Ignite Creation Date:
2025-12-25 @ 4:02 AM
Ignite Modification Date:
2026-03-10 @ 11:50 PM
Study NCT ID:
NCT06529302
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2025-01-24
First Post:
2024-07-25
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
The OPBC-07/microNAC Study
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['Cyprus', 'Tajikistan', 'United Arab Emirates']}, 'conditionBrowseModule': {'meshes': [{'id': 'D001943', 'term': 'Breast Neoplasms'}], 'ancestors': [{'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'RETROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 2000}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'ACTIVE_NOT_RECRUITING', 'startDateStruct': {'date': '2024-05-15', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-01', 'completionDateStruct': {'date': '2025-06', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-01-23', 'studyFirstSubmitDate': '2024-07-25', 'studyFirstSubmitQcDate': '2024-07-30', 'lastUpdatePostDateStruct': {'date': '2025-01-24', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2024-07-31', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-06', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': '5-year rate of any axillary recurrence', 'timeFrame': '5 years', 'description': 'Assessment of the incidence of any axillary recurrence, which is defined as isolated or combined with local or distant recurrence.'}, {'measure': '5-year rate of isolated axillary recurrence', 'timeFrame': '5 years', 'description': 'Assessment of the incidence of isolated axillary recurrence.'}, {'measure': 'Comparison of 5-year rate of axillary recurrence in patients treated with and without axillary dissection', 'timeFrame': '5 years', 'description': 'The incidence of axillary recurrence is compared between patients that were treated with and without axillary dissection.'}], 'secondaryOutcomes': [{'measure': 'Proportion of patients with additional micro- and macrometastases removed by axillary lymph node dissection', 'timeFrame': '5 years', 'description': 'Assessment of the proportion of patients with additional micro- and macrometastases that were removed by axillary lymph node dissection.'}, {'measure': '5-year rates of locoregional and any invasive recurrence', 'timeFrame': '5 years', 'description': 'Assessment of the incidence of locoregional and any invasive recurrence.'}, {'measure': 'Comparison of 5-year rate of locoregional and any invasive recurrence in patients treated with and without axillary lymph node dissection', 'timeFrame': '5 years', 'description': 'The incidence of locoregional and any invasive recurrence is compared between patients that were treated with and without axillary lymph node dissection.'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['Neoadjuvant chemotherapy', 'Axillary lymph node dissection', 'Residual micrometastases'], 'conditions': ['Breast Cancer']}, 'descriptionModule': {'briefSummary': 'The aim of this multicenter retrospective cohort study is to determine the safety of omission of axillary lymph node dissection in patients with residual micrometastases after neoadjuvant chemotherapy.', 'detailedDescription': 'Chemotherapy before surgery, known as neoadjuvant chemotherapy (NAC), is often used to treat patients with advanced breast cancer or aggressive early-stage breast cancer. Research shows that about one in four early-stage breast cancer patients receives this treatment.\n\nFor patients undergoing NAC, standard of care includes checking the lymph nodes under the arm (axillary lymph nodes) using a procedure called Sentinel lymph node biopsy to determine if the cancer has spread. In cases where the cancer has spread to the lymph nodes but then shrinks or disappears after chemotherapy, special techniques like dual tracer mapping, targeted axillary dissection, or the Marking Axillary Lymph Nodes with Iodine Seeds procedure are used to ensure accurate biopsy results.\n\nFor patients whose cancer shrinks completely in the lymph nodes, it is generally safe to skip further surgery to remove more lymph nodes, a procedure called axillary lymph node dissection (ALND). However, if cancer remains in the lymph nodes, more lymph nodes are typically removed because there is a high chance that cancer is still present.\n\nAn increasing number of surgeons are starting to omit ALND, especially when only tiny amounts of cancer (micrometastases) remain. To ensure this practice is safe, real-world data on patient outcomes over time is needed.\n\nThis multicenter retrospective cohort study aims to assess the safety of omitting ALND in patients with residual micrometastases after NAC for breast cancer. The study analyzes data of breast cancer patients treated between 2013 and 2024 at more than 50 centers that are part of the Oncoplastic Breast Consortium.\n\nThe results of this study will provide valuable information to help doctors determine the best treatment approach for their patients.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '100 Years', 'minimumAge': '18 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'The study assesses consecutive patients with residual micrometastases after neoadjuvant chemotherapy, treated with or without axillary dissection. The data originate from participating Oncoplastic Breast Consortium (OPBC) centers as well as from the US and Brazil, and have been collect within the clinical routine between 2013 and 2024.', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Consecutive women and men aged 18 years or older with a diagnosis of stage I-III breast cancer (any histological and receptor subtype)\n* For Clinically Node negative (cN0) at presentation: any axillary staging technique including palpation is allowed. Dual tracer mapping is not required for Sentinel Lymph Node Biopsy (SLNB)\n* For Clinically Node positive (cN+) at presentation: Biopsy proven confirmation is required. Staging techniques include: SLNB with dual mapping or targeted axillary dissection (Targeted Axillary Dissection, TAD: imaging-guided localization of sampled node in combination with Sentinel Lymph Node procedure with or without dual mapping) or the Marking Axillary Lymph Nodes with Iodine Seeds (MARI) procedure\n* Completed neoadjuvant chemotherapy\n* Residual micrometastases detected on SLNB or TAD or MARI (on frozen section or final pathology)\n* Concomitant presence of Isolated Tumor Cells (ITCs) and micrometastases in other sentinel lymph nodes is allowed\n* Received axillary treatment with completion axillary lymph node dissection (ALND), axillary Radiotherapy (ART), both or none\n* At least 1-year follow-up (inclusion should end in May 2023)\n* Had surgery at any time point until May 2023 at the latest\n* Prior history of stage I-III (not stage IV) breast cancer is allowed\n\nExclusion Criteria:\n\n* Did not undergo SLNB/TAD/MARI (e.g., went straight to ALND or ART)\n* Presence of ITCs alone or macrometastases on the sentinel nodes (or TAD nodes or MARI node)\n* Stage IV disease at presentation\n* Inflammatory breast cancer at presentation\n* Neoadjuvant endocrine therapy\n* Micrometastases detected by One-step nucleic acid amplification (OSNA)'}, 'identificationModule': {'nctId': 'NCT06529302', 'briefTitle': 'The OPBC-07/microNAC Study', 'organization': {'class': 'OTHER', 'fullName': 'University Hospital, Basel, Switzerland'}, 'officialTitle': 'Association of Axillary Lymph Node Dissection With Oncological Outcomes in Patients With Residual Micrometastases After Neoadjuvant Chemotherapy: The OPBC-07/microNAC Study', 'orgStudyIdInfo': {'id': '2024-00186; bb24Weber'}}, 'contactsLocationsModule': {'locations': [{'zip': '85008', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'Valleywise Health Medical Center', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Cedars-Sinai Medical Center', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '94158', 'city': 'San Francisco', 'state': 'California', 'country': 'United States', 'facility': 'University of California', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '90404', 'city': 'Santa Monica', 'state': 'California', 'country': 'United States', 'facility': "Providence Saint John's Cancer Institute", 'geoPoint': {'lat': 34.01949, 'lon': -118.49138}}, {'zip': '33146', 'city': 'Coral Gables', 'state': 'Florida', 'country': 'United States', 'facility': 'University of Miami', 'geoPoint': {'lat': 25.72149, 'lon': -80.26838}}, {'zip': '02215', 'city': 'Boston', 'state': 'Massachusetts', 'country': 'United States', 'facility': 'Dana-Farber Cancer Institute', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '48109', 'city': 'Ann Arbor', 'state': 'Michigan', 'country': 'United States', 'facility': 'University of Michigan', 'geoPoint': {'lat': 42.27756, 'lon': -83.74088}}, {'zip': '55905', 'city': 'Rochester', 'state': 'Minnesota', 'country': 'United States', 'facility': 'Mayo Clinic', 'geoPoint': {'lat': 44.02163, 'lon': -92.4699}}, {'zip': '10016', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'NYU Langone Health', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10065', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Memorial Sloan Kettering Cancer Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10467', 'city': 'New York', 'state': 'New York', 'country': 'United States', 'facility': 'Montefiore Medical Center', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '14642', 'city': 'Rochester', 'state': 'New York', 'country': 'United States', 'facility': 'University of Rochester', 'geoPoint': {'lat': 43.15478, 'lon': -77.61556}}, {'zip': '27708', 'city': 'Durham', 'state': 'North Carolina', 'country': 'United States', 'facility': 'Duke University', 'geoPoint': {'lat': 35.99403, 'lon': -78.89862}}, {'zip': '19104', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'University of Pennsylvania', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '19111', 'city': 'Philadelphia', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'Fox Chase Cancer Center', 'geoPoint': {'lat': 39.95238, 'lon': -75.16362}}, {'zip': '15219', 'city': 'Pittsburgh', 'state': 'Pennsylvania', 'country': 'United States', 'facility': 'University of Pittsburgh Medical Center', 'geoPoint': {'lat': 40.44062, 'lon': -79.99589}}, {'zip': '77030', 'city': 'Houston', 'state': 'Texas', 'country': 'United States', 'facility': 'MD Anderson Cancer Center', 'geoPoint': {'lat': 29.76328, 'lon': -95.36327}}, {'zip': '98104', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'Swedish Cancer Institute', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '98195', 'city': 'Seattle', 'state': 'Washington', 'country': 'United States', 'facility': 'University of Washington', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': 'B1878', 'city': 'Quilmes', 'country': 'Argentina', 'facility': 'Sanatorio Modelo Quilmes', 'geoPoint': {'lat': -34.72065, 'lon': -58.25454}}, {'zip': '2050', 'city': 'Sydney', 'country': 'Australia', 'facility': "Chris O'Brien Lifehouse (COBL)", 'geoPoint': {'lat': -33.86785, 'lon': 151.20732}}, {'zip': '4020', 'city': 'Linz', 'country': 'Austria', 'facility': 'Ordensklinikum Linz GmbH', 'geoPoint': {'lat': 48.30639, 'lon': 14.28611}}, {'zip': '1090', 'city': 'Vienna', 'country': 'Austria', 'facility': 'Medical University of Vienna Chirurgie', 'geoPoint': {'lat': 48.20849, 'lon': 16.37208}}, {'zip': '70330-150', 'city': 'Brasília', 'country': 'Brazil', 'facility': 'Hospital de Base do Distrito Federal', 'geoPoint': {'lat': -15.77972, 'lon': -47.92972}}, {'city': 'Brasília', 'country': 'Brazil', 'facility': 'Sirio Libanes Hospital Brasilia', 'geoPoint': {'lat': -15.77972, 'lon': -47.92972}}, {'zip': '80810-040', 'city': 'Curitiba', 'country': 'Brazil', 'facility': 'Hospital Nossa Senhora das Graças', 'geoPoint': {'lat': -25.42778, 'lon': -49.27306}}, {'zip': '60150-160,', 'city': 'Fortaleza', 'country': 'Brazil', 'facility': 'Hospital Geral de Fortaleza', 'geoPoint': {'lat': -3.71722, 'lon': -38.54306}}, {'zip': '60430-230', 'city': 'Fortaleza', 'country': 'Brazil', 'facility': 'Instituto do Cancer do Ceará', 'geoPoint': {'lat': -3.71722, 'lon': -38.54306}}, {'zip': '74110-060', 'city': 'Goiânia', 'country': 'Brazil', 'facility': 'Instituto de Mastologia e Oncologia', 'geoPoint': {'lat': -16.67861, 'lon': -49.25389}}, {'zip': '74605-070', 'city': 'Goiânia', 'country': 'Brazil', 'facility': 'Hospital de Câncer Araújo Jorge', 'geoPoint': {'lat': -16.67861, 'lon': -49.25389}}, {'zip': '01308-050', 'city': 'São Paulo', 'country': 'Brazil', 'facility': 'Sirio Libanes Hospital', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '01401-002', 'city': 'São Paulo', 'country': 'Brazil', 'facility': "Instituto D'OR de Pesquisa e Ensino", 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': 'H3T 1E2', 'city': 'Montreal', 'country': 'Canada', 'facility': 'Sir Mortimer B. Davis Jewish General Hospital', 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': '7500921', 'city': 'Providencia', 'country': 'Chile', 'facility': 'Arturo Lopez Perez Foundation', 'geoPoint': {'lat': -33.43107, 'lon': -70.60454}}, {'zip': '7630370', 'city': 'Vitacura', 'country': 'Chile', 'facility': 'Institute of Radiation Medicine', 'geoPoint': {'lat': -33.39227, 'lon': -70.58275}}, {'zip': '51000', 'city': 'Rijeka', 'country': 'Croatia', 'facility': 'Clinical Hospital Center Rijeka', 'geoPoint': {'lat': 45.32673, 'lon': 14.44241}}, {'city': 'Al Mansurah', 'country': 'Egypt', 'facility': 'Mansoura oncology center', 'geoPoint': {'lat': 31.03637, 'lon': 31.38069}}, {'zip': '86156', 'city': 'Augsburg', 'country': 'Germany', 'facility': 'University Hospital Augsburg', 'geoPoint': {'lat': 48.37154, 'lon': 10.89851}}, {'zip': '40225', 'city': 'Düsseldorf', 'country': 'Germany', 'facility': 'University Hospital Düsseldorf', 'geoPoint': {'lat': 51.22172, 'lon': 6.77616}}, {'zip': '45136', 'city': 'Essen', 'country': 'Germany', 'facility': 'KEM | Clinics Essen-Mitte', 'geoPoint': {'lat': 51.45657, 'lon': 7.01228}}, {'zip': '69120', 'city': 'Heidelberg', 'country': 'Germany', 'facility': 'University Hospital Heidelberg', 'geoPoint': {'lat': 49.40768, 'lon': 8.69079}}, {'zip': '23562', 'city': 'Lübeck', 'country': 'Germany', 'facility': 'University Hospital Lübeck', 'geoPoint': {'lat': 53.86893, 'lon': 10.68729}}, {'zip': '71110', 'city': 'Heraklion', 'country': 'Greece', 'facility': 'University General Hospital of Heraklion', 'geoPoint': {'lat': 35.32787, 'lon': 25.14341}}, {'zip': '151 25', 'city': 'Marousi', 'country': 'Greece', 'facility': 'Athens Medical Center', 'geoPoint': {'lat': 38.05, 'lon': 23.8}}, {'city': 'Ramat Gan', 'country': 'Israel', 'facility': 'Sheba Medical Center', 'geoPoint': {'lat': 32.08227, 'lon': 34.81065}}, {'zip': '20141', 'city': 'Milan', 'country': 'Italy', 'facility': 'Insituto Europeo di Oncologia', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'zip': '80131', 'city': 'Napoli', 'country': 'Italy', 'facility': 'University Hospital Federico II', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'zip': '35128', 'city': 'Padua', 'country': 'Italy', 'facility': 'IOV Padua', 'geoPoint': {'lat': 45.40797, 'lon': 11.88586}}, {'zip': '27100', 'city': 'Pavia', 'country': 'Italy', 'facility': 'Clinici Scientifici Maugeri IRCCS', 'geoPoint': {'lat': 45.19205, 'lon': 9.15917}}, {'zip': '00136', 'city': 'Roma', 'country': 'Italy', 'facility': 'Fondazione Policlinico Universitario Agostino Gemelli IRCCS', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'zip': 'LV-1002', 'city': 'Riga', 'country': 'Latvia', 'facility': 'Pauls Stradiņš Clinical University Hospital', 'geoPoint': {'lat': 56.946, 'lon': 24.10589}}, {'zip': '08406', 'city': 'Vilnius', 'country': 'Lithuania', 'facility': 'National Cancer Institute', 'geoPoint': {'lat': 54.68916, 'lon': 25.2798}}, {'zip': '1066 CX', 'city': 'Amsterdam', 'country': 'Netherlands', 'facility': 'The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital', 'geoPoint': {'lat': 52.37403, 'lon': 4.88969}}, {'zip': 'N-0424', 'city': 'Oslo', 'country': 'Norway', 'facility': 'Oslo University Hospital', 'geoPoint': {'lat': 59.91273, 'lon': 10.74609}}, {'zip': 'Sindh 74200', 'city': 'Karachi', 'country': 'Pakistan', 'facility': 'Dow University of Health Sciences', 'geoPoint': {'lat': 24.8608, 'lon': 67.0104}}, {'zip': '13', 'city': 'La Victoria', 'country': 'Peru', 'facility': 'Hospital Nacional Guillermo Almenara Irigoyen', 'geoPoint': {'lat': -7.1353, 'lon': -76.74165}}, {'zip': '15038', 'city': 'Surquillo', 'country': 'Peru', 'facility': 'Instituto Nacional de Enfermedades Neoplasicas', 'geoPoint': {'lat': -5.80111, 'lon': -77.26889}}, {'zip': '65-046', 'city': 'Zielona Góra', 'country': 'Poland', 'facility': 'University Hospital Zielona Gora', 'geoPoint': {'lat': 51.93548, 'lon': 15.50643}}, {'zip': '1400-038', 'city': 'Lisbon', 'country': 'Portugal', 'facility': 'Champalimaud Foundation', 'geoPoint': {'lat': 38.72509, 'lon': -9.1498}}, {'zip': '197758', 'city': 'Saint Petersburg', 'country': 'Russia', 'facility': 'N.N. Petrov National Medical Research Center of Oncology', 'geoPoint': {'lat': 59.93863, 'lon': 30.31413}}, {'zip': '974 01', 'city': 'Banská Bystrica', 'country': 'Slovakia', 'facility': 'AGEL Mammacentrum sv. Agáty', 'geoPoint': {'lat': 48.73947, 'lon': 19.14932}}, {'zip': '1000', 'city': 'Ljubljana', 'country': 'Slovenia', 'facility': 'Institute of Oncology Ljubljana', 'geoPoint': {'lat': 46.05108, 'lon': 14.50513}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'ASAN Medical Center', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'Gangnam Severance Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'Samsung Medical Center', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'city': 'Seoul', 'country': 'South Korea', 'facility': 'Seoul National University Hospital', 'geoPoint': {'lat': 37.566, 'lon': 126.9784}}, {'zip': '08003', 'city': 'Barcelona', 'country': 'Spain', 'facility': "Hospital del Mar d'Investigacions Mèdiques", 'geoPoint': {'lat': 41.38879, 'lon': 2.15899}}, {'zip': '28027', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Clinica Universidad de Navarra', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '28046', 'city': 'Madrid', 'country': 'Spain', 'facility': 'Hospital Universitario La Paz, ía Mamaria', 'geoPoint': {'lat': 40.4165, 'lon': -3.70256}}, {'zip': '112 19', 'city': 'Stockholm', 'country': 'Sweden', 'facility': "Capio Saint Göran's Hospital", 'geoPoint': {'lat': 59.32938, 'lon': 18.06871}}, {'zip': '5404', 'city': 'Baden', 'country': 'Switzerland', 'facility': 'Cantonal Hospital Baden', 'geoPoint': {'lat': 47.47333, 'lon': 8.30592}}, {'zip': '4031', 'city': 'Basel', 'country': 'Switzerland', 'facility': 'University Hospital Basel', 'geoPoint': {'lat': 47.55839, 'lon': 7.57327}}, {'zip': '3001', 'city': 'Bern', 'country': 'Switzerland', 'facility': 'Campus SLB Sonnenhof AG', 'geoPoint': {'lat': 46.94809, 'lon': 7.44744}}, {'zip': '6000', 'city': 'Lucerne', 'country': 'Switzerland', 'facility': 'Cantonal Hospital Luzern', 'geoPoint': {'lat': 47.05048, 'lon': 8.30635}}, {'zip': '6962', 'city': 'Lugano', 'country': 'Switzerland', 'facility': 'EOC Centro di Senologia della Svizzera Italiana', 'geoPoint': {'lat': 46.01008, 'lon': 8.96004}}, {'zip': '9016', 'city': 'Sankt Gallen', 'country': 'Switzerland', 'facility': 'Tumor und Brustzentrum Ostschweiz', 'geoPoint': {'lat': 47.42391, 'lon': 9.37477}}, {'zip': '8400', 'city': 'Winterthur', 'country': 'Switzerland', 'facility': 'Cantonal Hospital Winterthur', 'geoPoint': {'lat': 47.50564, 'lon': 8.72413}}, {'zip': '8008', 'city': 'Zurich', 'country': 'Switzerland', 'facility': 'Zürich Breast Center', 'geoPoint': {'lat': 47.36667, 'lon': 8.55}}, {'zip': '8091', 'city': 'Zurich', 'country': 'Switzerland', 'facility': 'University Hospital Zürich', 'geoPoint': {'lat': 47.36667, 'lon': 8.55}}, {'zip': '06010', 'city': 'Ankara', 'country': 'Turkey (Türkiye)', 'facility': 'Gülhane Training and Research Hospital', 'geoPoint': {'lat': 39.91987, 'lon': 32.85427}}, {'zip': '34093', 'city': 'Fatih', 'country': 'Turkey (Türkiye)', 'facility': 'Istanbul University Faculty of Medicine', 'geoPoint': {'lat': 39.94548, 'lon': 32.87302}}, {'city': 'Istanbul', 'country': 'Turkey (Türkiye)', 'facility': 'Marmara University', 'geoPoint': {'lat': 41.01384, 'lon': 28.94966}}, {'zip': '67100', 'city': 'Zonguldak', 'country': 'Turkey (Türkiye)', 'facility': 'Zonguldak Bülent Ecevit University', 'geoPoint': {'lat': 41.45139, 'lon': 31.79305}}, {'zip': 'CB2 0QQ', 'city': 'Cambridge', 'country': 'United Kingdom', 'facility': 'Cambridge University Hospitals', 'geoPoint': {'lat': 52.2, 'lon': 0.11667}}], 'overallOfficials': [{'name': 'Walter Paul Weber, Prof. Dr.', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'University Hospital, Basel, Switzerland'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'University Hospital, Basel, Switzerland', 'class': 'OTHER'}, 'collaborators': [{'name': 'Memorial Sloan Kettering Cancer Center', 'class': 'OTHER'}], 'responsibleParty': {'type': 'SPONSOR'}}}}