Ignite Creation Date:
2025-12-25 @ 3:45 AM
Ignite Modification Date:
2025-12-26 @ 2:32 AM
Study NCT ID:
NCT04136002
Status:
COMPLETED
Last Update Posted:
2025-08-11
First Post:
2019-10-21
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D015179', 'term': 'Colorectal Neoplasms'}], 'ancestors': [{'id': 'D007414', 'term': 'Intestinal Neoplasms'}, {'id': 'D005770', 'term': 'Gastrointestinal Neoplasms'}, {'id': 'D004067', 'term': 'Digestive System Neoplasms'}, {'id': 'D009371', 'term': 'Neoplasms by Site'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D004066', 'term': 'Digestive System Diseases'}, {'id': 'D005767', 'term': 'Gastrointestinal Diseases'}, {'id': 'D003108', 'term': 'Colonic Diseases'}, {'id': 'D007410', 'term': 'Intestinal Diseases'}, {'id': 'D012002', 'term': 'Rectal Diseases'}]}}, 'protocolSection': {'designModule': {'bioSpec': {'retention': 'SAMPLES_WITH_DNA', 'description': 'Blood specimens will be retained in order to investigate the performance characteristics of the LUNAR-2 device.'}, 'studyType': 'OBSERVATIONAL', 'designInfo': {'timePerspective': 'PROSPECTIVE', 'observationalModel': 'COHORT'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 44467}, 'patientRegistry': False}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2019-10-08', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2025-08', 'completionDateStruct': {'date': '2025-08-05', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2025-08-06', 'studyFirstSubmitDate': '2019-10-21', 'studyFirstSubmitQcDate': '2019-10-21', 'lastUpdatePostDateStruct': {'date': '2025-08-11', 'type': 'ACTUAL'}, 'studyFirstPostDateStruct': {'date': '2019-10-23', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2024-03-20', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Sensitivity of colorectal cancer detection', 'timeFrame': '60 days', 'description': 'Sensitivity of colorectal cancer detection'}, {'measure': 'Specificity of advanced neoplasia detection', 'timeFrame': '60 days', 'description': 'Specificity of advanced neoplasia detection'}], 'secondaryOutcomes': [{'measure': 'Positive predictive value of colorectal cancer detection', 'timeFrame': '60 days', 'description': 'Positive predictive value of colorectal cancer detection'}, {'measure': 'Negative predictive value of colorectal cancer detection', 'timeFrame': '60 days', 'description': 'Negative predictive value of colorectal cancer detection'}, {'measure': 'Sensitivity and specificity of advanced adenoma detection', 'timeFrame': '60 days', 'description': 'Sensitivity and specificity of advanced adenoma detection'}]}, 'oversightModule': {'isUsExport': False, 'oversightHasDmc': False, 'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Colorectal Cancer']}, 'referencesModule': {'references': [{'pmid': '38477993', 'type': 'DERIVED', 'citation': 'Lo YMD. Cell-free DNA for Colorectal Cancer Screening. N Engl J Med. 2024 Mar 14;390(11):1047-1050. doi: 10.1056/NEJMe2311101. No abstract available.'}, {'pmid': '38477985', 'type': 'DERIVED', 'citation': 'Chung DC, Gray DM 2nd, Singh H, Issaka RB, Raymond VM, Eagle C, Hu S, Chudova DI, Talasaz A, Greenson JK, Sinicrope FA, Gupta S, Grady WM. A Cell-free DNA Blood-Based Test for Colorectal Cancer Screening. N Engl J Med. 2024 Mar 14;390(11):973-983. doi: 10.1056/NEJMoa2304714.'}]}, 'descriptionModule': {'briefSummary': 'The ECLIPSE (Evaluation of the ctDNA LUNAR test in an Average Patient Screening Episode) study is a prospective, observational multi-site study without randomization. The primary objective of the study is to evaluate the performance characteristics of a blood-based ctDNA LUNAR-2 test to detect colorectal cancer in a screen-relevant, average risk population.', 'detailedDescription': 'The LUNAR-2 test has been developed to detect malignant disease in screen-relevant patients who would otherwise undergo screening for malignant disease using invasive methodologies such as colonoscopy. The intended use of such a test would be to return a result of ctDNA detected/ ctDNA not detected in a patient eligible for average risk screening for colorectal cancer. Those patients who receive a ctDNA detected result should undergo further investigation with colonoscopy.\n\nIn order to define the performance characteristics of the test in a relevant population, this study will perform a blood draw prior to the patient undergoing the standard of care colonoscopy (and all associated preparatory medications) and retrospectively compare the performance characteristics of the LUNAR-2 test with the findings of the index colonoscopy.\n\nOutcomes of patients at one and two-years post-procedure will be collected as secondary endpoints to investigate the possibility of incidental, non-colorectal cancer cases and interval cancers that had not reached the clinical threshold for detection at the time of the index colonoscopy.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'maximumAge': '84 Years', 'minimumAge': '45 Years', 'samplingMethod': 'NON_PROBABILITY_SAMPLE', 'studyPopulation': 'Single cohort of patients aged between 45 and 84, with no known high risk features, undergoing routine colorectal cancer screening as standard of care.', 'healthyVolunteers': True, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Subjects aged 45-84 years at time of consent\n2. Intended to undergo screening colonoscopy\n3. Considered by a physician or healthcare provider as being of 'average risk' for CRC\n4. Willing to consent to blood draw pre-bowel preparation administration prior to undergoing colonoscopy within 60 days of the date of the investigational blood draw\n5. Willing to consent to follow-up for two years as per protocol\n\nExclusion Criteria:\n\n1. Undergoing colonoscopy for investigation of symptoms\n2. Has undergone colonoscopy within preceding 9 years\n3. Positive FIT/FOBT result within the previous 6 months\n4. Has completed Cologuard or Epi proColon testing within the previous 3 years\n5. History of colorectal cancer\n6. History of any malignancy (patients who have undergone surgical removal of skin squamous cell cancer may be enrolled provided the procedure was completed at least 12 months prior to the date of provision of informed consent for the study)\n7. Known diagnosis of inflammatory bowel disease\n8. Currently taking any anti-neoplastic or disease-modifying anti-rheumatic drugs (DMARDs)\n9. Positive family history of colorectal cancer, defined as having one or more first- degree relatives (parent, sibling, or child) with CRC at any age\n10. Known hereditary/germline risk of colorectal cancer (for example, Lynch syndrome or Hereditary Non-Polyposis CRC \\[HNPCC\\], or Familial Adenomatous Polyposis \\[FAP\\])\n11. Any major physical trauma (e.g. disruption of tissue, surgery, organ transplant, blood product transfusion) within the 30 days leading up to the provision of informed consent\n12. Known medical condition which, in the opinion of the investigator, should preclude enrollment into the study\n13. Participation in a clinical research study in which an experimental medication has been administered or may be administered within the 30 days leading up to providing informed consent or may be administered through the time of colonoscopy"}, 'identificationModule': {'nctId': 'NCT04136002', 'acronym': 'ECLIPSE', 'briefTitle': 'Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode', 'organization': {'class': 'INDUSTRY', 'fullName': 'Guardant Health, Inc.'}, 'officialTitle': 'Evaluation of the ctDNA LUNAR Test in an Average Patient Screening Episode', 'orgStudyIdInfo': {'id': '02-GI-002'}}, 'contactsLocationsModule': {'locations': [{'zip': '36207', 'city': 'Anniston', 'state': 'Alabama', 'country': 'United States', 'facility': 'Pinnacle Research Group, LLC', 'geoPoint': {'lat': 33.65983, 'lon': -85.83163}}, {'zip': '35976', 'city': 'Guntersville', 'state': 'Alabama', 'country': 'United States', 'facility': 'Lakeview Clinical Research', 'geoPoint': {'lat': 34.35823, 'lon': -86.29446}}, {'zip': '35801', 'city': 'Huntsville', 'state': 'Alabama', 'country': 'United States', 'facility': 'Medical Affiliated Research Center', 'geoPoint': {'lat': 34.7304, 'lon': -86.58594}}, {'zip': '35501', 'city': 'Jasper', 'state': 'Alabama', 'country': 'United States', 'facility': 'Jasper Summit Research LLC', 'geoPoint': {'lat': 33.83122, 'lon': -87.27751}}, {'zip': '85224', 'city': 'Chandler', 'state': 'Arizona', 'country': 'United States', 'facility': 'Hope Research Institute', 'geoPoint': {'lat': 33.30616, 'lon': -111.84125}}, {'zip': '85224', 'city': 'Chandler', 'state': 'Arizona', 'country': 'United States', 'facility': 'Southeast Valley Gastroenterology', 'geoPoint': {'lat': 33.30616, 'lon': -111.84125}}, {'zip': '85296', 'city': 'Gilbert', 'state': 'Arizona', 'country': 'United States', 'facility': 'Prime Medical Group, LLC', 'geoPoint': {'lat': 33.35283, 'lon': -111.78903}}, {'zip': '85308', 'city': 'Glendale', 'state': 'Arizona', 'country': 'United States', 'facility': 'Hope Research Institute', 'geoPoint': {'lat': 33.53865, 'lon': -112.18599}}, {'zip': '85037', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': 'GI Research Associates, LLC', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85051', 'city': 'Phoenix', 'state': 'Arizona', 'country': 'United States', 'facility': '"Forty-Third Medical Associates Absolute Clinical Research"', 'geoPoint': {'lat': 33.44838, 'lon': -112.07404}}, {'zip': '85715', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'Del Sol Research Management, LLC', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '85741', 'city': 'Tucson', 'state': 'Arizona', 'country': 'United States', 'facility': 'Novak Clinical Research', 'geoPoint': {'lat': 32.22174, 'lon': -110.92648}}, {'zip': '85715', 'city': 'Tuscon', 'state': 'Arizona', 'country': 'United States', 'facility': 'Del Sol Research Management, LLC'}, {'zip': '72211', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Preferred Research Partners, Inc', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '72211', 'city': 'Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Premier Gastroenterology', 'geoPoint': {'lat': 34.74648, 'lon': -92.28959}}, {'zip': '72117', 'city': 'North Little Rock', 'state': 'Arkansas', 'country': 'United States', 'facility': 'Arkansas Gastroenterology', 'geoPoint': {'lat': 34.76954, 'lon': -92.26709}}, {'zip': '92801', 'city': 'Anaheim', 'state': 'California', 'country': 'United States', 'facility': 'Associated Gastroenterology Medical Group', 'geoPoint': {'lat': 33.83529, 'lon': -117.9145}}, {'zip': '91006', 'city': 'Arcadia', 'state': 'California', 'country': 'United States', 'facility': 'InSite Digestive Health Care', 'geoPoint': {'lat': 34.13973, 'lon': -118.03534}}, {'zip': '94010', 'city': 'Burlingame', 'state': 'California', 'country': 'United States', 'facility': 'Gastroenterology', 'geoPoint': {'lat': 37.5841, 'lon': -122.36608}}, {'zip': '93012', 'city': 'Camarillo', 'state': 'California', 'country': 'United States', 'facility': 'Ventura County Gastroenterology Medical Group', 'geoPoint': {'lat': 34.21639, 'lon': -119.0376}}, {'zip': '91303', 'city': 'Canoga Park', 'state': 'California', 'country': 'United States', 'facility': 'Hope Clinical Research', 'geoPoint': {'lat': 34.20112, 'lon': -118.59814}}, {'zip': '91304', 'city': 'Canoga Park', 'state': 'California', 'country': 'United States', 'facility': 'Alliance Research Institute', 'geoPoint': {'lat': 34.20112, 'lon': -118.59814}}, {'zip': '91910', 'city': 'Chula Vista', 'state': 'California', 'country': 'United States', 'facility': 'Gastro SB Clinic', 'geoPoint': {'lat': 32.64005, 'lon': -117.0842}}, {'zip': '91910', 'city': 'Chula Vista', 'state': 'California', 'country': 'United States', 'facility': 'Precision Research Institute', 'geoPoint': {'lat': 32.64005, 'lon': -117.0842}}, {'zip': '92024', 'city': 'Encinitas', 'state': 'California', 'country': 'United States', 'facility': 'BG Clinical Research and affiliate of The Clinical Trials Network, LLC', 'geoPoint': {'lat': 33.03699, 'lon': -117.29198}}, {'zip': '92024', 'city': 'Encinitas', 'state': 'California', 'country': 'United States', 'facility': 'Diagnamics, Inc', 'geoPoint': {'lat': 33.03699, 'lon': -117.29198}}, {'zip': '92831', 'city': 'Fullerton', 'state': 'California', 'country': 'United States', 'facility': 'Helping Hands Healthcare Group', 'geoPoint': {'lat': 33.87029, 'lon': -117.92534}}, {'zip': '92840', 'city': 'Garden Grove', 'state': 'California', 'country': 'United States', 'facility': 'Paragon RX Clinical, Inc.', 'geoPoint': {'lat': 33.77391, 'lon': -117.94145}}, {'zip': '92647', 'city': 'Huntington Beach', 'state': 'California', 'country': 'United States', 'facility': 'Digestive Health Research of Southern California', 'geoPoint': {'lat': 33.6603, 'lon': -117.99923}}, {'zip': '92618', 'city': 'Irvine', 'state': 'California', 'country': 'United States', 'facility': 'United Medical Doctors', 'geoPoint': {'lat': 33.66946, 'lon': -117.82311}}, {'zip': '93534', 'city': 'Lancaster', 'state': 'California', 'country': 'United States', 'facility': 'Gastro Care Institute', 'geoPoint': {'lat': 34.69804, 'lon': -118.13674}}, {'zip': '90004', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'LA Gastroenterology Group', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90033', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'University of Southern California', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '90048', 'city': 'Los Angeles', 'state': 'California', 'country': 'United States', 'facility': 'Gastroenterology Associates of Beverly Hills', 'geoPoint': {'lat': 34.05223, 'lon': -118.24368}}, {'zip': '92868', 'city': 'Orange', 'state': 'California', 'country': 'United States', 'facility': 'Knowledge Research Center', 'geoPoint': {'lat': 33.78779, 'lon': -117.85311}}, {'zip': '93030', 'city': 'Oxnard', 'state': 'California', 'country': 'United States', 'facility': 'InSite Digestive Health Care-San Gabriel', 'geoPoint': {'lat': 34.1975, 'lon': -119.17705}}, {'zip': '92262', 'city': 'Palm Springs', 'state': 'California', 'country': 'United States', 'facility': 'Desert Oasis Healthcare Medical Group', 'geoPoint': {'lat': 33.8303, 'lon': -116.54529}}, {'zip': '92262', 'city': 'Palm Springs', 'state': 'California', 'country': 'United States', 'facility': 'Palm Tree Clinical, Inc', 'geoPoint': {'lat': 33.8303, 'lon': -116.54529}}, {'zip': '91105', 'city': 'Pasadena', 'state': 'California', 'country': 'United States', 'facility': 'InSite Digestive Health Care - Gastroenterology Associates', 'geoPoint': {'lat': 34.14778, 'lon': -118.14452}}, {'zip': '95821', 'city': 'Sacramento', 'state': 'California', 'country': 'United States', 'facility': 'Northern California Research', 'geoPoint': {'lat': 38.58157, 'lon': -121.4944}}, {'zip': '92103', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'San Diego Gastroenterology Medical Associates', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '92103', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'SDG Clinical Research, Inc.', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '92114', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Precision Research Institute', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '92123', 'city': 'San Diego', 'state': 'California', 'country': 'United States', 'facility': 'Medical Associates Research Group', 'geoPoint': {'lat': 32.71571, 'lon': -117.16472}}, {'zip': '91360', 'city': 'Thousand Oaks', 'state': 'California', 'country': 'United States', 'facility': 'FOMAT Simoni AGI Medical', 'geoPoint': {'lat': 34.17056, 'lon': -118.83759}}, {'zip': '91602', 'city': 'Toluca Lake', 'state': 'California', 'country': 'United States', 'facility': 'Med Partners, Inc. dba Premiere Medical Center of Burbank, Inc', 'geoPoint': {'lat': 34.15206, 'lon': -118.35719}}, {'zip': '91789', 'city': 'Walnut Creek', 'state': 'California', 'country': 'United States', 'facility': 'Curebase', 'geoPoint': {'lat': 37.90631, 'lon': -122.06496}}, {'zip': '94598', 'city': 'Walnut Creek', 'state': 'California', 'country': 'United States', 'facility': 'Clinical Research of California', 'geoPoint': {'lat': 37.90631, 'lon': -122.06496}}, {'zip': '06606', 'city': 'Bridgeport', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Gastroenterology Associates of Fairfield County', 'geoPoint': {'lat': 41.17923, 'lon': -73.18945}}, {'zip': '06517', 'city': 'Hamden', 'state': 'Connecticut', 'country': 'United States', 'facility': 'CMR of Greater New Haven, LLC', 'geoPoint': {'lat': 41.39593, 'lon': -72.89677}}, {'zip': '06519', 'city': 'New Haven', 'state': 'Connecticut', 'country': 'United States', 'facility': 'Yale University', 'geoPoint': {'lat': 41.30815, 'lon': -72.92816}}, {'zip': '33180', 'city': 'Aventura', 'state': 'Florida', 'country': 'United States', 'facility': 'Innovative Medical Research of South Florida, Inc.', 'geoPoint': {'lat': 25.95648, 'lon': -80.13921}}, {'zip': '33472', 'city': 'Boynton Beach', 'state': 'Florida', 'country': 'United States', 'facility': 'Reciomed Clinical Research Network, Inc.', 'geoPoint': {'lat': 26.52535, 'lon': -80.06643}}, {'zip': '33134', 'city': 'Coral Gables', 'state': 'Florida', 'country': 'United States', 'facility': 'Clinical Research of South Florida, an AMR Company', 'geoPoint': {'lat': 25.72149, 'lon': -80.26838}}, {'zip': '33172', 'city': 'Doral', 'state': 'Florida', 'country': 'United States', 'facility': 'Dolphin Medical Research', 'geoPoint': {'lat': 25.81954, 'lon': -80.35533}}, {'zip': '32610', 'city': 'Gainesville', 'state': 'Florida', 'country': 'United States', 'facility': 'University of Florida College of Medicine', 'geoPoint': {'lat': 29.65163, 'lon': -82.32483}}, {'zip': '33016', 'city': 'Hialeah', 'state': 'Florida', 'country': 'United States', 'facility': 'Palmetto Research, LLC', 'geoPoint': {'lat': 25.8576, 'lon': -80.27811}}, {'zip': '33021', 'city': 'Hollywood', 'state': 'Florida', 'country': 'United States', 'facility': 'The Center for Gastrointestinal Disorders', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '33024', 'city': 'Hollywood', 'state': 'Florida', 'country': 'United States', 'facility': 'Research Centers of America', 'geoPoint': {'lat': 26.0112, 'lon': -80.14949}}, {'zip': '33458', 'city': 'Jupiter', 'state': 'Florida', 'country': 'United States', 'facility': 'Health Awareness, Inc', 'geoPoint': {'lat': 26.93422, 'lon': -80.09421}}, {'zip': '33458', 'city': 'Jupiter', 'state': 'Florida', 'country': 'United States', 'facility': 'Jupiter Medical Center', 'geoPoint': {'lat': 26.93422, 'lon': -80.09421}}, {'zip': '32055', 'city': 'Lake City', 'state': 'Florida', 'country': 'United States', 'facility': 'Multi-Specialty Research Associates', 'geoPoint': {'lat': 30.18968, 'lon': -82.63929}}, {'zip': '32746', 'city': 'Lake Mary', 'state': 'Florida', 'country': 'United States', 'facility': 'University Clinical Research-DeLand, LLC dba Accel Research Sites', 'geoPoint': {'lat': 28.75888, 'lon': -81.31784}}, {'zip': '34211', 'city': 'Lakewood Rch', 'state': 'Florida', 'country': 'United States', 'facility': 'Florida Research Institute', 'geoPoint': {'lat': 27.3863, 'lon': -82.4332}}, {'zip': '32901', 'city': 'Melbourne', 'state': 'Florida', 'country': 'United States', 'facility': 'University Clinical Research-DeLand, LLC dba Accel Research Sites', 'geoPoint': {'lat': 28.08363, 'lon': -80.60811}}, {'zip': '33014', 'city': 'Miami Lakes', 'state': 'Florida', 'country': 'United States', 'facility': 'Crystal Biomedical Research', 'geoPoint': {'lat': 25.90871, 'lon': -80.30866}}, {'zip': '34471', 'city': 'Ocala', 'state': 'Florida', 'country': 'United States', 'facility': 'Ocala GI Research, LLC', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '34474', 'city': 'Ocala', 'state': 'Florida', 'country': 'United States', 'facility': 'Sarkis Clinical Trials', 'geoPoint': {'lat': 29.1872, 'lon': -82.14009}}, {'zip': '32763', 'city': 'Orange City', 'state': 'Florida', 'country': 'United States', 'facility': 'Gastroenterology of Greater Orlando', 'geoPoint': {'lat': 28.94888, 'lon': -81.29867}}, {'zip': '32807', 'city': 'Orlando', 'state': 'Florida', 'country': 'United States', 'facility': 'Gastroenterology Institute of Orlando', 'geoPoint': {'lat': 28.53834, 'lon': -81.37924}}, {'zip': '34684', 'city': 'Palm Harbor', 'state': 'Florida', 'country': 'United States', 'facility': 'Advanced Gastroenterology Associates, LLC', 'geoPoint': {'lat': 28.07807, 'lon': -82.76371}}, {'zip': '33351', 'city': 'Sunrise', 'state': 'Florida', 'country': 'United States', 'facility': 'Precision Clinical Research, LLC', 'geoPoint': {'lat': 26.13397, 'lon': -80.1131}}, {'zip': '33614', 'city': 'Tampa', 'state': 'Florida', 'country': 'United States', 'facility': 'Guardian Angel Research Center, LLC', 'geoPoint': {'lat': 27.94752, 'lon': -82.45843}}, {'zip': '30309', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Digestive Health Care of Georgia', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30322', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Emory University School of Medicine', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '30342', 'city': 'Atlanta', 'state': 'Georgia', 'country': 'United States', 'facility': 'Metro Atlanta Gastroenterology, LLC.', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '31904', 'city': 'Columbus', 'state': 'Georgia', 'country': 'United States', 'facility': 'Columbus Regional Research Institute', 'geoPoint': {'lat': 32.46098, 'lon': -84.98771}}, {'zip': '30809', 'city': 'Evans', 'state': 'Georgia', 'country': 'United States', 'facility': 'Gastroenterology Consultants of Augusta', 'geoPoint': {'lat': 33.53375, 'lon': -82.13067}}, {'zip': '30044', 'city': 'Lawrenceville', 'state': 'Georgia', 'country': 'United States', 'facility': 'SKY Clinical Research Network Group', 'geoPoint': {'lat': 33.95621, 'lon': -83.98796}}, {'zip': '30274', 'city': 'Riverdale', 'state': 'Georgia', 'country': 'United States', 'facility': 'Infinite Clinical Trials', 'geoPoint': {'lat': 33.57261, 'lon': -84.41326}}, {'zip': '30328', 'city': 'Sandy Springs', 'state': 'Georgia', 'country': 'United States', 'facility': 'WR-Mount Vernon Clinical Research, LLC', 'geoPoint': {'lat': 33.92427, 'lon': -84.37854}}, {'zip': '30291', 'city': 'Union City', 'state': 'Georgia', 'country': 'United States', 'facility': 'Rolphe Adult and Pediatric Medicine', 'geoPoint': {'lat': 33.58706, 'lon': -84.54243}}, {'zip': '61822', 'city': 'Champaign', 'state': 'Illinois', 'country': 'United 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