Ignite Creation Date:
2025-12-25 @ 4:03 AM
Ignite Modification Date:
2026-03-06 @ 12:02 PM
Study NCT ID:
NCT00282802
Status:
UNKNOWN
Last Update Posted:
2009-07-02
First Post:
2006-01-26
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D010300', 'term': 'Parkinson Disease'}], 'ancestors': [{'id': 'D020734', 'term': 'Parkinsonian Disorders'}, {'id': 'D001480', 'term': 'Basal Ganglia Diseases'}, {'id': 'D001927', 'term': 'Brain Diseases'}, {'id': 'D002493', 'term': 'Central Nervous System Diseases'}, {'id': 'D009422', 'term': 'Nervous System Diseases'}, {'id': 'D009069', 'term': 'Movement Disorders'}, {'id': 'D000080874', 'term': 'Synucleinopathies'}, {'id': 'D019636', 'term': 'Neurodegenerative Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 250}}, 'statusModule': {'overallStatus': 'UNKNOWN', 'lastKnownStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2001-04'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2009-07', 'completionDateStruct': {'date': '2010-07', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2009-07-01', 'studyFirstSubmitDate': '2006-01-26', 'studyFirstSubmitQcDate': '2006-01-26', 'lastUpdatePostDateStruct': {'date': '2009-07-02', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2006-01-27', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': "Onset of Parkinson's disease", 'timeFrame': 'duration of the project'}], 'secondaryOutcomes': [{'measure': "Age of Parkinson's disease onset", 'timeFrame': 'duration of the project'}]}, 'oversightModule': {'oversightHasDmc': False}, 'conditionsModule': {'keywords': ["Parkinson's Disease", 'twins', 'SPECT', 'National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort Registry', 'NAS/NRC', 'World War II Veteran Twins'], 'conditions': ["Parkinson's Disease"]}, 'descriptionModule': {'briefSummary': "The purpose of this study is to examine the role of genetic and environmental factors in the cause of Parkinson's disease.", 'detailedDescription': 'Parkinson\'s disease (PD) is a growing health problem in the elderly, and genetic factors may provide substantial clues toward eventual treatment and/or prevention of the disorder. The National Academy of Sciences/National Resource Council (NAS/NRC) World War II (WWII) Veteran Twins Cohort Registry is one of the few population-based groups of elderly twins. Previous studies in this group indicated that genetic factors were involved only in early-onset PD, however there was no follow-up to these studies.\n\nThe purpose of the "Twins and the Risk of PD" study is to follow-up previous studies and confirm the initial findings. In this study, investigators will use the NAS/NRC WWII Veteran Twin Cohort Registry to compare the concordance rates for PD in monozygotic and dizygotic twins-at least one of whom has PD.\n\nThe overall goal of this research is determine the contributions of genetic and environmental factors in the cause of PD.\n\nThe study will involve traditional clinical research methods, such as a clinical examination, as well as innovative imaging techniques, such as single photon emission computed tomography (SPECT). SPECT-a nuclear imaging test involving blood flow to tissue-is used to evaluate certain brain functions.\n\nFindings from this study may help to set research priorities in PD, and to develop tools for early detection of the disorder.'}, 'eligibilityModule': {'sex': 'MALE', 'stdAges': ['OLDER_ADULT'], 'maximumAge': '88 Years', 'minimumAge': '77 Years', 'samplingMethod': 'PROBABILITY_SAMPLE', 'studyPopulation': 'Participants will be recruited from a closed cohort-the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion:\n\n* Participants will be recruited from a closed cohort-the National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort'}, 'identificationModule': {'nctId': 'NCT00282802', 'briefTitle': "Twins and the Risk of Parkinson's Disease: A Clinical and Imaging Study", 'organization': {'class': 'OTHER', 'fullName': "The Parkinson's Institute"}, 'officialTitle': 'Twins and the Risk of PD: A Clinical and Imaging Study', 'orgStudyIdInfo': {'id': 'R01NS040467', 'link': 'https://reporter.nih.gov/quickSearch/R01NS040467', 'type': 'NIH'}, 'secondaryIdInfos': [{'id': 'R01NS040467-01', 'link': 'https://reporter.nih.gov/quickSearch/R01NS040467-01', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'label': '1', 'description': 'National Academy of Sciences/National Resource Council (NAS/NRC) World War II Veteran Twins Cohort'}]}, 'contactsLocationsModule': {'locations': [{'zip': '94085', 'city': 'Sunnyvale', 'state': 'California', 'country': 'United States', 'facility': "The Parkinson's Institute, 675 Almanor Avene", 'geoPoint': {'lat': 37.36883, 'lon': -122.03635}}], 'overallOfficials': [{'name': 'Caroline M. Tanner, MD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': "The Parkinson's Institute"}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': "The Parkinson's Institute", 'class': 'OTHER'}, 'collaborators': [{'name': 'National Institute of Neurological Disorders and Stroke (NINDS)', 'class': 'NIH'}], 'responsibleParty': {'oldNameTitle': 'Caroline M. Tanner, MD, PhD, Director of Clinical Research', 'oldOrganization': "The Parkinson's Institute"}}}}