Ignite Creation Date:
2025-12-25 @ 3:55 AM
Ignite Modification Date:
2026-03-02 @ 11:04 PM
Study NCT ID:
NCT00553202
Status:
COMPLETED
Last Update Posted:
2020-04-16
First Post:
2007-11-02
Is NOT Gene Therapy:
True
Has Adverse Events:
True
Brief Title:
Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D007938', 'term': 'Leukemia'}], 'ancestors': [{'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000961', 'term': 'Antilymphocyte Serum'}, {'id': 'C512542', 'term': 'thymoglobulin'}, {'id': 'D002066', 'term': 'Busulfan'}, {'id': 'D003520', 'term': 'Cyclophosphamide'}, {'id': 'D016572', 'term': 'Cyclosporine'}, {'id': 'D003524', 'term': 'Cyclosporins'}, {'id': 'D008727', 'term': 'Methotrexate'}, {'id': 'D008775', 'term': 'Methylprednisolone'}, {'id': 'D008776', 'term': 'Methylprednisolone Hemisuccinate'}, {'id': 'D016559', 'term': 'Tacrolimus'}, {'id': 'C022780', 'term': 'allogenic effect factor'}, {'id': 'D014180', 'term': 'Transplantation'}], 'ancestors': [{'id': 'D007106', 'term': 'Immune Sera'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}, {'id': 'D001688', 'term': 'Biological Products'}, {'id': 'D045424', 'term': 'Complex Mixtures'}, {'id': 'D002072', 'term': 'Butylene Glycols'}, {'id': 'D006018', 'term': 'Glycols'}, {'id': 'D000438', 'term': 'Alcohols'}, {'id': 'D009930', 'term': 'Organic Chemicals'}, {'id': 'D008698', 'term': 'Mesylates'}, {'id': 'D000476', 'term': 'Alkanesulfonates'}, {'id': 'D017738', 'term': 'Alkanesulfonic Acids'}, {'id': 'D000473', 'term': 'Alkanes'}, {'id': 'D006839', 'term': 'Hydrocarbons, Acyclic'}, {'id': 'D006838', 'term': 'Hydrocarbons'}, {'id': 'D013451', 'term': 'Sulfonic Acids'}, {'id': 'D013456', 'term': 'Sulfur Acids'}, {'id': 'D013457', 'term': 'Sulfur Compounds'}, {'id': 'D010752', 'term': 'Phosphoramide Mustards'}, {'id': 'D009588', 'term': 'Nitrogen Mustard Compounds'}, {'id': 'D009150', 'term': 'Mustard Compounds'}, {'id': 'D006846', 'term': 'Hydrocarbons, Halogenated'}, {'id': 'D063088', 'term': 'Phosphoramides'}, {'id': 'D009943', 'term': 'Organophosphorus Compounds'}, {'id': 'D010456', 'term': 'Peptides, Cyclic'}, {'id': 'D047028', 'term': 'Macrocyclic Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D010455', 'term': 'Peptides'}, {'id': 'D000630', 'term': 'Aminopterin'}, {'id': 'D011622', 'term': 'Pterins'}, {'id': 'D011621', 'term': 'Pteridines'}, {'id': 'D006574', 'term': 'Heterocyclic Compounds, 2-Ring'}, {'id': 'D000072471', 'term': 'Heterocyclic Compounds, Fused-Ring'}, {'id': 'D006571', 'term': 'Heterocyclic Compounds'}, {'id': 'D011239', 'term': 'Prednisolone'}, {'id': 'D011246', 'term': 'Pregnadienetriols'}, {'id': 'D011245', 'term': 'Pregnadienes'}, {'id': 'D011278', 'term': 'Pregnanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D018942', 'term': 'Macrolides'}, {'id': 'D007783', 'term': 'Lactones'}, {'id': 'D013514', 'term': 'Surgical Procedures, Operative'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': 'resultsreportingcoordinator@childrensoncologygroup.org', 'phone': '626-447-0064', 'title': 'Results Reporting Coordinator', 'organization': "Children's Oncology Group"}, 'certainAgreement': {'otherDetails': 'Must obtain prior Sponsor approval.', 'restrictionType': 'OTHER', 'piSponsorEmployee': False, 'restrictiveAgreement': True}}, 'adverseEventsModule': {'eventGroups': [{'id': 'EG000', 'title': 'Group 1', 'description': 'All patients', 'otherNumAtRisk': 90, 'otherNumAffected': 32, 'seriousNumAtRisk': 90, 'seriousNumAffected': 7}], 'otherEvents': [{'term': 'Abdominal distension', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Abdominal pain', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Acute kidney injury', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 5}], 'organSystem': 'Renal and urinary disorders'}, {'term': 'Adult respiratory distress syndrome', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Allergic reaction', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Immune system disorders'}, {'term': 'Ascites', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 8}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Aspartate aminotransferase increased', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Investigations'}, {'term': 'Bladder spasm', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Renal and urinary disorders'}, {'term': 'Blood bilirubin increased', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 11}], 'organSystem': 'Investigations'}, {'term': 'Bronchopulmonary hemorrhage', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Cardiac disorders - Other, specify', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Cardiac disorders'}, {'term': 'Creatinine increased', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Investigations'}, {'term': 'Cystitis noninfective', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Renal and urinary disorders'}, {'term': 'Cytokine release syndrome', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Immune system disorders'}, {'term': 'Death NOS', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'General disorders'}, {'term': 'Diarrhea', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Electrocardiogram QT corrected interval prolonged', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 5}], 'organSystem': 'Investigations'}, {'term': 'Encephalitis infection', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Infections and infestations'}, {'term': 'Febrile neutropenia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Blood and lymphatic system disorders'}, {'term': 'Gastric hemorrhage', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Heart failure', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Cardiac disorders'}, {'term': 'Hematuria', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Renal and urinary disorders'}, {'term': 'Hepatic pain', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 4}], 'organSystem': 'Hepatobiliary disorders'}, {'term': 'Hepatobiliary disorders - Other, specify', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Hepatobiliary disorders'}, {'term': 'Hyperglycemia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypernatremia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypoalbuminemia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypoglycemia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypokalemia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 4}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hyponatremia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypophosphatemia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypotension', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Vascular disorders'}, {'term': 'Hypoxia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Ileus', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Infections and infestations - Other, specify', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Infections and infestations'}, {'term': 'Left ventricular systolic dysfunction', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 4}], 'organSystem': 'Cardiac disorders'}, {'term': 'Lower gastrointestinal hemorrhage', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Lung infection', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Infections and infestations'}, {'term': 'Mucositis oral', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Multi-organ failure', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'General disorders'}, {'term': 'Pain', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'General disorders'}, {'term': 'Pericardial effusion', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Cardiac disorders'}, {'term': 'Pharyngeal hemorrhage', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Pleural effusion', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Pneumothorax', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Portal hypertension', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Hepatobiliary disorders'}, {'term': 'Pulmonary edema', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Rash maculo-papular', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Skin and subcutaneous tissue disorders'}, {'term': 'Respiratory failure', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 5}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Respiratory, thoracic and mediastinal disorders - Other, specify', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Seizure', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Nervous system disorders'}, {'term': 'Sepsis', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Infections and infestations'}, {'term': 'Serum amylase increased', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Investigations'}, {'term': 'Sinus tachycardia', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Cardiac disorders'}, {'term': 'Sinusitis', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Infections and infestations'}, {'term': 'Skin and subcutaneous tissue disorders - Other, specify', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Skin and subcutaneous tissue disorders'}, {'term': 'Stevens-Johnson syndrome', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Skin and subcutaneous tissue disorders'}, {'term': 'Tumor lysis syndrome', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Upper gastrointestinal hemorrhage', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Urinary tract infection', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Infections and infestations'}, {'term': 'Urine output decreased', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Investigations'}, {'term': 'Vaginal hemorrhage', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Reproductive system and breast disorders'}, {'term': 'Vascular disorders - Other, specify', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Vascular disorders'}, {'term': 'Weight gain', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 8}], 'organSystem': 'Investigations'}, {'term': 'White blood cell decreased', 'notes': 'Adeers not subm', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Investigations'}], 'seriousEvents': [{'term': 'Adult respiratory distress syndrome', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Alanine aminotransferase increased', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Investigations'}, {'term': 'Ascites', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Atelectasis', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Blood bilirubin increased', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Investigations'}, {'term': 'Creatinine increased', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Investigations'}, {'term': 'Death NOS', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'General disorders'}, {'term': 'Hepatobiliary disorders - Other, specify', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Hepatobiliary disorders'}, {'term': 'Hypercalcemia', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Metabolism and nutrition disorders'}, {'term': 'Hypoxia', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Immune system disorders - Other, specify', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Immune system disorders'}, {'term': 'Infections and infestations - Other, specify', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Infections and infestations'}, {'term': 'Mucositis oral', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Gastrointestinal disorders'}, {'term': 'Multi-organ failure', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'General disorders'}, {'term': 'Pleural effusion', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Portal hypertension', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Hepatobiliary disorders'}, {'term': 'Productive cough', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Pulmonary edema', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Renal and urinary disorders - Other, specify', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Renal and urinary disorders'}, {'term': 'Respiratory failure', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 3}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Respiratory, thoracic and mediastinal disorders - Other, specify', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 1}], 'organSystem': 'Respiratory, thoracic and mediastinal disorders'}, {'term': 'Sepsis', 'notes': 'Adeers submitted', 'stats': [{'groupId': 'EG000', 'numAtRisk': 90, 'numAffected': 2}], 'organSystem': 'Infections and infestations'}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Overall Survival (OS)', 'denoms': [{'units': 'Participants', 'counts': [{'value': '90', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All Patients'}], 'classes': [{'categories': [{'measurements': [{'value': '45.9', 'groupId': 'OG000', 'lowerLimit': '33.7', 'upperLimit': '57.2'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'At 5 years from HSCT date', 'description': 'OS - Time from HSCT until death', 'unitOfMeasure': 'Percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients without completion of planned therapy (n=68) are excluded from analyses of OS'}, {'type': 'PRIMARY', 'title': 'Cumulative Incidence of NK Cell Reconstitution', 'denoms': [{'units': 'Participants', 'counts': [{'value': '52', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All Patients'}], 'classes': [{'categories': [{'measurements': [{'value': '48.1', 'groupId': 'OG000', 'lowerLimit': '33.8', 'upperLimit': '61.0'}]}]}], 'paramType': 'NUMBER', 'timeFrame': 'At 5 years from HSCT date', 'description': 'Cumulative incidence of successful reconstitution to donor level is calculated.', 'unitOfMeasure': 'Percentage of participants', 'dispersionType': '95% Confidence Interval', 'reportingStatus': 'POSTED', 'populationDescription': 'Patients without completion of planned therapy (n=68) or without NK cell status (n=38) are excluded from analyses of TExp'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Disease-free Survival', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All patients'}], 'timeFrame': 'From the date of SCT to the date of relapse, the date of death, or the date of last follow-up, whichever occurs first', 'description': 'The cumulative incidence of relapse or death after SCT will be calculated by considering relapse and death due to other causes as competing events.', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Acute and Chronic Graft-versus-host Disease', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All patients'}], 'timeFrame': 'Up to 5 years', 'description': 'Acute and chronic GVHD will be summarized.', 'reportingStatus': 'POSTED'}, {'type': 'OTHER_PRE_SPECIFIED', 'title': 'Time to the Donor-specific NK-cell Receptor Expression', 'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All patients'}], 'timeFrame': 'Up to 42 days after SCT', 'description': 'The presence of donor cells is demonstrated by the detection of informative variable-number tandem-repeat polymorphisms or by fluorescent in situ hybridization with a Y-chromosome-specific probe in cases of sex-mismatched transplants. Independent variables that will be examined include donor-recipient KIR mismatch, taking into consideration the interactions with donor-recipient human leukocyte antigen (HLA) compatibility, and the numbers of CD34+ cells and CD3+ cells in the graft.', 'reportingStatus': 'POSTED'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All patients'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '158'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '90'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '68'}]}], 'dropWithdraws': [{'type': 'Death', 'reasons': [{'groupId': 'FG000', 'numSubjects': '16'}]}, {'type': 'Lost to Follow-up', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}]}, {'type': 'Physician Decision', 'reasons': [{'groupId': 'FG000', 'numSubjects': '28'}]}, {'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}]}, {'type': 'No donor identified', 'reasons': [{'groupId': 'FG000', 'numSubjects': '16'}]}, {'type': 'Fails to meet organ function', 'reasons': [{'groupId': 'FG000', 'numSubjects': '6'}]}]}]}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '158', 'groupId': 'BG000'}]}], 'groups': [{'id': 'BG000', 'title': 'Treatment (Chemotherapy and Allogeneic SCT)', 'description': 'All Patients'}], 'measures': [{'title': 'Age, Categorical', 'classes': [{'categories': [{'title': '<=18 years', 'measurements': [{'value': '149', 'groupId': 'BG000'}]}, {'title': 'Between 18 and 65 years', 'measurements': [{'value': '9', 'groupId': 'BG000'}]}, {'title': '>=65 years', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Age, Continuous', 'classes': [{'categories': [{'measurements': [{'value': '3215.34', 'spread': '2240.48', 'groupId': 'BG000'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'Days', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'categories': [{'title': 'Female', 'measurements': [{'value': '75', 'groupId': 'BG000'}]}, {'title': 'Male', 'measurements': [{'value': '83', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race (NIH/OMB)', 'classes': [{'categories': [{'title': 'American Indian or Alaska Native', 'measurements': [{'value': '1', 'groupId': 'BG000'}]}, {'title': 'Asian', 'measurements': [{'value': '4', 'groupId': 'BG000'}]}, {'title': 'Native Hawaiian or Other Pacific Islander', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Black or African American', 'measurements': [{'value': '10', 'groupId': 'BG000'}]}, {'title': 'White', 'measurements': [{'value': '128', 'groupId': 'BG000'}]}, {'title': 'More than one race', 'measurements': [{'value': '0', 'groupId': 'BG000'}]}, {'title': 'Unknown or Not Reported', 'measurements': [{'value': '15', 'groupId': 'BG000'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Region of Enrollment', 'classes': [{'title': 'Canada', 'categories': [{'measurements': [{'value': '11', 'groupId': 'BG000'}]}]}, {'title': 'United States', 'categories': [{'measurements': [{'value': '147', 'groupId': 'BG000'}]}]}], 'paramType': 'NUMBER', 'unitOfMeasure': 'participants'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 158}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2008-01'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2016-07', 'completionDateStruct': {'date': '2020-03-31', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2020-04-07', 'studyFirstSubmitDate': '2007-11-02', 'resultsFirstSubmitDate': '2016-10-31', 'studyFirstSubmitQcDate': '2007-11-02', 'lastUpdatePostDateStruct': {'date': '2020-04-16', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2017-01-06', 'studyFirstPostDateStruct': {'date': '2007-11-05', 'type': 'ESTIMATED'}, 'resultsFirstPostDateStruct': {'date': '2017-02-24', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2016-06', 'type': 'ACTUAL'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Disease-free Survival', 'timeFrame': 'From the date of SCT to the date of relapse, the date of death, or the date of last follow-up, whichever occurs first', 'description': 'The cumulative incidence of relapse or death after SCT will be calculated by considering relapse and death due to other causes as competing events.'}, {'measure': 'Acute and Chronic Graft-versus-host Disease', 'timeFrame': 'Up to 5 years', 'description': 'Acute and chronic GVHD will be summarized.'}, {'measure': 'Time to the Donor-specific NK-cell Receptor Expression', 'timeFrame': 'Up to 42 days after SCT', 'description': 'The presence of donor cells is demonstrated by the detection of informative variable-number tandem-repeat polymorphisms or by fluorescent in situ hybridization with a Y-chromosome-specific probe in cases of sex-mismatched transplants. Independent variables that will be examined include donor-recipient KIR mismatch, taking into consideration the interactions with donor-recipient human leukocyte antigen (HLA) compatibility, and the numbers of CD34+ cells and CD3+ cells in the graft.'}], 'primaryOutcomes': [{'measure': 'Overall Survival (OS)', 'timeFrame': 'At 5 years from HSCT date', 'description': 'OS - Time from HSCT until death'}, {'measure': 'Cumulative Incidence of NK Cell Reconstitution', 'timeFrame': 'At 5 years from HSCT date', 'description': 'Cumulative incidence of successful reconstitution to donor level is calculated.'}]}, 'oversightModule': {'oversightHasDmc': True}, 'conditionsModule': {'keywords': ['recurrent childhood acute myeloid leukemia', 'childhood myelodysplastic syndromes'], 'conditions': ['Leukemia']}, 'descriptionModule': {'briefSummary': "RATIONALE: Giving chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune cells and help destroy any remaining cancer cells (graft-versus-tumor effect). Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving antithymocyte globulin before transplant and cyclosporine, tacrolimus, and methotrexate before and after transplant may stop this from happening.\n\nPURPOSE: Natural Killer (NK) cells from the donor's bone marrow may be important in fighting leukemia. Bone marrow donors can be selected based on the type of NK cells they have, specifically the killer immunoglobulin receptor (KIR) type. This study provides information on KIR type from potential donors, which can be used in selecting the bone marrow donor. This phase II trial of unrelated donor stem cell transplant in patients with high risk AML (monosomy 7, -5/5q-, high FLT3-ITD AR, or refractory or relapsed AML) in which KIR typing of the patients and potential donors will be available to the treating transplant physician at the time of donor selection.", 'detailedDescription': 'OBJECTIVES:\n\n* To define the relationship between the status of donor NK-cell receptor and patient outcomes after killer immunoglobulin-like receptor-incompatible unrelated donor (URD) and umbilical cord blood (UCB) hematopoietic cell transplantation (HCT) in young patients with acute myeloid leukemia with monosomy 7, -5/5q-, high FLT3 internal tandem duplication allelic ratio (High-FLT3-ITD AR), or refractory or relapsed acute myelogenous leukemia.\n* To correlate the relationships between factors affecting NK receptor status and clinical events.\n* To assess NK-cell development after URD and UCB HCT in patients with poor prognosis AML.\n* To evaluate NK-cell reconstitution and receptor-acquisition pattern in these patients.\n\nOUTLINE: This is a multicenter study.\n\n* Preparative regimen: Patients receive 1 of the following regimens:\n\n * Hematopoietic stem cell transplantation (SCT): Patients receive busulfan IV every 6 hours on days -9 to -6, high-dose cyclophosphamide IV over 1 hour on days -5 to -2, anti-thymocyte globulin IV once or twice daily over 4 hours on days -3 to -1, and methylprednisolone IV on days -3 to -1.\n * Umbilical cord blood (UCB) transplantation: Conditioning regimen, infusion procedures, and post-transplant immunoprophylaxis for patients with an UCB donor are according to institutional guidelines and standards.\n* Allogeneic hematopoietic stem cell transplantation (SCT) or umbilical cord blood (UCB) transplant: Patients undergo allogeneic SCT or UCB transplant on day 0.\n* Graft-vs-host disease (GVHD) prophylaxis: Patients receive cyclosporine or tacrolimus IV or orally beginning on day -2 and continuing until day 50, followed by a taper until week 24. Patients also receive methotrexate IV on days 1, 3, 6, and 11.\n\nBlood samples will be collected periodically from both patients and donors for studies of natural killer cells in support of the study objectives.\n\nAfter completion of study treatment, patients are followed every 6 months for 2 years and then annually for 3 years.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT'], 'maximumAge': '30 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'DISEASE CHARACTERISTICS:\n\n* Diagnosis of one of the following:\n\n * Patients with primary refractory acute myeloid leukemia (AML), defined as ≥ 5% bone marrow blasts after two induction courses of chemotherapy\n * Primary refractory AML, defined as ≥ 5% bone marrow blasts after two induction courses of chemotherapy\n * AML or myelodysplastic syndrome with -5/5q- or monosomy 7 without inv(16)/t(16;16) or t(8;21) cytogenetics or NPM or CEBPα mutations\n * Relapsed AML (≥ 5% bone marrow blasts) who meet the customary WHO criteria for AML\n * AML and high FLT3 internal tandem duplication allelic ratio (high FLT3-ITD AR), defined as \\> 0.4\n * All cases of therapy-related AML (therapy-related AML is considered high risk)\n * Patients with AML, without inv(16)/t(16;16) or t(8;21), monosomy 7, -5/5q-, NPM, or CEPBα mutations, or high FLT3-ITD AR, but with evidence of residual AML (≥ 0.1%) at the end of Induction I; or if a minimal residual disease (MRD) is not performed, then with \\> 15% bone marrow blasts by morphology after one induction course of chemotherapy\n\n * Any flow-based MRD is eligible for AAML05P1 for patients not on AAML1031, whereas patients on AAML1031 must utilize the central lab as per the AAML1031 protocol guidelines\n* No Fanconi anemia\n* Recipients of unrelated marrow or cord blood are eligible for this study\n\nPATIENT CHARACTERISTICS:\n\n* Karnofsky performance status (PS) (for patients over 16 years of age) or Lansky PS (for patients 16 and under) 50-100%\n* Total bilirubin ≤ 2 mg/dL\n* SGOT (AST) or SGPT (ALT) ≤ 2.5 times upper limit of normal\n* DLCO ≥ 50% OR a normal chest x-ray and pulse oximetry in patients who are unable to undergo pulmonary function tests\n* Shortening fraction ≥ 27% by ECHO\n* Creatinine clearance or radioisotope glomerular filtration rate at least 60 mL/min OR creatinine adjusted according to age\n* HIV negative\n* Not pregnant or nursing\n* Negative pregnancy test\n* Fertile patients must use effective contraception\n* Patients with proven or suspected bacterial sepsis, pneumonia, or meningitis are eligible provided appropriate therapeutic measures have been initiated to control the presumed or proven infection, and systemic signs are not life-threatening\n* No evidence or presence of a fungal infection within the past 30 days\n\nPRIOR CONCURRENT THERAPY:\n\n* Prior chemotherapy, radiotherapy or any antileukemic therapy allowed provided patients meet 1 of the following criteria:\n\n * Received initial treatment for relapsed AML\n * Patients with primary induction failure or relapse who have already received initial therapy and who may have gone on to have additional therapy prior to receiving protocol stipulated therapy on AAML05P1\n* No treatment for fungal infection within the past 30 days\n* Concurrent radiotherapy to localized painful lesions allowed\n* No other concurrent cancer chemotherapy or immunomodulating agents'}, 'identificationModule': {'nctId': 'NCT00553202', 'briefTitle': 'Donor Stem Cell Transplant in Treating Young Patients With Acute Myeloid Leukemia With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory or Relapsed Acute Myelogenous Leukemia', 'organization': {'class': 'NETWORK', 'fullName': "Children's Oncology Group"}, 'officialTitle': "Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Cell Transplantation (SCT) for AML With Monosomy 7, -5/5q-, High FLT3-ITD AR, or Refractory and Relapsed Acute Myelogenous Leukemia (AML) in Children: A Children's Oncology Group (COG) Study", 'orgStudyIdInfo': {'id': 'AAML05P1'}, 'secondaryIdInfos': [{'id': 'COG-AAML05P1', 'type': 'OTHER', 'domain': "Children's Oncology Group"}, {'id': 'NCI-2009-00321', 'type': 'REGISTRY', 'domain': 'NCI Trial Identifier'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Treatment (chemotherapy and allogeneic SCT)', 'description': 'Patients receive busulfan IV every 6 hours on days -9 to -6, high-dose cyclophosphamide IV over 1 hour on days -5 to -2, anti-thymocyte globulin IV once or twice daily over 4 hours on days -3 to -1, and methylprednisolone IV on days -3 to -1.\n\nPatients undergo allogeneic hematopoietic stem cell transplantation (SCT) or allogeneic bone marrow transplantation (BMT) on day 0.\n\nPatients receive cyclosporine or tacrolimus IV or orally beginning on day -2 and continuing until day 50, followed by a taper until week 24. Patients also receive methotrexate IV on days 1, 3, 6, and 11.\n\nBlood samples will be collected periodically from both patients and donors for studies of natural killer cells in support of the pharmacological study objectives', 'interventionNames': ['Biological: anti-thymocyte globulin', 'Drug: busulfan', 'Drug: cyclophosphamide', 'Drug: cyclosporine', 'Drug: methotrexate', 'Drug: methylprednisolone', 'Drug: tacrolimus', 'Other: laboratory biomarker analysis', 'Other: pharmacological study', 'Procedure: allogeneic bone marrow transplantation', 'Procedure: allogeneic hematopoietic stem cell transplantation']}], 'interventions': [{'name': 'anti-thymocyte globulin', 'type': 'BIOLOGICAL', 'otherNames': ['Rabbit ATG', 'RATG-Rabbit', 'Antithymocyte Globulin', 'Thymoglobulin', 'NSC #720095'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'busulfan', 'type': 'DRUG', 'otherNames': ['Busulfex', 'NSC #750'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'cyclophosphamide', 'type': 'DRUG', 'otherNames': ['Cytoxan', 'NSC #26271'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'cyclosporine', 'type': 'DRUG', 'otherNames': ['CYA', 'Sandimmune', 'Neoral', 'Gengraf', 'NSC #290193'], 'description': 'Given IV or orally', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'methotrexate', 'type': 'DRUG', 'otherNames': ['MTX', 'amethopterin', 'NSC #000740'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'methylprednisolone', 'type': 'DRUG', 'otherNames': ['Solu-Medrol', 'A-Methapred', 'Medrol', 'NSC #19987'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'tacrolimus', 'type': 'DRUG', 'otherNames': ['FK-506', 'Prograf', 'NSC #717865'], 'description': 'Given IV', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'laboratory biomarker analysis', 'type': 'OTHER', 'description': 'Correlative studies', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'pharmacological study', 'type': 'OTHER', 'description': 'Correlative studies', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'allogeneic bone marrow transplantation', 'type': 'PROCEDURE', 'otherNames': ['bone marrow therapy', 'allogeneic', 'allogenic', 'transplantation', 'allogeneic bone marrow', 'allogenic bone marrow'], 'description': 'allogeneic bone marrow transplantation', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}, {'name': 'allogeneic hematopoietic stem cell transplantation', 'type': 'PROCEDURE', 'description': 'Undergo allogeneic hematopoietic SCT', 'armGroupLabels': ['Treatment (chemotherapy and allogeneic SCT)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35294', 'city': 'Birmingham', 'state': 'Alabama', 'country': 'United States', 'facility': 'UAB Comprehensive Cancer Center', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '85016-7710', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': "Phoenix Children's Hospital", 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '90801', 'city': 'Long Beach', 'state': 'California', 'country': 'United States', 'facility': "Jonathan Jaques Children's Cancer Center at Miller Children's Hospital", 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '93638-8762', 'city': 'Madera', 'state': 'California', 'country': 'United States', 'facility': "Children's Hospital Central California", 'geoPoint': {'lat': 36.96134, 'lon': -120.06072}}, {'zip': '92123-4282', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': "Rady Children's Hospital - San Diego", 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '19803', 'city': 'Wilmington', 'state': 'Delaware', 'country': 'United States', 'facility': 'Alfred I. duPont Hospital for Children', 'geoPoint': {'lat': 39.74595, 'lon': -75.54659}}, {'zip': '20010-2970', 'city': 'Washington D.C.', 'state': 'District of Columbia', 'country': 'United States', 'facility': "Children's National Medical Center", 'geoPoint': {'lat': 38.89511, 'lon': -77.03637}}, {'zip': '33901', 'city': 'Fort Myers', 'state': 'Florida', 'country': 'United States', 'facility': 'Lee Cancer Care of Lee Memorial Health System', 'geoPoint': {'lat': 26.62168, 'lon': -81.84059}}, {'zip': '32207', 'city': 'Jacksonville', 'state': 'Florida', 'country': 'United States', 'facility': "Nemours Children's Clinic", 'geoPoint': {'lat': 30.33218, 'lon': -81.65565}}, {'zip': '32806', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': "Nemours Children's Clinic - Orlando", 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '32504', 'city': 'Pensacola', 'state': 'Florida', 'country': 'United States', 'facility': "Nemours Children's Clinic - 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