Ignite Creation Date:
2025-12-25 @ 3:56 AM
Ignite Modification Date:
2025-12-26 @ 2:47 AM
Study NCT ID:
NCT01091402
Status:
COMPLETED
Last Update Posted:
2010-03-24
First Post:
2010-03-23
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D014581', 'term': 'Urticaria'}], 'ancestors': [{'id': 'D017445', 'term': 'Skin Diseases, Vascular'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}, {'id': 'D006969', 'term': 'Hypersensitivity, Immediate'}, {'id': 'D006967', 'term': 'Hypersensitivity'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}}, 'protocolSection': {'designModule': {'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'CASE_CONTROL'}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2009-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2009-01', 'lastUpdateSubmitDate': '2010-03-23', 'studyFirstSubmitDate': '2010-03-23', 'studyFirstSubmitQcDate': '2010-03-23', 'lastUpdatePostDateStruct': {'date': '2010-03-24', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2010-03-24', 'type': 'ESTIMATED'}}, 'conditionsModule': {'keywords': ['autologous serum skin test, IL-18'], 'conditions': ['Urticaria', 'Respiratory Allergic Diseases']}, 'descriptionModule': {'briefSummary': 'One of the proposed mechanisms in CU is autoimmunity. It was shown by a positive response to autologous serum skin test (ASST)in almost half of chronic urticaria (CU) patients. IL-18 also play a role in autoimmune disorders. The investigators aim was to investigate the relationship of ASST and IL-18 in CU and respiratory allergic diseases.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '16 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'patients from Outpatient clinic', 'healthyVolunteers': True, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* adult patients\n* chronic urticaria patients\n* stable asthma patients\n* allergic rhinitis patients with sensitized to pollens\n* normal controls without atopic and skin disease.\n\nExclusion Criteria:\n\n* unwillingness to the study\n* other dermatological problems that could affect the skin test\n* use of antihistamine drugs'}, 'identificationModule': {'nctId': 'NCT01091402', 'briefTitle': 'Autologous Serum Skin Test and Serum IL-18 Levels in Chronic Idiopathic Urticaria and Respiratory Allergic Diseases', 'organization': {'class': 'OTHER', 'fullName': 'Eskisehir Osmangazi University'}, 'orgStudyIdInfo': {'id': '1'}}, 'armsInterventionsModule': {'armGroups': [{'label': 'chronic urticaria', 'interventionNames': ['Procedure: autologous serum skin test, serum IL-18']}, {'label': 'asthma', 'interventionNames': ['Procedure: autologous serum skin test, serum IL-18']}, {'label': 'seasonal allergic rhinitis', 'interventionNames': ['Procedure: autologous serum skin test, serum IL-18']}, {'label': 'normal controls', 'interventionNames': ['Procedure: autologous serum skin test, serum IL-18']}], 'interventions': [{'name': 'autologous serum skin test, serum IL-18', 'type': 'PROCEDURE', 'armGroupLabels': ['asthma', 'chronic urticaria', 'normal controls', 'seasonal allergic rhinitis']}]}, 'contactsLocationsModule': {'locations': [{'zip': '26040', 'city': 'Eskişehir', 'country': 'Turkey (Türkiye)', 'facility': 'Eskisehir Osmangazi University', 'geoPoint': {'lat': 39.77667, 'lon': 30.52056}}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'Eskisehir Osmangazi University', 'class': 'OTHER'}}}}