Ignite Creation Date:
2025-12-25 @ 4:29 AM
Ignite Modification Date:
2025-12-26 @ 3:32 AM
Study NCT ID:
NCT05024318
Status:
RECRUITING
Last Update Posted:
2024-05-16
First Post:
2021-03-29
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
NeoAdjuvant Pembrolizumab and STEreotactic Radiotherapy Prior to Nephrectomy for Renal Cell Carcinoma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D002292', 'term': 'Carcinoma, Renal Cell'}], 'ancestors': [{'id': 'D000230', 'term': 'Adenocarcinoma'}, {'id': 'D002277', 'term': 'Carcinoma'}, {'id': 'D009375', 'term': 'Neoplasms, Glandular and Epithelial'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D007680', 'term': 'Kidney Neoplasms'}, {'id': 'D014571', 'term': 'Urologic Neoplasms'}, {'id': 'D014565', 'term': 'Urogenital Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D007674', 'term': 'Kidney Diseases'}, {'id': 'D014570', 'term': 'Urologic Diseases'}, {'id': 'D052801', 'term': 'Male Urogenital Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'C582435', 'term': 'pembrolizumab'}, {'id': 'D009392', 'term': 'Nephrectomy'}], 'ancestors': [{'id': 'D013520', 'term': 'Urologic Surgical Procedures'}, {'id': 'D013519', 'term': 'Urogenital Surgical Procedures'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 20}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2022-02-08', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-05', 'completionDateStruct': {'date': '2025-12', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-05-15', 'studyFirstSubmitDate': '2021-03-29', 'studyFirstSubmitQcDate': '2021-08-22', 'lastUpdatePostDateStruct': {'date': '2024-05-16', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2021-08-27', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-12', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Radiological features including contrast enhancement consistent with mPR', 'timeFrame': '2 weeks prior to nephrectomy', 'description': 'Post treatment radiological features including contrast enhancement'}, {'measure': 'Radiological features including size reduction consistent with mPR', 'timeFrame': '2 weeks prior to nephrectomy', 'description': 'Post treatment radiological features including size reduction'}, {'measure': 'Radiological features including maximum tumour diameter consistent with mPR', 'timeFrame': '2 weeks prior to nephrectomy', 'description': 'Post treatment radiological features including maximum tumour diameter'}, {'measure': 'Radiological features including margins consistent with mPR', 'timeFrame': '2 weeks prior to nephrectomy', 'description': 'Post treatment radiological features including margins'}, {'measure': 'Baseline versus post-nephrectomy tissue for immune context changes', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'To investigate baseline versus post-nephrectomy tissue for immune context changes, using a broad panel of assays which will be further developed through the lifetime of the study'}, {'measure': 'Baseline versus post-nephrectomy tissue immune network signalling', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'Baseline and post-nephrectomy immune network signalling , using a broad panel of assays which will be further developed through the lifetime of the study'}, {'measure': 'Systemic immune cells in baseline and post-nephrectomy blood samples', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'To investigate changes in systemic immunity of patients with primary ccRCC treated with SABR with or without pembrolizumab'}], 'primaryOutcomes': [{'measure': 'mPR post-SABR with or without pembrolizumab', 'timeFrame': 'At nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'The mPR rate is defined as \\<10% residual tumour at post-nephrectomy specimens'}, {'measure': 'CD8+ TRM in baseline biopsy and post-nephrectomy specimen, all measured as a continuous variable.', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'To describe changes in tumour-responsive T-cells, TRM CD8+ T-cells from baseline to post-nephrectomy in patients treated with SABR with or without pembrolizumab treatment followed by nephrectomy'}, {'measure': 'TCF-1 + tumour infiltrating lymphocytes (TILs) in baseline biopsy and post-nephrectomy specimen, measured as a continuous variable', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'To describe changes in TCF-1+ T-cells from baseline to post-nephrectomy in patients treated with SABR with or without pembrolizumab treatment followed by nephrectomy'}], 'secondaryOutcomes': [{'measure': 'Immune response cells in baseline biopsy and post-nephrectomy specimen', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'Change in immune response from baseline to post-nephrectomy'}, {'measure': 'The tumour-responsive TRM cells inclusive of CD4+ and CD8+ compartments', 'timeFrame': '2 weeks prior to nephrectomy', 'description': 'Percentage of tumour responsive T-cells (inclusive CD4/CD8) after neo-adjuvant treatment'}, {'measure': 'Safety of SABR with or without pembrolizumab in the neo-adjuvant setting', 'timeFrame': '60 days post nephrectomy', 'description': 'Adverse events, as measured by CTCAE v5.0'}, {'measure': 'Change in immune response associated with mPR', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'Immune response cells in baseline biopsy and post-nephrectomy specimens'}, {'measure': 'Change in PD-L1 and PD-L2 expression in tumour', 'timeFrame': 'Baseline and at nephrectomy performed 9-12 weeks after first dose of pembrolizumab', 'description': 'PD-L1 and PD-L2 expression in baseline biopsy and post-nephrectomy specimens'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Renal Cell Carcinoma, Clear Cell, Somatic']}, 'descriptionModule': {'briefSummary': 'This is a prospective, open label, phase II, randomised, non-comparative clinical trial, evaluating changes in tumour-responsive T-cells following neoadjuvant stereotactic ablative body radiotherapy (SABR) with or without pembrolizumab, prior to nephrectomy, in patients with localised primary clear cell renal cell carcinoma (ccRCC).'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Patient has provided written informed consent\n2. Male or female aged 18 years or older at written informed consent\n3. Histologically or cytologically confirmed diagnosis of RCC with clear cell, rhabdoid or sarcomatoid components\n4. Tumour stage T1B-T3, N0 or N1, M0 or low volume M1 planned for nephrectomy\n5. Patients must have adequate bone marrow, hepatic and renal function documented within 28 days prior to randomisation:\n\n * White Blood Cell (WBC) ≥ 3 X 10\\^9/L\n * Absolute neutrophil count (ANC) ≥1.5 X 10\\^9/L\n * Platelets ≥ 100 X 10\\^9/L\n * Haemoglobin ≥ 100 g/L independent of transfusion\n * Serum Creatinine ≤1.5 X Upper Limit of Normal (ULN) or measured or calculated CrCl calculated as per institutional standard ≥ 30 ml/min. GFR can also be used in place of serum creatinine or CrCl.\n * Total bilirubin ≤1.5 X ULN except for patients with known Gilbert's Syndrome\n * Albumin \\> 30 g/L\n * AST and ALT ≤1.5 X ULN\n * INR or PT ≤1.5 X ULN unless patient is receiving anticoagulant therapy\n6. ECOG performance status of 0 or 1\n7. Women of child birth potential (WOCBP) must have a negative urine or serum pregnancy test within 72 hours prior to randomisation. If the urine test is positive or cannot be confirmed as negative, a serum pregnancy test will be required\n8. WOCBP should be willing to use two methods of birth control, or be surgically sterile, or abstain from heterosexual activity for the course of the study through 120 days after the last dose of study medication. Patients of childbearing potential are those who have not been surgically sterilised or have not been free from menses for more than 1 year\n9. Male patients should agree to use an adequate method of contraception starting with the first dose of study therapy through 120 days after the last dose of study therapy\n10. Patient agrees to the collection and use of their fresh tumour samples and peripheral blood for translational research\n11. Patient is willing and able to comply with the protocol for the duration of the study including undergoing biopsies, treatment, and scheduled visits and examination\n\nExclusion Criteria:\n\n1. Had prior treatment with any anti-PD-1, or anti-PD-L1, or PD-L2 agent or with an antibody targeting any other immune-regulatory receptors or mechanisms. Examples of such antibodies include antibodies against IDO, PD-L1, IL-2R, and GITR\n2. Known or active inflammatory bowel disease involving colon and small bowels\n3. Previous radiotherapy to the upper abdomen with radiation dose overlap to the involved kidney\n4. Is currently participating in or has participated in a study of an investigational agent or has used an investigational device within 4 weeks prior to randomisation\n5. Has a diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy exceeding 10 mg daily dose of prednisone or equivalent or any other form of immunosuppressive therapy within 7 days prior to randomisation\n6. Has an active autoimmune disease that has required systemic treatment in the last 2 years (i.e. with use of disease modifying agents, corticosteroids or immunosuppressive drugs). Replacement therapy (eg., thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic treatment and is allowed\n7. Has a known additional malignancy that is progressing or has required active treatment in the last 2 years Note: Basal cell carcinoma of the skin, squamous cell carcinoma of the skin, superficial bladder cancer, or carcinoma in situ, such as breast cancer in situ, that has undergone potentially curative therapy are not excluded\n8. Has known active CNS metastases and/or carcinomatous meningitis. Patients with previously treated brain metastases may participate provided they are radiologically stable, i.e. without evidence of progression for at least 4 weeks by repeat imaging (note that the repeat imaging should be performed during study screening), clinically stable and without requirement of steroid treatment for at least 14 days prior to randomisation\n9. Has severe hypersensitivity (≥Grade 3) to pembrolizumab and/or any of its excipients\n10. Has a history of (non-infectious) pneumonitis that required steroids or has current pneumonitis\n11. Has an active infection requiring systemic therapy\n12. Has a known history of HIV infection\n13. Has known history of Hepatitis B (defined as Hepatitis B surface antigen \\[HBsAg\\] reactive)or known active Hepatitis C (defined as HCV RNA \\[qualitative\\] is detected) infection\n14. Has a history or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the study, interfere with the patient's participation for the full duration of the study, or is not in the best interest of the patient to participate, in the opinion of the treating investigator\n15. Has a known psychiatric or substance abuse disorders that would interfere with cooperation with the requirements of the trial\n16. Has received a live virus vaccine within 30 days prior to randomisation. Examples of live vaccines include, but are not limited to, the following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever, rabies, Bacillus Calmette-Guérin (BCG), and typhoid vaccine. Seasonal influenza vaccines for injection are generally killed virus vaccines and are allowed; however, intranasal influenza vaccines (eg, FluMist®) are live attenuated vaccines and are not allowed\n17. Has had a prior solid organ transplant\n18. Is pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the study, starting with the screening visit through 120 days after the last dose of study drug.\n19. Any contraindications for surgery"}, 'identificationModule': {'nctId': 'NCT05024318', 'acronym': 'NAPSTER', 'briefTitle': 'NeoAdjuvant Pembrolizumab and STEreotactic Radiotherapy Prior to Nephrectomy for Renal Cell Carcinoma', 'organization': {'class': 'OTHER', 'fullName': 'Peter MacCallum Cancer Centre, Australia'}, 'officialTitle': 'NeoAdjuvant Pembrolizumab and STEreotactic Radiotherapy Prior to Nephrectomy for Renal Cell Carcinoma: Investigating Induced Immune Context Changes', 'orgStudyIdInfo': {'id': '19/007'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'SABR plus nephrectomy', 'description': 'Stereotactic Ablative Radiotherapy (SABR) will be prescribed to a dose of 42Gy in 3 fractions. All radiotherapy treatment be completed within 3 weeks.Patients will undergo nephrectomy within 9-12 weeks after the first dose of treatment.', 'interventionNames': ['Radiation: Stereotactic Ablative Radiotherapy', 'Procedure: Nephrectomy']}, {'type': 'EXPERIMENTAL', 'label': 'Pembrolizumab followed by SABR after cycle 1 plus nephrectomy', 'description': 'Pembrolizumab 200 mg (flat dose) will be administered as a 30 minute IV infusion every 21 days for 3 cycles. Patients will receive 1 cycle of pembolizumab prior to SABR followed by an additional 2 cycles of pembrolizumab (1 cycle is 21 days). Patients will undergo nephrectomy 9-12 weeks after commencement of treatment.', 'interventionNames': ['Drug: Pembrolizumab', 'Radiation: Stereotactic Ablative Radiotherapy', 'Procedure: Nephrectomy']}], 'interventions': [{'name': 'Pembrolizumab', 'type': 'DRUG', 'otherNames': ['MK-3475'], 'description': 'Pembrolizumab 200 mg tobe administered as a 30 minute IV infusion every 21 days for 3 cycles', 'armGroupLabels': ['Pembrolizumab followed by SABR after cycle 1 plus nephrectomy']}, {'name': 'Stereotactic Ablative Radiotherapy', 'type': 'RADIATION', 'otherNames': ['SABR'], 'description': '42Gy delivered in 3 fractions', 'armGroupLabels': ['Pembrolizumab followed by SABR after cycle 1 plus nephrectomy', 'SABR plus nephrectomy']}, {'name': 'Nephrectomy', 'type': 'PROCEDURE', 'otherNames': ['Surgical removal of a kidney'], 'description': 'Partial or total nephrectomy performed 9-12 weeks after first dose of Pembrolizumab', 'armGroupLabels': ['Pembrolizumab followed by SABR after cycle 1 plus nephrectomy', 'SABR plus nephrectomy']}]}, 'contactsLocationsModule': {'locations': [{'zip': '4102', 'city': 'Woolloongabba', 'state': 'Queensland', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'David Pryor', 'role': 'CONTACT'}], 'facility': 'Princess Alexandra Hospital', 'geoPoint': {'lat': -27.48855, 'lon': 153.03655}}, {'zip': '3000', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'contacts': [{'name': 'Shankar Siva, A/Prof', 'role': 'CONTACT', 'email': 'Shankar.Siva@petermac.org', 'phone': '+61 3 8559 7988'}, {'name': 'Arun Azad, A/Prof', 'role': 'CONTACT', 'email': 'Arun.Azad@petermac.org', 'phone': '+61 3 8559 7165'}], 'facility': 'Peter MacCallum Cancer Centre', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}], 'centralContacts': [{'name': 'Shankar Siva, A/Prof', 'role': 'CONTACT', 'email': 'Shankar.Siva@petermac.org', 'phone': '+61 3 8559 7988'}, {'name': 'Arun Azad, A/Prof', 'role': 'CONTACT', 'email': 'Arun.Azad@petermac.org', 'phone': '+61 3 8559 7165'}], 'overallOfficials': [{'name': 'Shankar Siva, A/Prof', 'role': 'STUDY_CHAIR', 'affiliation': 'Peter MacCallum Cancer Centre, Australia'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Peter MacCallum Cancer Centre, Australia', 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}