Ignite Creation Date:
2025-12-25 @ 4:08 AM
Ignite Modification Date:
2025-12-26 @ 3:05 AM
Study NCT ID:
NCT06055920
Status:
RECRUITING
Last Update Posted:
2025-12-12
First Post:
2023-09-15
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
The PEERLESS II Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D011655', 'term': 'Pulmonary Embolism'}], 'ancestors': [{'id': 'D008171', 'term': 'Lung Diseases'}, {'id': 'D012140', 'term': 'Respiratory Tract Diseases'}, {'id': 'D004617', 'term': 'Embolism'}, {'id': 'D016769', 'term': 'Embolism and Thrombosis'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000925', 'term': 'Anticoagulants'}], 'ancestors': [{'id': 'D006401', 'term': 'Hematologic Agents'}, {'id': 'D045506', 'term': 'Therapeutic Uses'}, {'id': 'D020228', 'term': 'Pharmacologic Actions'}, {'id': 'D020164', 'term': 'Chemical Actions and Uses'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 1200}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2023-11-17', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-12', 'completionDateStruct': {'date': '2026-07', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-05', 'studyFirstSubmitDate': '2023-09-15', 'studyFirstSubmitQcDate': '2023-09-20', 'lastUpdatePostDateStruct': {'date': '2025-12-12', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2023-09-28', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-07', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Composite clinical endpoint constructed as a win ratio, a hierarchy of the following, which are assessed post-randomization:', 'timeFrame': 'through discharge or 30 days, whichever is sooner / dyspnea at 48 hours', 'description': '* All-cause mortality by 30 days, or\n* Clinical deterioration, defined by hemodynamic or respiratory worsening, through discharge or up to 30 days after randomization, whichever is sooner, or\n* All-cause hospital re-admission by 30 days, or\n* Bailout therapy, either after a deterioration or after documented failure to progress, through discharge or up to 30 days after randomization, whichever is sooner, or\n* Change in Dyspnea, by mMRC from Baseline to the 48-hour visit'}], 'secondaryOutcomes': [{'measure': 'Composite clinical endpoint constructed as a win ratio hierarchy of the following three components, assessed post randomization:', 'timeFrame': 'up to 30 days', 'description': '* All-cause mortality, by 30 days, or\n* Clinical deterioration defined by hemodynamic or respiratory worsening, through discharge or up to 30 days after randomization, whichever is sooner, or\n* All-cause readmission, by 30 days'}, {'measure': 'All-cause and PE-related mortality', 'timeFrame': 'At 30 and 90 days'}, {'measure': 'All-cause and PE-related readmissions', 'timeFrame': 'At 30 and 90 days'}, {'measure': 'Clinical deterioration', 'timeFrame': 'Through discharge or up to 30 days after randomization, whichever is sooner', 'description': 'defined by hemodynamic or respiratory worsening'}, {'measure': 'Bailout therapy', 'timeFrame': 'Through discharge or up to 30 days after randomization, whichever is sooner', 'description': 'either after a deterioration or after documented failure to progress,'}, {'measure': 'Major Bleeding, defined by the Bleeding Academic Research Consortium (BARC), level 3b, 3c, 5a, or 5b', 'timeFrame': 'At 30 and 90 days', 'description': '3b: Overt bleeding plus hemoglobin drop of ≥ 5 g/dL (provided hemoglobin drop is related to bleed); cardiac tamponade, bleeding requiring surgical intervention for control (excluding dental/nasal/skin/hemorrhoid); bleeding requiring intravenous vasoactive agents 3c: Intracranial hemorrhage (does not include microbleeds or hemorrhagic transformation, does include intraspinal), subcategories confirmed by autopsy or imaging or lumbar puncture, intraocular bleed compromising vision.\n\n5a: Probable fatal bleeding; no autopsy or imaging confirmation but clinically suspicious 5b: Definite fatal bleeding; overt bleeding or autopsy or imaging confirmation'}, {'measure': 'Dyspnea severity by mMRC score', 'timeFrame': 'At the 48-hour, 1-month, and 3-month visits', 'description': '0, no breathlessness except on strenuous exercise;\n\n* 1, shortness of breath when hurrying on the level or walking up a slight hill;\n* 2, walks slower than people of same age on the level because of breathlessness or has to stop to catch breath when walking at their own pace on the level;\n* 3, stops for breath after walking ∼100 m or after few minutes on the level; and\n* 4, too breathless to leave the house, or breathless when dressing or undressing'}, {'measure': 'PE-related quality of life, by PEmb-QoL', 'timeFrame': 'At the 1- and 3-month visits', 'description': 'Pulmonary Embolism Quality of Life: (higher = better)'}, {'measure': 'General health-related quality of life, by EQ-5D-5L', 'timeFrame': 'At the 1- and 3-month visits', 'description': 'Higher score = worse'}, {'measure': '6-minute walk distance', 'timeFrame': 'At the 1-month visit'}, {'measure': 'RV/LV ratio', 'timeFrame': 'At the 48-hour visit'}, {'measure': 'Post-PE Impairment diagnosis (PPEI)', 'timeFrame': 'Through the 3-month visit'}]}, 'oversightModule': {'isUsExport': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': True}, 'conditionsModule': {'conditions': ['Pulmonary Embolism']}, 'referencesModule': {'references': [{'pmid': '39132600', 'type': 'BACKGROUND', 'citation': 'Giri J, Mahfoud F, Gebauer B, Andersen A, Friedman O, Gandhi RT, Jaber WA, Pereira K, West FM. PEERLESS II: A Randomized Controlled Trial of Large-Bore Thrombectomy Versus Anticoagulation in Intermediate-Risk Pulmonary Embolism. J Soc Cardiovasc Angiogr Interv. 2024 May 3;3(6):101982. doi: 10.1016/j.jscai.2024.101982. eCollection 2024 Jun.'}]}, 'descriptionModule': {'briefSummary': 'This study is a prospective, multicenter, randomized controlled trial of the FlowTriever System plus anticoagulation compared to anticoagulation alone for intermediate-risk acute PE.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Age at enrollment ≥ 18 years\n2. Objective evidence of a proximal filling defect in at least one main or lobar pulmonary artery, as confirmed by CTPA, pulmonary angiography, or other imaging modality\n3. RV dysfunction, as defined as one or more of the following: RV/LV ratio ≥ 0.9 or RV dilation or hypokinesis\n4. At least two additional risk factors, identified by at least one measure in two separate categories noted below:\n\n a. Hemodynamic: i. SBP 90-100mmHg ii. Resting heart rate \\> 100 bpm b. Biomarker: i. Elevated\\* cardiac troponin (troponin I or troponin T, conventional or high sensitivity) ii. Elevated\\* BNP or NT-proBNP iii. Elevated venous lactate ≥2 mmol/L \\* Elevated, meaning at or above the upper limit of normal, per local standards for the assay used c. Respiratory: i. O2 saturation \\< 90% on room air ii. Supplemental O2 requirement ≥ 4 L/min iii. Respiratory rate ≥ 20 breaths/min iv. mMRC score \\> 0\n5. Symptom onset within 14 days of confirmed PE diagnosis\n6. Willing and able to provide informed consent\n\nExclusion Criteria:\n\n1. Unable to be anticoagulated with heparin, enoxaparin or other parenteral antithrombin\n2. Presentation with hemodynamic instability\\* that meets the high-risk PE definition in the 2019 ESC Guidelines1, including ANY of the following\n\n 1. Cardiac arrest OR\n 2. Systolic BP \\< 90 mmHg or vasopressors required to achieve a BP ≥ 90 mmHg despite adequate filling status, AND end-organ hypoperfusion OR\n 3. Systolic BP \\< 90 mmHg or systolic BP drop ≥ 40 mmHg, lasting longer than 15 min and not caused by new-onset arrhythmia, hypovolemia, or sepsis \\* Patients who are stable at time of screening or randomization (i.e., SBP ≥ 90 mmHg and adequate organ perfusion without catecholamine or vasopressor infusion) may be included despite initial presentation including temporary, low-dose catecholamines or vasopressors, or temporary fluid resuscitation.\n3. Known sensitivity to radiographic contrast agents that, in the Investigator's opinion, cannot be adequately pre-treated\n4. Imaging evidence or other evidence that suggests, in the opinion of the Investigator, the patient is not appropriate for catheter-based intervention (e.g., inability to navigate to target location, clot limited to segmental/subsegmental distribution, predominately chronic clot)\n5. End stage medical condition with life expectancy \\< 3 months, as determined by the Investigator\n6. Current participation in another drug or device study that, in the investigator's opinion, would interfere with participation in this study\n7. Current or history of chronic thromboembolic pulmonary hypertension (CTEPH) or chronic thromboembolic disease (CTED) diagnosis, per 2019 ESC Guidelines1\n8. If objective testing was performed\\*, estimated RV systolic pressure \\> 70 mmHg on standard of care echocardiography \\* If clinical suspicion of acute-on-chronic PE, chronic obstruction, or chronic thromboembolism, echocardiographic estimated RVSP must be confirmed ≤70 mmHg to meet eligibility. Pressure assessment not required if Investigator attests to absence of such clinical suspicion\n9. Administration of advanced therapies (thrombolytic bolus, thrombolytic drip/infusion, catheter-directed thrombolytic therapy, mechanical thrombectomy, or ECMO) for the index PE event within 30 days prior to enrollment\n10. Ventricular arrhythmias refractory to treatment at the time of enrollment\n11. Known to have heparin-induced thrombocytopenia (HIT)\n12. Subject has any condition for which, in the opinion of the investigator, participation would not be in the best interest of the subject (e.g., compromise the well-being or that could prevent, limit, or confound the protocol-specified assessments). This includes a contraindication to use of FlowTriever System per local approved labeling\n13. Subject is currently pregnant\n14. Subject has previously completed or withdrawn from this study"}, 'identificationModule': {'nctId': 'NCT06055920', 'briefTitle': 'The PEERLESS II Study', 'organization': {'class': 'INDUSTRY', 'fullName': 'Inari Medical'}, 'officialTitle': 'PEERLESS II: RCT of FlowTriever vs. Anticoagulation Alone in Pulmonary Embolism', 'orgStudyIdInfo': {'id': '23-001'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'FlowTriever', 'description': 'Mechanical thrombectomy for pulmonary embolism using the FlowTriever System.', 'interventionNames': ['Device: FlowTriever System']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Anticoagulation', 'description': "Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.\n\nAnticoagulants are a group of medications that decrease your blood's ability to clot.", 'interventionNames': ['Drug: Anticoagulation Agents']}], 'interventions': [{'name': 'FlowTriever System', 'type': 'DEVICE', 'description': 'Mechanical Thrombectomy for pulmonary embolism', 'armGroupLabels': ['FlowTriever']}, {'name': 'Anticoagulation Agents', 'type': 'DRUG', 'description': "Commercially available/market approved anticoagulation medication including but not limited to: Heparin Sodium, Coumadin, Rivaroxaban, Apixaban, etc.\n\nAnticoagulants are a group of medications that decrease your blood's ability to clot.", 'armGroupLabels': ['Anticoagulation']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35205', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Samuel McElwee, MD', 'role': 'CONTACT'}], 'facility': 'UAB Division of Cardiovascular Disease', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '35243', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'ACTIVE_NOT_RECRUITING', 'country': 'United States', 'facility': 'Brookwood Medical Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Nikhil Daga, MD', 'role': 'CONTACT'}], 'facility': 'Huntington Memorial Hospital', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '80045', 'city': 'Aurora', 'state': 'Colorado', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Peter Hountras, MD', 'role': 'CONTACT'}], 'facility': 'University of Colorado, Denver', 'geoPoint': {'lat': 39.72943, 'lon': -104.83192}}, {'zip': '06520', 'city': 'New Haven', 'state': 'Connecticut', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Akhil Khosla, MD', 'role': 'CONTACT'}], 'facility': 'Yale University', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '33770', 'city': 'Largo', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jesse J Klein, DO', 'role': 'CONTACT'}], 'facility': 'HCA FL Largo Medical Center', 'geoPoint': {'lat': 27.90979, 'lon': -82.78842}}, {'zip': '32803', 'city': 'Orlando', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Barry Weinstock, MD', 'role': 'CONTACT'}], 'facility': 'AdventHealth Orlando', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Wissam Jaber, MD', 'role': 'CONTACT'}], 'facility': 'Emory University', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60611', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daniel Schimmel, MD', 'role': 'CONTACT'}], 'facility': 'Northwestern University', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '40207', 'city': 'Louisville', 'state': 'Kentucky', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Baptist Health Louisville', 'geoPoint': {'lat': 38.25424, 'lon': -85.75941}}, {'zip': '48910', 'city': 'Lansing', 'state': 'Michigan', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Ibrahim Shah, MD', 'role': 'CONTACT'}], 'facility': 'McLaren Greater Lansing', 'geoPoint': {'lat': 42.73253, 'lon': -84.55553}}, {'zip': '55433', 'city': 'Coon Rapids', 'state': 'Minnesota', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Metropolitan Heart & Vascular Institute', 'geoPoint': {'lat': 45.11997, 'lon': -93.28773}}, {'zip': '55905', 'city': 'Rochester', 'state': 'Minnesota', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 44.02163, 'lon': -92.4699}}, {'zip': '64111', 'city': 'Kansas City', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jennifer Buckley, MD', 'role': 'CONTACT'}], 'facility': "Saint Luke's Hospital of Kansas City", 'geoPoint': {'lat': 39.09973, 'lon': -94.57857}}, {'zip': '65804', 'city': 'Springfield', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Madhu Kalyan Pendurthi, MD', 'role': 'CONTACT'}], 'facility': 'Mercy Hospital Springfield', 'geoPoint': {'lat': 37.21533, 'lon': -93.29824}}, {'zip': '68105', 'city': 'Omaha', 'state': 'Nebraska', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jason Cook, MD', 'role': 'CONTACT'}], 'facility': 'Nebraska Medical Center', 'geoPoint': {'lat': 41.25626, 'lon': -95.94043}}, {'zip': '08103', 'city': 'Camden', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Rita Butler, MD', 'role': 'CONTACT'}], 'facility': 'Virtua Health', 'geoPoint': {'lat': 39.92595, 'lon': -75.11962}}, {'zip': '07450', 'city': 'Ridgewood', 'state': 'New Jersey', 'status': 'WITHDRAWN', 'country': 'United States', 'facility': 'Valley Health', 'geoPoint': {'lat': 40.97926, 'lon': -74.11653}}, {'zip': '14203', 'city': 'Buffalo', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'David Zlotnick, MD', 'role': 'CONTACT'}], 'facility': 'SUNY, The University of Buffalo/Gates Vascular', 'geoPoint': {'lat': 42.88645, 'lon': -78.87837}}, {'zip': '10075', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Bushra Mina, MD', 'role': 'CONTACT'}], 'facility': 'Northwell Health', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '11418', 'city': 'Queens', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Zoran Lasic, MD', 'role': 'CONTACT'}], 'facility': 'Jamaica Hospital', 'geoPoint': {'lat': 40.68149, 'lon': -73.83652}}, {'zip': '14642', 'city': 'Rochester', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jeffrey Bruckel, MD', 'role': 'CONTACT'}], 'facility': 'University of Rochester Medical Center', 'geoPoint': {'lat': 43.15478, 'lon': -77.61556}}, {'zip': '11794', 'city': 'Stony Brook', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Daniel Ohngemach, MD', 'role': 'CONTACT'}], 'facility': 'Stony Brook University Hospital', 'geoPoint': {'lat': 40.92565, 'lon': -73.14094}}, {'zip': '10467', 'city': 'The Bronx', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Asma Khaliq, MD', 'role': 'CONTACT'}], 'facility': 'Montefiore Medical Center', 'geoPoint': {'lat': 40.84985, 'lon': -73.86641}}, {'zip': '45219', 'city': 'Cincinnati', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Rishi Sukhija, MD', 'role': 'CONTACT'}], 'facility': 'University of Cincinnati Medical Center', 'geoPoint': {'lat': 39.12711, 'lon': -84.51439}}, {'zip': '44195', 'city': 'Cleveland', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Aravinda Nanjundappa, MD', 'role': 'CONTACT'}], 'facility': 'The Cleveland Clinic Foundation', 'geoPoint': {'lat': 41.4995, 'lon': -81.69541}}, {'zip': '43210', 'city': 'Columbus', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Richard Gumina, MD', 'role': 'CONTACT'}], 'facility': 'Ohio State University - Wexner Medical Center', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '18015', 'city': 'Bethlehem', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Neal Fitzpatrick, MD', 'role': 'CONTACT'}], 'facility': "St. Luke's University Hospital", 'geoPoint': {'lat': 40.62593, 'lon': -75.37046}}, {'zip': '16505', 'city': 'Erie', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Orestis Pappas, MD', 'role': 'CONTACT'}], 'facility': 'AHN Saint Vincent Hospital', 'geoPoint': {'lat': 42.12922, 'lon': -80.08506}}, {'zip': '16507', 'city': 'Erie', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Robert Maholic, DO', 'role': 'CONTACT'}], 'facility': 'UPMC Hamot', 'geoPoint': {'lat': 42.12922, 'lon': -80.08506}}, {'zip': '17101', 'city': 'Harrisburg', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Torrey Schmidt, DO', 'role': 'CONTACT'}], 'facility': 'UPMC Harrisburg', 'geoPoint': {'lat': 40.2737, 'lon': -76.88442}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sameer Khandhar, MD', 'role': 'CONTACT'}], 'facility': 'The University of Pennsylvania', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '19144', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'status': 'NOT_YET_RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mae West, MD', 'role': 'CONTACT'}], 'facility': 'Thomas Jefferson University', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '15212', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Mithun Chakravarthy', 'role': 'CONTACT'}], 'facility': 'Allegheny Health Network Research Institute', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '15213', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Catalin Toma, MD', 'role': 'CONTACT'}], 'facility': 'UPMC Heart and Vascular Institute', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '17403', 'city': 'York', 'state': 'Pennsylvania', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Paul Tolerico, MD', 'role': 'CONTACT'}], 'facility': 'Wellspan York Hospital', 'geoPoint': {'lat': 39.9626, 'lon': -76.72774}}, {'zip': '37027', 'city': 'Brentwood', 'state': 'Tennessee', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Sam Horr, MD', 'role': 'CONTACT'}], 'facility': 'HCA Tristar', 'geoPoint': {'lat': 36.03312, 'lon': -86.78278}}, {'zip': '37920', 'city': 'Knoxville', 'state': 'Tennessee', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Chris Walker, MD', 'role': 'CONTACT'}], 'facility': 'UTMC Knoxville', 'geoPoint': {'lat': 35.96064, 'lon': -83.92074}}, {'zip': '37203', 'city': 'Nashville', 'state': 'Tennessee', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jimmy Kerrigan, MD', 'role': 'CONTACT'}], 'facility': 'Ascension Saint Thomas Hospital', 'geoPoint': {'lat': 36.16589, 'lon': -86.78444}}, {'zip': '75235', 'city': 'Dallas', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Akram Sadeghi, MD', 'role': 'CONTACT'}], 'facility': 'Parkland Hospital', 'geoPoint': {'lat': 32.78306, 'lon': -96.80667}}, {'zip': '76104', 'city': 'Fort Worth', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'John Hollingsworth, MD', 'role': 'CONTACT'}], 'facility': 'Texas Health Harris Methodist Hospital', 'geoPoint': {'lat': 32.72541, 'lon': -97.32085}}, {'zip': '78229', 'city': 'San Antonio', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Chandra Kunavarapu, MD', 'role': 'CONTACT'}, {'name': 'Jeffrey DellaVolpe, MD', 'role': 'CONTACT'}], 'facility': 'Methodist Main Hospital', 'geoPoint': {'lat': 29.42412, 'lon': -98.49363}}, {'zip': '76508', 'city': 'Temple', 'state': 'Texas', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Tasnim Lat, DO', 'role': 'CONTACT'}], 'facility': 'Baylor Scott & White - Temple', 'geoPoint': {'lat': 31.09823, 'lon': -97.34278}}, {'zip': '22042', 'city': 'Falls Church', 'state': 'Virginia', 'status': 'RECRUITING', 'country': 'United States', 'contacts': [{'name': 'Jonathan Keung, MD', 'role': 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