Ignite Creation Date:
2025-12-25 @ 4:23 AM
Ignite Modification Date:
2025-12-26 @ 3:26 AM
Study NCT ID:
NCT01310920
Status:
UNKNOWN
Last Update Posted:
2011-03-09
First Post:
2011-03-06
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D012804', 'term': 'Sick Sinus Syndrome'}], 'ancestors': [{'id': 'D001146', 'term': 'Arrhythmia, Sinus'}, {'id': 'D001145', 'term': 'Arrhythmias, Cardiac'}, {'id': 'D006331', 'term': 'Heart Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D006327', 'term': 'Heart Block'}, {'id': 'D000075224', 'term': 'Cardiac Conduction System Disease'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D019370', 'term': 'Observation'}], 'ancestors': [{'id': 'D008722', 'term': 'Methods'}, {'id': 'D008919', 'term': 'Investigative Techniques'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'observationalModel': 'CASE_CONTROL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 400}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'RECRUITING', 'startDateStruct': {'date': '2011-02'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2011-03', 'lastUpdateSubmitDate': '2011-03-08', 'studyFirstSubmitDate': '2011-03-06', 'studyFirstSubmitQcDate': '2011-03-08', 'lastUpdatePostDateStruct': {'date': '2011-03-09', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2011-03-09', 'type': 'ESTIMATED'}}, 'conditionsModule': {'conditions': ['Sick Sinus Syndrome']}, 'referencesModule': {'references': [{'pmid': '10706901', 'type': 'BACKGROUND', 'citation': 'Mangrum JM, DiMarco JP. The evaluation and management of bradycardia. N Engl J Med. 2000 Mar 9;342(10):703-9. doi: 10.1056/NEJM200003093421006. No abstract available.'}]}, 'descriptionModule': {'briefSummary': 'Evidence has been documented for the close relationship between the arrhythmia pathogenesis and the gene expression in renin-angiotensin system. However, it remains unclear for involvement of RAS in the pathogenesis of non-familial sick sinus syndrome. The researchers thus investigated the possible relationship between non-familial sick sinus syndrome and the polymorphism and haplotype of the AGT promoter.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'The case group includes 200 patients and the control group includes 200 patients.', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* sick sinus syndrome\n\nExclusion Criteria:\n\n* 1.Severe systemic disease.\n* 2.Acute coronary syndrome.\n* 3.bradycardia with reversible cause.'}, 'identificationModule': {'nctId': 'NCT01310920', 'briefTitle': 'The Role of Angiotensinogen Gene Polymorphism in the Pathogenesis of Non-familial Sick Sinus Syndrome', 'organization': {'class': 'OTHER', 'fullName': 'China Medical University Hospital'}, 'orgStudyIdInfo': {'id': 'DMR99-IRB-316'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'sick sinus syndrome', 'interventionNames': ['Other: observation']}, {'label': 'control'}], 'interventions': [{'name': 'observation', 'type': 'OTHER', 'description': 'genotyping', 'armGroupLabels': ['sick sinus syndrome']}]}, 'contactsLocationsModule': {'locations': [{'zip': '404', 'city': 'Dawan', 'state': 'Taiwan', 'status': 'RECRUITING', 'country': 'Taiwan', 'contacts': [{'name': 'Jan-Yow Chen, M.D.', 'role': 'CONTACT', 'email': 'janyow@ms77.hinet.net', 'phone': '+886-4-22062121', 'phoneExt': '2311'}, {'name': 'Jan-Yow Chen, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'China Medical University Hospital', 'geoPoint': {'lat': 23.20917, 'lon': 120.18722}}], 'centralContacts': [{'name': 'Jan-Yow Chen, MD', 'role': 'CONTACT', 'email': 'janyow@ms77.hinet.net', 'phone': '+886-4-22062121', 'phoneExt': '2311'}], 'overallOfficials': [{'name': 'Jan-Yow Chen, M.D.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'China Medical University Hospital'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'China Medical University Hospital', 'class': 'OTHER'}, 'responsibleParty': {'oldNameTitle': 'Jan-Yow Chen', 'oldOrganization': 'China Medical University hospital'}}}}