 'Dartmouth', 'state': 'Nova Scotia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59748', 'geoPoint': {'lat': 44.67134, 'lon': -63.57719}}, {'zip': 'B3H 4M2', 'city': 'Halifax', 'state': 'Nova Scotia', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59755', 'geoPoint': {'lat': 44.64269, 'lon': -63.57688}}, {'zip': 'L4M 7G1', 'city': 'Barrie', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59753', 'geoPoint': {'lat': 44.40011, 'lon': -79.66634}}, {'zip': 'L4M 7G1', 'city': 'Barrie', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59777', 'geoPoint': {'lat': 44.40011, 'lon': -79.66634}}, {'zip': 'L7M 3Z5', 'city': 'Burlington', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59744', 'geoPoint': {'lat': 43.38621, 'lon': -79.83713}}, {'zip': 'N0N 1G0', 'city': 'Corunna', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59766', 'geoPoint': {'lat': 42.88338, 'lon': -82.43313}}, {'zip': 'P3B 1R6', 'city': 'Greater Sudbury', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59773', 'geoPoint': {'lat': 46.49, 'lon': -80.99001}}, {'zip': 'P3E 1H5', 'city': 'Greater Sudbury', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59751', 'geoPoint': {'lat': 46.49, 'lon': -80.99001}}, {'zip': 'L8L 5G8', 'city': 'Hamilton', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59752', 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'zip': 'N0A 1J0', 'city': 'Jarvis', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59764', 'geoPoint': {'lat': 42.88559, 'lon': -80.1122}}, {'zip': 'K9V 5N7', 'city': 'Lindsay', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59774', 'geoPoint': {'lat': 44.35012, 'lon': -78.73286}}, {'zip': 'N5Y 5K7', 'city': 'London', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59768', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'L3R 4C3', 'city': 'Markham', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59776', 'geoPoint': {'lat': 43.86682, 'lon': -79.2663}}, {'zip': 'L4X 2Z9', 'city': 'Mississauga', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59759', 'geoPoint': {'lat': 43.5789, 'lon': -79.6583}}, {'zip': 'L4Y 2N7', 'city': 'Mississauga', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59761', 'geoPoint': {'lat': 43.5789, 'lon': -79.6583}}, {'zip': 'M2J 1V1', 'city': 'North York', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 54484'}, {'zip': 'K2P 0W4', 'city': 'Ottawa', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59760', 'geoPoint': {'lat': 45.41117, 'lon': -75.69812}}, {'zip': 'L1V 6M4', 'city': 'Pickering', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59747', 'geoPoint': {'lat': 43.90012, 'lon': -79.13289}}, {'zip': 'N7T 4X3', 'city': 'Sarnia', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59750', 'geoPoint': {'lat': 42.97866, 'lon': -82.40407}}, {'zip': 'M1T 3T6', 'city': 'Scarborough Village', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59745', 'geoPoint': {'lat': 43.73899, 'lon': -79.22124}}, {'zip': 'J1E 2X4', 'city': 'Sherbrooke', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59771'}, {'zip': 'L8G 3L2', 'city': 'Stoney Creek', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # / Investigator 59772', 'geoPoint': {'lat': 43.21681, 'lon': -79.76633}}, {'zip': 'M4K 1N2', 'city': 'Toronto', 'state': 'Ontario', 'country': 'Canada', 'facility': 'Site Ref # 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