Ignite Creation Date:
2025-12-25 @ 3:47 AM
Ignite Modification Date:
2026-03-05 @ 10:45 AM
Study NCT ID:
NCT03677102
Status:
RECRUITING
Last Update Posted:
2025-06-05
First Post:
2018-08-27
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Fluids in Septic Shock (FISSH)
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D018805', 'term': 'Sepsis'}, {'id': 'D012772', 'term': 'Shock, Septic'}], 'ancestors': [{'id': 'D007239', 'term': 'Infections'}, {'id': 'D018746', 'term': 'Systemic Inflammatory Response Syndrome'}, {'id': 'D007249', 'term': 'Inflammation'}, {'id': 'D010335', 'term': 'Pathologic Processes'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}, {'id': 'D012769', 'term': 'Shock'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2018-04-20', 'size': 836127, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2018-09-11T08:13', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE2', 'PHASE3'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'QUADRUPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR', 'OUTCOMES_ASSESSOR']}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 1096}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2018-09-09', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-06', 'completionDateStruct': {'date': '2026-03-31', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-06-03', 'studyFirstSubmitDate': '2018-08-27', 'studyFirstSubmitQcDate': '2018-09-17', 'lastUpdatePostDateStruct': {'date': '2025-06-05', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2018-09-19', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2025-11-28', 'type': 'ESTIMATED'}}, 'outcomesModule': {'otherOutcomes': [{'measure': 'Hospital/ICU length of stay', 'timeFrame': 'up to 30 days', 'description': 'length of hospital/ICU stay up to 30 days'}, {'measure': 'Ventilator free days', 'timeFrame': 'censored at 30 days', 'description': 'Number of ventilator free days'}, {'measure': 'Number of days requiring vasoactive agents', 'timeFrame': 'up to 30 days', 'description': 'defined as the number of days requiring great than or equal to 2 hours of intravenous vasopressor support'}, {'measure': 'Incidence of biochemical abnormalities during study period', 'timeFrame': 'up to 30 days', 'description': 'any serum blood test results showing hyperchloremia, hyperkalemia, hypernatremia, or acidosis'}], 'primaryOutcomes': [{'measure': '30-day Mortality', 'timeFrame': 'up to 30 days', 'description': 'We expect that if a difference in survival is demonstrated, that this will be evident within 30 days'}], 'secondaryOutcomes': [{'measure': 'Acute Kidney Injury', 'timeFrame': 'up to 30 days', 'description': 'Development of stage 2 or worse acute kidney injury (AKI) according to KIDGO guidelines on serum creatinine criteria'}]}, 'oversightModule': {'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Sepsis, Septic Shock']}, 'descriptionModule': {'briefSummary': "Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world. Given uncertainty about the impact of lower chloride versus higher chloride solutions on mortality, it is unlikely that clinical practice will change without new and direct randomized controlled trial (RCT) evidence. Editorials published in leading critical care journals have called for RCT's to address this important clinical question. This trial will directly compare low chloride versus normal chloride for resuscitation in septic shock on patient-important outcomes such as mortality and AKI.", 'detailedDescription': 'Severe infection can lead to many complications within the human body including low blood pressure, which is called septic shock. The main treatments for septic shock are intravenous antibiotics and intravenous fluid.\n\nThere are many different intravenous fluids available for doctors to use. Each one of these fluids has potential advantages as well as potential disadvantages. Doctors will often look at many things when deciding which fluid to give including the results of bloodwork and the clinical characteristics of the patients themselves. There is limited direction from research studies that using one fluid type is better than another. Some preliminary research in the field has suggested that one specific electrolyte, call chloride, may be harmful when given to patients in high concentrations. Animal research has shown that the administration of high chloride fluids may be harmful to the lungs, kidneys, gastrointestinal and muscle cells. Some intravenous fluids have higher concentrations of chloride than others.\n\nThe investigators plan to study the impact of giving patients with severe infection intravenous fluids with either a high chloride concentration (normal saline or high chloride albumin) or a low chloride concentration (Ringers Lactate or low chloride albumin). This trial will build on the earlier pilot, phase 1 study and will look at patient-important outcomes such as rate of death, kidney failure and length of stay in the ICU. This larger study has the potential to guide the care of critically ill patients with infection worldwide.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['CHILD', 'ADULT', 'OLDER_ADULT'], 'minimumAge': '16 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* patients 16 years or greater who meet all of the following:\n* require fluid resuscitation for refractory hypotension (systolic blood pressure \\<90 mmHg or mean arterial blood pressure\\<65 mmHg after 1 Litre bolus over 1 hour or less or organ hypo-perfusion (serum lactate \\>4 mmol/L)\n* have a clinical suspicion of infection\n* are within 6 hours of hospital admission or critical care response team consultation\n* are anticipated to require ICU admission\n\nExclusion Criteria:\n\n* intracranial bleed or intracranial hypertension during the index hospital admission\n* 10% of body surface area acute burn injury\n* bleeding/hemorrhage as likely cause of hypotension\n* a lack of commitment to life support\n* have previously enrolled in FISSH, or a confounding trial (e.g. a trial examining the effect of other intravenous fluids in septic shock patients)\n* been transferred from another hospital or facility \\>6 hours since presentation to first hospital\n* pre-established end stage renal disease (ESRD) or are receiving hemodialysis (intermittent or continuous) at time of enrolment, or\n* been admitted to ICU directly from the operating room or post anaesthetic care unit'}, 'identificationModule': {'nctId': 'NCT03677102', 'acronym': 'FISSH', 'briefTitle': 'Fluids in Septic Shock (FISSH)', 'organization': {'class': 'OTHER', 'fullName': 'McMaster University'}, 'officialTitle': 'Fluids in Septic Shock (FISSH): a Randomized Controlled Trial', 'orgStudyIdInfo': {'id': '1515'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'ACTIVE_COMPARATOR', 'label': 'higher chloride solutions', 'description': 'higher chloride crystalloid (Normal saline - chloride concentration 154 mmol/L)', 'interventionNames': ['Other: higher chloride crystalloid']}, {'type': 'ACTIVE_COMPARATOR', 'label': 'lower chloride solutions', 'description': "lower chloride crystalloid (Ringer's lactate - chloride concentration 110 mmol/L)", 'interventionNames': ['Other: lower chloride crystalloid']}], 'interventions': [{'name': 'higher chloride crystalloid', 'type': 'OTHER', 'description': 'Normal saline (chloride concentration 154 mmol/L)', 'armGroupLabels': ['higher chloride solutions']}, {'name': 'lower chloride crystalloid', 'type': 'OTHER', 'description': "Ringer's Lactate (chloride concentration 110 mmol/L)", 'armGroupLabels': ['lower chloride solutions']}]}, 'contactsLocationsModule': {'locations': [{'city': 'Calgary', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Delphine Roche, M.Sc', 'role': 'CONTACT', 'email': 'delphine.roche@albertahealthservices.ca', 'phone': '(403)-944-8748'}, {'name': 'Ken Parhar, MD MSc FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Calgary - Foothills Medical Centre', 'geoPoint': {'lat': 51.05011, 'lon': -114.08529}}, {'city': 'Calgary', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Delphine Roche, M.Sc.', 'role': 'CONTACT', 'email': 'delphine.roche@albertahealthservices.ca', 'phone': '(403)-944-8748'}, {'name': 'Ken Parhar, MD MSc FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'University of Calgary - Rockyview General Hospital', 'geoPoint': {'lat': 51.05011, 'lon': -114.08529}}, {'city': 'Edmonton', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Anushka Jayasekara, RC', 'role': 'CONTACT', 'email': 'Anushka.Jayasekara@covenanthealth.ca'}, {'name': 'Janek Senaratne, MD,MSc,ABIM,FRCPC,FACC,FESC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Lazar Milovanovic, MD,FRCPC', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Grey Nuns Community Hospital', 'geoPoint': {'lat': 53.55014, 'lon': -113.46871}}, {'city': 'Halifax', 'state': 'Nova Scotia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Sharon Oldford, PhD', 'role': 'CONTACT', 'email': 'sharon.oldford@iwk.nshealth.ca', 'phone': '902-473-5643'}, {'name': 'Osama Loubani, MD,FRCPC,DABEM', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Stephen Beed, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Volker Eichhorn, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Robert Green, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Jennifer Hancock, MD, FRCP', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Babar Haroon, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Sarah McMullen, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Samuel Minor, MD, FRCSC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Laurel Murphy, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': "Tony O'Leary, MD, FRCP", 'role': 'SUB_INVESTIGATOR'}, {'name': 'Patrick Ward, MD, FRCP', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Jack Rasmussen, MD, FRCSC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Edmund Chong-How (Edmund) Tan, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Tobias Witter, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Halifax Infirmary', 'geoPoint': {'lat': 44.64269, 'lon': -63.57688}}, {'city': 'Halifax', 'state': 'Nova Scotia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Sharon Oldford, PhD', 'role': 'CONTACT', 'email': 'sharon.oldford@iwk.nshealth.ca', 'phone': '902-473-5643'}, {'name': 'Osama Loubani, MD,FRCPC,DABEM', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Stephen Beed, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Volker Eichhorn, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Robert Green, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Jennifer Hancock, MD, FRCP', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Babar Haroon, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Sarah McMullen, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Samuel Minor, MD, FRCSC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Laurel Murphy, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': "Tony O'Leary, MD, FRCP", 'role': 'SUB_INVESTIGATOR'}, {'name': 'Patrick Ward, MD, FRCP', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Jack Rasmussen, MD, FRCSC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Edmund Chong-How (Edmund) Tanter, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Tobias Witter, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Victoria General', 'geoPoint': {'lat': 44.64269, 'lon': -63.57688}}, {'city': 'Sydney', 'state': 'Nova Scotia', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Cheryl Furey, RN, BScN', 'role': 'CONTACT'}, {'name': 'Kevin Klassen, MD, FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Cape Breton Regional Hospital', 'geoPoint': {'lat': 46.1351, 'lon': -60.1831}}, {'city': 'Ajax', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Ankita Das, MBBS, MSc', 'role': 'CONTACT', 'email': 'adas@lh.ca', 'phone': '905-683-2320', 'phoneExt': '13544'}, {'name': 'Shannon Fernando, MD,MSc,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Karim Soliman, MD,FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Kavita Sridhar, MD,MHSc,FRCPC', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Lakeridge Health - Ajax Pickering', 'geoPoint': {'lat': 43.85012, 'lon': -79.03288}}, {'zip': 'N3R 1G9', 'city': 'Brantford', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'William Dechert, MSc', 'role': 'CONTACT', 'email': 'wdechert@stjosham.on.ca', 'phone': '519-752-7871', 'phoneExt': '4531'}, {'name': 'Brenda Reeve, MD, FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Brantford General Hospital', 'geoPoint': {'lat': 43.1334, 'lon': -80.26636}}, {'zip': 'L8N 4A6', 'city': 'Hamilton', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'France Clarke, RRT', 'role': 'CONTACT', 'email': 'clarkef@mcmaster.ca', 'phone': '905-522-1155', 'phoneExt': '33633'}, {'name': 'Deborah J Cook, MD,FRCPC,MSc', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "St Joseph's Healthcare", 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'zip': 'L8V 1C1', 'city': 'Hamilton', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Bram Rochwerg, MSc,MD,FRCPC', 'role': 'CONTACT', 'email': 'rochwerg@mcmaster.ca', 'phone': '905-521-2100', 'phoneExt': '42442'}, {'name': 'Tina Millen, RRT', 'role': 'CONTACT', 'email': 'millent@mcmaster.ca', 'phone': '905-719-6133'}, {'name': 'Bram Rochwerg, MSc,MD,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Juravinski Hospital-Hamilton Health Sciences', 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'city': 'Hamilton', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Lori Hand, RRT', 'role': 'CONTACT', 'email': 'handlori@HHSC.CA'}, {'name': 'Maureen Meade, MD,FRCPC,MSc', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Hamilton General Hospital', 'geoPoint': {'lat': 43.25011, 'lon': -79.84963}}, {'zip': 'K7L 2V7', 'city': 'Kingston', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Tracy Boyd, CCRC', 'role': 'CONTACT', 'email': 'Tracy.Boyd@kingstonhsc.ca', 'phone': '613-549-6666', 'phoneExt': '2608'}, {'name': 'Gordon Boyd, MD,PhD,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Kingston General Hospital', 'geoPoint': {'lat': 44.22976, 'lon': -76.48098}}, {'zip': 'N6A 5W9', 'city': 'London', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Eileen Campbell, RN', 'role': 'CONTACT', 'email': 'Eileen.Campbell@lhsc.on.ca', 'phone': '519-685-8500', 'phoneExt': '55664'}, {'name': 'Ian Ball, MC,MSc,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Marat Slessarev, MD, FRCPC', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'London Health Sciences Centre - Victoria Hospital', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'city': 'London', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Tracey C Bentall', 'role': 'CONTACT', 'email': 'TraceyC.Bentall@lhsc.on.ca'}, {'name': 'Eileen Campbell', 'role': 'CONTACT', 'email': 'Eileen.Campbell@lhsc.on.ca'}, {'name': 'Ian Ball, MD,MSc(Epi),FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'John Basmaji, MD,FRCPC', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'London Health Sciences - University Hospital', 'geoPoint': {'lat': 42.98339, 'lon': -81.23304}}, {'zip': 'L1G 2B9', 'city': 'Oshawa', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Barbara Flynn, RN BScN', 'role': 'CONTACT', 'email': 'bflynn@lh.ca'}, {'name': 'Sarah Dulmage, ScH', 'role': 'CONTACT', 'email': 'sdulmage@lh.ca'}, {'name': 'Shannon Fernando, MD,MSc,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Karim Soliman, MD,FRCPC', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Kavita Sridhar, MD,MHSc,FRCPC', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Lakeridge Health', 'geoPoint': {'lat': 43.90012, 'lon': -78.84957}}, {'zip': 'L2S 0A9', 'city': 'St. Catharines', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Emily Baker, RC', 'role': 'CONTACT', 'email': 'EmilyD.Baker@niagarahealth.on.ca', 'phone': '289-929-9148'}, {'name': 'Erick Duan, MD, FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Jennifer Tsang, MD,PhD,FRCPC', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Niagara Health, St Catharines Site', 'geoPoint': {'lat': 43.17126, 'lon': -79.24267}}, {'zip': 'M5B 1W8', 'city': 'Toronto', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Marlene Santos, MD, ACRP', 'role': 'CONTACT', 'email': 'Marlene.Santos@unityhealth.to', 'phone': '416-864-6060', 'phoneExt': '2322'}, {'name': 'Karen E Burns, MD,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Jan Friedrich, MD, PhD, MSc', 'role': 'SUB_INVESTIGATOR'}], 'facility': "Unity Health (St. Michael's Hospital)", 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'zip': 'M5G 1X5', 'city': 'Toronto', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Sumesh Shah, CCRP', 'role': 'CONTACT', 'email': 'Sumesh.Shah@SinaiHealthSystem.ca', 'phone': '416-586-4800', 'phoneExt': '8445'}, {'name': 'SANGEETA MEHTA, MD,FRCPC', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Mount Sinai Hospital', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'city': 'Toronto', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Nicole Marinoff, RN, CCRP', 'role': 'CONTACT', 'email': 'Nicole.Marinoff@sunnybrook.ca'}, {'name': 'Neill Adhikari, MDCM, MSc.', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': 'Sunnybrook Health Sciences Centre', 'geoPoint': {'lat': 43.70643, 'lon': -79.39864}}, {'city': 'Windsor', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Batul Khumushi, CCRP', 'role': 'CONTACT', 'email': 'Batul.Khumushi@wrh.on.ca', 'phone': '519-254-5577', 'phoneExt': '52899'}, {'name': 'Adam Rahman, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Ian Mazzetti, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Natalie Malus, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Hassan Masri, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Windsor Regional Hospital - Ouellette Campus', 'geoPoint': {'lat': 42.30008, 'lon': -83.01654}}, {'city': 'Windsor', 'state': 'Ontario', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Batul Khumushi, CCRP', 'role': 'CONTACT', 'email': 'Batul.Khumushi@wrh.on.ca', 'phone': '519-254-5577', 'phoneExt': '52899'}, {'name': 'Adam Rahman, MD', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': 'Ian Mazzetti, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Natalie Malus, MD', 'role': 'SUB_INVESTIGATOR'}, {'name': 'Hassan Masri, MD', 'role': 'SUB_INVESTIGATOR'}], 'facility': 'Windsor Regional Hospital -Metropolitan Campus', 'geoPoint': {'lat': 42.30008, 'lon': -83.01654}}, {'zip': 'H4J 1C5', 'city': 'Montreal', 'state': 'Quebec', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Virginie Williams, PhD', 'role': 'CONTACT', 'email': 'virginie.williams.cnmtl@ssss.gouv.qc.ca', 'phone': '514 338 2222', 'phoneExt': '583-3272'}, {'name': 'Karim Serri, BSc,MD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Centre intégré Universitaire de santé et de services sociaux du Nord de l'île de Montréal", 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'city': 'Montreal', 'state': 'Quebec', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Andrea Gagnon-Hamelin', 'role': 'CONTACT', 'email': 'andrea.gagnon-hamelin.chum@ssss.gouv.qc.ca'}, {'name': 'Emmanuel Charbonney, MD, PhD', 'role': 'PRINCIPAL_INVESTIGATOR'}], 'facility': "Centre Hospitalier de l'Universite de Montreal (CHUM)", 'geoPoint': {'lat': 45.50884, 'lon': -73.58781}}, {'zip': 'J1H 5N4', 'city': 'Sherbrooke', 'state': 'Quebec', 'status': 'RECRUITING', 'country': 'Canada', 'contacts': [{'name': 'Marie-Pier Bouchard, RA', 'role': 'CONTACT', 'email': 'marie-pier.bouchard.ciussse-chus@ssss.gouv.qc.ca'}, {'name': 'François Lamontagne, MD,MSc', 'role': 'PRINCIPAL_INVESTIGATOR'}, {'name': "Fred D'aragon, MD, MSc", 'role': 'SUB_INVESTIGATOR'}], 'facility': "Centre de recherche du CIUSSS de l'Estrie - 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