Ignite Creation Date:
2025-12-25 @ 4:12 AM
Ignite Modification Date:
2026-02-25 @ 5:20 AM
Study NCT ID:
NCT02656420
Status:
COMPLETED
Last Update Posted:
2019-05-01
First Post:
2016-01-05
Is Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'tkensle1@jhu.edu', 'phone': '410-955-1292', 'title': 'Dr. Thomas W. Kensler', 'organization': 'JHSPH'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': 'Daily during the course of the 10-day study and again 1 week after completion of the study', 'eventGroups': [{'id': 'EG000', 'title': 'Placebo', 'description': 'Beverage (100 mL) containing pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.', 'otherNumAtRisk': 55, 'otherNumAffected': 0, 'seriousNumAtRisk': 55, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'High Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (600 micromole) and sulforaphane-rich (40 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.', 'otherNumAtRisk': 25, 'otherNumAffected': 0, 'seriousNumAtRisk': 25, 'seriousNumAffected': 0}, {'id': 'EG002', 'title': 'Medium Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (300 micromole) and sulforaphane-rich (20 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.', 'otherNumAtRisk': 35, 'otherNumAffected': 0, 'seriousNumAtRisk': 35, 'seriousNumAffected': 0}, {'id': 'EG003', 'title': 'Low Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (120 micromole) and sulforaphane-rich (8 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.', 'otherNumAtRisk': 55, 'otherNumAffected': 0, 'seriousNumAtRisk': 55, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}, {'value': '24', 'groupId': 'OG001'}, {'value': '35', 'groupId': 'OG002'}, {'value': '55', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Beverage (100 mL) containing pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'OG001', 'title': 'High Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (600 micromole) and sulforaphane-rich (40 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'OG002', 'title': 'Medium Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (300 micromole) and sulforaphane-rich (20 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'OG003', 'title': 'Low Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (120 micromole) and sulforaphane-rich (8 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}], 'classes': [{'categories': [{'measurements': [{'value': '24.8', 'groupId': 'OG001', 'lowerLimit': '16.8', 'upperLimit': '33.5'}, {'value': '11.0', 'groupId': 'OG002', 'lowerLimit': '8.4', 'upperLimit': '13.2'}, {'value': '4.3', 'groupId': 'OG003', 'lowerLimit': '3.6', 'upperLimit': '5.2'}]}]}], 'analyses': [{'pValue': '<0.001', 'groupIds': ['OG001', 'OG002', 'OG003'], 'paramType': 'Mean Difference (Final Values)', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '-1.73', 'ciLowerLimit': '-1.89', 'ciUpperLimit': '-1.57', 'pValueComment': 'Using a linear mixed effects model with random intercepts and slope, SF level (in the log scale) was regressed on categorical treatment group (medium dose and low dose; high as the reference) as well as day (continuous variable).', 'dispersionType': 'STANDARD_ERROR_OF_MEAN', 'dispersionValue': '0.090', 'groupDescription': 'The null hypothesis is that the urinary sulforaphane levels are equal across treatment arms. Sulforaphane metabolite levels were measured daily for 10 days in each arm.', 'statisticalMethod': 'Mixed Models Analysis', 'nonInferiorityType': 'EQUIVALENCE', 'nonInferiorityComment': 'Statistical significance of the treatment effect (p \\< 0.01) for the lower doses compared to the high dose as the reference.'}], 'paramType': 'GEOMETRIC_MEAN', 'timeFrame': '10 days', 'description': 'Urinary excretion of broccoli-derived sulforaphane metabolites: sulforaphane-mercapturic acid. The metabolites were measured all 20 of the sequential 12-hour urine collections from each participant over the 10-day intervention period. Data from each individual were summed to provide a single "per 24-hours" value for each participant.', 'unitOfMeasure': 'micromoles/24 hours', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Placebo arm samples were not analyzed f because no sulforaphane was administered to this group. Historically, background levels from dietary sources in this population are very low compared to active intervention levels. In addition, one participant in the High Dose Broccoli Sprout arm did not complete the full protocol and was not included.'}, {'type': 'SECONDARY', 'title': 'Modulation of Air Pollutant Excretion in Sequential Overnight 12-Hour Urine Samples', 'denoms': [{'units': 'Participants', 'counts': [{'value': '42', 'groupId': 'OG000'}, {'value': '44', 'groupId': 'OG001'}, {'value': '26', 'groupId': 'OG002'}, {'value': '20', 'groupId': 'OG003'}]}], 'groups': [{'id': 'OG000', 'title': 'Placebo', 'description': 'Beverage (100 mL) containing pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'OG001', 'title': 'Low Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (120 micromole) and sulforaphane-rich (8 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'OG002', 'title': 'Medium Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (300 micromole) and sulforaphane-rich (20 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'OG003', 'title': 'High Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (600 micromole) and sulforaphane-rich (40 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}], 'classes': [{'categories': [{'measurements': [{'value': '0.67', 'groupId': 'OG000', 'lowerLimit': '0.43', 'upperLimit': '0.97'}, {'value': '0.62', 'groupId': 'OG001', 'lowerLimit': '0.39', 'upperLimit': '1.02'}, {'value': '0.74', 'groupId': 'OG002', 'lowerLimit': '0.62', 'upperLimit': '1.18'}, {'value': '1.09', 'groupId': 'OG003', 'lowerLimit': '0.67', 'upperLimit': '1.64'}]}]}], 'analyses': [{'pValue': '<0.05', 'groupIds': ['OG000', 'OG001', 'OG002', 'OG003'], 'paramType': 'Mean Difference (Final Values)', 'ciNumSides': 'TWO_SIDED', 'ciPctValue': '95', 'paramValue': '63.2', 'ciLowerLimit': '10.6', 'ciUpperLimit': '140.9', 'estimateComment': 'This Estimation Parameter was based on the comparison between the full dose group and the placebo group.', 'groupDescription': 'All broccoli sprout arms were compared with the placebo arm.', 'statisticalMethod': 'Regression, Linear', 'nonInferiorityType': 'SUPERIORITY', 'nonInferiorityComment': 'To summarize first 12-hour SPMA levels over the study course by participant, the SPMA geometric mean (in the log scale) for each individual was calculated and used as the outcome. Treatment arms (placebo, fifth, half and full doses) were independent (categorical) variables in a linear regression model with placebo as the reference.'}], 'paramType': 'GEOMETRIC_MEAN', 'timeFrame': '10 days', 'description': 'Benzene-mercapturic acid (SPMA) excretion was measured in the sequential overnight 12-hour urine samples collected across the 10-day study period. Data from each individual were summed and averaged to provide a single "per 12-hours" value for each participant.', 'unitOfMeasure': 'nmol SPMA excreted/ 12 hours', 'dispersionType': 'Inter-Quartile Range', 'reportingStatus': 'POSTED', 'populationDescription': 'Due to irreversible failure of the mass spectrometer used in this analysis, not all urine samples were evaluated for SPMA levels. Only individuals for whom all 10 samples were collected and analyzed are included in this summary (132/169).'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Placebo', 'description': 'Beverage (100 mL) containing pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'FG001', 'title': 'High Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (600 micromole) and sulforaphane-rich (40 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'FG002', 'title': 'Medium Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (300 micromole) and sulforaphane-rich (20 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'FG003', 'title': 'Low Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (120 micromole) and sulforaphane-rich (8 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '55'}, {'groupId': 'FG001', 'numSubjects': '25'}, {'groupId': 'FG002', 'numSubjects': '35'}, {'groupId': 'FG003', 'numSubjects': '55'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '55'}, {'groupId': 'FG001', 'numSubjects': '24'}, {'groupId': 'FG002', 'numSubjects': '35'}, {'groupId': 'FG003', 'numSubjects': '55'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '0'}, {'groupId': 'FG001', 'numSubjects': '1'}, {'groupId': 'FG002', 'numSubjects': '0'}, {'groupId': 'FG003', 'numSubjects': '0'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '55', 'groupId': 'BG000'}, {'value': '25', 'groupId': 'BG001'}, {'value': '35', 'groupId': 'BG002'}, {'value': '55', 'groupId': 'BG003'}, {'value': '170', 'groupId': 'BG004'}]}], 'groups': [{'id': 'BG000', 'title': 'Placebo', 'description': 'Beverage (100 mL) containing pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'BG001', 'title': 'High Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (600 micromole) and sulforaphane-rich (40 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'BG002', 'title': 'Medium Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (300 micromole) and sulforaphane-rich (20 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'BG003', 'title': 'Low Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (120 micromole) and sulforaphane-rich (8 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.\n\nBroccoli Sprout Powder: Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebo.'}, {'id': 'BG004', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '55', 'groupId': 'BG000'}, {'value': '25', 'groupId': 'BG001'}, {'value': '35', 'groupId': 'BG002'}, {'value': '55', 'groupId': 'BG003'}, {'value': '170', 'groupId': 'BG004'}]}, {'title': '>=65 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}, {'value': '0', 'groupId': 'BG003'}, {'value': '0', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '56', 'groupId': 'BG000', 'lowerLimit': '53', 'upperLimit': '61'}, {'value': '59', 'groupId': 'BG001', 'lowerLimit': '56', 'upperLimit': '62'}, {'value': '58', 'groupId': 'BG002', 'lowerLimit': '50', 'upperLimit': '64'}, {'value': '60', 'groupId': 'BG003', 'lowerLimit': '53', 'upperLimit': '63'}, {'value': '58', 'groupId': 'BG004', 'lowerLimit': '50', 'upperLimit': '64'}]}]}], 'paramType': 'MEDIAN', 'unitOfMeasure': 'years', 'dispersionType': 'FULL_RANGE'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '38', 'groupId': 'BG000'}, {'value': '18', 'groupId': 'BG001'}, {'value': '28', 'groupId': 'BG002'}, {'value': '43', 'groupId': 'BG003'}, {'value': '127', 'groupId': 'BG004'}]}, {'title': 'Male', 'measurements': [{'value': '17', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '7', 'groupId': 'BG002'}, {'value': '12', 'groupId': 'BG003'}, {'value': '43', 'groupId': 'BG004'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'China', 'categories': [{'measurements': [{'value': '55', 'groupId': 'BG000'}, {'value': '25', 'groupId': 'BG001'}, {'value': '35', 'groupId': 'BG002'}, {'value': '55', 'groupId': 'BG003'}, {'value': '170', 'groupId': 'BG004'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1', 'PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'SINGLE', 'whoMasked': ['PARTICIPANT']}, 'primaryPurpose': 'PREVENTION', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 170}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2016-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2019-04', 'completionDateStruct': {'date': '2016-03', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2019-04-10', 'studyFirstSubmitDate': '2016-01-05', 'resultsFirstSubmitDate': '2018-07-19', 'studyFirstSubmitQcDate': '2016-01-12', 'lastUpdatePostDateStruct': {'date': '2019-05-01', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2019-04-10', 'studyFirstPostDateStruct': {'date': '2016-01-15', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2019-05-01', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2016-03', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Sulforaphane Bioavailability Measured in Sequential 12-Hour Urine Samples', 'timeFrame': '10 days', 'description': 'Urinary excretion of broccoli-derived sulforaphane metabolites: sulforaphane-mercapturic acid. The metabolites were measured all 20 of the sequential 12-hour urine collections from each participant over the 10-day intervention period. Data from each individual were summed to provide a single "per 24-hours" value for each participant.'}], 'secondaryOutcomes': [{'measure': 'Modulation of Air Pollutant Excretion in Sequential Overnight 12-Hour Urine Samples', 'timeFrame': '10 days', 'description': 'Benzene-mercapturic acid (SPMA) excretion was measured in the sequential overnight 12-hour urine samples collected across the 10-day study period. Data from each individual were summed and averaged to provide a single "per 12-hours" value for each participant.'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'conditions': ['Environmental Carcinogenesis']}, 'referencesModule': {'references': [{'pmid': '24913818', 'type': 'BACKGROUND', 'citation': 'Egner PA, Chen JG, Zarth AT, Ng DK, Wang JB, Kensler KH, Jacobson LP, Munoz A, Johnson JL, Groopman JD, Fahey JW, Talalay P, Zhu J, Chen TY, Qian GS, Carmella SG, Hecht SS, Kensler TW. Rapid and sustainable detoxication of airborne pollutants by broccoli sprout beverage: results of a randomized clinical trial in China. Cancer Prev Res (Phila). 2014 Aug;7(8):813-823. doi: 10.1158/1940-6207.CAPR-14-0103. Epub 2014 Jun 9.'}, {'pmid': '31268126', 'type': 'DERIVED', 'citation': 'Chen JG, Johnson J, Egner P, Ng D, Zhu J, Wang JB, Xue XF, Sun Y, Zhang YH, Lu LL, Chen YS, Wu Y, Zhu YR, Carmella S, Hecht S, Jacobson L, Munoz A, Kensler K, Rule A, Fahey J, Kensler T, Groopman J. Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China. Am J Clin Nutr. 2019 Sep 1;110(3):675-684. doi: 10.1093/ajcn/nqz122.'}]}, 'descriptionModule': {'briefSummary': 'This study will examine the extent to which lower doses of a broccoli-derived beverage enhance the detoxication of air pollutants excreted in urine as compared to an maximal dose shown to be effective previously.', 'detailedDescription': 'This is a 10-day placebo control Phase II broccoli sprout intervention to be conducted in Qidong, P.R. China. Up to twelve hundred people from the farming townships will be screened and one hundred seventy eligible individuals will be enrolled in the study. Participants will be randomized into 4 treatment groups: one will receive a juice beverage containing a standard dose of glucoraphanin- and sulforaphane-rich broccoli sprout powder mixed in pineapple juice, lime juice and water, the second will receive one-half dose, the third one-fifth dose and the fourth group will receive placebo beverage containing pineapple juice, lime juice and water. Participants will drink their assigned beverage every evening and provide consecutive 12-hour urine collections throughout the duration of the study.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '65 Years', 'minimumAge': '21 Years', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* in good general health with no history of chronic illness\n* normal liver function tests\n* normal renal function tests\n\nExclusion Criteria:\n\n* personal history of cancer except for non-melanoma skin cancer\n* use of prescribed medicines\n* for women, a positive pregnancy test'}, 'identificationModule': {'nctId': 'NCT02656420', 'briefTitle': 'Broccoli Sprout Dose Response: Bioavailability and Effects of Air Pollutants', 'organization': {'class': 'OTHER', 'fullName': 'Johns Hopkins Bloomberg School of Public Health'}, 'officialTitle': 'Broccoli Sprout Dose Response: Bioavailability and Effects on Air Pollutants', 'orgStudyIdInfo': {'id': 'IRB00006734'}, 'secondaryIdInfos': [{'id': 'R01CA190610', 'link': 'https://reporter.nih.gov/quickSearch/R01CA190610', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'PLACEBO_COMPARATOR', 'label': 'Placebos', 'description': 'Beverage (100 mL) containing pineapple juice, lime juice and water. Nightly for 10 days.', 'interventionNames': ['Drug: Placebos']}, {'type': 'EXPERIMENTAL', 'label': 'High Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (600 micromole) and sulforaphane-rich (40 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.', 'interventionNames': ['Drug: Broccoli Sprout-derived Beverage']}, {'type': 'EXPERIMENTAL', 'label': 'Medium Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (300 micromole) and sulforaphane-rich (20 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.', 'interventionNames': ['Drug: Broccoli Sprout-derived Beverage']}, {'type': 'EXPERIMENTAL', 'label': 'Low Dose Broccoli Sprout', 'description': 'Beverage (100 mL) containing glucoraphanin-rich (120 micromole) and sulforaphane-rich (8 micromole) broccoli sprout powder mixed in pineapple juice, lime juice and water. Nightly for 10 days.', 'interventionNames': ['Drug: Broccoli Sprout-derived Beverage']}], 'interventions': [{'name': 'Broccoli Sprout-derived Beverage', 'type': 'DRUG', 'description': 'Maximum, half and one-fifth doses of broccoli sprout-derived beverage compared to placebos.', 'armGroupLabels': ['High Dose Broccoli Sprout', 'Low Dose Broccoli Sprout', 'Medium Dose Broccoli Sprout']}, {'name': 'Placebos', 'type': 'DRUG', 'description': 'Placebo as comparison to broccoli sprout-derived beverages', 'armGroupLabels': ['Placebos']}]}, 'contactsLocationsModule': {'locations': [{'zip': '226200', 'city': 'Qidong', 'state': 'Jiangsu', 'country': 'China', 'facility': 'Qidong Liver Cancer Institute', 'geoPoint': {'lat': 33.41667, 'lon': 119.21667}}], 'overallOfficials': [{'name': 'Thomas Kensler, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'Johns Hopkins Bloomberg School of Public Health'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Johns Hopkins Bloomberg School of Public Health', 'class': 'OTHER'}, 'collaborators': [{'name': 'Qidong Liver Cancer Institute', 'class': 'OTHER'}, {'name': 'National Cancer Institute (NCI)', 'class': 'NIH'}], 'responsibleParty': {'type': 'SPONSOR'}}}}