Ignite Creation Date:
2025-12-25 @ 4:48 AM
Ignite Modification Date:
2026-03-06 @ 9:43 PM
Study NCT ID:
NCT04166318
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-11-13
First Post:
2019-11-06
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'C563020', 'term': 'Anal Canal Carcinoma'}, {'id': 'D001005', 'term': 'Anus Neoplasms'}], 'ancestors': [{'id': 'D012004', 'term': 'Rectal Neoplasms'}, {'id': 'D015179', 'term': 'Colorectal Neoplasms'}, {'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D001004', 'term': 'Anus Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D001706', 'term': 'Biopsy'}, {'id': 'D013048', 'term': 'Specimen Handling'}, {'id': 'D000069287', 'term': 'Capecitabine'}, {'id': 'D019788', 'term': 'Fluorodeoxyglucose F18'}, {'id': 'D005472', 'term': 'Fluorouracil'}, {'id': 'C029917', 'term': 'dehydroftorafur'}, {'id': 'D050397', 'term': 'Radiotherapy, Intensity-Modulated'}, {'id': 'D009682', 'term': 'Magnetic Resonance Spectroscopy'}, {'id': 'D016685', 'term': 'Mitomycin'}, {'id': 'C473651', 'term': 'Mitozytrex'}], 'ancestors': [{'id': 'D003581', 'term': 'Cytodiagnosis'}, {'id': 'D003584', 'term': 'Cytological Techniques'}, {'id': 'D019411', 'term': 'Clinical Laboratory Techniques'}, {'id': 'D019937', 'term': 'Diagnostic Techniques and Procedures'}, {'id': 'D003933', 'term': 'Diagnosis'}, {'id': 'D003949', 'term': 'Diagnostic Techniques, Surgical'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D003841', 'term': 'Deoxycytidine'}, {'id': 'D003562', 'term': 'Cytidine'}, {'id': 'D011741', 'term': 'Pyrimidine Nucleosides'}, {'id': 'D011743', 'term': 'Pyrimidines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D014498', 'term': 'Uracil'}, {'id': 'D011744', 'term': 'Pyrimidinones'}, {'id': 'D003853', 'term': 'Deoxyribonucleosides'}, {'id': 'D009705', 'term': 'Nucleosides'}, {'id': 'D009706', 'term': 'Nucleic Acids, Nucleotides, and Nucleosides'}, {'id': 'D003847', 'term': 'Deoxyglucose'}, {'id': 'D003837', 'term': 'Deoxy Sugars'}, {'id': 'D002241', 'term': 'Carbohydrates'}, {'id': 'D020266', 'term': 'Radiotherapy, Conformal'}, {'id': 'D011881', 'term': 'Radiotherapy, Computer-Assisted'}, {'id': 'D011878', 'term': 'Radiotherapy'}, {'id': 'D013812', 'term': 'Therapeutics'}, {'id': 'D013057', 'term': 'Spectrum Analysis'}, {'id': 'D002623', 'term': 'Chemistry Techniques, Analytical'}, {'id': 'D008937', 'term': 'Mitomycins'}, {'id': 'D045563', 'term': 'Indolequinones'}, {'id': 'D011809', 'term': 'Quinones'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D001389', 'term': 'Azirines'}, {'id': 'D007211', 'term': 'Indoles'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 252}}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2020-01-02', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-11', 'completionDateStruct': {'date': '2029-12-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-11', 'studyFirstSubmitDate': '2019-11-06', 'studyFirstSubmitQcDate': '2019-11-15', 'lastUpdatePostDateStruct': {'date': '2025-11-13', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2019-11-18', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2029-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Overall survival', 'timeFrame': 'Up to 5 years', 'description': 'Will be compared between experimental and control arm. Will be estimated for all treatment arms using the Kaplan-Meier method (1958).'}], 'primaryOutcomes': [{'measure': 'Disease control in the de-intensified chemoradiation therapy (CRT) arm', 'timeFrame': 'Up to 2 years', 'description': 'An event is local-regional failure, distant metastasis and chemoradiation-related death. Will determine if de-intensified chemoradiation achieves 2-year disease control of 85% or higher while improving anorectal health-related quality of life (HRQL), compared to standard-dose CRT, as measured by the change in the Fecal Incontinence Quality of Life scale (FIQoL) instrument coping/behavior domain from baseline to 1 year. The co-primary endpoints of disease control and FIQoL will be formally assessed in a hierarchical manner with disease control being assessed first. Will be estimated for all treatment arms using the Kaplan-Meier method (1958).'}, {'measure': 'Change in FIQoL in the de-intensified CRT arm', 'timeFrame': 'Baseline up to 1 year', 'description': 'Quality of life analyses, will be compared between arms using a two-sample independent t-tests at a significance level of 0.05 and appropriate longitudinal models will be evaluated to assess the trajectory of HRQL endpoints over time and to evaluate those trajectories between treatment arms. Overall score and change from baseline will be summarized using mean and standard deviation at each time point for each arm.'}], 'secondaryOutcomes': [{'measure': 'Changes in patient-reported outcomes', 'timeFrame': 'Baseline up to 5 years', 'description': 'Will compare changes as per Fecal Incontinence Severity Index \\[FISI\\], Patient Reported Outcomes Measurement Information System \\[PROMIS\\], International Index of Erectile Function \\[IIEF\\], Sexual Function-Vaginal Changes Questionnaire \\[SVQ\\], and Vaginal Assessment Scale \\[VAS\\]/Vulvar Assessment Scale \\[VuAS\\] instruments between the experimental and control arm. Quality of life analyses, will be compared between arms using a two-sample independent t-tests at a significance level of 0.05 and appropriate longitudinal models will be evaluated to assess the trajectory of HRQL endpoints over time and to evaluate those trajectories between treatment arms. Overall score and change from baseline will be summarized using mean and standard deviation at each time point for each arm.'}, {'measure': 'Patterns of failure (local and regional relapse versus distant; in-field versus out-of-field of radiation)', 'timeFrame': 'Up to 5 years', 'description': 'Will be compared between experimental and control arm. The cumulative incidence method will be used to estimate local-regional and distant failure rates and the failure rates for the experimental treatment will be compared against the control using a failure specific log rank test.'}, {'measure': 'Disease control', 'timeFrame': 'Up to 5 years', 'description': 'Will be compared between experimental and control arm. Will be estimated for all treatment arms using the Kaplan-Meier method (1958).'}, {'measure': 'Effect of vaginal dilator use during radiation delivery on sexual function', 'timeFrame': 'Up to 5 years', 'description': 'Vaginal dilator use during radiation delivery will be correlated with sexual function.'}, {'measure': 'Change in serum total testosterone', 'timeFrame': 'Baseline up to 12 months after radiation'}, {'measure': 'Utility of image features of inguinal and pelvic lymph nodes obtained prior to treatment', 'timeFrame': 'Baseline', 'description': 'Will be validated as a prognostic indicator that can identify patients with early-stage anal squamous cell carcinoma for whom treatment with de-intensified CRT is appropriate.'}, {'measure': 'Incidence of and predictors for cardiovascular toxicity in patients receiving fluorouracil or capecitabine', 'timeFrame': 'Up to 5 years', 'description': "Rates of grade 3+ adverse events (Common Terminology Criteria for Adverse Events \\[CTCAE\\], version \\[v.\\] 5) will be estimated using a binomial distribution along with their associated 95% confidence intervals and compared using Fisher's exact test between arms."}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Anal Basaloid Carcinoma', 'Anal Canal Cloacogenic Carcinoma', 'Anal Canal Squamous Cell Carcinoma', 'Anal Margin Squamous Cell Carcinoma', 'Stage I Anal Cancer AJCC v8', 'Stage IIA Anal Cancer AJCC v8']}, 'descriptionModule': {'briefSummary': 'This phase II trial studies how well lower-dose chemotherapy plus radiation (chemoradiation) therapy works in comparison to standard-dose chemoradiation in treating patients with early-stage anal cancer. Drugs used in chemotherapy, such as mitomycin, fluorouracil, and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high-energy x-rays to kill tumor cells and shrink tumors. Giving chemotherapy with radiation therapy may kill more tumor cells. This study may help doctors find out if lower-dose chemoradiation is as effective and has fewer side effects than standard-dose chemoradiation, which is the usual approach for treatment of this cancer type.', 'detailedDescription': 'PRIMARY OBJECTIVE:\n\nI. To determine whether de-intensified chemoradiation for early stage squamous cell carcinoma of the anal canal (SCCA) is able to maintain excellent 2-year disease control of 85% or higher while improving anorectal health-related quality of life (HRQL), compared to standard-dose chemoradiation therapy (CRT), as measured by the change in the Fecal Incontinence Quality of Life scale (FIQoL) instrument coping/behavior domain from baseline to 1 year.\n\nSECONDARY OBJECTIVES:\n\nI. To compare changes in patient-reported HRQL (as per Fecal Incontinence Severity Index \\[FISI\\], Patient Reported Outcomes Measurement Information System \\[PROMIS\\], International Index of Erectile Function \\[IIEF\\], Sexual Function-Vaginal Changes Questionnaire \\[SVQ\\], and Vaginal Assessment Scale \\[VAS\\]/Vulvar Assessment Scale \\[VuAS\\] instruments) between the experimental and control arm.\n\nII. To compare patterns of failure (local and regional relapse versus distant; in-field versus out-of-field of radiation), disease control, and overall survival between experimental and control arm.\n\nIII. To correlate vaginal dilator use during radiation delivery with sexual function.\n\nIV. To measure changes in serum total testosterone from baseline to up to 12 months after radiation.\n\nV. To validate the utility of imaging features of inguinal and pelvic lymph nodes obtained prior to treatment as a prognostic indicator that can identify patients with early-stage anal squamous cell carcinoma for whom treatment with de-intensified chemoradiation is appropriate.\n\nVI. To determine the incidence of and predictors for cardiovascular toxicity in patients receiving fluorouracil (5-FU) or capecitabine.\n\nOUTLINE: Patients are randomized to 1 of 2 arms.\n\nARM A (STANDARD-DOSE CHEMORADIATION): Patients undergo 28 fractions of intensity-modulated radiation therapy (IMRT). Within 24 hours, patients also receive mitomycin intravenously (IV) over 30 minutes or less on day 1 and either fluorouracil IV over 24 hours on days 1-4 and 29-32 or capecitabine orally (PO) twice daily (BID) 5 days per week (Monday - Friday) until completion of IMRT in the absence of disease progression or unacceptable toxicity.\n\nARM B (DE-INTENSIFIED CHEMORADIATION): Patients undergo 20 or 23 fractions of IMRT. Within 24 hours, patients also receive mitomycin IV over 30 minutes or less on day 1 and either fluorouracil IV over 24 hours on days 1-4 or capecitabine PO BID 5 days per week (Monday - Friday) until completion of IMRT in the absence of disease progression or unacceptable toxicity.\n\nAll patients receive fludeoxyglucose F-18 (FDG) and undergo positron emission tomography (PET)/magnetic resonance imaging (MRI) or receive FDG and undergo PET/computed tomography (CT) during baseline. Patients undergo CT or MRI on the trial. Patients also undergo tissue biopsy during screening and at the discretion of the treating physician. Additionally, patients undergo blood sample collection throughout the trial.\n\nAfter completion of study treatment, patients are followed up at 6 weeks, every 3 months for years 1-2, every 6 months for year 3, then annually for years 4-5.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* STEP 0 (PRE-REGISTRATION)\n* Patient must be ≥ 18 years of age\n* Patients must be English speaking to participate in the trial. (Please note that this requirement is due to the fact that the quality-of-life studies are mandatory and we currently do not have full translated versions of the questionnaires into other languages)\n* Patient must have histologically proven T1-2N0M0 invasive anal canal or anal margin squamous cell carcinoma with tumors measuring =\\< 4 cm. This may include tumors of non-keratinizing histology such as basaloid, transitional cell or cloacogenic histology. Measurable disease is not required\n* Patients who are status/post local excision or excisional biopsy procedure are eligible provided there was tumor involvement of the anal canal and/or anal verge prior to the reaction, if the margins were positive, and/or if the stage is T2N0 based on tumor size before the procedure. This means that patients with T1N0M0 anal margin squamous cell carcinoma who underwent surgical excision with negative margins and no involvement of the anal verge and/or anal canal are not eligible\n* Tumor size must be documented based on physical examination including digital rectal exam and/or anoscopy/proctoscopy within 4 weeks prior to Step 0 pre-registration\n* Patient's human immunodeficiency virus (HIV) status must be known and documented at baseline\n\n * NOTE: For patients without a history of HIV infection, it is recommended (but not required) that updated HIV testing be performed within one year of study enrollment\n* Patients who are HIV-negative will be registered to Arm R. They must not have lymph nodes that are radiographically-concerning for cancer involvement using computed tomography (CT) and fludeoxyglucose F-18 (FDG) - positron emission tomography (PET)/CT-based criteria\n\n * NOTE: Patients who are HIV-negative and meet the below criteria may proceed directly to Step 1 Randomization\n * Patients will be considered to be lymph node (LN) positive and thereby not eligible in this study if the lymph nodes meet any of the following criteria:\n\n * Mesorectal, presacral, internal iliac or obturator LN with:\n\n * Short axis measuring \\> 5 mm based on CT/magnetic resonance imaging (MRI) OR\n * Morphologic features of irregular border or central necrosis if assessed on MRI and LN measures \\> 3 mm OR\n * FDG uptake \\> blood pool (Deauville 3-5) based on FDG-PET/CT or PET/MRI\n * Internal Iliac and obturator LN with:\n\n * Short-axis measuring \\> 7 mm based on CT/MRI OR\n * Morphologic features of irregular border or central necrosis based on CT/MRI OR\n * FDG uptake \\> blood pool (Deauville 3-5) based on FDG-PET/CT or PET/MRI\n * External Iliac and common Iliac:\n\n * Short-axis measuring \\> 10 mm based on CT/MRI OR\n * Morphologic features of irregular border or central necrosis based on CT/MRI OR\n * FDG uptake \\> blood pool (Deauville 3-5) based on FDG-PET/CT or PET/MRI\n * Inguinal LN (superficial and deep) meeting any of the following criteria will be ineligible unless an fine needle aspiration (FNA) is performed and resulting cytology is negative.\n\n * Morphologic features of irregular border or central necrosis based on CT/MRI\n * FDG uptake \\> liver (Deauville 4) based on FDG-PET/CT.\n * Patients who are HIV-negative and have inguinal lymph nodes that do not meet the above criteria must undergo fine needle aspiration and have negative histology to be eligible\n* Patients who are HIV-positive will be registered to Arm S. They must meet the eligibility criteria below:\n\n * A CD4 count \\>= 200\n * Imaging submitted to ECOG-ACRIN for central review for confirmation of no lymph node involvement\n * No history of acquired immunodeficiency syndrome (AIDS)-related complications within past year other than a history of low CD4+ T-cell count (\\> 200/mm\\^3) prior to initiation of combination antiretroviral therapy\n * Patient must be healthy on the basis of HIV disease with high likelihood of near normal life span were it not for the anal cancer\n * Patient MUST receive appropriate care and treatment for HIV infection, including antiretroviral medications when clinically indicated, and should be under the care of a physician experienced in HIV management. Patients will be eligible regardless of antiretroviral medication provided the regimen has been stable for at least 4 weeks\n* STEP 1 RANDOMIZATION\n* Patient must have met the eligibility criteria as outlined Step 0 Pre-registration\n* Patient must have Eastern Cooperative Oncology Group (ECOG) - American College of Radiology Imaging Network (ACRIN) performance status of 0-2\n* Patient must have no history of prior chemotherapy for this malignancy\n* Patients must not have undergone previous radiation to the pelvis such that overlapping radiation fields would be expected\n* Patient must not have had prior potentially curative surgery (i.e. abdominal-perineal resection) for carcinoma of the anus. However, patients who undergo local excision or excisional biopsy are eligible provided they meet inclusion criteria\n* Patients with T1N0M0 anal margin squamous cell carcinoma must not have undergone surgical excision with negative margins and no involvement of the anal verge and/or anal canal\n* Patient must not be receiving any other standard anti-cancer therapy or experimental agent concurrently with the study drugs\n* Patient must not have intercurrent illness including, but not limited to, ongoing or active infection or psychiatric/social situations that, in the judgement of the investigator, would limit compliance with study requirements\n* Patient must not have had significant cardiovascular disease including myocardial infarction, unstable angina, stroke, transient ischemic attack, symptomatic coronary artery disease, symptomatic congestive heart failure, or uncontrolled cardiac arrhythmia within 6 months of Step 1 randomization\n* Patient must not have a history of a different malignancy unless they have been disease-free for at least 2 years and are deemed by the investigator to be at low risk of recurrence\n\n * Exceptions to this rule are individuals with cervical cancer in situ, non-melanoma skin cancers, and colon polyps\n* Patient must not have active inflammatory bowel disease (patients requiring current medical interventions or who are symptomatic)\n* Patients must not have an active autoimmune or connective tissue disease that has required systemic treatment in the past two years (i.e., with the use of modifying agents, corticosteroids, or immunosuppressive drugs) Replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment\n* Patients who are on anti-coagulation with warfarin within 2 weeks prior to Step 1 randomization and are considering the use of capecitabine, must use an alternative anti-coagulant\n\n * NOTE: Low molecular weight heparin is permitted provided the patient's prothrombin time (PT)/international normalized ratio (INR) is \\< 1.5\n* Patients who will receive capecitabine and are on Dilantin for a seizure disorder must have Dilantin levels checked weekly\n* Hemoglobin \\> 10 g/dL (within 2 weeks prior to Step 1 Randomization)\n* Platelets \\>= 100,000/mm\\^3 (within 2 weeks prior to Step 1 Randomization)\n* Absolute neutrophil count \\>= 1500/mm\\^3 (within 2 weeks prior to Step 1 Randomization)\n* Serum creatinine must be \\< 1.5 X upper limit of normal (ULN), or calculated creatinine clearance must be \\> 50 ml/min (within 2 weeks prior to Step 1 Randomization)\n* Total bilirubin must be \\< 2 X ULN (within 2 weeks prior to Step 1 Randomization)\n* Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =\\< 2.5 X institutional ULN (within 2 weeks prior to Step 1 Randomization)\n* Albumin \\>= 3.0 g/dL (within 2 weeks prior to Step 1 Randomization)\n* Women must not be pregnant or breast-feeding because the study treatment administered may cause harm to an unborn fetus or breastfeeding child. All females of childbearing potential must have a blood test or urine study within 2 weeks prior to Step 1 Randomization to rule out pregnancy. A female of childbearing potential is any woman, regardless of sexual orientation or whether they have undergone tubal ligation, who meets the following criteria: 1) has achieved menarche at some point, 2) has not undergone a hysterectomy or bilateral oophorectomy; or 2) has not been naturally postmenopausal (amenorrhea following cancer therapy does not rule out childbearing potential) for at least 24 consecutive months (i.e., has had menses at any time in the preceding 24 consecutive months)\n* Women of childbearing potential and sexually active males must be strongly advised to use accepted and effective method(s) of contraception or to abstain from sexual intercourse for the duration of their participation in the study and for at least 6 months after the completion of treatment"}, 'identificationModule': {'nctId': 'NCT04166318', 'briefTitle': 'Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study', 'organization': {'class': 'NETWORK', 'fullName': 'Eastern Cooperative Oncology Group'}, 'officialTitle': 'A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE)', 'orgStudyIdInfo': {'id': 'EA2182'}, 'secondaryIdInfos': [{'id': 'NCI-2019-02259', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trial Reporting Program)'}, {'id': 'EA2182', 'type': 'OTHER', 'domain': 'ECOG-ACRIN Cancer Research Group'}, {'id': 'EA2182', 'type': 'OTHER', 'domain': 'CTEP'}, {'id': 'U10CA180820', 'link': 'https://reporter.nih.gov/quickSearch/U10CA180820', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'Arm A (standard-dose chemoradiation)', 'description': 'Patients undergo 28 fractions of intensity-modulated radiation therapy (IMRT). Within 24 hours, patients also receive mitomycin IV over 30 minutes or less on day 1 and either fluorouracil IV over 24 hours on days 1-4 and 29-32 or capecitabine PO BID 5 days per week (Monday - Friday) until completion of IMRT in the absence of disease progression or unacceptable toxicity. Patients receive FDG and undergo PET/MRI or receive FDG and undergo PET/CT during baseline. Patients undergo CT or MRI on the trial. Patients also undergo tissue biopsy during screening and at the discretion of the treating physician. Additionally, patients undergo blood sample collection throughout the trial.', 'interventionNames': ['Procedure: Biopsy', 'Procedure: Biospecimen Collection', 'Drug: Capecitabine', 'Procedure: Computed Tomography', 'Other: Fludeoxyglucose F-18', 'Drug: Fluorouracil', 'Radiation: Intensity-Modulated Radiation Therapy', 'Procedure: Magnetic Resonance Imaging', 'Drug: Mitomycin', 'Procedure: Positron Emission Tomography', 'Other: Quality-of-Life Assessment', 'Other: Questionnaire Administration']}, {'type': 'EXPERIMENTAL', 'label': 'Arm B (de-intensified chemoradiation)', 'description': 'Patients undergo 20 or 23 fractions of IMRT. Within 24 hours, patients also receive mitomycin IV over 30 minutes or less on day 1 and either fluorouracil IV over 24 hours on days 1-4 or capecitabine PO BID 5 days per week (Monday - Friday) until completion of IMRT in the absence of disease progression or unacceptable toxicity. Patients receive FDG and undergo PET/MRI or receive FDG and undergo PET/CT during baseline. Patients undergo CT or MRI on the trial. Patients also undergo tissue biopsy during screening and at the discretion of the treating physician. Additionally, patients undergo blood sample collection throughout the trial.', 'interventionNames': ['Procedure: Biopsy', 'Procedure: Biospecimen Collection', 'Drug: Capecitabine', 'Procedure: Computed Tomography', 'Other: Fludeoxyglucose F-18', 'Drug: Fluorouracil', 'Radiation: Intensity-Modulated Radiation Therapy', 'Procedure: Magnetic Resonance Imaging', 'Drug: Mitomycin', 'Procedure: Positron Emission Tomography', 'Other: Quality-of-Life Assessment', 'Other: Questionnaire Administration']}], 'interventions': [{'name': 'Biopsy', 'type': 'PROCEDURE', 'otherNames': ['BIOPSY_TYPE', 'Bx'], 'description': 'Undergo tissue biopsy', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Biospecimen Collection', 'type': 'PROCEDURE', 'otherNames': ['Biological Sample Collection', 'Biospecimen Collected', 'Specimen Collection'], 'description': 'Undergo blood sample collection', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Capecitabine', 'type': 'DRUG', 'otherNames': ['Ro 09-1978/000', 'Xeloda'], 'description': 'Given PO', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Computed Tomography', 'type': 'PROCEDURE', 'otherNames': ['CAT', 'CAT Scan', 'Computed Axial Tomography', 'Computerized Axial Tomography', 'Computerized axial tomography (procedure)', 'Computerized Tomography', 'Computerized Tomography (CT) scan', 'CT', 'CT Scan', 'tomography'], 'description': 'Undergo PET/CT', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Fludeoxyglucose F-18', 'type': 'OTHER', 'otherNames': ['18FDG', 'FDG', 'Fludeoxyglucose (18F)', 'fludeoxyglucose F 18', 'Fludeoxyglucose F18', 'Fluorine-18 2-Fluoro-2-deoxy-D-Glucose', 'Fluorodeoxyglucose F18'], 'description': 'Receive FDG', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Fluorouracil', 'type': 'DRUG', 'otherNames': ['5 Fluorouracil', '5 Fluorouracilum', '5 FU', '5-Fluoro-2,4(1H, 3H)-pyrimidinedione', '5-Fluorouracil', '5-Fluracil', '5-Fu', '5FU', 'AccuSite', 'Carac', 'Fluoro Uracil', 'Fluouracil', 'Flurablastin', 'Fluracedyl', 'Fluracil', 'Fluril', 'Fluroblastin', 'Ribofluor', 'Ro 2-9757', 'Ro-2-9757'], 'description': 'Given IV', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Intensity-Modulated Radiation Therapy', 'type': 'RADIATION', 'otherNames': ['IMRT', 'Intensity modulated radiation therapy (procedure)', 'Intensity Modulated RT', 'Intensity-Modulated Radiotherapy', 'Radiation, Intensity-Modulated Radiotherapy'], 'description': 'Undergo IMRT', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Magnetic Resonance Imaging', 'type': 'PROCEDURE', 'otherNames': ['Magnetic Resonance', 'Magnetic Resonance Imaging (MRI)', 'Magnetic resonance imaging (procedure)', 'Magnetic Resonance Imaging Scan', 'Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance', 'MR', 'MR Imaging', 'MRI', 'MRI Scan', 'MRIs', 'NMR Imaging', 'NMRI', 'Nuclear Magnetic Resonance Imaging', 'sMRI', 'Structural MRI'], 'description': 'Undergo PET/MRI', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Mitomycin', 'type': 'DRUG', 'otherNames': ['Ametycine', 'Jelmyto', 'MITO', 'Mito-C', 'Mito-Medac', 'Mitocin', 'Mitocin-C', 'Mitolem', 'Mitomycin C', 'Mitomycin pyelocalyceal', 'Mitomycin-C', 'Mitomycin-X', 'Mitomycine C', 'Mitosol', 'Mitozytrex', 'Mutamycin', 'Mutamycine', 'NCI-C04706'], 'description': 'Given IV', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Positron Emission Tomography', 'type': 'PROCEDURE', 'otherNames': ['Medical Imaging, Positron Emission Tomography', 'PET', 'PET Scan', 'Positron emission tomography (procedure)', 'Positron Emission Tomography Scan', 'Positron-Emission Tomography', 'proton magnetic resonance spectroscopic imaging', 'PT'], 'description': 'Undergo PET/CT', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Quality-of-Life Assessment', 'type': 'OTHER', 'otherNames': ['Quality of Life Assessment'], 'description': 'Ancillary studies', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}, {'name': 'Questionnaire Administration', 'type': 'OTHER', 'description': 'Ancillary studies', 'armGroupLabels': ['Arm A (standard-dose chemoradiation)', 'Arm B (de-intensified chemoradiation)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35233', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'University of Alabama at Birmingham Cancer Center', 'geoPoint': {'lat': 33.52066, 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