Ignite Creation Date:
2025-12-25 @ 3:54 AM
Ignite Modification Date:
2026-02-18 @ 2:48 AM
Study NCT ID:
NCT04168502
Status:
RECRUITING
Last Update Posted:
2024-11-08
First Post:
2019-11-11
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Gemtuzumab Chemotherapy MRD Levels; Adult Untreated, de Novo, Fav Interm Risk AML
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015470', 'term': 'Leukemia, Myeloid, Acute'}], 'ancestors': [{'id': 'D007951', 'term': 'Leukemia, Myeloid'}, {'id': 'D007938', 'term': 'Leukemia'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D000079982', 'term': 'Gemtuzumab'}], 'ancestors': [{'id': 'D000080084', 'term': 'Calicheamicins'}, {'id': 'D000617', 'term': 'Aminoglycosides'}, {'id': 'D006027', 'term': 'Glycosides'}, {'id': 'D002241', 'term': 'Carbohydrates'}, {'id': 'D061067', 'term': 'Antibodies, Monoclonal, Humanized'}, {'id': 'D000911', 'term': 'Antibodies, Monoclonal'}, {'id': 'D000906', 'term': 'Antibodies'}, {'id': 'D007136', 'term': 'Immunoglobulins'}, {'id': 'D007162', 'term': 'Immunoproteins'}, {'id': 'D001798', 'term': 'Blood Proteins'}, {'id': 'D011506', 'term': 'Proteins'}, {'id': 'D000602', 'term': 'Amino Acids, Peptides, and Proteins'}, {'id': 'D012712', 'term': 'Serum Globulins'}, {'id': 'D005916', 'term': 'Globulins'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'NA', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'SINGLE_GROUP'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 414}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2020-09-24', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-10', 'completionDateStruct': {'date': '2027-04', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2024-11-07', 'studyFirstSubmitDate': '2019-11-11', 'studyFirstSubmitQcDate': '2019-11-15', 'lastUpdatePostDateStruct': {'date': '2024-11-08', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2019-11-19', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-04', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Activity of GO in combination with chemotherapy in terms of MRD negativity achievement', 'timeFrame': '2 months', 'description': 'Percentage of MRD negativity after consolidation in patients treated in induction and consolidation with GO'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['De-novo', 'Favorable risk', 'Intermediate risk', 'Gemtuzumab ozogamicin', 'Acute Myeloid Leukemia'], 'conditions': ['Acute Myeloid Leukemia']}, 'descriptionModule': {'briefSummary': 'MRD driven study. Addition of gemtuzumab to conventional chemotherapy to reduce MRD of patients with favorable/intermediate-risk AML. Post-consolidation assessment of MRD.', 'detailedDescription': 'Setting up a multicenter, MRD (Minimal Residual Disease)-driven study that relies on addition of gemtuzumab ozogamicin to conventional chemotherapy to reduce the pre-transplant levels of MRD of patients with favorable/intermediate-risk (according to ELN 2017) AML. Post-consolidation assessment of MRD will be exploited to establish the final risk assignment and to verify whether the delivery of a post remission therapy intensity (AuSCT, Autologous Stem Cell Transplant, vs ASCT, Allogeneic Stem Cell Transplant) of which is MRD-driven will improve the outcome in terms of anti-leukemic efficacy.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '60 Years', 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n1. Signed written informed consent according to ICH/EU/GCP and national/local laws\n2. Patients aged between 18 and 60 years\n3. Patients previously untreated for their AML by other chemotherapeutic agents (except for no more than 7 days HU) or radiotherapy\n4. Unequivocal diagnosis of de novo AML according to WHO diagnostic criteria (at least 20% blasts in the bone marrow), other than acute promyelocytic leukemia, documented by bone marrow aspiration (or biopsy in case of dry tap) (not supervening after other myeloproliferative disease or myelodysplastic syndromes of ≥ 6 months duration)\n5. Patients with favorable-intermediate AML according to ELN 2017 (except for FLT3-ITD/TKD positive AML)\n6. WHO performance status 0-3\n7. Adequate renal (serum creatinine ≤ 2 x the institutional ULN) and liver (total serum bilirubin ≤ 2 x ULN; serum ALT and AST ≤ 2.5 x ULN) function, unless considered due to organ leukemic involvement\n8. Left Ventricular Ejection Fraction (LVEF) ≥ 50%, as determined by echocardiogram\n9. Absence of severe concomitant neurological or psychiatric diseases and congestive heart failure or active uncontrolled infection\n10. Absence of any psychological, familial, sociological and geographical condition potentially hampering compliance with the study protocol and the follow-up schedule.\n\nExclusion Criteria:\n\n1. Patients already treated for their AML by other chemotherapeutic agents (except for no more than 7 days HU) or radiotherapy\n2. Acute promyelocytic leukemia\n3. Blast crisis of chronic myeloid leukemia\n4. FLT3-ITD/TKD positive AML\n5. AML supervening after other myeloproliferative disease\n6. AML supervening after antecedent myelodysplastic syndromes ≥ 6 months duration\n7. Therapy-related AML\n8. Other active or progressive malignant diseases.\n9. Inadequate renal or liver function (metabolic abnormalities \\> 2-2.5 times the normal upper limit)\n10. Severe heart failure requiring diuretics\n11. Ejection fraction \\< 50%\n12. Uncontrolled infections\n13. Severe concomitant neurological or psychiatric diseases\n14. Patients who are pregnant or adults of reproductive potential not employing an effective method of birth control. Women of childbearing potential must have a negative serum pregnancy test within 48 hours prior to administration of chemotherapy. Post-menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential. Male and female patients must agree to employ an effective barrier method of birth control throughout the study and for at least 6 months following discontinuation of study drug.'}, 'identificationModule': {'nctId': 'NCT04168502', 'briefTitle': 'Gemtuzumab Chemotherapy MRD Levels; Adult Untreated, de Novo, Fav Interm Risk AML', 'organization': {'class': 'OTHER', 'fullName': "Gruppo Italiano Malattie EMatologiche dell'Adulto"}, 'officialTitle': 'Phase 3 Study to Assess Gemtuzumab, in Combination With Standard Chemotherapy, on MRD Levels, in Adult, 18-60 Years, With Previously Untreated de Novo Fav-interm Risk AML', 'orgStudyIdInfo': {'id': 'AML1819'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Experimental arm', 'description': 'Induction:\n\nGemtuzumab 3 mg/m2 day 1,4,7 Daunorubicin 60 mg/m2 day 1-3 Cytosine arabinoside 200 mg/m2 day 1-7\n\nConsolidation:\n\nGemtuzumab 3 mg/m2 day 1 Daunorubicin 50 mg/m2 day 4-6 Cytosine arabinoside 500 mg/m2 twice a day, day 1-6\n\nAllogeneic transplantation or Autologous transplantation according to MRD level\n\nclinical observation', 'interventionNames': ['Drug: Gemtuzumab Ozogamicin']}], 'interventions': [{'name': 'Gemtuzumab Ozogamicin', 'type': 'DRUG', 'description': 'Patients will receive induction and consolidation with Gemtuzumab ozogamicin, Daunorubicin and Cytarabine', 'armGroupLabels': ['Experimental arm']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Alessandria', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Zallio', 'role': 'CONTACT'}], 'facility': 'A.O. - SS. Antonio e Biagio e Cesare Arrigo - SC Ematologia', 'geoPoint': {'lat': 44.90924, 'lon': 8.61007}}, {'city': 'Ancona', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Attilio Olivieri', 'role': 'CONTACT', 'email': 'a.olivieri@univpm.it'}], 'facility': 'Aou Ospedali Riuniti "Umberto I - G.M. Lancisi - G. Salesi"- Ancona - Sod Clinica Ematologica', 'geoPoint': {'lat': 43.60717, 'lon': 13.5103}}, {'city': 'Ascoli Piceno', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Piero Galieni', 'role': 'CONTACT', 'email': 'piero.galieni@sanita.marche.it', 'phone': '3388149974'}], 'facility': 'Area Vasta N. 5 Ascoli Piceno - S. Benedetto Del Tronto, Presidio Ospedaliero Av5 Osp. Gen. Prov.Le "C.G.Mazzoni" - Uoc Ematologia', 'geoPoint': {'lat': 42.85351, 'lon': 13.57395}}, {'city': 'Avellino', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Storti', 'role': 'CONTACT'}], 'facility': 'AO "San Giuseppe Moscati" - UOC Ematologia con unità di trapianto', 'geoPoint': {'lat': 40.91494, 'lon': 14.79103}}, {'city': 'Bari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Carluccio', 'role': 'CONTACT'}], 'facility': 'AOU Consorziale Policlinico "Aldo Moro" - UO Ematologia con trapianto', 'geoPoint': {'lat': 41.12066, 'lon': 16.86982}}, {'city': 'Bologna', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Curti', 'role': 'CONTACT'}], 'facility': 'Policlinico S. Orsola - Malpighi - UOC Ematologia', 'geoPoint': {'lat': 44.49381, 'lon': 11.33875}}, {'city': 'Caserta', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Andrea Camera', 'role': 'CONTACT', 'email': 'ancamera@unina.it', 'phone': '330344420'}], 'facility': "Ao Sant'Anna E San Sebastiano - Caserta - Uoc Onco Ematologia", 'geoPoint': {'lat': 41.07262, 'lon': 14.33231}}, {'city': 'Castelfranco Veneto', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Michele Gottardi', 'role': 'CONTACT', 'email': 'michele.gottardi@aulss2.veneto.it', 'phone': '3476260749'}], 'facility': 'U.O.C. Oncoematologia - Istituto Oncologico Veneto Irccs, Presidio Ospedaliero S. Giacomo Apostolo', 'geoPoint': {'lat': 45.67146, 'lon': 11.92755}}, {'city': 'Civitanova Marche', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Milena Mirabile', 'role': 'CONTACT', 'email': 'milena.mirabile@hotmail.it'}], 'facility': 'Asur Marche Area Vasta 3 - Presidio Ospedaliero Civitanova Marche - Uods Ematologia', 'geoPoint': {'lat': 43.30491, 'lon': 13.72068}}, {'city': 'Cona', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Maria Ciccone', 'role': 'CONTACT', 'email': 'm.ciccone@ospfe.it'}], 'facility': "Aou Arcispedale Sant'Anna - Cona (Fe) - Uoc Ematologia E Fisiopatologia Della Coagulazione", 'geoPoint': {'lat': 44.80583, 'lon': 11.7069}}, {'city': 'Cremona', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alfredo Molteni', 'role': 'CONTACT', 'email': 'alfredo.molteni@asst-cremona.it', 'phone': '338/3169286'}], 'facility': 'Asst Di Cremona - Ospedale Di Cremona - Uo Ematologia', 'geoPoint': {'lat': 45.13325, 'lon': 10.02129}}, {'city': 'Florence', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Barbara Scappini', 'role': 'CONTACT', 'email': 'scappinib@aou-careggi.toscana.it'}], 'facility': 'Aou Careggi - Firenze - Sod Ematologia', 'geoPoint': {'lat': 43.77925, 'lon': 11.24626}}, {'city': 'Frosinone', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Vincenza Martini', 'role': 'CONTACT', 'email': 'vincenzamartini@inwind.it'}], 'facility': 'Asl Frosinone, Ospedale F. Spaziani - Ematologia', 'geoPoint': {'lat': 41.63976, 'lon': 13.34109}}, {'city': 'Genova', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Germana Beltrami', 'role': 'CONTACT', 'email': 'germana.beltrami@hsanmartino.it'}], 'facility': 'Irccs Aou San Martino - Genova - Uo Ematologia E Trapianti', 'geoPoint': {'lat': 45.21604, 'lon': 11.87211}}, {'city': 'Latina', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Cimino', 'role': 'CONTACT'}], 'facility': 'Presidio Ospedaliero Nord "Santa Maria Goretti" - UOC Ematologia', 'geoPoint': {'lat': 41.46614, 'lon': 12.9043}}, {'city': 'Lecce', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Di Renzo', 'role': 'CONTACT'}], 'facility': 'ASL Le/1 P.O. Vito Fazzi - UO Ematologia', 'geoPoint': {'lat': 40.35481, 'lon': 18.17244}}, {'city': 'Mestre', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Renato Bassan', 'role': 'CONTACT', 'email': 'Renato.Bassan@aulss3.veneto.it'}], 'facility': "Aulss 3 Serenissima, Ospedale Dell'Angelo - Mestre - Uo Ematologia", 'geoPoint': {'lat': 45.49167, 'lon': 12.24538}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Roberto Cairoli', 'role': 'CONTACT', 'email': 'roberto.cairoli@ospedaleniguarda.it'}], 'facility': 'Asst Grande Ospedale Metropolitano Niguarda - Milano - Sc Ematologia', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Fabio Ciceri', 'role': 'CONTACT', 'email': 'ciceri.clinicaltrials@hsr.it'}], 'facility': 'Irccs Ospedale S. Raffaele - Milano - Uo Oncoematologia', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Milan', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Elisabetta Todisco', 'role': 'CONTACT', 'email': 'Elisabetta.Todisco@ieo.it'}], 'facility': 'ISTITUTO EUROPEO DI ONCOLOGIA IRCCS - MILANO - DIVISIONE DI ONCOEMATOLOGIA 176 Milano Divisione di Onco-Ematologia Istituto Europeo', 'geoPoint': {'lat': 42.78235, 'lon': 12.59836}}, {'city': 'Modena', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Mario Luppi', 'role': 'CONTACT', 'email': 'mario.luppi@unimore.it'}], 'facility': 'Aou Di Modena - Sc Ematologia', 'geoPoint': {'lat': 44.64783, 'lon': 10.92539}}, {'city': 'Napoli', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Felicetto Ferrara', 'role': 'CONTACT', 'email': 'felicettoferrara@katamail.com', 'phone': '3388272964'}], 'facility': 'Ao Di Rilievo Nazionale Antonio Cardarelli - Napoli - Uoc Ematologia Con Trapianto Di Midollo', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'city': 'Napoli', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Fabrizio Pane', 'role': 'CONTACT', 'email': 'fabrizio.pane@unina.it'}], 'facility': 'Aou Federico Ii - Napoli - Uoc Ematologia', 'geoPoint': {'lat': 40.87618, 'lon': 14.5195}}, {'city': 'Orbassano', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Daniela Cilloni', 'role': 'CONTACT', 'email': 'daniela.cilloni@unito.it'}], 'facility': 'Aou San Luigi Gonzaga - Orbassano - Scdu Ematologia Generale E Oncoematologia', 'geoPoint': {'lat': 45.00547, 'lon': 7.53813}}, {'city': 'Pagani', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Catello Califano', 'role': 'CONTACT', 'email': 'c.califano@aslsalerno.it'}], 'facility': 'Asl Salerno, Presidio Ospedaliero Tortora Pagani - Ematologia', 'geoPoint': {'lat': 40.74199, 'lon': 14.61448}}, {'city': 'Palermo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Antonino Mulè', 'role': 'CONTACT', 'email': 'a.mule@villasofia.it'}], 'facility': 'Ao Ospedali Riuniti Villa Sofia Cervello - Palermo - Uo Ematologia Con Utmo', 'geoPoint': {'lat': 38.1166, 'lon': 13.3636}}, {'city': 'Palermo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Maria Enza Mitra', 'role': 'CONTACT', 'email': 'memitra@yahoo.com'}], 'facility': 'Aou Policlinico P. Giaccone - Palermo - Uo Ematologia', 'geoPoint': {'lat': 38.1166, 'lon': 13.3636}}, {'city': 'Pavia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Patrizia Zappasodi', 'role': 'CONTACT', 'email': 'p.zappasodi@smatteo.pv.it'}], 'facility': 'Fondazione Ircss Policlinico San Matteo - Pavia - Uo Ematologia', 'geoPoint': {'lat': 45.19205, 'lon': 9.15917}}, {'city': 'Perugia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Maria Paola Martelli', 'role': 'CONTACT', 'email': 'mpmartelli@libero.it'}], 'facility': 'Ao Di Perugia, Ospedale S. Maria Della Misericordia - Ematologia E Trapianto Midollo Osseo', 'geoPoint': {'lat': 43.1122, 'lon': 12.38878}}, {'city': 'Pesaro', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giuseppe Visani', 'role': 'CONTACT', 'email': 'giuseppe.visani@ospedalimarchenord.it'}], 'facility': 'Ao Ospedali Riuniti Marche Nord - Ospedale San Salvatore - Pesaro - Uoc Ematologia E Centro Trapianti', 'geoPoint': {'lat': 43.90921, 'lon': 12.9164}}, {'city': 'Pescara', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Prassede Salutari', 'role': 'CONTACT', 'email': 'prassede.salutari@gmail.com'}], 'facility': "Asl Pescara, Presidio Ospedaliero 'Spirito Santo' - Uoc Ematologia Clinica", 'geoPoint': {'lat': 42.4584, 'lon': 14.20283}}, {'city': 'Piacenza', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Daniele Vallisa', 'role': 'CONTACT', 'email': 'd.vallisa@ausl.pc.it'}], 'facility': 'Asl Di Piacenza, Ospedale "Guglielmo Da Saliceto" - Ematologia E Centro Trapianti', 'geoPoint': {'lat': 45.05242, 'lon': 9.69342}}, {'city': 'Ravenna', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Michela Rondoni', 'role': 'CONTACT', 'email': 'michela.rondoni@auslromagna.it'}], 'facility': 'Ausl Della Romagna, Ospedale "Santa Maria Delle Croci" - Ravenna - Ematologia', 'geoPoint': {'lat': 44.41344, 'lon': 12.20121}}, {'city': 'Reggio Emilia', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Alessia Tieghi', 'role': 'CONTACT', 'email': 'alessia.tieghi@ausl.re.it'}], 'facility': 'Ausl Di Reggio Emilia - Arcispedale Santa Maria Nuova, Irccs - Sc Ematologia', 'geoPoint': {'lat': 44.69825, 'lon': 10.63125}}, {'city': 'Rimini', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Anna Maria Mianulli', 'role': 'CONTACT', 'email': 'annamariamianulli@libero.it'}], 'facility': 'Ausl Della Romagna, Ospedale "Infermi" - Rimini - Uo Ematologia', 'geoPoint': {'lat': 44.05755, 'lon': 12.56528}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Laura Cudillo', 'role': 'CONTACT', 'email': 'lcudillo@hsangiovanni.roma.it'}], 'facility': 'Ao Complesso Ospedaliero San Giovanni / Addolorata - Roma - Uoc Ematologia', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Adriano Venditti', 'role': 'CONTACT', 'email': 'adriano.venditti@uniroma2.it'}], 'facility': 'AOU Policlinico Tor Vergata- UOC Trapianto cellule staminali', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Agostino Tafuri', 'role': 'CONTACT', 'email': 'agostino.tafuri@ospedalesantandrea.it'}], 'facility': "Aou Sant'Andrea - Roma - Uoc Ematologia", 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Patrizia Chiusolo', 'role': 'CONTACT', 'email': 'patrizia.chiusolo@Unicatt.it'}], 'facility': 'Fondazione Policlinico Universitario Agostino Gemelli Irccs - Roma - Area Ematologica', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Andrea Mengarelli', 'role': 'CONTACT', 'email': 'andreamengarelli@libero.it'}], 'facility': 'Istituti Fisioterapici Ospitalieri - Ifo - Istituto Regina Elena - Roma - Uosd Ematologia', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Giuseppe Avvisati', 'role': 'CONTACT', 'email': 'g.avvisati@unicampus.it'}], 'facility': 'Policlinico Universitario Campus Bio Medico - Roma - Uoc Ematologia E Trapianto Di Cellule Staminali', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'Roma', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Maurizio Martelli', 'role': 'CONTACT', 'email': 'martelli@bce.uniroma1.it'}], 'facility': 'Università Degli Studi Di Roma "Sapienza" - Dipartimento Di Medicina Traslazionale E Di Precisione - U.O.C. Ematologia', 'geoPoint': {'lat': 44.99364, 'lon': 11.10642}}, {'city': 'San Giovanni Rotondo', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Nicola Cascavilla', 'role': 'CONTACT', 'email': 'n.cascavilla@operapadrepio.it'}], 'facility': 'Ente Ecclesiastico Casa Sollievo Della Sofferenza - San Giovanni Rotondo - Ematologia', 'geoPoint': {'lat': 41.70643, 'lon': 15.7277}}, {'city': 'Sassari', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Claudio Fozza', 'role': 'CONTACT', 'email': 'cfozza@uniss.it'}], 'facility': 'Aou Di Sassari - Cliniche Universitarie - Stabilimento Cliniche Di San Pietro - Uoc Ematologia', 'geoPoint': {'lat': 40.72586, 'lon': 8.55552}}, {'city': 'Torino', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Ernesta Audisio', 'role': 'CONTACT', 'email': 'eaudisio@cittadellasalute.to.it'}], 'facility': 'Aou Città Della Salute E Della Scienza, Ospedale S. Giovanni Battista Molinette - Torino - Sc Ematologia 2', 'geoPoint': {'lat': 44.88856, 'lon': 11.99138}}, {'city': 'Treviso', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Endri Mauro', 'role': 'CONTACT', 'email': 'endri.mauro@aas5.sanita.fvg.it'}], 'facility': 'Unità Operativa Di Ematologia - Presidio Ospedaliero Di Treviso - Azienda Ulss N.2 Marca Trevigiana', 'geoPoint': {'lat': 45.66673, 'lon': 12.2416}}, {'city': 'Trieste', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Francesco Zaja', 'role': 'CONTACT', 'email': 'francesco.zaja@asuits.sanita.fvg.it'}], 'facility': 'Azienda Sanitaria Universitaria Integrata Di Trieste - Sc Ematologia', 'geoPoint': {'lat': 45.64953, 'lon': 13.77678}}, {'city': 'Udine', 'status': 'RECRUITING', 'country': 'Italy', 'contacts': [{'name': 'Anna Candoni', 'role': 'CONTACT', 'email': 'candoni.anna@aoud.sanita.fvg.it'}], 'facility': 'Asui Di Udine - Presidio Ospedaliero "Santa Maria Della Misericordia" - Clinica Ematologica', 'geoPoint': {'lat': 46.0693, 'lon': 13.23715}}], 'centralContacts': [{'name': 'Paola Fazi', 'role': 'CONTACT', 'email': 'p.fazi@gimema.it', 'phone': '0670390528'}, {'name': 'Enrico Crea', 'role': 'CONTACT', 'email': 'e.crea@gimema.it', 'phone': '0670390514'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': "Gruppo Italiano Malattie EMatologiche dell'Adulto", 'class': 'OTHER'}, 'responsibleParty': {'type': 'SPONSOR'}}}}