Ignite Creation Date:
2025-12-25 @ 4:26 AM
Ignite Modification Date:
2025-12-26 @ 3:29 AM
Study NCT ID:
NCT03719820
Status:
UNKNOWN
Last Update Posted:
2020-03-31
First Post:
2018-10-22
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D000083242', 'term': 'Ischemic Stroke'}], 'ancestors': [{'id': 'D020521', 'term': 'Stroke'}, {'id': 'D002561', 'term': 'Cerebrovascular Disorders'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D001241', 'term': 'Aspirin'}, {'id': 'D000077144', 'term': 'Clopidogrel'}, {'id': 'D000068718', 'term': 'Rosuvastatin Calcium'}], 'ancestors': [{'id': 'D012459', 'term': 'Salicylates'}, {'id': 'D062385', 'term': 'Hydroxybenzoates'}, {'id': 'D010636', 'term': 'Phenols'}, {'id': 'D001555', 'term': 'Benzene Derivatives'}, {'id': 'D006841', 'term': 'Hydrocarbons, Aromatic'}, {'id': 'D006844', 'term': 'Hydrocarbons, Cyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D013988', 'term': 'Ticlopidine'}, {'id': 'D058924', 'term': 'Thienopyridines'}, {'id': 'D013876', 'term': 'Thiophenes'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D011725', 'term': 'Pyridines'}, {'id': 'D006573', 'term': 'Heterocyclic Compounds, 1-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}, {'id': 'D013449', 'term': 'Sulfonamides'}, {'id': 'D000577', 'term': 'Amides'}, {'id': 'D005464', 'term': 'Fluorobenzenes'}, {'id': 'D006845', 'term': 'Hydrocarbons, Fluorinated'}, {'id': 'D006846', 'term': 'Hydrocarbons, Halogenated'}, {'id': 'D013450', 'term': 'Sulfones'}, {'id': 'D011743', 'term': 'Pyrimidines'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 550}, 'targetDuration': '12 Months', 'patientRegistry': True}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2018-11-14', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2020-03', 'completionDateStruct': {'date': '2021-06-30', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2020-03-28', 'studyFirstSubmitDate': '2018-10-22', 'studyFirstSubmitQcDate': '2018-10-23', 'lastUpdatePostDateStruct': {'date': '2020-03-31', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2018-10-25', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2020-12-31', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Number of Participants with Adverse Events That Are Related to Anti-platelet Treatment', 'timeFrame': '12 months after stroke onset', 'description': 'intracranial bleeding confirmed by CT，fatal bleeding causing hemodynamic abnormalities needed blood tranfusion or surgical intervention'}, {'measure': 'Number of Participants with Adverse Events That Are Related to StatinTreatment', 'timeFrame': '12 months after stroke onset', 'description': 'more than 3-fold liver enzyme increase，rhabdomyolysis'}], 'primaryOutcomes': [{'measure': 'poor functional outcome', 'timeFrame': '90 day after stroke onset', 'description': 'The Rankin Score runs from 0-6, running from perfect health without symptoms to death. mRS 0-2 are defined as favorable outcomes while mRS 3-6 as unfavorable outcomes.0 - No symptoms.1 - No significant disability. Able to carry out all usual activities, despite some symptoms.2 - Slight disability. Able to look after own affairs without assistance, but unable to carry out all previous activities.3 - Moderate disability. Requires some help, but able to walk unassisted.4 - Moderately severe disability. Unable to attend to own bodily needs without assistance, and unable to walk unassisted.5 - Severe disability. Requires constant nursing care and attention, bedridden, incontinent.6 - Dead.'}, {'measure': 'Number of Participants with stroke recurrence', 'timeFrame': '12 months after stroke onset', 'description': 'stroke recurrence with new lesions on DWI'}, {'measure': 'Evolution of intracranial atherosclerosis burden', 'timeFrame': '6 months after stroke onset', 'description': 'Changes of plaque and thrombus volume on HR-MRI images at the admission and the follow-up'}], 'secondaryOutcomes': [{'measure': 'Number of Participants with Death due to Heart Disease, Cerebravascular Disease or Other Vascular Etiology', 'timeFrame': '12 months after stroke onset', 'description': 'death due to stroke, intracranial hemorrhage,heart attack,heart failure, arrhythmia,pulmonary embolism,visceral hemorrhage or other vascular etiology'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Acute Ischemic Stroke', 'Intracranial Atherosclerosis ICAS', 'HRMRI'], 'conditions': ['Acute Ischemic Stroke AIS', 'Intracranial Atherosclerosis ICAS']}, 'referencesModule': {'references': [{'pmid': '19041971', 'type': 'BACKGROUND', 'citation': 'Li ML, Xu WH, Song L, Feng F, You H, Ni J, Gao S, Cui LY, Jin ZY. Atherosclerosis of middle cerebral artery: evaluation with high-resolution MR imaging at 3T. Atherosclerosis. 2009 Jun;204(2):447-52. doi: 10.1016/j.atherosclerosis.2008.10.019. Epub 2008 Oct 25.'}, {'pmid': '18309170', 'type': 'BACKGROUND', 'citation': 'Mazighi M, Labreuche J, Gongora-Rivera F, Duyckaerts C, Hauw JJ, Amarenco P. Autopsy prevalence of intracranial atherosclerosis in patients with fatal stroke. Stroke. 2008 Apr;39(4):1142-7. doi: 10.1161/STROKEAHA.107.496513. Epub 2008 Feb 28.'}, {'pmid': '20638663', 'type': 'BACKGROUND', 'citation': 'Xu WH, Li ML, Gao S, Ni J, Zhou LX, Yao M, Peng B, Feng F, Jin ZY, Cui LY. In vivo high-resolution MR imaging of symptomatic and asymptomatic middle cerebral artery atherosclerotic stenosis. Atherosclerosis. 2010 Oct;212(2):507-11. doi: 10.1016/j.atherosclerosis.2010.06.035. Epub 2010 Jun 25.'}, {'pmid': '21799160', 'type': 'BACKGROUND', 'citation': 'Xu WH, Li ML, Gao S, Ni J, Zhou LX, Yao M, Peng B, Feng F, Jin ZY, Cui LY. Plaque distribution of stenotic middle cerebral artery and its clinical relevance. Stroke. 2011 Oct;42(10):2957-9. doi: 10.1161/STROKEAHA.111.618132. Epub 2011 Jul 28.'}, {'pmid': '22367991', 'type': 'BACKGROUND', 'citation': 'Xu WH, Li ML, Gao S, Ni J, Yao M, Zhou LX, Peng B, Feng F, Jin ZY, Cui LY. Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance. Ann Neurol. 2012 Feb;71(2):195-8. doi: 10.1002/ana.22626.'}, {'pmid': '24423003', 'type': 'BACKGROUND', 'citation': 'Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S. Intracranial artery atherosclerosis and lumen dilation in cerebral small-vessel diseases: a high-resolution MRI Study. CNS Neurosci Ther. 2014 Apr;20(4):364-7. doi: 10.1111/cns.12224. Epub 2014 Jan 15.'}, {'pmid': '24530171', 'type': 'BACKGROUND', 'citation': 'Xu WH, Li ML, Niu JW, Feng F, Jin ZY, Gao S. Deep tiny flow voids along middle cerebral artery atherosclerotic occlusions: a high-resolution MR imaging study. J Neurol Sci. 2014 Apr 15;339(1-2):130-3. doi: 10.1016/j.jns.2014.01.042. Epub 2014 Feb 6.'}, {'pmid': '25666631', 'type': 'BACKGROUND', 'citation': 'Li M, Wu SW, Xu WH. High-resolution MRI of radiation-induced intracranial vasculopathy. Neurology. 2015 Feb 10;84(6):631. doi: 10.1212/WNL.0000000000001223. No abstract available.'}, {'pmid': '24168957', 'type': 'BACKGROUND', 'citation': 'Derdeyn CP, Chimowitz MI, Lynn MJ, Fiorella D, Turan TN, Janis LS, Montgomery J, Nizam A, Lane BF, Lutsep HL, Barnwell SL, Waters MF, Hoh BL, Hourihane JM, Levy EI, Alexandrov AV, Harrigan MR, Chiu D, Klucznik RP, Clark JM, McDougall CG, Johnson MD, Pride GL Jr, Lynch JR, Zaidat OO, Rumboldt Z, Cloft HJ; Stenting and Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis Trial Investigators. Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial. Lancet. 2014 Jan 25;383(9914):333-41. doi: 10.1016/S0140-6736(13)62038-3. Epub 2013 Oct 26.'}, {'pmid': '27164677', 'type': 'BACKGROUND', 'citation': 'Xu YY, Li ML, Gao S, Hou B, Sun ZY, Zhou HL, Feng F, Xu WH. Non-moyamoya vessel network formation along steno-occlusive middle cerebral artery. Neurology. 2016 May 24;86(21):1957-63. doi: 10.1212/WNL.0000000000002698. Epub 2016 Apr 27.'}]}, 'descriptionModule': {'briefSummary': 'A prospective, multicenter, cohort study to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus high-resolution magnetic resonance (HR-MRI).', 'detailedDescription': '1. First-ever stroke patients attributed to intracranial artery stenosis (\\> 50% or occlusion) within 7 days after onset will be prospectively enrolled in our study and undergo new imaging technique package assessment at baseline.\n2. The imaging technique package includes conventional cranial MRI （T1,T2,T2 FLAIR,DWI), cranial magnetic resonance angiography (MRA),high-resolution magnetic resonance (HR-MRI) and susceptibility weighted imaging (SWI) or T2\\*-weighted imaging.\n3. Enrolled patients are recommended to receive aggressive medical management consisted of Aspirin (100 mg daily) and Clopidogrel (75 mg daily) for 3 months and Rosuvastatin (20mg daily) for at least 6 months as well as traditional risk factors management.\n4. Patients were followed up for mRS score, stroke recurrence, medication compliance and laboratory examination including blood routine tests, liver functions and creatine kinase et al at 3 months, 6 months and 12 months after stroke onset. Additionally, patients are required to retake new HRMRI imaging of brain at 6 months.Remote patient education by We-Chat will be performed.\n5. Our study aims to explore the stroke mechanisms of symptomatic intracranial atherosclerosis, the dynamic changes under aggressive medical treatment and their associations with clinical events using conventional MRI sequences plus HR-MRI.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '35 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'hospital based population', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Age 35-80 years old\n2. First-ever stroke patients confirmed by diffusion weighted imaging (DWI) attributed to intracranial artery stenosis (\\> 50%) within 7 days after onset.\n3. Patients with stable vital signs.\n4. Patients who have underwent thrombolytic/intravascular therapy are allowed to enroll in the study.\n\nExclusion Criteria:\n\n1. Patients with \\> 50% ipsilateral carotid artery stenosis, cardiac embolism ,and any other stroke etiologies such as vasculitis, dissection or other causes.\n2. Patients with absolute/relative contraindication to MRI (including but not confined to metal in the body and claustrophobia).\n3. Patients who cannot comply with MRI exam.\n4. Patients who decline the consent.'}, 'identificationModule': {'nctId': 'NCT03719820', 'acronym': 'SIPS-ICAS', 'briefTitle': 'Stroke Imaging Package Study of Intracranial Atherosclerosis ( SIPS-ICAS )', 'organization': {'class': 'OTHER', 'fullName': 'Peking Union Medical College Hospital'}, 'officialTitle': 'Stroke Imaging Package Study of Intracranial Atherosclerosis', 'orgStudyIdInfo': {'id': 'HRMRI II'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'Intracranial Atherosclerosis', 'description': 'First-ever stroke patients attributed to intracranial artery stenosis (\\> 50% or occlusion) who receive aggressive medical management', 'interventionNames': ['Drug: aggressive medical management']}], 'interventions': [{'name': 'aggressive medical management', 'type': 'DRUG', 'otherNames': ['Aspirin', 'Clopidogrel', 'Rosuvastatin'], 'description': 'Aspirin (100 mg daily) and Clopidogrel (75 mg daily) for 3 months and Rosuvastatin (20mg daily) for at least 6 months as well as traditional risk factors management', 'armGroupLabels': ['Intracranial Atherosclerosis']}]}, 'contactsLocationsModule': {'locations': [{'zip': '100010', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Tao Gong', 'role': 'CONTACT', 'email': 'gb20598@sina.com', 'phone': '13718907701'}], 'facility': 'Beijing Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100010', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jiawei Wang', 'role': 'CONTACT', 'email': 'wangjwcq@1163.com', 'phone': '18811612263'}], 'facility': 'Beijing Tongren Hospital Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100020', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Guangzhi Liu', 'role': 'CONTACT', 'email': 'guangzhi2002@hotmali.com', 'phone': '13391777952'}], 'facility': 'Beijing Anzhen Hospital Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100020', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Wenli Hu', 'role': 'CONTACT', 'email': 'huwenli@sina.com', 'phone': '13552983366'}], 'facility': 'Beijing Chao-Yang hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100020', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Dantao Peng', 'role': 'CONTACT', 'email': '18513415053@163.com', 'phone': '13910908579'}], 'facility': 'China-Japan Friendship Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100032', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yongbo Zhang', 'role': 'CONTACT', 'email': 'ybzhangcn@sina.com', 'phone': '13552909549'}], 'facility': 'Beijing Friendship Hospital Capital Medical University', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100032', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Yining Huang', 'role': 'CONTACT', 'email': 'ynhuang@sina.com', 'phone': '13910432166'}], 'facility': 'Peking University First Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100039', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Shiwen Wu, MD', 'role': 'CONTACT', 'email': 'neurowu@gmail.com', 'phone': '13910238117'}], 'facility': 'General Hospital of Chinese Armed Police Forces', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '100730', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Weihai Xu, MD', 'role': 'CONTACT', 'email': 'xuwh@pumch.cn', 'phone': '010-69156372'}], 'facility': 'Peking Union Medical College Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'zip': '102200', 'city': 'Beijing', 'state': 'Beijing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xianzeng Liu', 'role': 'CONTACT', 'email': 'liuxianzeng@pkuih.edu.cn', 'phone': '13911879817'}], 'facility': 'Peking University International Hospital', 'geoPoint': {'lat': 39.9075, 'lon': 116.39723}}, {'city': 'Chongqing', 'state': 'Chongqing Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhenhua Zhou', 'role': 'CONTACT', 'email': 'exploiter001@126.com'}], 'facility': 'The first affiliated hospital affiliated to AMU (Southwest Hospital)', 'geoPoint': {'lat': 29.56026, 'lon': 106.55771}}, {'zip': '350001', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Changyun Liu, MD', 'role': 'CONTACT', 'email': '13365910778@139.com', 'phone': '13365910778'}], 'facility': 'Fujian Medical University Union Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '510630', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhengqi Lu', 'role': 'CONTACT', 'email': 'lzq1828@aliyun.com', 'phone': '13570102668'}], 'facility': 'The Third Affiliated Hospital of Sun Yat-sen University', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '518000', 'city': 'Shenzhen', 'state': 'Guangdong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaofan Chu', 'role': 'CONTACT', 'email': 'chuxf@hku-szh.org'}], 'facility': 'The University of HongKong-Shenzhen Hospital', 'geoPoint': {'lat': 22.54554, 'lon': 114.0683}}, {'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Litao Li', 'role': 'CONTACT', 'email': 'dingding51800@163.com'}], 'facility': 'Hebei General Hospital', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaoyun Liu', 'role': 'CONTACT', 'email': 'AUDREY-L@163.com'}], 'facility': 'The Second Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '063000', 'city': 'Tangshan', 'state': 'Hebei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Baoquan Lu', 'role': 'CONTACT', 'email': 'balcom@163.com', 'phone': '13930565557'}], 'facility': 'Tangshan Gongren Hospital', 'geoPoint': {'lat': 39.64381, 'lon': 118.18319}}, {'city': 'Shuangyashan', 'state': 'Heilongjiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Degang Sun', 'role': 'CONTACT'}], 'facility': 'Hong Xinglong Central Hospital', 'geoPoint': {'lat': 46.67686, 'lon': 131.13273}}, {'city': 'Nanyang', 'state': 'Henan', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaohua Xiao', 'role': 'CONTACT', 'email': '2207988910@qq.com'}], 'facility': 'Nanshi Hospital of Nanyang', 'geoPoint': {'lat': 32.99472, 'lon': 112.53278}}, {'city': 'Shiyan', 'state': 'Hubei', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhibing Ai', 'role': 'CONTACT'}], 'facility': 'Affiliated Taihe Hospital of Hubei University of Medicine', 'geoPoint': {'lat': 32.6475, 'lon': 110.77806}}, {'zip': '430000', 'city': 'Wuhan', 'state': 'Hubei', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Daishi Tian', 'role': 'CONTACT', 'email': 'tiands@foxmail.com'}], 'facility': 'Tongji Hospital, Huazhong University of Science and Technology', 'geoPoint': {'lat': 30.58333, 'lon': 114.26667}}, {'zip': 'Hunan', 'city': 'Hengyang', 'state': 'Hunan', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'The First Affiliated Hospital of University of South China', 'geoPoint': {'lat': 26.88946, 'lon': 112.61888}}, {'zip': '225001', 'city': 'Yangzhou', 'state': 'Jiangsu', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jun Xu, MD', 'role': 'CONTACT', 'email': '13611572068@126.com', 'phone': '18051061768'}], 'facility': "Subei People's Hospital of Jiangsu Province", 'geoPoint': {'lat': 32.39722, 'lon': 119.43583}}, {'city': 'Changchun', 'state': 'Jilin', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Le Fang, MD', 'role': 'CONTACT', 'email': 'drfangle@sina.com'}], 'facility': 'China-Japan Union Hospital, Jilin University', 'geoPoint': {'lat': 43.88, 'lon': 125.32278}}, {'zip': '110840', 'city': 'Shenyang', 'state': 'Liaoning', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Huishen Chen, MD', 'role': 'CONTACT', 'email': 'chszh@aliyun.com', 'phone': '13352452086'}], 'facility': 'General Hospital of Shen Yang Millitary Command', 'geoPoint': {'lat': 41.79222, 'lon': 123.43278}}, {'city': 'Yinchuan', 'state': 'Ningxia', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhimin Shi', 'role': 'CONTACT'}], 'facility': "People's Hospital Ningxia Hui Autonomous Region", 'geoPoint': {'lat': 38.46806, 'lon': 106.27306}}, {'city': 'Jinan', 'state': 'Shandong', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'China', 'facility': 'Shandong Provincial Hospital', 'geoPoint': {'lat': 36.66833, 'lon': 116.99722}}, {'zip': '272000', 'city': 'Jining', 'state': 'Shandong', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Zhongrui Yan', 'role': 'CONTACT', 'email': 'zhongruiy@163.com', 'phone': '18678769700'}], 'facility': 'JiNing NO.1 People Hospital', 'geoPoint': {'lat': 35.405, 'lon': 116.58139}}, {'zip': '266000', 'city': 'Qingdao', 'state': 'Shandong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jintai Yu', 'role': 'CONTACT', 'email': 'yu-jintai@163.com'}], 'facility': 'Qingdao Municipal Hospital', 'geoPoint': {'lat': 36.06488, 'lon': 120.38042}}, {'zip': '266555', 'city': 'Qingdao', 'state': 'Shandong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Haifeng Li', 'role': 'CONTACT', 'email': 'drlhf@163.com', 'phone': '18561810375'}], 'facility': 'Qilu Hospital of Shandong University (Qingdao)', 'geoPoint': {'lat': 36.06488, 'lon': 120.38042}}, {'city': 'Weihai', 'state': 'Shandong', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Haixia Zhang', 'role': 'CONTACT', 'email': '371704058@qq.com'}], 'facility': 'Weihai Municipal Hospital', 'geoPoint': {'lat': 37.50914, 'lon': 122.11356}}, {'zip': '200050', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Jun Liu', 'role': 'CONTACT', 'email': 'jly0520@hotmail.com'}], 'facility': 'Shanghai Ruijin Hospital, Shanghai Jiaotong University School of Medicine', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'zip': '200050', 'city': 'Shanghai', 'state': 'Shanghai Municipality', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Ailian Du', 'role': 'CONTACT', 'email': 'lotusdu@126.com'}], 'facility': 'Tongren Hospital, Shanghai Jiaotong University School of Medicine', 'geoPoint': {'lat': 31.22222, 'lon': 121.45806}}, {'city': 'Changzhi', 'state': 'Shanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Lifang Zhang', 'role': 'CONTACT'}], 'facility': "Changzhi People's Hospital", 'geoPoint': {'lat': 36.18389, 'lon': 113.10528}}, {'city': 'Taiyuan', 'state': 'Shanxi', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Weirong Li', 'role': 'CONTACT'}], 'facility': 'Taiyuan Central Hospital of Shanxi Meidical University', 'geoPoint': {'lat': 37.86944, 'lon': 112.56028}}, {'zip': '610000', 'city': 'Chengdu', 'state': 'Sichuan', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Bo Wu', 'role': 'CONTACT', 'email': 'dr.bowu@hotmail.com'}], 'facility': 'West China Hospital of Sichuan University', 'geoPoint': {'lat': 30.66667, 'lon': 104.06667}}, {'city': 'Hangzhou', 'state': 'Zhejiang', 'status': 'RECRUITING', 'country': 'China', 'contacts': [{'name': 'Hui Liang', 'role': 'CONTACT', 'email': 'wen1937@163.com'}], 'facility': 'First Affiliated Hospital of Zhejiang University', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}, {'city': 'Hangzhou', 'state': 'Zhejiang', 'status': 'NOT_YET_RECRUITING', 'country': 'China', 'contacts': [{'name': 'Xiaodong Zou', 'role': 'CONTACT'}], 'facility': 'Zhejiang Provincial Tongde Hospital', 'geoPoint': {'lat': 30.29365, 'lon': 120.16142}}], 'centralContacts': [{'name': 'Weihai Xu, MD', 'role': 'CONTACT', 'email': 'xuwh@pumch.cn', 'phone': '010-69156114'}, {'name': 'Yining Huang, MD', 'role': 'CONTACT', 'email': 'ynhuang@sina.com'}], 'overallOfficials': [{'name': 'Weihai Xu, MD', 'role': 'STUDY_CHAIR', 'affiliation': 'Peking Union Medical College Hospital'}]}, 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