Ignite Creation Date:
2025-12-25 @ 4:26 AM
Ignite Modification Date:
2025-12-26 @ 3:30 AM
Study NCT ID:
NCT01062620
Status:
COMPLETED
Last Update Posted:
2011-09-15
First Post:
2010-02-03
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Dose Escalating Clinical Trial of the IGF-1 Receptor Inhibitor AXL1717 in Patients With Advanced Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'interventionBrowseModule': {'meshes': [{'id': 'C415032', 'term': 'picropodophyllin'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 49}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2008-04'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2011-09', 'lastUpdateSubmitDate': '2011-09-14', 'studyFirstSubmitDate': '2010-02-03', 'studyFirstSubmitQcDate': '2010-02-03', 'lastUpdatePostDateStruct': {'date': '2011-09-15', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2010-02-04', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2011-05', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'To define and confirm recommended Phase 2 dose'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'conditions': ['Solid Tumors']}, 'referencesModule': {'references': [{'pmid': '26161618', 'type': 'DERIVED', 'citation': 'Ekman S, Harmenberg J, Frodin JE, Bergstrom S, Wassberg C, Eksborg S, Larsson O, Axelson M, Jerling M, Abrahmsen L, Hedlund A, Alvfors C, Stahl B, Bergqvist M. A novel oral insulin-like growth factor-1 receptor pathway modulator and its implications for patients with non-small cell lung carcinoma: A phase I clinical trial. Acta Oncol. 2016;55(2):140-8. doi: 10.3109/0284186X.2015.1049290. Epub 2015 Jul 10.'}]}, 'descriptionModule': {'briefSummary': 'A dose escalating phase Ia-b clinical trial of the IGF-1 receptor inhibitor AXL1717 in patients with advanced cancer.\n\nThe objective is to study the safety and pharmacokinetics of AXL1717 and to define an appropriate Phase 2 dose for further studies. This is the first study in man. The study is not designed to show tumor response.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. At least 18 years of age.\n2. Histologically confirmed diagnosis of advanced solid or haematological malignancy not amenable to standard treatment.\n3. Pharmacological treatment attempt justified\n4. Preserved major organ functions, i.e:\n\n * B-Leukocyte count ≥ 3.0 x 109/L\n * B-Neutrophil count ≥ 1.5 x 109/L\n * B-Platelet count ≥ 75 x109/L\n * B-Haemoglobin ≥ 100 g/L (transfusions are allowed)\n * P-Total bilirubin level ≤ 1.5 times the upper institutional limit of the "normal" (i.e. reference) range\n * P-ASAT or P-ALAT ≤ 2.5 times upper institutional limit of the "normal" range, ≤5 times if liver metastases have been documented\n * P-Creatinine ≤ 1.5 times upper institutional limit of the "normal" range\n5. Females of childbearing potential should use adequate contraception (oral or injectable contraceptives, hormone releasing intrauterine device) throughout the study period.\n6. Signed written informed consent.\n\nExclusion Criteria:\n\n1. Ongoing infection or other major recent or ongoing disease that, according to the investigator, poses an unacceptable risk to the patient\n2. Known malignancy in CNS\n3. Prior anti-tumour therapy within 4 weeks from enrolment (6 weeks for nitrosurea and MitC).\n4. Pregnancy or lactation\n5. Current participation in any other interventional clinical trial\n6. Performance status \\> ECOG 2 after optimization of analgesics\n7. Life expectancy less than 3 months\n8. Contraindications to the investigational product, e.g. known or suspected hypersensitivity.\n9. Lack of suitability for participation in the trial, for any reason, as judged by the Investigator.'}, 'identificationModule': {'nctId': 'NCT01062620', 'briefTitle': 'A Dose Escalating Clinical Trial of the IGF-1 Receptor Inhibitor AXL1717 in Patients With Advanced Cancer', 'organization': {'class': 'INDUSTRY', 'fullName': 'Axelar AB'}, 'officialTitle': 'A Dose Escalating Phase Ia-b Clinical Trial of the IGF-1 Receptor Inhibitor AXL1717 in Patients With Advanced Cancer: A Prospective, Single Armed, Open Label, Dose-finding Phase Ia-b Study', 'orgStudyIdInfo': {'id': 'AXL-001'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'AXL1717', 'interventionNames': ['Drug: AXL1717']}], 'interventions': [{'name': 'AXL1717', 'type': 'DRUG', 'description': 'Phase I study with increasing dosage and treatment duration', 'armGroupLabels': ['AXL1717']}]}, 'contactsLocationsModule': {'locations': [{'zip': 'SE-75185', 'city': 'Uppsala', 'country': 'Sweden', 'facility': 'Uppsala University Hospital', 'geoPoint': {'lat': 59.85882, 'lon': 17.63889}}], 'overallOfficials': [{'name': 'Michael Bergqvist, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Uppsala University Hospital'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Axelar AB', 'class': 'INDUSTRY'}, 'responsibleParty': {'oldNameTitle': 'Michael Bergqvist', 'oldOrganization': 'Uppsala University Hospital'}}}}