Ignite Creation Date:
2025-12-25 @ 4:14 AM
Ignite Modification Date:
2025-12-26 @ 3:13 AM
Study NCT ID:
NCT00824720
Status:
COMPLETED
Last Update Posted:
2015-03-06
First Post:
2009-01-09
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Safety and Efficacy of a Glaucoma Drug Delivery System
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D005902', 'term': 'Glaucoma, Open-Angle'}, {'id': 'D009798', 'term': 'Ocular Hypertension'}], 'ancestors': [{'id': 'D005901', 'term': 'Glaucoma'}, {'id': 'D005128', 'term': 'Eye Diseases'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'phone': '904-443-1482', 'title': 'Brian Schwam MD/Director Clinical Affairs & Ocular Sciences', 'organization': 'Vistakon'}, 'certainAgreement': {'otherDetails': 'Prior to submission for publication or presentation, the PI will provide the Sponsor 60 days for review of the manuscript. The Sponsor may request that the PI withhold the publication for an additional 60 days.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': 'High Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, high dose', 'otherNumAtRisk': 16, 'otherNumAffected': 13, 'seriousNumAtRisk': 16, 'seriousNumAffected': 1}, {'id': 'EG001', 'title': 'Low Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, low dose', 'otherNumAtRisk': 15, 'otherNumAffected': 11, 'seriousNumAtRisk': 15, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Placebo', 'description': 'punctal plug without bimatoprost', 'otherNumAtRisk': 20, 'otherNumAffected': 11, 'seriousNumAtRisk': 20, 'seriousNumAffected': 0}], 'otherEvents': [{'term': 'Foreign body sensation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 8}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 3}], 'organSystem': 'Eye disorders'}, {'term': 'Eye pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 6}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Eye disorders'}, {'term': 'abnormal sensation in eyes', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 3}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 4}], 'organSystem': 'Eye disorders'}, {'term': 'Conjunctival hyperaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 2}], 'organSystem': 'Eye disorders'}, {'term': 'corneal erosion', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'dry eye', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'erythema of eyelid', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'eye irritation', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'eye puritus', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Eye disorders'}, {'term': 'eyelid margin crusting', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 4}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 2}], 'organSystem': 'Eye disorders'}, {'term': 'eyelid pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Eye disorders'}, {'term': 'eyelids puritus', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Eye disorders'}, {'term': 'inflammation of lacrimal passage', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 5}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 4}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 2}], 'organSystem': 'Eye disorders'}, {'term': 'lacrimation increased', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 2}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 5}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 4}], 'organSystem': 'Eye disorders'}, {'term': 'ocular hyperaemia', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 3}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 2}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Eye disorders'}, {'term': 'visual acuity reduced', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Eye disorders'}, {'term': 'upper respiratory tract infection', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Infections and infestations'}, {'term': 'contusion', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 1}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Injury, poisoning and procedural complications'}, {'term': 'procedural complication', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 2}], 'organSystem': 'Injury, poisoning and procedural complications'}, {'term': 'musculoskeletal chest pain', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Musculoskeletal and connective tissue disorders'}, {'term': 'sinus headache', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 0}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 1}], 'organSystem': 'Nervous system disorders'}], 'seriousEvents': [{'term': 'cerebrovascular accident', 'notes': 'unrelated to study treatment', 'stats': [{'groupId': 'EG000', 'numAtRisk': 16, 'numAffected': 1}, {'groupId': 'EG001', 'numAtRisk': 15, 'numAffected': 0}, {'groupId': 'EG002', 'numAtRisk': 20, 'numAffected': 0}], 'organSystem': 'Nervous system disorders'}], 'frequencyThreshold': '5'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'SECONDARY', 'title': 'Intraocular Pressure (IOP)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '15', 'groupId': 'OG001'}, {'value': '19', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'High Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, high dose'}, {'id': 'OG001', 'title': 'Low Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, low dose'}, {'id': 'OG002', 'title': 'Placebo', 'description': 'punctal plug without bimatoprost'}], 'classes': [{'categories': [{'measurements': [{'value': '-1.9', 'spread': '2.3', 'groupId': 'OG000'}, {'value': '-2.2', 'spread': '3.5', 'groupId': 'OG001'}, {'value': '-1.3', 'spread': '3.6', 'groupId': 'OG002'}]}]}], 'analyses': [{'pValue': '0.9737', 'groupIds': ['OG000', 'OG002'], 'paramType': 'least square mean difference', 'paramValue': '-0.22', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '2.3', 'estimateComment': 'Mean difference was calculated as high dose minus placebo.', 'groupDescription': 'The alternative hypothesis was that the high dose was different from the placebo.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'testedNonInferiority': False}, {'pValue': '0.4711', 'groupIds': ['OG001', 'OG002'], 'paramType': 'least square mean difference', 'paramValue': '-1.11', 'dispersionType': 'STANDARD_DEVIATION', 'dispersionValue': '3.5', 'estimateComment': 'The mean difference was calculated as low dose minus placebo.', 'groupDescription': 'The alternative hypothesis is that the low dose was different from placebo.', 'statisticalMethod': 'ANCOVA', 'nonInferiorityType': 'SUPERIORITY_OR_OTHER', 'testedNonInferiority': False}], 'paramType': 'MEAN', 'timeFrame': 'from baseline to 14 days', 'unitOfMeasure': 'mmHg', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED', 'populationDescription': 'The analysis population includes all subjects with a plug insertion that completed the study per protocol.'}, {'type': 'PRIMARY', 'title': 'Visual Acuity - Right Eye', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '15', 'groupId': 'OG001'}, {'value': '19', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'High Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, high dose'}, {'id': 'OG001', 'title': 'Low Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, low dose'}, {'id': 'OG002', 'title': 'Placebo', 'description': 'punctal plug without bimatoprost'}], 'classes': [{'categories': [{'measurements': [{'value': '0.015', 'spread': '0.046', 'groupId': 'OG000'}, {'value': '-0.044', 'spread': '0.092', 'groupId': 'OG001'}, {'value': '-0.012', 'spread': '0.044', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'at 14 days', 'description': 'This outcome measures visual acuity in logMARs. logMAR is the logarithm of the minimum angle of resolution (logMAR). The ideal is 0.0 and represents 20/20 Snellen acuity. logMar values \\> 0.00 indicate vision poorer than the ideal and values \\<0.00 indicate vision greater than the ideal.', 'unitOfMeasure': 'logMAR units', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Visual Acuity - Left Eye', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '15', 'groupId': 'OG001'}, {'value': '19', 'groupId': 'OG002'}]}], 'groups': [{'id': 'OG000', 'title': 'High Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, high dose'}, {'id': 'OG001', 'title': 'Low Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, low dose'}, {'id': 'OG002', 'title': 'Placebo', 'description': 'punctal plug without bimatoprost'}], 'classes': [{'categories': [{'measurements': [{'value': '-0.011', 'spread': '0.081', 'groupId': 'OG000'}, {'value': '-0.008', 'spread': '0.101', 'groupId': 'OG001'}, {'value': '-0.019', 'spread': '0.044', 'groupId': 'OG002'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'at 14 days', 'description': 'This outcome measures visual acuity in logMARs. logMAR is the logarithm of the minimum angle of resolution (logMAR. The ideal is 0.0 and represents 20/20 Snellen acuity. logMar values \\> 0.00 indicate vision poorer than the ideal and values \\<0.00 indicate vision greater than the ideal.', 'unitOfMeasure': 'logMARs', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'High Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, high dose'}, {'id': 'FG001', 'title': 'Low Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, low dose'}, {'id': 'FG002', 'title': 'Placebo', 'description': 'punctal plug without bimatoprost'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'comment': '3 subjects in the high dose group did not receive device - unable to insert.', 'groupId': 'FG000', 'numSubjects': '19'}, {'comment': '1 subject in the low dose group did not receive device - unable to insert.', 'groupId': 'FG001', 'numSubjects': '16'}, {'groupId': 'FG002', 'numSubjects': '20'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '16'}, {'groupId': 'FG001', 'numSubjects': '15'}, {'groupId': 'FG002', 'numSubjects': '19'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '1'}]}], 'dropWithdraws': [{'type': 'failed plug insertion', 'reasons': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '0'}]}, {'type': 'Protocol Violation', 'reasons': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '0'}, {'groupId': 'FG002', 'numSubjects': '1'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '16', 'groupId': 'BG000'}, {'value': '15', 'groupId': 'BG001'}, {'value': '20', 'groupId': 'BG002'}, {'value': '51', 'groupId': 'BG003'}]}], 'groups': [{'id': 'BG000', 'title': 'High Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, high dose'}, {'id': 'BG001', 'title': 'Low Dose Bimatoprost Punctal Plug', 'description': 'punctal plug with bimatoprost, low dose'}, {'id': 'BG002', 'title': 'Placebo', 'description': 'punctal plug without bimatoprost'}, {'id': 'BG003', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '66.7', 'spread': '13.4', 'groupId': 'BG000'}, {'value': '64.6', 'spread': '12.9', 'groupId': 'BG001'}, {'value': '64.5', 'spread': '10.6', 'groupId': 'BG002'}, {'value': '65.2', 'spread': '12.0', 'groupId': 'BG003'}]}]}], 'paramType': 'MEAN', 'description': 'This baseline measure includes all subjects with a plug insertion.', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '9', 'groupId': 'BG000'}, {'value': '9', 'groupId': 'BG001'}, {'value': '13', 'groupId': 'BG002'}, {'value': '31', 'groupId': 'BG003'}]}, {'title': 'Male', 'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '7', 'groupId': 'BG002'}, {'value': '20', 'groupId': 'BG003'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 55}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2008-12'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2015-02', 'completionDateStruct': {'date': '2009-04', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2015-02-18', 'studyFirstSubmitDate': '2009-01-09', 'resultsFirstSubmitDate': '2010-04-15', 'studyFirstSubmitQcDate': '2009-01-15', 'lastUpdatePostDateStruct': {'date': '2015-03-06', 'type': 'ESTIMATED'}, 'resultsFirstSubmitQcDate': '2010-04-15', 'studyFirstPostDateStruct': {'date': '2009-01-19', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2010-05-14', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2009-04', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Visual Acuity - Right Eye', 'timeFrame': 'at 14 days', 'description': 'This outcome measures visual acuity in logMARs. logMAR is the logarithm of the minimum angle of resolution (logMAR). The ideal is 0.0 and represents 20/20 Snellen acuity. logMar values \\> 0.00 indicate vision poorer than the ideal and values \\<0.00 indicate vision greater than the ideal.'}, {'measure': 'Visual Acuity - Left Eye', 'timeFrame': 'at 14 days', 'description': 'This outcome measures visual acuity in logMARs. logMAR is the logarithm of the minimum angle of resolution (logMAR. The ideal is 0.0 and represents 20/20 Snellen acuity. logMar values \\> 0.00 indicate vision poorer than the ideal and values \\<0.00 indicate vision greater than the ideal.'}], 'secondaryOutcomes': [{'measure': 'Intraocular Pressure (IOP)', 'timeFrame': 'from baseline to 14 days'}]}, 'conditionsModule': {'conditions': ['Glaucoma, Open-Angle', 'Ocular Hypertension']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to evaluate the ocular safety and efficacy of a glaucoma drug delivery system in open-angle glaucoma or ocular hypertension.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '21 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Man or woman 21 years of age or greater\n* must have open angle glaucoma or ocular hypertension.\n* Corrected visual acuity in each eye of 20/200 or better.\n\nExclusion Criteria:\n\n* Previous glaucoma intraocular surgery or refractive surgery.\n* Planned contact lens use during the study.\n* Clinically significant ocular or systemic disease that might interfere with the study.\n* Use of chronic corticosteroids by any route.'}, 'identificationModule': {'nctId': 'NCT00824720', 'briefTitle': 'Safety and Efficacy of a Glaucoma Drug Delivery System', 'organization': {'class': 'INDUSTRY', 'fullName': 'Vistakon Pharmaceuticals'}, 'orgStudyIdInfo': {'id': 'CR-1630'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'High Dose Device', 'description': 'device worn continuously for 14 days', 'interventionNames': ['Drug: High Dose Device']}, {'type': 'EXPERIMENTAL', 'label': 'Low Dose Device', 'description': 'device worn continuously for 14 days', 'interventionNames': ['Drug: Low Dose Device']}, {'type': 'PLACEBO_COMPARATOR', 'label': 'Placebo Device', 'description': 'device worn continuously for 14 days', 'interventionNames': ['Device: Placebo Device']}], 'interventions': [{'name': 'High Dose Device', 'type': 'DRUG', 'description': 'inserted for 14 days', 'armGroupLabels': ['High Dose Device']}, {'name': 'Low Dose Device', 'type': 'DRUG', 'description': 'inserted for 14 days', 'armGroupLabels': ['Low Dose Device']}, {'name': 'Placebo Device', 'type': 'DEVICE', 'description': 'inserted for 14 days', 'armGroupLabels': ['Placebo Device']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Artesia', 'state': 'California', 'country': 'United States', 'geoPoint': {'lat': 33.86585, 'lon': -118.08312}}, {'city': 'Louisville', 'state': 'Kentucky', 'country': 'United States', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': 'USA', 'city': 'Baltimore', 'state': 'Maryland', 'country': 'United States', 'geoPoint': {'lat': 39.29038, 'lon': -76.61219}}, {'city': 'Mt. Pleasant', 'state': 'South Carolina', 'country': 'United States', 'geoPoint': {'lat': 32.79407, 'lon': -79.86259}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Vistakon Pharmaceuticals', 'class': 'INDUSTRY'}, 'responsibleParty': {'type': 'SPONSOR'}}}}