Ignite Creation Date:
2025-12-25 @ 4:57 AM
Ignite Modification Date:
2025-12-26 @ 3:56 AM
Study NCT ID:
NCT07134218
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-08-21
First Post:
2025-08-14
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D012004', 'term': 'Rectal Neoplasms'}], 'ancestors': [{'id': 'D015179', 'term': 'Colorectal Neoplasms'}, {'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D020360', 'term': 'Neoadjuvant Therapy'}], 'ancestors': [{'id': 'D003131', 'term': 'Combined Modality Therapy'}, {'id': 'D013812', 'term': 'Therapeutics'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 180}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2025-10', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2027-10', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-08-20', 'studyFirstSubmitDate': '2025-08-14', 'studyFirstSubmitQcDate': '2025-08-20', 'lastUpdatePostDateStruct': {'date': '2025-08-21', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2025-08-21', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2027-10', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'The rate of cCR', 'timeFrame': '2 years', 'description': 'Rate of patients who achieve clinical complete response'}], 'secondaryOutcomes': [{'measure': 'Major Pathological Response', 'timeFrame': '2 years', 'description': 'Rate of major pathological response assessed by postoperative pathology'}, {'measure': 'Objective Response Rate', 'timeFrame': '2 years', 'description': 'Objective response rate assessed by RECIST 1.1 criteria'}, {'measure': 'Disease-Free Survival (DFS)', 'timeFrame': '2 years', 'description': 'DFS was defined as the duration from the date of randomization to the date of the first recurrence (local, distant, or mixed) or death.'}, {'measure': 'Overall Survival (OS)', 'timeFrame': '2 years', 'description': 'Time from randomization to death due to any cause'}, {'measure': 'Organ Preservation Rate (OPR)', 'timeFrame': '2 years', 'description': 'Proportion of patients who achieve organ preservation by choosing a watch-and-wait strategy or local excision after attaining clinical or pathological complete response'}, {'measure': 'Neoadjuvant Rectal Score (NAR)', 'timeFrame': '2 years', 'description': 'Neoadjuvant rectal score assessed by postoperative pathology'}, {'measure': 'Quality of Life Score (QoL)', 'timeFrame': '2 years', 'description': 'Quality of life score during treatment and follow-up'}, {'measure': 'Safety and Tolerability', 'timeFrame': '2 years', 'description': 'Incidence of adverse events (AEs), incidence of abnormal laboratory values, and dose adjustments during treatment and follow-up'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Rectal Cancer']}, 'descriptionModule': {'briefSummary': 'This is a multicenter, prospective, randomized phase II trial designed to evaluate the efficacy and safety of short-course neoadjuvant chemoradiotherapy combined with the PD-1 monoclonal antibody serplulimab and the anti-angiogenic agent bevacizumab in patients with previously untreated pMMR/MSS middle and low locally advanced rectal cancer. The study plans to enroll a total of 200 participants (100 in the experimental arm and 100 in the control arm).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '75 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Signed written informed consent to voluntarily participate in the study;\n* Aged 18 to 75 years, inclusive, regardless of sex;\n* Histologically confirmed rectal adenocarcinoma with immunohistochemistry results showing proficient mismatch repair (pMMR) or molecular testing results indicating microsatellite stability (MSS);\n* Clinical baseline staging assessed by MRI as T3-4N0M0/TanyN+M, with negative mesorectal fascia (MRF);\n* Tumor lower margin ≤7 cm from the anal verge;\n* Surgically resectable;\n* Capable of swallowing tablets normally;\n* Eastern Cooperative Oncology Group Performance Status (ECOG PS) 0-1;\n* No prior anti-tumor treatment for rectal cancer, including radiotherapy, chemotherapy, or surgery;\n* Planned to undergo surgical treatment after completion of neoadjuvant therapy;\n* No contraindications to surgery;\n* Normal function of major organs.\n\nExclusion Criteria:\n\n* History of allergy to any component of bevacizumab, serplulimab, 5-FU, or oxaliplatin.\n* Prior or ongoing treatment with any of the following:\n\n 1. Any tumor-targeted surgery, radiotherapy, chemotherapy, targeted therapy, or immunotherapy.\n 2. Immunosuppressive drugs or systemic corticosteroid therapy for immunosuppressive purposes within 2 weeks before the first administration of the study drug (dose \\> 10 mg/day prednisone or equivalent). Inhaled or topical corticosteroids and adrenal corticosteroid replacement therapy (dose \\> 10 mg/day prednisone or equivalent) are permitted in the absence of active autoimmune disease.\n 3. Live-attenuated vaccine within 4 weeks before the first administration of the study drug.\n 4. Major surgery or severe trauma within 4 weeks before the first administration of the study drug.\n* Presence of any active autoimmune disease or history of autoimmune disease, including but not limited to: interstitial pneumonia, enteritis, hepatitis, hypophysitis, vasculitis, nephritis, hyperthyroidism, hypothyroidism (participants on hormone replacement therapy may be considered for inclusion). Participants with psoriasis or childhood asthma/allergy that has fully resolved and requires no intervention in adulthood may be considered for inclusion, but those requiring bronchodilator therapy are not eligible.\n* History of immunodeficiency, including HIV positivity, or other acquired or congenital immunodeficiency diseases, or history of organ transplant or allogeneic bone marrow transplant.\n* Uncontrolled cardiac symptoms or diseases, including but not limited to: (1) NYHA class II or higher heart failure, (2) unstable angina, (3) myocardial infarction within the past year, (4) clinically significant supraventricular or ventricular arrhythmias that are not controlled or remain poorly controlled after clinical intervention.\n* Severe infection (CTCAE \\> grade 2) within 4 weeks before the first administration of the study drug, such as severe pneumonia, bacteremia, or infection with complications requiring hospitalization. Baseline chest imaging showing active pulmonary inflammation, or presence of signs and symptoms of infection or need for oral or intravenous antibiotic therapy within 14 days before the first administration of the study drug (excluding prophylactic antibiotic use). History of active pulmonary tuberculosis infection identified through medical history or CT scan, or history of active pulmonary tuberculosis infection within the past year, or history of active pulmonary tuberculosis infection more than 1 year ago that was not properly treated.\n* Active hepatitis B (HBV DNA ≥ 2000 IU/mL or 10⁴ copies/mL), hepatitis C (positive HCV antibody and HCV RNA above the lower limit of detection of the assay).\n* Diagnosis of other malignancies within 5 years before the first administration of the study drug, unless the malignancy has a low risk of metastasis or death (5-year survival rate \\> 90%), such as adequately treated basal cell carcinoma or squamous cell carcinoma of the skin or cervical carcinoma in situ, which may be considered for inclusion.\n* Pregnant or breastfeeding women.\n* Presence of other factors that, in the investigator's judgment, may lead to forced discontinuation of the study, such as other severe diseases (including psychiatric conditions) requiring concomitant treatment, alcoholism, drug abuse, family or social factors that may affect the participant's safety or compliance."}, 'identificationModule': {'nctId': 'NCT07134218', 'briefTitle': 'Neoadjuvant Chemoradiotherapy Combined With Immunotherapy and Anti-angiogenesis in Treating Locally Advanced Rectal Cancer', 'organization': {'class': 'OTHER', 'fullName': 'Changhai Hospital'}, 'officialTitle': 'A National Multicenter, Prospective, Randomized Controlled Study of Serplulimab Injection Combined With Bevacizumab to Improve the Complete Response Rate of Neoadjuvant Therapy for Locally Advanced Stage Intermediate and Low Rectal Cancer', 'orgStudyIdInfo': {'id': 'CHOICE IV'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'neoadjuvant chemoradiation therapy + serplulimab + bevacizumab', 'interventionNames': ['Drug: serplulimab、bevacizumab']}, {'type': 'OTHER', 'label': 'neoadjuvant chemoradiation therapy', 'interventionNames': ['Drug: serplulimab、bevacizumab', 'Other: neoadjuvant chemoradiation therapy']}], 'interventions': [{'name': 'serplulimab、bevacizumab', 'type': 'DRUG', 'description': 'short-course radiotherapy 25 Gy in 5 fractions → 2-week break → 2 cycles of FOLFOX + serplulimab + bevacizumab → 2 cycles of FOLFOX + serplulimab.', 'armGroupLabels': ['neoadjuvant chemoradiation therapy', 'neoadjuvant chemoradiation therapy + serplulimab + bevacizumab']}, {'name': 'neoadjuvant chemoradiation therapy', 'type': 'OTHER', 'description': 'short-course radiotherapy 25 Gy in 5 fractions → 2-week break → 4 cycles of FOLFOX alone.', 'armGroupLabels': ['neoadjuvant chemoradiation therapy']}]}, 'contactsLocationsModule': {'locations': [{'zip': '200433', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'country': 'China', 'contacts': [{'name': 'Wei Zhang', 'role': 'CONTACT', 'email': 'weizhang2000cn@163.com', 'phone': '021-31161613'}], 'facility': 'Department of Colorectal Surgery in Changhai Hospital', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}]}, 'ipdSharingStatementModule': {'infoTypes': ['STUDY_PROTOCOL'], 'timeFrame': '2 years', 'ipdSharing': 'YES', 'description': 'IPD would be available upon reasonable request.'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Changhai Hospital', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}