Ignite Creation Date:
2025-12-25 @ 3:53 AM
Ignite Modification Date:
2025-12-26 @ 2:43 AM
Study NCT ID:
NCT07226102
Status:
NOT_YET_RECRUITING
Last Update Posted:
2025-11-07
First Post:
2025-10-16
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D016889', 'term': 'Endometrial Neoplasms'}, {'id': 'D005833', 'term': 'Genital Neoplasms, Female'}, {'id': 'D010051', 'term': 'Ovarian Neoplasms'}, {'id': 'D014625', 'term': 'Vaginal Neoplasms'}, {'id': 'D014846', 'term': 'Vulvar Neoplasms'}, {'id': 'D064726', 'term': 'Triple Negative Breast Neoplasms'}], 'ancestors': [{'id': 'D014594', 'term': 'Uterine Neoplasms'}, {'id': 'D014565', 'term': 'Urogenital Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D014591', 'term': 'Uterine Diseases'}, {'id': 'D005831', 'term': 'Genital Diseases, Female'}, {'id': 'D052776', 'term': 'Female Urogenital Diseases'}, {'id': 'D005261', 'term': 'Female Urogenital Diseases and Pregnancy Complications'}, {'id': 'D000091642', 'term': 'Urogenital Diseases'}, {'id': 'D000091662', 'term': 'Genital Diseases'}, {'id': 'D004701', 'term': 'Endocrine Gland Neoplasms'}, {'id': 'D010049', 'term': 'Ovarian Diseases'}, {'id': 'D000291', 'term': 'Adnexal Diseases'}, {'id': 'D004700', 'term': 'Endocrine System Diseases'}, {'id': 'D006058', 'term': 'Gonadal Disorders'}, {'id': 'D014623', 'term': 'Vaginal Diseases'}, {'id': 'D014845', 'term': 'Vulvar Diseases'}, {'id': 'D001943', 'term': 'Breast Neoplasms'}, {'id': 'D001941', 'term': 'Breast Diseases'}, {'id': 'D012871', 'term': 'Skin Diseases'}, {'id': 'D017437', 'term': 'Skin and Connective Tissue Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D001521', 'term': 'Behavior Therapy'}, {'id': 'D018479', 'term': 'Early Intervention, Educational'}, {'id': 'D004522', 'term': 'Educational Status'}, {'id': 'D008722', 'term': 'Methods'}, {'id': 'D007407', 'term': 'Interviews as Topic'}], 'ancestors': [{'id': 'D011613', 'term': 'Psychotherapy'}, {'id': 'D004191', 'term': 'Behavioral Disciplines and Activities'}, {'id': 'D002662', 'term': 'Child Health Services'}, {'id': 'D003153', 'term': 'Community Health Services'}, {'id': 'D006296', 'term': 'Health Services'}, {'id': 'D005159', 'term': 'Health Care Facilities Workforce and Services'}, {'id': 'D011314', 'term': 'Preventive Health Services'}, {'id': 'D012959', 'term': 'Socioeconomic Factors'}, {'id': 'D011154', 'term': 'Population Characteristics'}, {'id': 'D008919', 'term': 'Investigative Techniques'}, {'id': 'D003625', 'term': 'Data Collection'}, {'id': 'D004812', 'term': 'Epidemiologic Methods'}, {'id': 'D017531', 'term': 'Health Care Evaluation Mechanisms'}, {'id': 'D011787', 'term': 'Quality of Health Care'}, {'id': 'D017530', 'term': 'Health Care Quality, Access, and Evaluation'}, {'id': 'D011634', 'term': 'Public Health'}, {'id': 'D004778', 'term': 'Environment and Public Health'}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER'], 'maskingDescription': 'Following completion of baseline questionnaires and the intake call, the clinical research assistant will be informed of the group assignment. The study team is blinded to assignment until this point. The study participants will be blinded to group assignment (single-blind).'}, 'primaryPurpose': 'SUPPORTIVE_CARE', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 126}}, 'statusModule': {'overallStatus': 'NOT_YET_RECRUITING', 'startDateStruct': {'date': '2025-12-19', 'type': 'ESTIMATED'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-11', 'completionDateStruct': {'date': '2026-07-16', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-11-05', 'studyFirstSubmitDate': '2025-10-16', 'studyFirstSubmitQcDate': '2025-11-05', 'lastUpdatePostDateStruct': {'date': '2025-11-07', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2025-11-07', 'type': 'ESTIMATED'}, 'primaryCompletionDateStruct': {'date': '2026-07-16', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Fear of cancer progression (FOP-SF)', 'timeFrame': 'Baseline, 6 weeks, up to 12 weeks', 'description': 'FOP-SF consists of 12 items pertaining to 4 subscales: affective reactions; partnership/family; occupation; loss of autonomy. Scores range from 12-60; higher levels indicate greater FOP; a cut-off of 34 and above indicates dysfunctional FOP levels. The FOP-SF has been validated in a large sample of breast and mixed cancer patients (a=.87) patients who completed a rehabilitation program (a=.90). The correlation between the long and short form of the questionnaires is r=0.92. Validity has been demonstrated by correlation with HADS anxiety (r=.65 to .71), GAD anxiety (r=.57) and depression (r=.49). In a descriptive FOP study in 135 English-speaking cancer survivors, the FOP-SF showed high internal consistency (a=0.88) and was correlated with similar constructs: Intrusions (r=.72), metacognitive beliefs (r=0.62); death anxiety (r=0.67) (Curran et al., 2020).'}], 'secondaryOutcomes': [{'measure': 'Cancer-related distress - Impact of Event Scale-R (IES-R)', 'timeFrame': 'Baseline, 6 weeks, Up to 12 weeks', 'description': 'The IES-R measures cancer-related distress. It consists of 22-likert-scale items representing 3 subscales: Intrusion; Avoidance; and Hyperarousal. Items are scored on a 0-4 response format. Total scores range from 0-88. A score of 24 or greater indicates clinical levels of distress. It demonstrates good internal consistency; a=.79-.92. The IES has been used in several studies with cancer patients. It has been found to be sensitive to change in these interventions (Butow et al. 2017).'}, {'measure': 'Anxiety - PROMIS - Anxiety 8-a', 'timeFrame': 'Baseline, 6 weeks, Up to 12 weeks', 'description': 'This measures fear, worry, hyperarousal, and related somatic symptoms (Cella et al., 2010). It consists of 8 items scored on a 0-5 response format. Scores are standardized to continuous T scores with a mean of 50 and SD of 10; higher scores reflect higher distress. PROMIS T score thresholds for anxiety are less than 55 normal; 55-64 mild; 65-74 moderate; greater than or equal to 75 severe. Validity was established in a large sample of patients with chronic illnesses, including cancer. Construct validity was demonstrated using the anxiety scale from the MASQ as the convergent measure (r=.80) and the CES-D as the divergent measure (r=.75).'}, {'measure': 'Metacognitive Beliefs - Metacognitions questionnaire (MCQ-18)', 'timeFrame': 'Baseline, 6 weeks, Up to 12 weeks', 'description': 'The MCQ assesses different beliefs about worry. We will use 18 items from three subscales of the parent MCQ-30 questionnaire a) positive beliefs about worry; b) negative beliefs about worry; and c) need to control thoughts. Items are scored on a 1-4 Likert scale. Subscale scores range from 6-24. Higher scores indicate more dysfunctional metacognitions. Internal consistency was a=.93 for the total score and ranged from .72-.93 for the subscale scores. It has been validated in cancer patients showing good convergent validit7 (Cook et al., 2014). Internal consistency of the subscales ranged from .73-.89 (pre-treatment) and .79-.91 (post-treatment).'}, {'measure': 'Mindfulness - Five Facet Mindfulness Questionnaire (FFMQ-15)', 'timeFrame': 'Baseline, 6 weeks, Up to 12 weeks', 'description': 'FFMQ-15 assesses 5 facets of mindfulness: Observing, Describing, Acting with awareness, non-reactivity to inner experience, and non-judging of inner experience. Items are rated on a 5-point Likert scale ranging from 1-5 scale (never/ rarely to very often). Three items comprise each subscale. Subscale scores range from 3-15. Higher scores indicate greater mindfulness skills engagement. The measure is sensitive to change over the course of mindfulness-based cognitive therapy (Chambers et al., 2017). For scoring, the Observing subscale score is excluded based on psychometric testing data from previous research. The total FFMQ score is calculated by summing the 4 subscale scores. For the subscales, internal consistency is adequate (a=.66-.83) (Baer et al., 2006). The FFMQ has been used in studies of advanced cancer patients.'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': True, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Anatomic Stage III Breast Cancer AJCC v8', 'Anatomic Stage IV Breast Cancer AJCC v8', 'Endometrial Carcinoma', 'Endometrial Endometrioid Adenocarcinoma', 'Female Reproductive System Neoplasm', 'Stage II Ovarian Cancer AJCC v8', 'Stage III Ovarian Cancer AJCC v8', 'Stage III Vaginal Cancer AJCC v8', 'Stage III Vulvar Cancer AJCC v8', 'Stage IV Ovarian Cancer AJCC v8', 'Stage IV Vaginal Cancer AJCC v8', 'Stage IV Vulvar Cancer AJCC v8', 'Triple-Negative Breast Carcinoma']}, 'descriptionModule': {'briefSummary': 'This clinical trial tests feasibility, acceptability and how well a virtual mental health intervention, compared to enhanced usual care consisting of an educational intervention, works to address fear of progression for women with high risk or stage III-IV gynecologic or breast cancer. Worrying about cancer coming back or progression is natural for cancer patients. Many cancer patients face stress and uncertainty as they live longer and attend regular check-ups. A supportive program can help to develop skills to feel calmer and more resilient during uncertain times and better manage feelings of fear. The virtual mental health intervention may be a feasible, acceptable and effective may to address fear of progression for women with high risk or stage III-IV gynecologic or breast cancer.', 'detailedDescription': 'PRIMARY OBJECTIVE:\n\nI. To determine the feasibility and acceptability of a blended e-health intervention to manage fear of progression (FOP) in patients with stage III or IV gynecologic (GYN) or breast cancer.\n\nSECONDARY OBJECTIVE:\n\nI. To determine the effects of the intervention on reducing fear of cancer progression (FOP) (primary outcome) and improving secondary outcomes of distress, anxiety, metacognitions, and mindfulness.\n\nOUTLINE: Patients are randomized to 1 of 2 arms.\n\nARM I: Patients receive access to the Day by Day platform that includes patient partner videos, testimonials, handouts and a community forum. Patients may optionally utilize these resources for 6 weeks. Patients attend online group sessions, over 60 minutes, for every other week for 3 sessions and complete online educational sessions on values clarification, managing worry and unhelpful thoughts, and skills practices to promote healthy coping on alternate weeks for 3 sessions. Patients complete a check in call, for 15-20 minutes, at week 3-4. Patients are asked to practice the skills including attention training, mindfulness, worry postponement, guided imagery and other practices from the intervention for 10-12 minutes, at least 6 days per week for and track their practice on the Day to Day platform for 6 weeks. Patients may be loaned a tablet if needed for 6 weeks.\n\nARM II: Patients receive access to the Empower Hope platform. Patients attend online group sessions, over 60 minutes, for every other week for 3 sessions and complete online educational sessions on clinical trial participation, identifying reliable online information, healthy living on nutrition and activity/exercise and coping with fatigue on alternate weeks for 3 sessions. Patients complete a check in call, for 15-20 minutes, at week 3-4. Patients may be loaned a tablet if needed for 6 weeks.\n\nAfter completion of study intervention, patients are followed up at 12 weeks.'}, 'eligibilityModule': {'sex': 'FEMALE', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Women with stage III or IV GYN (ovarian, endometrial, cervical, vulvar/vaginal) or breast cancer who are at least 2 months from initial diagnosis\n* Women with high-risk disease e.g., carcinosarcoma; ovarian cancer stage II or grade III histology; endometrioid endometrial cancer stage II or III; grade III with LVI or deep invasion; serous, clear cell or undifferentiated histologies; triple negative breast cancer\n* Score ≥ 34 on the Fear of Progression Short-Form, indicating dysfunctional levels\n* Age 18 or older; able to read and understand English\n* Patients in remission or with progressive disease\n\nExclusion Criteria:\n\n* Enrolled in hospice\n* Major depression as assessed by patient health questionnaire (PHQ)-9\n* Non-English speaking\n* Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics)'}, 'identificationModule': {'nctId': 'NCT07226102', 'briefTitle': 'Virtual Mental Health Intervention to Address Fear of Progression for Women With High Risk or Stage III-IV Gynecologic or Breast Cancer', 'organization': {'class': 'OTHER', 'fullName': 'City of Hope Medical Center'}, 'officialTitle': 'An E-Health Intervention for Fear of Progression in Women With Gynecologic or Breast Cancer', 'orgStudyIdInfo': {'id': '24425'}, 'secondaryIdInfos': [{'id': 'NCI-2025-07274', 'type': 'REGISTRY', 'domain': 'CTRP (Clinical Trial Reporting Program)'}, {'id': '24425', 'type': 'OTHER', 'domain': 'CITY OF Hope Medical Center'}, {'id': 'P30CA033572', 'link': 'https://reporter.nih.gov/quickSearch/P30CA033572', 'type': 'NIH'}, {'id': 'R21CA293326', 'link': 'https://reporter.nih.gov/quickSearch/R21CA293326', 'type': 'NIH'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Arm I (Fear of progression intervention)', 'description': 'Patients receive access to the Day by Day platform that includes patient partner videos, testimonials, handouts and a community forum. Patients may optionally utilize these resources for 6 weeks. Patients attend online group sessions, over 60 minutes, for every other week for 3 sessions and complete online educational sessions on values clarification, managing worry and unhelpful thoughts, and skills practices to promote healthy coping on alternate weeks for 3 sessions. Patients complete a check in call, for 15-20 minutes, at week 3-4. Patients are asked to practice the skills including attention training, mindfulness, worry postponement, guided imagery and other practices from the intervention for 10-12 minutes, at least 6 days per week for and track their practice on the Day to Day platform for 6 weeks. Patients may be loaned a tablet if needed for 6 weeks.', 'interventionNames': ['Behavioral: Behavioral Intervention', 'Other: Educational Intervention', 'Other: Internet-Based Intervention', 'Other: Interview', 'Other: Survey Administration', 'Other: Virtual Technology Intervention']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'Arm II (Educational intervention)', 'description': 'Patients receive access to the Empower Hope platform. Patients attend online group sessions, over 60 minutes, for every other week for 3 sessions and complete online educational sessions on clinical trial participation, identifying reliable online information, healthy living on nutrition and activity/exercise and coping with fatigue on alternate weeks for 3 sessions. Patients complete a check in call, for 15-20 minutes, at week 3-4. Patients may be loaned a tablet if needed for 6 weeks.', 'interventionNames': ['Behavioral: Behavioral Intervention', 'Other: Educational Intervention', 'Other: Internet-Based Intervention', 'Other: Interview', 'Other: Survey Administration', 'Other: Virtual Technology Intervention']}], 'interventions': [{'name': 'Behavioral Intervention', 'type': 'BEHAVIORAL', 'otherNames': ['Behavior Conditioning Therapy', 'Behavior Modification', 'Behavior or Life Style Modifications', 'Behavior Therapy', 'Behavioral', 'Behavioral Interventions', 'Behavioral Modification', 'Behavioral Therapy', 'Behavioral Treatment', 'Behavioral Treatments'], 'description': 'Attend online group sessions', 'armGroupLabels': ['Arm I (Fear of progression intervention)']}, {'name': 'Behavioral Intervention', 'type': 'BEHAVIORAL', 'otherNames': ['Behavior Conditioning Therapy', 'Behavior Modification', 'Behavior or Life Style Modifications', 'Behavior Therapy', 'Behavioral', 'Behavioral Interventions', 'Behavioral Modification', 'Behavioral Therapy', 'Behavioral Treatment', 'Behavioral Treatments'], 'description': 'Complete online educational sessions', 'armGroupLabels': ['Arm I (Fear of progression intervention)']}, {'name': 'Behavioral Intervention', 'type': 'BEHAVIORAL', 'otherNames': ['Behavior Conditioning Therapy', 'Behavior Modification', 'Behavior or Life Style Modifications', 'Behavior Therapy', 'Behavioral', 'Behavioral Interventions', 'Behavioral Modification', 'Behavioral Therapy', 'Behavioral Treatment', 'Behavioral Treatments'], 'description': 'Complete check in call', 'armGroupLabels': ['Arm I (Fear of progression intervention)', 'Arm II (Educational intervention)']}, {'name': 'Behavioral Intervention', 'type': 'BEHAVIORAL', 'otherNames': ['Behavior Conditioning Therapy', 'Behavior Modification', 'Behavior or Life Style Modifications', 'Behavior Therapy', 'Behavioral', 'Behavioral Interventions', 'Behavioral Modification', 'Behavioral Therapy', 'Behavioral Treatment', 'Behavioral Treatments'], 'description': 'Complete daily skills practice', 'armGroupLabels': ['Arm I (Fear of progression intervention)']}, {'name': 'Educational Intervention', 'type': 'OTHER', 'otherNames': ['Education for Intervention', 'Intervention by Education', 'Intervention through Education', 'Intervention, Educational'], 'description': 'Receive access to patient partner videos, testimonials, handouts and a community forum', 'armGroupLabels': ['Arm I (Fear of progression intervention)']}, {'name': 'Educational Intervention', 'type': 'OTHER', 'otherNames': ['Education for Intervention', 'Intervention by Education', 'Intervention through Education', 'Intervention, Educational'], 'description': 'Attend online group sessions', 'armGroupLabels': ['Arm II (Educational intervention)']}, {'name': 'Educational Intervention', 'type': 'OTHER', 'otherNames': ['Education for Intervention', 'Intervention by Education', 'Intervention through Education', 'Intervention, Educational'], 'description': 'Complete online education sessions', 'armGroupLabels': ['Arm II (Educational intervention)']}, {'name': 'Internet-Based Intervention', 'type': 'OTHER', 'description': 'Receive access to Day to Day platform', 'armGroupLabels': ['Arm I (Fear of progression intervention)']}, {'name': 'Internet-Based Intervention', 'type': 'OTHER', 'description': 'Receive access to the Empower Hope platform', 'armGroupLabels': ['Arm II (Educational intervention)']}, {'name': 'Interview', 'type': 'OTHER', 'description': 'Ancillary studies', 'armGroupLabels': ['Arm I (Fear of progression intervention)', 'Arm II (Educational intervention)']}, {'name': 'Survey Administration', 'type': 'OTHER', 'description': 'Ancillary studies', 'armGroupLabels': ['Arm I (Fear of progression intervention)', 'Arm II (Educational intervention)']}, {'name': 'Virtual Technology Intervention', 'type': 'OTHER', 'otherNames': ['Virtual Reality Intervention', 'Virtual Technology'], 'description': 'Receive a tablet', 'armGroupLabels': ['Arm I (Fear of progression intervention)', 'Arm II (Educational intervention)']}]}, 'contactsLocationsModule': {'locations': [{'zip': '91007', 'city': 'Arcadia', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope at Arcadia', 'geoPoint': {'lat': 34.13973, 'lon': -118.03534}}, {'zip': '91010', 'city': 'Duarte', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope Medical Center', 'geoPoint': {'lat': 34.13945, 'lon': -117.97729}}, {'zip': '92618', 'city': 'Irvine', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope at Irvine Lennar', 'geoPoint': {'lat': 33.66946, 'lon': -117.82311}}, {'zip': '93534', 'city': 'Lancaster', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope Antelope Valley', 'geoPoint': {'lat': 34.69804, 'lon': -118.13674}}, {'zip': '90808', 'city': 'Long Beach', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope at Long Beach Worsham', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '90813', 'city': 'Long Beach', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope at Long Beach Elm', 'geoPoint': {'lat': 33.76696, 'lon': -118.18923}}, {'zip': '91345', 'city': 'Mission Hills', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope Mission Hills', 'geoPoint': {'lat': 34.68609, 'lon': -120.43683}}, {'zip': '91355', 'city': 'Santa Clarita', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope - Santa Clarita', 'geoPoint': {'lat': 34.39166, 'lon': -118.54259}}, {'zip': '93065', 'city': 'Simi Valley', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope at Simi Valley', 'geoPoint': {'lat': 34.26945, 'lon': -118.78148}}, {'zip': '91361', 'city': 'Thousand Oaks', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope at Thousand Oaks', 'geoPoint': {'lat': 34.17056, 'lon': -118.83759}}, {'zip': '90503', 'city': 'Torrance', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope South Bay', 'geoPoint': {'lat': 33.83585, 'lon': -118.34063}}, {'zip': '91786', 'city': 'Upland', 'state': 'California', 'country': 'United States', 'contacts': [{'name': 'Anne Reb', 'role': 'CONTACT', 'email': 'areb@coh.org', 'phone': '626-218-5673'}, {'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'City of Hope Upland', 'geoPoint': {'lat': 34.09751, 'lon': -117.64839}}], 'overallOfficials': [{'name': 'Anne Reb', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'City of Hope Medical Center'}]}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'City of Hope Medical Center', 'class': 'OTHER'}, 'collaborators': [{'name': 'National Cancer Institute (NCI)', 'class': 'NIH'}], 'responsibleParty': {'type': 'SPONSOR'}}}}