Ignite Creation Date:
2025-12-25 @ 4:23 AM
Ignite Modification Date:
2025-12-26 @ 3:26 AM
Study NCT ID:
NCT04714320
Status:
COMPLETED
Last Update Posted:
2025-02-18
First Post:
2021-01-14
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'submissionTracking': {'firstMcpInfo': {'postDateStruct': {'date': '2024-10-09', 'type': 'ACTUAL'}}}}, 'conditionBrowseModule': {'meshes': [{'id': 'D006973', 'term': 'Hypertension'}], 'ancestors': [{'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'globalregulatoryaffairs@ionis.com', 'phone': '760-603-2346', 'title': 'Ionis Pharmaceuticals, Inc.', 'organization': 'Ionis Pharmaceuticals, Inc.'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'timeFrame': 'From signing of informed consent up to end of post-treatment period (up to 25 weeks)', 'description': 'Safety set included all randomized participants that received at least 1 dose of study drug.', 'eventGroups': [{'id': 'EG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.', 'otherNumAtRisk': 53, 'deathsNumAtRisk': 53, 'otherNumAffected': 9, 'seriousNumAtRisk': 53, 'deathsNumAffected': 0, 'seriousNumAffected': 1}, {'id': 'EG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.', 'otherNumAtRisk': 54, 'deathsNumAtRisk': 54, 'otherNumAffected': 18, 'seriousNumAtRisk': 54, 'deathsNumAffected': 0, 'seriousNumAffected': 2}, {'id': 'EG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.', 'otherNumAtRisk': 53, 'deathsNumAtRisk': 53, 'otherNumAffected': 14, 'seriousNumAtRisk': 53, 'deathsNumAffected': 1, 'seriousNumAffected': 1}], 'otherEvents': [{'term': 'Nausea', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Vomiting', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 2}], 'organSystem': 'Gastrointestinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Injection site erythema', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 3}], 'organSystem': 'General disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'COVID-19', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 3}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Urinary tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 3}], 'organSystem': 'Infections and infestations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Alanine aminotransferase increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 1}], 'organSystem': 'Investigations', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Hyperkalaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 4}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 0}], 'organSystem': 'Metabolism and nutrition disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Arthralgia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 1}], 'organSystem': 'Musculoskeletal and connective tissue disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 4}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 2}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Hypertension', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 2}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}], 'seriousEvents': [{'term': 'Atrial fibrillation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 0}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Cardiac arrest', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 1}], 'organSystem': 'Cardiac disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Cerebral infarction', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Transient ischaemic attack', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 0}], 'organSystem': 'Nervous system disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Respiratory failure', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}, {'term': 'Aortic dissection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 53, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 54, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 53, 'numAffected': 1}], 'organSystem': 'Vascular disorders', 'assessmentType': 'SYSTEMATIC_ASSESSMENT', 'sourceVocabulary': 'MedDRA 24.0'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Change From Baseline in Seated Automated Office SBP to Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'categories': [{'measurements': [{'value': '-9', 'groupId': 'OG000', 'lowerLimit': '-14', 'upperLimit': '-3'}, {'value': '-13', 'groupId': 'OG001', 'lowerLimit': '-18', 'upperLimit': '-8'}, {'value': '-9', 'groupId': 'OG002', 'lowerLimit': '-14', 'upperLimit': '-4'}]}]}], 'analyses': [{'pValue': '=0.135', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening estimated glomerular filtration rate (eGFR) status \\[\\<60 vs. ≥60 mL/min/1.73 m\\^2\\]), treatment received, and baseline measure were included in the analysis of covariate (ANCOVA) model as independent variables.', 'groupDescription': 'Change From Baseline in Seated Automated Office SBP to Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.867', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change From Baseline in Seated Automated Office SBP to Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'LEAST_SQUARES_MEAN', 'timeFrame': 'Baseline to Day 85', 'unitOfMeasure': 'mmHg', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the treatment period and prior to Day 85, and had no significant protocol deviations that would have been expected to affect efficacy assessment.'}, {'type': 'SECONDARY', 'title': 'Absolute Concentration of Plasma AGT at Each Scheduled, Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'At Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '878.36', 'spread': '239.895', 'groupId': 'OG000'}, {'value': '575.68', 'spread': '248.708', 'groupId': 'OG001'}, {'value': '446.29', 'spread': '189.521', 'groupId': 'OG002'}]}]}, {'title': 'At Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '836.74', 'spread': '228.202', 'groupId': 'OG000'}, {'value': '388.61', 'spread': '193.723', 'groupId': 'OG001'}, {'value': '293.27', 'spread': '129.051', 'groupId': 'OG002'}]}]}, {'title': 'At Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '837.24', 'spread': '251.610', 'groupId': 'OG000'}, {'value': '319.86', 'spread': '180.741', 'groupId': 'OG001'}, {'value': '239.02', 'spread': '133.633', 'groupId': 'OG002'}]}]}, {'title': 'At Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '848.45', 'spread': '256.088', 'groupId': 'OG000'}, {'value': '303.03', 'spread': '168.530', 'groupId': 'OG001'}, {'value': '293.12', 'spread': '157.651', 'groupId': 'OG002'}]}]}, {'title': 'At Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '790.50', 'spread': '256.568', 'groupId': 'OG000'}, {'value': '308.99', 'spread': '174.893', 'groupId': 'OG001'}, {'value': '308.86', 'spread': '156.533', 'groupId': 'OG002'}]}]}, {'title': 'At Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '793.77', 'spread': '202.796', 'groupId': 'OG000'}, {'value': '328.28', 'spread': '199.364', 'groupId': 'OG001'}, {'value': '321.71', 'spread': '176.356', 'groupId': 'OG002'}]}]}, {'title': 'At Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '748.11', 'spread': '204.231', 'groupId': 'OG000'}, {'value': '330.68', 'spread': '176.868', 'groupId': 'OG001'}, {'value': '317.93', 'spread': '159.204', 'groupId': 'OG002'}]}]}, {'title': 'At Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '756.89', 'spread': '212.891', 'groupId': 'OG000'}, {'value': '429.04', 'spread': '175.316', 'groupId': 'OG001'}, {'value': '443.95', 'spread': '196.226', 'groupId': 'OG002'}]}]}, {'title': 'At Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '746.63', 'spread': '190.789', 'groupId': 'OG000'}, {'value': '531.33', 'spread': '203.681', 'groupId': 'OG001'}, {'value': '562.27', 'spread': '202.035', 'groupId': 'OG002'}]}]}, {'title': 'At Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '753.35', 'spread': '186.906', 'groupId': 'OG000'}, {'value': '658.33', 'spread': '248.413', 'groupId': 'OG001'}, {'value': '662.13', 'spread': '130.207', 'groupId': 'OG002'}]}]}, {'title': 'At Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '797.92', 'spread': '238.442', 'groupId': 'OG000'}, {'value': '676.60', 'spread': '236.881', 'groupId': 'OG001'}, {'value': '700.48', 'spread': '195.702', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'Days 15, 29, 43, 57, 71, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'nmol/L', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the Treatment Period and prior to Study Day 85, and have no significant protocol deviations that would be expected to affect efficacy assessment. 'Number analyzed' indicates the number of participants with data available for analysis at the specified time point."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Plasma AGT to Each Scheduled, Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'Baseline', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '833.42', 'spread': '196.561', 'groupId': 'OG000'}, {'value': '877.70', 'spread': '290.487', 'groupId': 'OG001'}, {'value': '836.60', 'spread': '189.204', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '44.94', 'spread': '137.033', 'groupId': 'OG000'}, {'value': '-303.67', 'spread': '187.426', 'groupId': 'OG001'}, {'value': '-390.31', 'spread': '189.039', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '3.31', 'spread': '132.768', 'groupId': 'OG000'}, {'value': '-489.09', 'spread': '260.294', 'groupId': 'OG001'}, {'value': '-543.33', 'spread': '211.294', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '8.15', 'spread': '152.008', 'groupId': 'OG000'}, {'value': '-557.84', 'spread': '267.373', 'groupId': 'OG001'}, {'value': '-544.34', 'spread': '227.409', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '15.03', 'spread': '182.246', 'groupId': 'OG000'}, {'value': '-577.72', 'spread': '282.528', 'groupId': 'OG001'}, {'value': '-542.84', 'spread': '223.631', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-47.31', 'spread': '239.488', 'groupId': 'OG000'}, {'value': '-578.49', 'spread': '276.950', 'groupId': 'OG001'}, {'value': '-522.65', 'spread': '216.465', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-39.65', 'spread': '171.289', 'groupId': 'OG000'}, {'value': '-544.60', 'spread': '314.195', 'groupId': 'OG001'}, {'value': '-517.42', 'spread': '230.730', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-73.33', 'spread': '153.744', 'groupId': 'OG000'}, {'value': '-542.20', 'spread': '281.935', 'groupId': 'OG001'}, {'value': '-523.31', 'spread': '219.037', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-57.84', 'spread': '169.818', 'groupId': 'OG000'}, {'value': '-449.05', 'spread': '288.731', 'groupId': 'OG001'}, {'value': '-395.60', 'spread': '218.864', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-64.61', 'spread': '131.455', 'groupId': 'OG000'}, {'value': '-341.33', 'spread': '259.403', 'groupId': 'OG001'}, {'value': '-282.34', 'spread': '182.477', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-62.29', 'spread': '153.117', 'groupId': 'OG000'}, {'value': '-225.14', 'spread': '233.595', 'groupId': 'OG001'}, {'value': '-165.06', 'spread': '139.585', 'groupId': 'OG002'}]}]}, {'title': 'Change From Baseline at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-18.31', 'spread': '170.377', 'groupId': 'OG000'}, {'value': '-189.48', 'spread': '260.868', 'groupId': 'OG001'}, {'value': '-129.72', 'spread': '146.013', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change From Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change From Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 43', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 43', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 71', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 71', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 85', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 85', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 92', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 92', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 106', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 106', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables', 'groupDescription': 'Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables', 'groupDescription': 'Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 148', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.002', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 148', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 169', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.002', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 169', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, Days 15, 29, 43, 57, 71, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'nmol/L', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the treatment period and prior to Day 85, and had no significant protocol deviations that would have been expected to affect efficacy assessment. 'Number analyzed' indicates the number of participants with data available for analysis at the specified time point."}, {'type': 'SECONDARY', 'title': 'Percent Change From Baseline in Plasma AGT at Each Scheduled, Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'Percent Change from Baseline at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '5.6', 'spread': '16.8', 'groupId': 'OG000'}, {'value': '-34.3', 'spread': '17.2', 'groupId': 'OG001'}, {'value': '-46.4', 'spread': '18.8', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '0.5', 'spread': '16.7', 'groupId': 'OG000'}, {'value': '-54.4', 'spread': '18.3', 'groupId': 'OG001'}, {'value': '-63.6', 'spread': '17.5', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '0.3', 'spread': '18.6', 'groupId': 'OG000'}, {'value': '-62.4', 'spread': '16.5', 'groupId': 'OG001'}, {'value': '-63.2', 'spread': '20.4', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '1.6', 'spread': '21.1', 'groupId': 'OG000'}, {'value': '-63.7', 'spread': '17.9', 'groupId': 'OG001'}, {'value': '-64.0', 'spread': '18.3', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-4.8', 'spread': '25.5', 'groupId': 'OG000'}, {'value': '-63.3', 'spread': '19.4', 'groupId': 'OG001'}, {'value': '-62.0', 'spread': '19.0', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-3.3', 'spread': '19.6', 'groupId': 'OG000'}, {'value': '-59.2', 'spread': '27.4', 'groupId': 'OG001'}, {'value': '-60.7', 'spread': '23.1', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-8.3', 'spread': '19.5', 'groupId': 'OG000'}, {'value': '-60.0', 'spread': '18.7', 'groupId': 'OG001'}, {'value': '-61.4', 'spread': '19.0', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-6.3', 'spread': '20.4', 'groupId': 'OG000'}, {'value': '-47.6', 'spread': '22.8', 'groupId': 'OG001'}, {'value': '-46.4', 'spread': '21.9', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-7.3', 'spread': '14.9', 'groupId': 'OG000'}, {'value': '-36.3', 'spread': '20.6', 'groupId': 'OG001'}, {'value': '-33.2', 'spread': '20.0', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-6.1', 'spread': '20.0', 'groupId': 'OG000'}, {'value': '-22.8', 'spread': '25.4', 'groupId': 'OG001'}, {'value': '-18.4', 'spread': '15.9', 'groupId': 'OG002'}]}]}, {'title': 'Percent Change from Baseline at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-2.0', 'spread': '19.8', 'groupId': 'OG000'}, {'value': '-18.3', 'spread': '29.6', 'groupId': 'OG001'}, {'value': '-15.2', 'spread': '17.3', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day at 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day at 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 43', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 43', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 71', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 71', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 85', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 85', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 92', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received were included in the Van Elteren model as independent variables', 'groupDescription': 'Percent Change from Baseline at Day 92', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 106', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 106', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 148', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.005', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 148', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '<0.001', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 169', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.002', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received were included in the Van Elteren model as independent variables.', 'groupDescription': 'Percent Change from Baseline at Day 169', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, Days 15, 29, 43, 57, 71, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'percent change', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of 12 doses of study drug did not alter antihypertensive medications during treatment period \\& prior to Day 85 have no significant protocol deviations that would be expected to affect efficacy assessment. 'Number analyzed' indicates number of participants with data available for analysis at specified time point."}, {'type': 'SECONDARY', 'title': 'Change From Baseline to Study Day 85 in 24-hour Mean SBP and Diastolic Blood Pressure (DBP) Measured by Ambulatory Blood Pressure Monitoring (ABPM)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '34', 'groupId': 'OG000'}, {'value': '35', 'groupId': 'OG001'}, {'value': '36', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'Change from Baseline in 24-hour Mean SBP at Day 85', 'categories': [{'measurements': [{'value': '-1.362', 'groupId': 'OG000', 'lowerLimit': '-5.696', 'upperLimit': '2.973'}, {'value': '-5.675', 'groupId': 'OG001', 'lowerLimit': '-9.631', 'upperLimit': '-1.718'}, {'value': '-0.862', 'groupId': 'OG002', 'lowerLimit': '-5.035', 'upperLimit': '3.311'}]}]}, {'title': 'Change from Baseline in 24-hour Mean DBP at Day 85', 'categories': [{'measurements': [{'value': '-1.667', 'groupId': 'OG000', 'lowerLimit': '-4.201', 'upperLimit': '0.867'}, {'value': '-4.406', 'groupId': 'OG001', 'lowerLimit': '-6.725', 'upperLimit': '-2.087'}, {'value': '-2.792', 'groupId': 'OG002', 'lowerLimit': '-5.214', 'upperLimit': '-0.369'}]}]}], 'analyses': [{'pValue': '=0.094', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline in 24-hour Mean SBP at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.842', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline in 24-hour Mean SBP at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.066', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change From Baseline in 24-hour Mean DBP at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.442', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change From Baseline in 24-hour Mean DBP at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'LEAST_SQUARES_MEAN', 'timeFrame': 'Baseline, Day 85', 'unitOfMeasure': 'mmHg', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the Treatment Period and prior to Study Day 85, and have no significant protocol deviations that would be expected to affect efficacy assessment. 'Overall number of participants analyzed' indicates the number of participants with data available for the analysis of this outcome measure."}, {'type': 'SECONDARY', 'title': 'Percentage of Participants Who Achieved Seated Automated Office SBP ≤ 140 mmHg, DBP ≤ 90 mmHg, and Both at Each Scheduled Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '37.5', 'groupId': 'OG000'}, {'value': '38.5', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '31.3', 'groupId': 'OG000'}, {'value': '53.8', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '31.3', 'groupId': 'OG000'}, {'value': '65.4', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '46.9', 'groupId': 'OG000'}, {'value': '53.8', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '48.4', 'groupId': 'OG000'}, {'value': '60.0', 'groupId': 'OG001'}, {'value': '52.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '40.6', 'groupId': 'OG000'}, {'value': '69.2', 'groupId': 'OG001'}, {'value': '45.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '58.1', 'groupId': 'OG000'}, {'value': '57.7', 'groupId': 'OG001'}, {'value': '41.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '46.9', 'groupId': 'OG000'}, {'value': '53.8', 'groupId': 'OG001'}, {'value': '56.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '22', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '59.4', 'groupId': 'OG000'}, {'value': '36.0', 'groupId': 'OG001'}, {'value': '68.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '48.4', 'groupId': 'OG000'}, {'value': '48.0', 'groupId': 'OG001'}, {'value': '56.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '56.7', 'groupId': 'OG000'}, {'value': '50.0', 'groupId': 'OG001'}, {'value': '58.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '40.6', 'groupId': 'OG000'}, {'value': '64.0', 'groupId': 'OG001'}, {'value': '33.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '21', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '55.2', 'groupId': 'OG000'}, {'value': '52.0', 'groupId': 'OG001'}, {'value': '23.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '23', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '55.2', 'groupId': 'OG000'}, {'value': '60.9', 'groupId': 'OG001'}, {'value': '56.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '27', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '51.9', 'groupId': 'OG000'}, {'value': '48.0', 'groupId': 'OG001'}, {'value': '43.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '44.8', 'groupId': 'OG000'}, {'value': '48.0', 'groupId': 'OG001'}, {'value': '34.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'OG000'}, {'value': '24', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '50.0', 'groupId': 'OG000'}, {'value': '58.3', 'groupId': 'OG001'}, {'value': '37.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '81.3', 'groupId': 'OG000'}, {'value': '73.1', 'groupId': 'OG001'}, {'value': '72.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '78.1', 'groupId': 'OG000'}, {'value': '80.8', 'groupId': 'OG001'}, {'value': '88.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '87.5', 'groupId': 'OG000'}, {'value': '88.5', 'groupId': 'OG001'}, {'value': '72.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '81.3', 'groupId': 'OG000'}, {'value': '88.5', 'groupId': 'OG001'}, {'value': '80.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '83.9', 'groupId': 'OG000'}, {'value': '92.0', 'groupId': 'OG001'}, {'value': '92.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '90.6', 'groupId': 'OG000'}, {'value': '84.6', 'groupId': 'OG001'}, {'value': '79.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '87.1', 'groupId': 'OG000'}, {'value': '96.2', 'groupId': 'OG001'}, {'value': '83.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '90.6', 'groupId': 'OG000'}, {'value': '80.8', 'groupId': 'OG001'}, {'value': '82.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '22', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '96.9', 'groupId': 'OG000'}, {'value': '80.0', 'groupId': 'OG001'}, {'value': '86.4', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '93.5', 'groupId': 'OG000'}, {'value': '84.0', 'groupId': 'OG001'}, {'value': '92.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '93.3', 'groupId': 'OG000'}, {'value': '84.6', 'groupId': 'OG001'}, {'value': '79.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '81.3', 'groupId': 'OG000'}, {'value': '88.0', 'groupId': 'OG001'}, {'value': '83.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '21', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '82.8', 'groupId': 'OG000'}, {'value': '88.0', 'groupId': 'OG001'}, {'value': '85.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '23', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '86.2', 'groupId': 'OG000'}, {'value': '95.7', 'groupId': 'OG001'}, {'value': '82.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '27', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '81.5', 'groupId': 'OG000'}, {'value': '72.0', 'groupId': 'OG001'}, {'value': '95.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '82.8', 'groupId': 'OG000'}, {'value': '80.0', 'groupId': 'OG001'}, {'value': '95.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 90 mmHg at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'OG000'}, {'value': '24', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '86.7', 'groupId': 'OG000'}, {'value': '83.3', 'groupId': 'OG001'}, {'value': '87.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '37.5', 'groupId': 'OG000'}, {'value': '34.6', 'groupId': 'OG001'}, {'value': '36.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '28.1', 'groupId': 'OG000'}, {'value': '50.0', 'groupId': 'OG001'}, {'value': '36.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '28.1', 'groupId': 'OG000'}, {'value': '65.4', 'groupId': 'OG001'}, {'value': '36.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '46.9', 'groupId': 'OG000'}, {'value': '50.0', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '45.2', 'groupId': 'OG000'}, {'value': '57.7', 'groupId': 'OG001'}, {'value': '52.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '40.6', 'groupId': 'OG000'}, {'value': '65.4', 'groupId': 'OG001'}, {'value': '41.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '58.1', 'groupId': 'OG000'}, {'value': '57.7', 'groupId': 'OG001'}, {'value': '37.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '46.9', 'groupId': 'OG000'}, {'value': '50.0', 'groupId': 'OG001'}, {'value': '52.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '22', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '59.4', 'groupId': 'OG000'}, {'value': '36.0', 'groupId': 'OG001'}, {'value': '63.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '31', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '25', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '48.4', 'groupId': 'OG000'}, {'value': '44.0', 'groupId': 'OG001'}, {'value': '52.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'OG000'}, {'value': '26', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '56.7', 'groupId': 'OG000'}, {'value': '46.2', 'groupId': 'OG001'}, {'value': '54.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '32', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '40.6', 'groupId': 'OG000'}, {'value': '60.0', 'groupId': 'OG001'}, {'value': '33.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '21', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '51.7', 'groupId': 'OG000'}, {'value': '48.0', 'groupId': 'OG001'}, {'value': '23.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '23', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '55.2', 'groupId': 'OG000'}, {'value': '60.9', 'groupId': 'OG001'}, {'value': '52.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '27', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '51.9', 'groupId': 'OG000'}, {'value': '44.0', 'groupId': 'OG001'}, {'value': '39.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '29', 'groupId': 'OG000'}, {'value': '25', 'groupId': 'OG001'}, {'value': '23', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '37.9', 'groupId': 'OG000'}, {'value': '44.0', 'groupId': 'OG001'}, {'value': '34.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '30', 'groupId': 'OG000'}, {'value': '24', 'groupId': 'OG001'}, {'value': '24', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '50.0', 'groupId': 'OG000'}, {'value': '54.2', 'groupId': 'OG001'}, {'value': '37.5', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '=0.834', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in the Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.945', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in the Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.208', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in the Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.740', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in the Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.019', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in the Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.560', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in the Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.903', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure are included in Logistic Regression model, firth correction will be applied if quasi-complete separation of data points is detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.268', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure are included in Logistic Regression model, firth correction will be applied if quasi-complete separation of data points is detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.702', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.885', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.066', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.783', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.456', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.102', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.668', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.454', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.044', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.704', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.878', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.681', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.199', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.602', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.135', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.407', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.795', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.036', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.915', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.957', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.804', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.775', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.801', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.329', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.882', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.235', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.505', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.436', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.637', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.254', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.848', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.240', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.382', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.935', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.278', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.211', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.562', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.250', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.114', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.550', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.423', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.422', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.073', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.278', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.338', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.969', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.489', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.156', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.389', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.775', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.437', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.618', 'groupIds': ['OG000', 'OG002'], 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.079', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.349', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.580', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.106', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.955', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.134', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.933', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.502', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 90 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.653', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.816', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.184', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.765', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.009', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.578', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.725', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.287', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.705', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.975', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.118', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.959', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.413', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.043', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.849', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.662', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.047', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.950', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.656', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.922', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.143', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.452', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.231', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.405', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.718', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.053', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.893', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.662', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.688', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.611', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.907', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.699', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.802', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.206', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 140 mmHg and DBP ≤ 90 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'NUMBER', 'timeFrame': 'Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'percentage of participants', 'reportingStatus': 'POSTED', 'populationDescription': "PPS analysis set was used. Participants with SBP ≤ 140 mmHg at baseline were excluded from this analysis. 'Overall number of participants analyzed' indicates the number of participants with data available for the analysis of this outcome measure. 'Number analyzed' indicates number of participants with data available for analysis at specified time point."}, {'type': 'SECONDARY', 'title': 'Percentage of Participants Who Achieved Seated Automated SBP ≤ 130 mmHg, DBP ≤ 80 mmHg, and Both at Each Scheduled Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once-weekly for 12 weeks.'}], 'classes': [{'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '20.0', 'groupId': 'OG000'}, {'value': '37.8', 'groupId': 'OG001'}, {'value': '30.4', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '20.0', 'groupId': 'OG000'}, {'value': '35.6', 'groupId': 'OG001'}, {'value': '26.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '27.3', 'groupId': 'OG000'}, {'value': '31.1', 'groupId': 'OG001'}, {'value': '34.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '28.9', 'groupId': 'OG000'}, {'value': '44.4', 'groupId': 'OG001'}, {'value': '43.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '36.4', 'groupId': 'OG000'}, {'value': '43.2', 'groupId': 'OG001'}, {'value': '48.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '28.9', 'groupId': 'OG000'}, {'value': '46.7', 'groupId': 'OG001'}, {'value': '44.4', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '27.3', 'groupId': 'OG000'}, {'value': '44.4', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '24.4', 'groupId': 'OG000'}, {'value': '43.2', 'groupId': 'OG001'}, {'value': '39.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '40.0', 'groupId': 'OG000'}, {'value': '31.8', 'groupId': 'OG001'}, {'value': '34.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '30.2', 'groupId': 'OG000'}, {'value': '44.2', 'groupId': 'OG001'}, {'value': '40.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '41.9', 'groupId': 'OG000'}, {'value': '44.2', 'groupId': 'OG001'}, {'value': '37.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '26.7', 'groupId': 'OG000'}, {'value': '50.0', 'groupId': 'OG001'}, {'value': '37.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '40.5', 'groupId': 'OG000'}, {'value': '34.1', 'groupId': 'OG001'}, {'value': '33.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '35.7', 'groupId': 'OG000'}, {'value': '52.4', 'groupId': 'OG001'}, {'value': '40.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '28.2', 'groupId': 'OG000'}, {'value': '34.1', 'groupId': 'OG001'}, {'value': '30.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '31.7', 'groupId': 'OG000'}, {'value': '33.3', 'groupId': 'OG001'}, {'value': '27.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '30.2', 'groupId': 'OG000'}, {'value': '42.9', 'groupId': 'OG001'}, {'value': '34.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '53.3', 'groupId': 'OG000'}, {'value': '64.4', 'groupId': 'OG001'}, {'value': '60.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '48.9', 'groupId': 'OG000'}, {'value': '66.7', 'groupId': 'OG001'}, {'value': '56.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '59.1', 'groupId': 'OG000'}, {'value': '64.4', 'groupId': 'OG001'}, {'value': '58.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '60.0', 'groupId': 'OG000'}, {'value': '68.9', 'groupId': 'OG001'}, {'value': '65.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '56.8', 'groupId': 'OG000'}, {'value': '75.0', 'groupId': 'OG001'}, {'value': '55.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '57.8', 'groupId': 'OG000'}, {'value': '71.1', 'groupId': 'OG001'}, {'value': '60.0', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '63.6', 'groupId': 'OG000'}, {'value': '66.7', 'groupId': 'OG001'}, {'value': '53.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '66.7', 'groupId': 'OG000'}, {'value': '68.2', 'groupId': 'OG001'}, {'value': '65.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '60.0', 'groupId': 'OG000'}, {'value': '68.2', 'groupId': 'OG001'}, {'value': '62.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '58.1', 'groupId': 'OG000'}, {'value': '58.1', 'groupId': 'OG001'}, {'value': '62.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '67.4', 'groupId': 'OG000'}, {'value': '69.8', 'groupId': 'OG001'}, {'value': '66.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '60.0', 'groupId': 'OG000'}, {'value': '75.0', 'groupId': 'OG001'}, {'value': '66.7', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '66.7', 'groupId': 'OG000'}, {'value': '70.5', 'groupId': 'OG001'}, {'value': '64.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '61.9', 'groupId': 'OG000'}, {'value': '66.7', 'groupId': 'OG001'}, {'value': '59.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '64.1', 'groupId': 'OG000'}, {'value': '63.6', 'groupId': 'OG001'}, {'value': '60.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '53.7', 'groupId': 'OG000'}, {'value': '61.9', 'groupId': 'OG001'}, {'value': '60.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With DBP ≤ 80 mmHg at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '55.8', 'groupId': 'OG000'}, {'value': '66.7', 'groupId': 'OG001'}, {'value': '48.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '17.8', 'groupId': 'OG000'}, {'value': '33.3', 'groupId': 'OG001'}, {'value': '26.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '20.0', 'groupId': 'OG000'}, {'value': '33.3', 'groupId': 'OG001'}, {'value': '17.4', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '27.3', 'groupId': 'OG000'}, {'value': '24.4', 'groupId': 'OG001'}, {'value': '30.4', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '24.4', 'groupId': 'OG000'}, {'value': '40.0', 'groupId': 'OG001'}, {'value': '34.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '27.3', 'groupId': 'OG000'}, {'value': '37.8', 'groupId': 'OG001'}, {'value': '35.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '24.4', 'groupId': 'OG000'}, {'value': '37.8', 'groupId': 'OG001'}, {'value': '35.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '25.0', 'groupId': 'OG000'}, {'value': '37.8', 'groupId': 'OG001'}, {'value': '28.9', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '22.2', 'groupId': 'OG000'}, {'value': '40.9', 'groupId': 'OG001'}, {'value': '30.2', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '33.3', 'groupId': 'OG000'}, {'value': '25.0', 'groupId': 'OG001'}, {'value': '25.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '30.2', 'groupId': 'OG000'}, {'value': '34.9', 'groupId': 'OG001'}, {'value': '31.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '37.2', 'groupId': 'OG000'}, {'value': '37.2', 'groupId': 'OG001'}, {'value': '37.8', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '26.7', 'groupId': 'OG000'}, {'value': '40.9', 'groupId': 'OG001'}, {'value': '31.1', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '38.1', 'groupId': 'OG000'}, {'value': '27.3', 'groupId': 'OG001'}, {'value': '28.6', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '31.0', 'groupId': 'OG000'}, {'value': '40.5', 'groupId': 'OG001'}, {'value': '29.5', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '25.6', 'groupId': 'OG000'}, {'value': '31.8', 'groupId': 'OG001'}, {'value': '23.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '26.8', 'groupId': 'OG000'}, {'value': '31.0', 'groupId': 'OG001'}, {'value': '23.3', 'groupId': 'OG002'}]}]}, {'title': 'Percentage of Participants With SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '27.9', 'groupId': 'OG000'}, {'value': '38.1', 'groupId': 'OG001'}, {'value': '27.9', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '=0.280', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.648', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.416', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.900', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.627', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.921', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.464', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.458', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.779', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.629', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.242', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.290', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.349', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.532', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.205', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.368', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.084', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.179', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.584', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.762', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.675', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.166', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.090', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.488', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.218', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.232', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.421', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.815', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.711', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.514', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.479', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.292', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.528', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.946', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.552', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.598', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.184', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.614', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.933', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.803', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.686', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.752', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.106', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.779', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.323', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.991', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.973', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.230', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.792', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.744', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.925', 'groupIds': ['OG000', 'OG001'], 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY', 'nonInferiorityComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.'}, {'pValue': '=0.991', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.530', 'groupIds': ['OG000', 'OG001'], 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY', 'nonInferiorityComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.'}, {'pValue': '=0.849', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.953', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.884', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.230', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.589', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.919', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.753', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.747', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.764', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.527', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.639', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.744', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.539', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.417', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.466', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office DBP ≤ 80 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.380', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.730', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 8', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.595', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.279', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 15', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.196', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.728', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 22', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.453', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.681', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 29', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.863', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.837', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 36', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.504', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.531', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 43', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.600', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.830', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 50', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.209', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.809', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 57', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.045', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.104', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 64', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.690', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.590', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 71', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.538', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.407', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 78', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.398', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.930', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 85', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.111', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.196', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 92', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.816', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.473', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 106', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.615', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.214', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 120', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.575', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.276', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 148', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.573', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.706', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'Stratification factor (screening eGFR status (\\<60 vs ≤ 60 mL/min/1.73 m2)), treatment received and baseline measure were included in Logistic Regression model, firth correction was applied if quasi-complete separation of data points was detected.', 'groupDescription': 'Seated Automated Office SBP ≤ 130 mmHg and DBP ≤ 80 mmHg at Day 169', 'statisticalMethod': 'Regression, Logistic', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'NUMBER', 'timeFrame': 'Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'percentage of participants', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the Treatment Period and prior to study day 85, and have no significant protocol deviations that would be expected to affect efficacy assessment. 'Number analyzed' indicates the number of participants with data available for analysis at the specified time point."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Seated Automated Office SBP to Each Scheduled, Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'Change from Baseline at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-7.98', 'spread': '13.973', 'groupId': 'OG000'}, {'value': '-5.87', 'spread': '12.427', 'groupId': 'OG001'}, {'value': '-4.78', 'spread': '13.306', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-7.38', 'spread': '14.967', 'groupId': 'OG000'}, {'value': '-7.73', 'spread': '13.768', 'groupId': 'OG001'}, {'value': '-4.11', 'spread': '11.443', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.50', 'spread': '15.725', 'groupId': 'OG000'}, {'value': '-7.84', 'spread': '16.100', 'groupId': 'OG001'}, {'value': '-6.80', 'spread': '13.881', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.49', 'spread': '16.385', 'groupId': 'OG000'}, {'value': '-9.13', 'spread': '14.258', 'groupId': 'OG001'}, {'value': '-6.91', 'spread': '12.096', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-11.48', 'spread': '15.953', 'groupId': 'OG000'}, {'value': '-11.57', 'spread': '13.971', 'groupId': 'OG001'}, {'value': '-6.40', 'spread': '14.318', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.31', 'spread': '11.853', 'groupId': 'OG000'}, {'value': '-11.73', 'spread': '15.193', 'groupId': 'OG001'}, {'value': '-7.24', 'spread': '16.563', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-10.93', 'spread': '12.250', 'groupId': 'OG000'}, {'value': '-9.64', 'spread': '17.112', 'groupId': 'OG001'}, {'value': '-6.13', 'spread': '16.453', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-10.13', 'spread': '13.844', 'groupId': 'OG000'}, {'value': '-9.89', 'spread': '14.257', 'groupId': 'OG001'}, {'value': '-7.47', 'spread': '18.194', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-13.31', 'spread': '13.019', 'groupId': 'OG000'}, {'value': '-7.70', 'spread': '14.305', 'groupId': 'OG001'}, {'value': '-8.19', 'spread': '15.241', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-12.26', 'spread': '14.671', 'groupId': 'OG000'}, {'value': '-8.35', 'spread': '15.426', 'groupId': 'OG001'}, {'value': '-5.71', 'spread': '16.045', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-14.19', 'spread': '11.827', 'groupId': 'OG000'}, {'value': '-9.37', 'spread': '16.435', 'groupId': 'OG001'}, {'value': '-8.22', 'spread': '14.734', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.64', 'spread': '16.346', 'groupId': 'OG000'}, {'value': '-10.93', 'spread': '15.319', 'groupId': 'OG001'}, {'value': '-6.98', 'spread': '15.995', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-11.76', 'spread': '18.127', 'groupId': 'OG000'}, {'value': '-7.57', 'spread': '15.855', 'groupId': 'OG001'}, {'value': '-6.57', 'spread': '13.110', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-12.14', 'spread': '13.258', 'groupId': 'OG000'}, {'value': '-8.57', 'spread': '16.476', 'groupId': 'OG001'}, {'value': '-6.61', 'spread': '16.158', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.36', 'spread': '13.240', 'groupId': 'OG000'}, {'value': '-5.14', 'spread': '15.514', 'groupId': 'OG001'}, {'value': '-5.14', 'spread': '15.020', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.07', 'spread': '13.650', 'groupId': 'OG000'}, {'value': '-6.76', 'spread': '15.637', 'groupId': 'OG001'}, {'value': '-4.30', 'spread': '14.393', 'groupId': 'OG002'}]}]}, {'title': 'Change from Baseline at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-9.23', 'spread': '13.336', 'groupId': 'OG000'}, {'value': '-8.76', 'spread': '16.798', 'groupId': 'OG001'}, {'value': '-2.02', 'spread': '17.468', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '=0.853', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables', 'groupDescription': 'Change from Baseline at Day 8', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.542', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 8', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.430', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.587', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.910', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 22', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.846', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 22', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '0.634', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.767', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.399', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 36', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.323', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 36', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.115', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 43', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.982', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 43', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.859', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 50', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.344', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 50', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.633', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.889', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.241', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 64', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.367', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 64', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.716', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 71', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.210', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 71', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.363', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 78', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.193', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 78', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.135', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.867', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.761', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 92', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.618', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 92', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.363', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received are included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 106', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.125', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status (\\<60 vs ≥60 mL/min/1.73 m2)) and treatment received are included in the Van Elteren model as independent variables.', 'groupDescription': 'Change from Baseline at Day 106', 'statisticalMethod': 'Van Elteren', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.435', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.413', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.658', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 148', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.275', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 148', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.578', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 169', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.114', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 169', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'MEAN', 'timeFrame': 'Baseline, Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'mmHg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of 12 doses of study drug did not alter antihypertensive medications during treatment period \\& prior to Day 85 have no significant protocol deviations that would be expected to affect efficacy assessment. 'Number analyzed' indicates number of participants with data available for analysis at specified time point."}, {'type': 'SECONDARY', 'title': 'Change From Baseline in Seated Automated Office DBP to Each Scheduled, Post-Baseline Visit', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'OG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'OG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'classes': [{'title': 'Change from Baseline at Day 8', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-5.07', 'groupId': 'OG000', 'lowerLimit': '-8.20', 'upperLimit': '1.94'}, {'value': '-3.47', 'groupId': 'OG001', 'lowerLimit': '-6.44', 'upperLimit': '-0.49'}, {'value': '-4.25', 'groupId': 'OG002', 'lowerLimit': '-7.31', 'upperLimit': '-1.19'}]}]}, {'title': 'Change from Baseline at Day 15', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-4.78', 'groupId': 'OG000', 'lowerLimit': '-7.84', 'upperLimit': '-1.73'}, {'value': '-4.70', 'groupId': 'OG001', 'lowerLimit': '-7.59', 'upperLimit': '-1.80'}, {'value': '-4.38', 'groupId': 'OG002', 'lowerLimit': '-7.36', 'upperLimit': '-1.40'}]}]}, {'title': 'Change from Baseline at Day 22', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-6.05', 'groupId': 'OG000', 'lowerLimit': '-9.48', 'upperLimit': '-2.62'}, {'value': '-5.62', 'groupId': 'OG001', 'lowerLimit': '-8.78', 'upperLimit': '-2.45'}, {'value': '-4.31', 'groupId': 'OG002', 'lowerLimit': '-7.57', 'upperLimit': '-1.04'}]}]}, {'title': 'Change from Baseline at Day 29', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '46', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-5.93', 'groupId': 'OG000', 'lowerLimit': '-9.02', 'upperLimit': '-2.85'}, {'value': '-6.72', 'groupId': 'OG001', 'lowerLimit': '-9.65', 'upperLimit': '-3.79'}, {'value': '-4.84', 'groupId': 'OG002', 'lowerLimit': '-7.86', 'upperLimit': '-1.83'}]}]}, {'title': 'Change from Baseline at Day 36', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-4.87', 'groupId': 'OG000', 'lowerLimit': '-8.03', 'upperLimit': '-1.72'}, {'value': '-6.32', 'groupId': 'OG001', 'lowerLimit': '-9.32', 'upperLimit': '-3.33'}, {'value': '-3.90', 'groupId': 'OG002', 'lowerLimit': '-6.98', 'upperLimit': '-0.82'}]}]}, {'title': 'Change from Baseline at Day 43', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-6.37', 'groupId': 'OG000', 'lowerLimit': '-9.52', 'upperLimit': '-3.23'}, {'value': '-6.87', 'groupId': 'OG001', 'lowerLimit': '-9.86', 'upperLimit': '-3.89'}, {'value': '-5.42', 'groupId': 'OG002', 'lowerLimit': '-8.50', 'upperLimit': '-2.33'}]}]}, {'title': 'Change from Baseline at Day 50', 'denoms': [{'units': 'Participants', 'counts': [{'value': '44', 'groupId': 'OG000'}, {'value': '45', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-4.72', 'groupId': 'OG000', 'lowerLimit': '-7.64', 'upperLimit': '-1.81'}, {'value': '-5.99', 'groupId': 'OG001', 'lowerLimit': '-8.74', 'upperLimit': '-3.24'}, {'value': '-3.29', 'groupId': 'OG002', 'lowerLimit': '-6.13', 'upperLimit': '-0.45'}]}]}, {'title': 'Change from Baseline at Day 57', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-8.06', 'groupId': 'OG000', 'lowerLimit': '-11.14', 'upperLimit': '-4.97'}, {'value': '-7.90', 'groupId': 'OG001', 'lowerLimit': '-10.84', 'upperLimit': '-4.97'}, {'value': '-6.26', 'groupId': 'OG002', 'lowerLimit': '-9.38', 'upperLimit': '-3.14'}]}]}, {'title': 'Change from Baseline at Day 64', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-7.52', 'groupId': 'OG000', 'lowerLimit': '-10.31', 'upperLimit': '-4.72'}, {'value': '-5.73', 'groupId': 'OG001', 'lowerLimit': '-8.40', 'upperLimit': '-3.06'}, {'value': '-5.26', 'groupId': 'OG002', 'lowerLimit': '-8.03', 'upperLimit': '-2.48'}]}]}, {'title': 'Change from Baseline at Day 71', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-7.59', 'groupId': 'OG000', 'lowerLimit': '-10.54', 'upperLimit': '-4.64'}, {'value': '-5.36', 'groupId': 'OG001', 'lowerLimit': '-8.16', 'upperLimit': '-2.56'}, {'value': '-6.46', 'groupId': 'OG002', 'lowerLimit': '-9.32', 'upperLimit': '-3.59'}]}]}, {'title': 'Change from Baseline at Day 78', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '43', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-7.83', 'groupId': 'OG000', 'lowerLimit': '-10.79', 'upperLimit': '-4.87'}, {'value': '-6.11', 'groupId': 'OG001', 'lowerLimit': '-8.91', 'upperLimit': '-3.31'}, {'value': '-5.87', 'groupId': 'OG002', 'lowerLimit': '-8.74', 'upperLimit': '-2.99'}]}]}, {'title': 'Change from Baseline at Day 85', 'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '45', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-5.20', 'groupId': 'OG000', 'lowerLimit': '-8.24', 'upperLimit': '-2.16'}, {'value': '-6.78', 'groupId': 'OG001', 'lowerLimit': '-9.68', 'upperLimit': '-3.88'}, {'value': '-6.13', 'groupId': 'OG002', 'lowerLimit': '-9.11', 'upperLimit': '-3.14'}]}]}, {'title': 'Change from Baseline at Day 92', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '42', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-6.13', 'groupId': 'OG000', 'lowerLimit': '-9.37', 'upperLimit': '-2.90'}, {'value': '-5.82', 'groupId': 'OG001', 'lowerLimit': '-8.85', 'upperLimit': '-2.79'}, {'value': '-4.87', 'groupId': 'OG002', 'lowerLimit': '-8.11', 'upperLimit': '-1.62'}]}]}, {'title': 'Change from Baseline at Day 106', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '44', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-5.61', 'groupId': 'OG000', 'lowerLimit': '-8.95', 'upperLimit': '-2.27'}, {'value': '-5.94', 'groupId': 'OG001', 'lowerLimit': '-9.08', 'upperLimit': '-2.79'}, {'value': '-4.85', 'groupId': 'OG002', 'lowerLimit': '-8.01', 'upperLimit': '-1.68'}]}]}, {'title': 'Change from Baseline at Day 120', 'denoms': [{'units': 'Participants', 'counts': [{'value': '39', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-5.50', 'groupId': 'OG000', 'lowerLimit': '-8.77', 'upperLimit': '-2.24'}, {'value': '-3.50', 'groupId': 'OG001', 'lowerLimit': '-6.36', 'upperLimit': '-0.63'}, {'value': '-4.68', 'groupId': 'OG002', 'lowerLimit': '-7.67', 'upperLimit': '-1.70'}]}]}, {'title': 'Change from Baseline at Day 148', 'denoms': [{'units': 'Participants', 'counts': [{'value': '41', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-4.67', 'groupId': 'OG000', 'lowerLimit': '-8.18', 'upperLimit': '-1.71'}, {'value': '-4.80', 'groupId': 'OG001', 'lowerLimit': '-7.93', 'upperLimit': '-1.67'}, {'value': '-3.86', 'groupId': 'OG002', 'lowerLimit': '-7.17', 'upperLimit': '-0.55'}]}]}, {'title': 'Change from Baseline at Day 169', 'denoms': [{'units': 'Participants', 'counts': [{'value': '43', 'groupId': 'OG000'}, {'value': '42', 'groupId': 'OG001'}, {'value': '43', 'groupId': 'OG002'}]}], 'categories': [{'measurements': [{'value': '-4.07', 'groupId': 'OG000', 'lowerLimit': '-7.39', 'upperLimit': '-0.75'}, {'value': '-5.34', 'groupId': 'OG001', 'lowerLimit': '-8.43', 'upperLimit': '-2.26'}, {'value': '-1.54', 'groupId': 'OG002', 'lowerLimit': '-4.79', 'upperLimit': '1.72'}]}]}], 'analyses': [{'pValue': '=0.378', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 8', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.648', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 8', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.961', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.817', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 15', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.823', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 22', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.362', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 22', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.660', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.539', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 29', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.430', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 36', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.594', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 36', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.783', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 43', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.599', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 43', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.454', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 50', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.394', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 50', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.930', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.313', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 57', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.276', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 64', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.168', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 64', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.199', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 71', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.506', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 71', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.320', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 78', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.250', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 78', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.373', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.597', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 85', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.867', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 92', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.500', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 92', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.863', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 106', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.681', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 106', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.262', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.645', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 120', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.947', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 148', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.665', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 148', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.498', 'groupIds': ['OG000', 'OG001'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 169', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}, {'pValue': '=0.173', 'groupIds': ['OG000', 'OG002'], 'pValueComment': 'The stratification factor (screening eGFR status \\[\\<60 vs. ≥60 mL/min/1.73 m2\\]), treatment received, and baseline measure were included in the ANCOVA model as independent variables.', 'groupDescription': 'Change from Baseline at Day 169', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY'}], 'paramType': 'LEAST_SQUARES_MEAN', 'timeFrame': 'Baseline, Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169', 'unitOfMeasure': 'mmHg', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': "PPS included all FAS participants who received at least 10 of 12 doses of study drug, did not alter antihypertensive medications during treatment period and prior to Day 85,and had no significant protocol deviations that would have been expected to affect efficacy assessment. 'Number analyzed' is the number of participants with data available for analysis at the specified timepoint"}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, subcutaneous (SC) injection, once weekly for 12 weeks.'}, {'id': 'FG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'FG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '53'}, {'groupId': 'FG001', 'numSubjects': '54'}, {'groupId': 'FG002', 'numSubjects': '53'}]}, {'type': 'Per Protocol Set (PPS)', 'comment': 'PPS included all Full Analysis Set (FAS) participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the treatment period and prior to Day 85, and have no significant protocol deviations that would be expected to affect efficacy assessment.', 'achievements': [{'groupId': 'FG000', 'numSubjects': '45'}, {'groupId': 'FG001', 'numSubjects': '45'}, {'groupId': 'FG002', 'numSubjects': '46'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '48'}, {'groupId': 'FG001', 'numSubjects': '50'}, {'groupId': 'FG002', 'numSubjects': '47'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '5'}, {'groupId': 'FG001', 'numSubjects': '4'}, {'groupId': 'FG002', 'numSubjects': '6'}]}], 'dropWithdraws': [{'type': 'Voluntary Withdrawal', 'reasons': [{'groupId': 'FG000', 'numSubjects': '4'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '2'}]}, {'type': 'Adverse Event or Serious Adverse Event (SAE)', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '1'}]}, {'type': 'Reason Not Specified', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '3'}, {'groupId': 'FG002', 'numSubjects': '3'}]}]}], 'recruitmentDetails': 'Participants took part in the study at investigative sites in the US and Canada from 28 April 2021 to 03 October 2022.', 'preAssignmentDetails': 'Participants with uncontrolled hypertension who were on ≥ 3 antihypertensive medications were enrolled and randomized to receive either ISIS 757456 80 mg, ISIS 757456 120 mg or ISIS 757456 matched placebo for a 12-week treatment period.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo, SC injection, once weekly for 12 weeks.'}, {'id': 'BG001', 'title': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80mg, SC injection, once weekly for 12 weeks.'}, {'id': 'BG002', 'title': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'categories': [{'measurements': [{'value': '63.1', 'spread': '8.29', 'groupId': 'BG000'}, {'value': '64.0', 'spread': '7.47', 'groupId': 'BG001'}, {'value': '61.3', 'spread': '9.17', 'groupId': 'BG002'}, {'value': '62.8', 'spread': '8.36', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'categories': [{'title': 'Female', 'measurements': [{'value': '33', 'groupId': 'BG000'}, {'value': '32', 'groupId': 'BG001'}, {'value': '32', 'groupId': 'BG002'}, {'value': '97', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '20', 'groupId': 'BG000'}, {'value': '22', 'groupId': 'BG001'}, {'value': '21', 'groupId': 'BG002'}, {'value': '63', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Ethnicity (NIH/OMB)', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'categories': [{'title': 'Hispanic or Latino', 'measurements': [{'value': '20', 'groupId': 'BG000'}, {'value': '15', 'groupId': 'BG001'}, {'value': '14', 'groupId': 'BG002'}, {'value': '49', 'groupId': 'BG003'}]}, {'title': 'Not Hispanic or Latino', 'measurements': [{'value': '33', 'groupId': 'BG000'}, {'value': '39', 'groupId': 'BG001'}, {'value': '39', 'groupId': 'BG002'}, {'value': '111', 'groupId': 'BG003'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race/Ethnicity, Customized', 'classes': [{'title': 'Race', 'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'categories': [{'title': 'White', 'measurements': [{'value': '35', 'groupId': 'BG000'}, {'value': '30', 'groupId': 'BG001'}, {'value': '29', 'groupId': 'BG002'}, {'value': '94', 'groupId': 'BG003'}]}, {'title': 'Black', 'measurements': [{'value': '16', 'groupId': 'BG000'}, {'value': '20', 'groupId': 'BG001'}, {'value': '21', 'groupId': 'BG002'}, {'value': '57', 'groupId': 'BG003'}]}, {'title': 'Asian', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}, {'value': '3', 'groupId': 'BG003'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}, {'value': '2', 'groupId': 'BG003'}]}, {'title': 'Other Race', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '1', 'groupId': 'BG003'}]}, {'title': 'Multiple Races', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '3', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Seated Automated Office Systolic Blood Pressure (SBP)- PPS', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'BG000'}, {'value': '45', 'groupId': 'BG001'}, {'value': '46', 'groupId': 'BG002'}, {'value': '136', 'groupId': 'BG003'}]}], 'categories': [{'measurements': [{'value': '148.8', 'spread': '12.51', 'groupId': 'BG000'}, {'value': '143.3', 'spread': '10.29', 'groupId': 'BG001'}, {'value': '144.0', 'spread': '11.35', 'groupId': 'BG002'}, {'value': '145.3', 'spread': '11.59', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'millimeters of mercury (mmHg)', 'dispersionType': 'STANDARD_DEVIATION', 'populationDescription': 'PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the treatment period and prior to Day 85, and have no significant protocol deviations that would be expected to affect efficacy assessment.'}, {'title': 'Seated Automated Office Diastolic Blood Pressure (DBP)- PPS', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '45', 'groupId': 'BG000'}, {'value': '45', 'groupId': 'BG001'}, {'value': '46', 'groupId': 'BG002'}, {'value': '136', 'groupId': 'BG003'}]}], 'categories': [{'measurements': [{'value': '82.5', 'spread': '8.50', 'groupId': 'BG000'}, {'value': '80.6', 'spread': '10.18', 'groupId': 'BG001'}, {'value': '81.7', 'spread': '10.48', 'groupId': 'BG002'}, {'value': '81.6', 'spread': '9.72', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'mmHg', 'dispersionType': 'STANDARD_DEVIATION', 'populationDescription': 'PPS included all FAS participants who received at least 10 of the 12 doses of study drug, did not alter antihypertensive medications during the treatment period and prior to Day 85, and have no significant protocol deviations that would be expected to affect efficacy assessment.'}, {'title': 'Seated Automated Office Systolic Blood Pressure (SBP) -FAS', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'categories': [{'measurements': [{'value': '147.6', 'spread': '13.92', 'groupId': 'BG000'}, {'value': '143.6', 'spread': '10.04', 'groupId': 'BG001'}, {'value': '144.1', 'spread': '11.42', 'groupId': 'BG002'}, {'value': '145.1', 'spread': '11.95', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'mmHg', 'dispersionType': 'STANDARD_DEVIATION', 'populationDescription': 'FAS included all randomized participants who received at least 1 injection of study drug (ISIS 757456 or placebo) and had at least 1 post-baseline efficacy measurements.'}, {'title': 'Seated Automated Office Diastolic Blood Pressure (DBP) -FAS', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '53', 'groupId': 'BG000'}, {'value': '54', 'groupId': 'BG001'}, {'value': '53', 'groupId': 'BG002'}, {'value': '160', 'groupId': 'BG003'}]}], 'categories': [{'measurements': [{'value': '82.1', 'spread': '8.91', 'groupId': 'BG000'}, {'value': '81.5', 'spread': '10.20', 'groupId': 'BG001'}, {'value': '82.8', 'spread': '10.32', 'groupId': 'BG002'}, {'value': '82.1', 'spread': '9.78', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'mmHg', 'dispersionType': 'STANDARD_DEVIATION', 'populationDescription': 'FAS included all randomized participants who received at least 1 injection of study drug (ISIS 757456 or placebo) and had at least 1 post-baseline efficacy measurements.'}], 'populationDescription': 'FAS included all randomized participants who received at least 1 injection of study drug (ISIS 757456 or placebo) and had at least 1 post-baseline efficacy measurements.'}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2022-08-15', 'size': 3651022, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_001.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2025-02-14T12:56', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 160}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2021-04-28', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-02', 'dispFirstSubmitDate': '2022-09-14', 'completionDateStruct': {'date': '2022-10-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-02-14', 'studyFirstSubmitDate': '2021-01-14', 'resultsFirstSubmitDate': '2024-09-13', 'studyFirstSubmitQcDate': '2021-01-14', 'dispFirstPostDateStruct': {'date': '2025-02-18', 'type': 'ACTUAL'}, 'lastUpdatePostDateStruct': {'date': '2025-02-18', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2025-02-14', 'studyFirstPostDateStruct': {'date': '2021-01-19', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2025-02-18', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-06-29', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Change From Baseline in Seated Automated Office SBP to Day 85', 'timeFrame': 'Baseline to Day 85'}], 'secondaryOutcomes': [{'measure': 'Absolute Concentration of Plasma AGT at Each Scheduled, Post-Baseline Visit', 'timeFrame': 'Days 15, 29, 43, 57, 71, 85, 92, 106, 120, 148, and 169'}, {'measure': 'Change From Baseline in Plasma AGT to Each Scheduled, Post-Baseline Visit', 'timeFrame': 'Baseline, Days 15, 29, 43, 57, 71, 85, 92, 106, 120, 148, and 169'}, {'measure': 'Percent Change From Baseline in Plasma AGT at Each Scheduled, Post-Baseline Visit', 'timeFrame': 'Baseline, Days 15, 29, 43, 57, 71, 85, 92, 106, 120, 148, and 169'}, {'measure': 'Change From Baseline to Study Day 85 in 24-hour Mean SBP and Diastolic Blood Pressure (DBP) Measured by Ambulatory Blood Pressure Monitoring (ABPM)', 'timeFrame': 'Baseline, Day 85'}, {'measure': 'Percentage of Participants Who Achieved Seated Automated Office SBP ≤ 140 mmHg, DBP ≤ 90 mmHg, and Both at Each Scheduled Post-Baseline Visit', 'timeFrame': 'Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169'}, {'measure': 'Percentage of Participants Who Achieved Seated Automated SBP ≤ 130 mmHg, DBP ≤ 80 mmHg, and Both at Each Scheduled Post-Baseline Visit', 'timeFrame': 'Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169'}, {'measure': 'Change From Baseline in Seated Automated Office SBP to Each Scheduled, Post-Baseline Visit', 'timeFrame': 'Baseline, Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169'}, {'measure': 'Change From Baseline in Seated Automated Office DBP to Each Scheduled, Post-Baseline Visit', 'timeFrame': 'Baseline, Days 8, 15, 22, 29, 36, 43, 50, 57, 64, 71, 78, 85, 92, 106, 120, 148, and 169'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Hypertension', 'Hypertensive', 'AGT', 'Angiotensinogen', 'Blood Pressure'], 'conditions': ['Hypertension']}, 'descriptionModule': {'briefSummary': 'The purpose of this study was to evaluate the effect of IONIS-AGT-LRx compared to placebo on seated automated office systolic blood pressure (SBP) from baseline to Study Day 85 in uncontrolled hypertensive participants on ≥ 3 antihypertensive medications and to evaluate the effect of IONIS-AGT-LRx on ambulatory blood pressure, seated automated office SBP, seated automated office diastolic blood pressure (DBP), and plasma angiotensinogen (AGT) at each scheduled visit in uncontrolled hypertensive participants on ≥ 3 antihypertensive medications.', 'detailedDescription': 'This was a phase 2, double-blind, randomized, placebo-controlled study in up to 160 participants. Participants were randomized in a 2:1 ratio and received a once-weekly subcutaneous (SC) treatment with either IONIS-AGT-LRx or matching placebo. The length of participation in the study was approximately 31 weeks, which included an up to 6-week screening period, a 12-week treatment period, and a 13-week post-treatment period.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '80 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n* Males or females aged 18-80 inclusive and weighing ≥ 50 kilograms (kg) at the time of informed consent\n* Females: must be non-pregnant and non-lactating, and either surgically sterile or post-menopausal\n* Males must be abstinent, surgically sterile or if engaged in sexual relations with a woman of childbearing potential (WOCBP), a highly effective contraceptive method must be used\n* Body mass index (BMI) ≤ 45.0 kilograms per square meter (kg/m\\^2)\n* At screening, the participant must have been on a stable, maximally tolerated regimen (per Investigator judgement) of 3 or more antihypertensive medications for at least 1 month prior to screening and will be required to maintain this regimen throughout the study. The combination of antihypertensive medications must be in the following categories: a) angiotensin-converting enzyme inhibitor (ACEi) or angiotensin II receptor blocker (ARB), b) beta blocker: c) calcium channel blocker d) diuretic, e) alpha-1 blocker f) centrally acting sympatholytic agent or g) direct acting vasodilators (e.g. hydralazine)\n\nExclusion Criteria:\n\n* Clinically significant abnormalities in screening laboratory results, medical history according to Investigator judgment\n* History of secondary hypertension (HTN) including, but not limited to any of the following: renovascular HTN (unilateral or bilateral renal artery stenosis), coarctation of the aorta, primary hyperaldosteronism, Cushing's disease, pheochromocytoma, polycystic kidney disease, and drug-induced HTN\n* The use of the following at time of screening and during the course of the study:\n\n * Other medications for the treatment of HTN (e.g., minoxidil, diazoxide, renin inhibitors)\n * Medications that may cause hyperkalemia unless on a stable dose at least 1 month prior to the screening visit and no known history of hyperkalemia per Investigator judgement\n * Use of oral anticoagulants, unless stable for 4 weeks prior to the first dose of study drug and regular monitoring must be performed per clinical practice during the study unless the participant is receiving vitamin K agonists. If the participant is receiving vitamin K antagonists (e.g., warfarin) international normalized ratio (INR) should be in therapeutic range, as established by the Investigator, for 4 weeks prior to the first dose\n * Chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs) or cyclooxygenase 2 (COX-2) inhibitors (except aspirin for cardiovascular disease provided the total daily dose does not exceed 325 mg)\n* History of bleeding diathesis, coagulopathy, immune thrombocytopenic purpura (ITP), thrombotic cytopenic purpura (TTP), or any qualitative or quantitative platelet defect\n* Unstable/underlying known cardiovascular disease defined as:\n\n * Any history of congestive heart failure (New York Heart Association \\[NYHA\\] Class III-IV)\n * Any history of previous myocardial infarction, coronary revascularization, unstable or stable angina pectoris ˂ 1 year prior to screening\n * Any hemodynamically unstable atrial or ventricular arrhythmias\n * Significant uncorrected valvular heart disease\n * Any history of stroke or transient ischemic attack \\< 1 year prior to screening\n* A cardiac valve repair, cardiac device implantation, and/or a hospitalization for heart failure within 3 months of screening\n* Participant works nighttime shifts (e.g., 11 PM to 7 AM)"}, 'identificationModule': {'nctId': 'NCT04714320', 'acronym': 'ASTRAAS', 'briefTitle': 'A Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx in Hypertensive Participants With Uncontrolled Blood Pressure', 'organization': {'class': 'INDUSTRY', 'fullName': 'Ionis Pharmaceuticals, Inc.'}, 'officialTitle': 'A Double-Blind, Placebo-Controlled, Phase 2 Study to Assess the Safety, Tolerability and Efficacy of IONIS-AGT-LRx, an Antisense Inhibitor of Angiotensinogen Production Administered Subcutaneously for 12 Weeks to Hypertensive Patients With Uncontrolled Blood Pressure', 'orgStudyIdInfo': {'id': 'ISIS 757456-CS4'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'Pooled Placebo', 'description': 'Participants received ISIS 757456 matching placebo subcutaneously once weekly for 12 weeks.', 'interventionNames': ['Drug: Placebo']}, {'type': 'EXPERIMENTAL', 'label': 'IONIS-AGT-LRx 80 mg', 'description': 'Participants received ISIS 757456 80 milligrams (mg), subcutaneous (SC) injection, once weekly for 12 weeks.', 'interventionNames': ['Drug: IONIS-AGT-LRx']}, {'type': 'EXPERIMENTAL', 'label': 'IONIS-AGT-LRx 120 mg', 'description': 'Participants received ISIS 757456 120 mg, SC injection, once weekly for 12 weeks.', 'interventionNames': ['Drug: IONIS-AGT-LRx']}], 'interventions': [{'name': 'Placebo', 'type': 'DRUG', 'description': 'ISIS 757456 matching placebo administered by SC injection.', 'armGroupLabels': ['Pooled Placebo']}, {'name': 'IONIS-AGT-LRx', 'type': 'DRUG', 'otherNames': ['ISIS 757456'], 'description': 'IONIS-AGT-LRx administered by SC injection.', 'armGroupLabels': ['IONIS-AGT-LRx 120 mg', 'IONIS-AGT-LRx 80 mg']}]}, 'contactsLocationsModule': {'locations': [{'zip': '36207', 'city': 'Anniston', 'state': 'Alabama', 'country': 'United States', 'facility': 'Pinnacle Research Group', 'geoPoint': {'lat': 33.65983, 'lon': -85.83163}}, {'zip': '35205', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Central Research Associates, Inc.', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35216', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Achieve Clinical Research, LLC', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35124', 'city': 'Pelham', 'state': 'Alabama', 'country': 'United States', 'facility': 'Cahaba Research, Inc.', 'geoPoint': {'lat': 33.28567, 'lon': -86.80999}}, {'zip': '35660', 'city': 'Sheffield', 'state': 'Alabama', 'country': 'United States', 'facility': 'Syed Research Consultants LLC', 'geoPoint': {'lat': 34.76509, 'lon': -87.69864}}, {'zip': '72204', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Cardiology and Medicine Clinic', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '92805', 'city': 'Anaheim', 'state': 'California', 'country': 'United States', 'facility': 'Advanced Research Center', 'geoPoint': {'lat': 33.83529, 'lon': -117.9145}}, {'zip': '90255', 'city': 'Huntington Park', 'state': 'California', 'country': 'United States', 'facility': 'National Research Institute - 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