Ignite Creation Date:
2025-12-25 @ 3:44 AM
Ignite Modification Date:
2025-12-26 @ 2:29 AM
Study NCT ID:
NCT04661202
Status:
COMPLETED
Last Update Posted:
2024-08-02
First Post:
2020-12-03
Is NOT Gene Therapy:
False
Has Adverse Events:
True
Brief Title:
Effects of Exercise Training on Pelvic Floor Symptoms and Function in Adults With Constipation
Sponsor:
Organization:
Raw JSON
{'hasResults': True, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24'}, 'conditionBrowseModule': {'meshes': [{'id': 'D003248', 'term': 'Constipation'}], 'ancestors': [{'id': 'D012817', 'term': 'Signs and Symptoms, Digestive'}, {'id': 'D012816', 'term': 'Signs and Symptoms'}, {'id': 'D013568', 'term': 'Pathological Conditions, Signs and Symptoms'}]}}, 'resultsSection': {'moreInfoModule': {'pointOfContact': {'email': '10802003@gs.ncku.edu.tw', 'phone': '06-2353535', 'title': 'Dr. Kuan-Yin Lin', 'phoneExt': '6737', 'organization': 'National Cheng Kung University'}, 'certainAgreement': {'piSponsorEmployee': False, 'restrictiveAgreement': False}}, 'adverseEventsModule': {'timeFrame': 'through 8-week program', 'description': 'In our study, adverse events were monitored but no adverse events were reported.', 'eventGroups': [{'id': 'EG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction.", 'otherNumAtRisk': 14, 'deathsNumAtRisk': 14, 'otherNumAffected': 0, 'seriousNumAtRisk': 14, 'deathsNumAffected': 0, 'seriousNumAffected': 0}, {'id': 'EG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.', 'otherNumAtRisk': 13, 'deathsNumAtRisk': 13, 'otherNumAffected': 0, 'seriousNumAtRisk': 13, 'deathsNumAffected': 0, 'seriousNumAffected': 0}], 'frequencyThreshold': '0'}, 'outcomeMeasuresModule': {'outcomeMeasures': [{'type': 'PRIMARY', 'title': 'Severity of Constipation Symptoms', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'title': 'Total', 'categories': [{'measurements': [{'value': '0.96', 'spread': '0.59', 'groupId': 'OG000'}, {'value': '0.97', 'spread': '0.78', 'groupId': 'OG001'}]}]}, {'title': 'Abdominal', 'categories': [{'measurements': [{'value': '0.63', 'spread': '0.47', 'groupId': 'OG000'}, {'value': '0.67', 'spread': '0.98', 'groupId': 'OG001'}]}]}, {'title': 'Rectal', 'categories': [{'measurements': [{'value': '0.67', 'spread': '0.81', 'groupId': 'OG000'}, {'value': '0.64', 'spread': '1.17', 'groupId': 'OG001'}]}]}, {'title': 'Stool', 'categories': [{'measurements': [{'value': '1.40', 'spread': '0.94', 'groupId': 'OG000'}, {'value': '1.40', 'spread': '0.74', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'The Patient Assessment of Constipation Symptoms questionnaire will be used to assess the severity of constipation symptoms. This questionnaire includes a total of 12 items in 3 subscales: abdominal (4 items), rectal (3 items), and stool (5 items). Participant will be asked to rank the symptoms on a five-point Likert scale, ranging from 0 (absent) to 4 (very severe). The total score ranges from 0 to 48 which will be divided by the actual number of items answered. The higher score indicates the greater severity of constipation symptoms.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Constipation Symptoms', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'title': 'Stool frequency', 'categories': [{'measurements': [{'value': '5.14', 'spread': '1.70', 'groupId': 'OG000'}, {'value': '5.54', 'spread': '1.76', 'groupId': 'OG001'}]}]}, {'title': 'Incontinence', 'categories': [{'measurements': [{'value': '0', 'spread': '0', 'groupId': 'OG000'}, {'value': '0', 'spread': '0', 'groupId': 'OG001'}]}]}, {'title': 'Excessive straining', 'categories': [{'measurements': [{'value': '0.43', 'spread': '0.85', 'groupId': 'OG000'}, {'value': '0.62', 'spread': '0.96', 'groupId': 'OG001'}]}]}, {'title': 'Manual maneuver', 'categories': [{'measurements': [{'value': '0.07', 'spread': '0.27', 'groupId': 'OG000'}, {'value': '0.46', 'spread': '1.66', 'groupId': 'OG001'}]}]}, {'title': 'Pain during defecation', 'categories': [{'measurements': [{'value': '0.64', 'spread': '0.93', 'groupId': 'OG000'}, {'value': '0.46', 'spread': '0.97', 'groupId': 'OG001'}]}]}, {'title': 'Use of laxatives', 'categories': [{'measurements': [{'value': '1.14', 'spread': '2.51', 'groupId': 'OG000'}, {'value': '1.15', 'spread': '2.61', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'A Seven Day Bowel Diary includes items regarding the stool frequency, presence of incontinence, excessive straining, manual maneuver, or pain during defecation, and the use of laxatives.', 'unitOfMeasure': 'number/week', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Constipation Symptom-Stool Consistency', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'categories': [{'measurements': [{'value': '3.74', 'spread': '1.44', 'groupId': 'OG000'}, {'value': '3.46', 'spread': '1.33', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'A Seven Day Bowel Diary includes the item regarding stool consistency. The Bristol Stool Form Scale describing the shapes and types of stools is used to evaluate stool consistency. This scale assigns a number (1-7) with 1 indicating hardest to 7 indicating loosest, to classify human feces based on its shape and and how formed or loose it is.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'PRIMARY', 'title': 'Constipation Symptom-Time Spent During Defecation', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'categories': [{'measurements': [{'value': '12.06', 'spread': '15.15', 'groupId': 'OG000'}, {'value': '9.46', 'spread': '9.60', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'A Seven Day Bowel Diary includes items regarding time spent during defecation.', 'unitOfMeasure': 'minute/bowel movement', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'The Pelvic Floor Muscle Coordination Measured by the Pelvic Floor Muscle Coordination Scale', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'categories': [{'measurements': [{'value': '1.79', 'spread': '1.25', 'groupId': 'OG000'}, {'value': '2.31', 'spread': '2.10', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'The Pelvic Floor Muscle Coordination Scale including 5 items, respiration, pelvic floor muscle contraction, extrapelvic muscle activation, pelvic floor muscle expansion, and cough will be used to evaluate pelvic floor muscle coordination. All will be evaluated by observation. The total score ranges from 0 to 10 and a higher score indicates the poorer pelvic floor muscle coordination.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'The Pelvic Floor Muscle Strength Will be Measured by Digital Rectal Examination.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'title': 'External anal sphincter resting tone', 'categories': [{'measurements': [{'value': '0.71', 'spread': '0.47', 'groupId': 'OG000'}, {'value': '0.62', 'spread': '0.51', 'groupId': 'OG001'}]}]}, {'title': 'Puborectalis resting tone', 'categories': [{'measurements': [{'value': '1.14', 'spread': '0.36', 'groupId': 'OG000'}, {'value': '1.15', 'spread': '0.38', 'groupId': 'OG001'}]}]}, {'title': 'External anal sphincter maximal voluntary contraction', 'categories': [{'measurements': [{'value': '1.50', 'spread': '0.65', 'groupId': 'OG000'}, {'value': '1.31', 'spread': '0.48', 'groupId': 'OG001'}]}]}, {'title': 'Puborectalis maximal voluntary contraction', 'categories': [{'measurements': [{'value': '1.64', 'spread': '0.50', 'groupId': 'OG000'}, {'value': '1.77', 'spread': '0.73', 'groupId': 'OG001'}]}]}, {'title': 'Voluntary relaxation', 'categories': [{'measurements': [{'value': '1.71', 'spread': '0.61', 'groupId': 'OG000'}, {'value': '1.85', 'spread': '0.38', 'groupId': 'OG001'}]}]}, {'title': 'Push effort', 'categories': [{'measurements': [{'value': '0.86', 'spread': '0.36', 'groupId': 'OG000'}, {'value': '0.54', 'spread': '0.52', 'groupId': 'OG001'}]}]}, {'title': 'Anal relaxation', 'categories': [{'measurements': [{'value': '1.21', 'spread': '0.43', 'groupId': 'OG000'}, {'value': '1.23', 'spread': '0.44', 'groupId': 'OG001'}]}]}, {'title': 'Perineal descent', 'categories': [{'measurements': [{'value': '1.07', 'spread': '0.27', 'groupId': 'OG000'}, {'value': '0.85', 'spread': '0.38', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Resting tone, maximal voluntary contraction (MVC) of external anal sphincter and puborectalis, voluntary relaxation, and three components of defecation attempts (push effort, anal relaxation, and perineal descent) will be measured.\n\nResting pressure was scored as "0=decreased", "1=normal", or "2=increased". Maximal voluntary contraction of external anal sphincter and puborectalis were scored separately for each muscle based on the International Continence Society scale criteria as "0=absent", "1=weak", "2=moderate", "3=strong". Voluntary relaxation was assessed after MVCs and scored as "0=absent", "1=partial", or "2=complete". Push effort was scored as "0=weak", "1=normal", or "2=excessive", anal relaxation was scored as "0=impaired", "1=normal", or "2=paradoxical contraction", and perineal descent was scored as "0=absent", "1=normal", or "2=excessive".', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'The Pelvic Floor Muscle Function Will be Measured Using Anorectal Manometry.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'title': 'Resting pressure', 'categories': [{'measurements': [{'value': '2.14', 'spread': '2.01', 'groupId': 'OG000'}, {'value': '1.82', 'spread': '1.26', 'groupId': 'OG001'}]}]}, {'title': 'Maximal voluntary contraction', 'categories': [{'measurements': [{'value': '50.73', 'spread': '40.42', 'groupId': 'OG000'}, {'value': '46.52', 'spread': '31.92', 'groupId': 'OG001'}]}]}, {'title': 'Average of maximal voluntary contraction', 'categories': [{'measurements': [{'value': '23.01', 'spread': '25.34', 'groupId': 'OG000'}, {'value': '16.42', 'spread': '17.48', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Participants will be asked to relax for 10 seconds, squeeze 3 times by holding 5 seconds with 5 seconds of rest in between, and squeeze by holding the contraction for 30 seconds. Anorectal pressure will be recorded in unit of millimeter of mercury (mmHg).', 'unitOfMeasure': 'millimeter of mercury', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'The Pelvic Floor Muscle Endurance Will be Measured Using Anorectal Manometry and Stopwatch.', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'categories': [{'measurements': [{'value': '6.78', 'spread': '7.53', 'groupId': 'OG000'}, {'value': '6.11', 'spread': '8.04', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Participants will be asked to voluntarily squeeze their pelvic floor muscles by holding the contraction for 30 seconds. Anorectal squeeze pressure is measured using an anorectal manometry. The pelvic floor muscle endurance is recorded as the time (seconds) holding at \\>50% of maximal voluntary contraction (squeeze pressure) in 30 seconds.', 'unitOfMeasure': 'seconds', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Physical Activity Levels', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'title': 'Total', 'categories': [{'measurements': [{'value': '1069.25', 'spread': '747.76', 'groupId': 'OG000'}, {'value': '1253.85', 'spread': '1889.07', 'groupId': 'OG001'}]}]}, {'title': 'Vigorous', 'categories': [{'measurements': [{'value': '262.86', 'spread': '354.22', 'groupId': 'OG000'}, {'value': '418.46', 'spread': '821.81', 'groupId': 'OG001'}]}]}, {'title': 'Moderate', 'categories': [{'measurements': [{'value': '331.43', 'spread': '275.09', 'groupId': 'OG000'}, {'value': '378.46', 'spread': '608.51', 'groupId': 'OG001'}]}]}, {'title': 'Walking', 'categories': [{'measurements': [{'value': '474.96', 'spread': '539.54', 'groupId': 'OG000'}, {'value': '456.92', 'spread': '601.91', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': "The International Physical Activity Questionnaire will be used to measure participants' physical activity levels. This questionnaire includes seven questions on different physical activity levels of duration and frequency and then calculated in metabolic equivalent-minutes/week. A higher score indicates a greater physical activity levels.", 'unitOfMeasure': 'metabolic equivalent-minutes/week', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Constipation Quality of Life', 'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'OG000'}, {'value': '13', 'groupId': 'OG001'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'OG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'classes': [{'title': 'Total', 'categories': [{'measurements': [{'value': '1.30', 'spread': '0.75', 'groupId': 'OG000'}, {'value': '1.60', 'spread': '0.85', 'groupId': 'OG001'}]}]}, {'title': 'Physical discomfort', 'categories': [{'measurements': [{'value': '1.16', 'spread': '0.68', 'groupId': 'OG000'}, {'value': '1.38', 'spread': '0.88', 'groupId': 'OG001'}]}]}, {'title': 'Worries and concerns', 'categories': [{'measurements': [{'value': '1.28', 'spread': '0.97', 'groupId': 'OG000'}, {'value': '1.69', 'spread': '1.12', 'groupId': 'OG001'}]}]}, {'title': 'Satisfaction', 'categories': [{'measurements': [{'value': '2.36', 'spread': '0.85', 'groupId': 'OG000'}, {'value': '2.71', 'spread': '0.51', 'groupId': 'OG001'}]}]}, {'title': 'Psychosocial discomfort', 'categories': [{'measurements': [{'value': '0.72', 'spread': '0.70', 'groupId': 'OG000'}, {'value': '0.89', 'spread': '0.85', 'groupId': 'OG001'}]}]}], 'paramType': 'MEAN', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Patient Assessment of Constipation Quality of Life Questionnaire will be used to evaluate the quality of life in constipation patients. This questionnaire includes a total of 28 items in 4 subscales: worries and concerns (11 items), physical discomfort (4 items), psychosocial discomfort (8 items), and satisfaction (5 items). Participants will be asked to rank how constipation affects their quality of life on a five-point Likert scale, ranging from 0 to 4. A higher score indicates greater impact on quality of life.', 'unitOfMeasure': 'score on a scale', 'dispersionType': 'Standard Deviation', 'reportingStatus': 'POSTED'}, {'type': 'SECONDARY', 'title': 'Adherence', 'denoms': [{'units': 'Participants', 'counts': [{'value': '11', 'groupId': 'OG000'}]}, {'units': 'days', 'counts': [{'value': '56', 'groupId': 'OG000'}]}], 'groups': [{'id': 'OG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}], 'classes': [{'title': 'Pelvic floor muscle training', 'categories': [{'measurements': [{'value': '33', 'groupId': 'OG000'}]}]}, {'title': 'Walking', 'categories': [{'measurements': [{'value': '28', 'groupId': 'OG000'}]}]}], 'paramType': 'COUNT_OF_UNITS', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Participants in intervention group will be asked to record the number of completed home exercises (pelvic floor muscle training and walking) in the exercise diary. Adherence will be calculated separately for pelvic floor muscle training and walking as the days of home exercises completed over 56 days.', 'unitOfMeasure': 'days', 'reportingStatus': 'POSTED', 'typeUnitsAnalyzed': 'days', 'denomUnitsSelected': 'days', 'populationDescription': 'There were three missing data of adherence (n=3) in intervention group as the participants dropped out during the eight-week program.'}]}, 'participantFlowModule': {'groups': [{'id': 'FG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'FG001', 'title': 'Control Group', 'description': '．Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'periods': [{'title': 'Overall Study', 'milestones': [{'type': 'STARTED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '14'}, {'groupId': 'FG001', 'numSubjects': '13'}]}, {'type': 'COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '11'}, {'groupId': 'FG001', 'numSubjects': '12'}]}, {'type': 'NOT COMPLETED', 'achievements': [{'groupId': 'FG000', 'numSubjects': '3'}, {'groupId': 'FG001', 'numSubjects': '1'}]}], 'dropWithdraws': [{'type': 'Withdrawal by Subject', 'reasons': [{'groupId': 'FG000', 'numSubjects': '1'}, {'groupId': 'FG001', 'numSubjects': '1'}]}, {'type': 'Lack of Efficacy', 'reasons': [{'groupId': 'FG000', 'numSubjects': '2'}, {'groupId': 'FG001', 'numSubjects': '0'}]}]}], 'recruitmentDetails': 'Participants were recruited from the outpatient department of Colorectal Surgery of National Cheng Kung University Hospital, Tainan, Taiwan, the clinic, community, and social media from January 2021 to June 2022.'}, 'baselineCharacteristicsModule': {'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'groups': [{'id': 'BG000', 'title': 'Exercise Training Group', 'description': "* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise\n\nMultimodal exercise training:\n\nA supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction."}, {'id': 'BG001', 'title': 'Control Group', 'description': '●Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}, {'id': 'BG002', 'title': 'Total', 'description': 'Total of all reporting groups'}], 'measures': [{'title': 'Age, Continuous', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '36.07', 'spread': '12.47', 'groupId': 'BG000'}, {'value': '37.92', 'spread': '16.19', 'groupId': 'BG001'}, {'value': '36.96', 'spread': '14.13', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'years', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Sex: Female, Male', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Female', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}]}, {'title': 'Male', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Race and Ethnicity Not Collected', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '0', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '0', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '0', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants', 'populationDescription': 'Race and Ethnicity were not collected from any participant.'}, {'title': 'Height', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '161.6', 'spread': '7.51', 'groupId': 'BG000'}, {'value': '159.7', 'spread': '6.12', 'groupId': 'BG001'}, {'value': '160.7', 'spread': '6.81', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'centimeter', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Weight', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '59.5', 'spread': '8.02', 'groupId': 'BG000'}, {'value': '60.5', 'spread': '16.66', 'groupId': 'BG001'}, {'value': '60.0', 'spread': '12.67', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'kilogram', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Body mass index (BMI)', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '22.8', 'spread': '2.82', 'groupId': 'BG000'}, {'value': '23.6', 'spread': '5.43', 'groupId': 'BG001'}, {'value': '23.2', 'spread': '4.21', 'groupId': 'BG002'}]}]}], 'paramType': 'MEAN', 'unitOfMeasure': 'kilogram/meter^2', 'dispersionType': 'STANDARD_DEVIATION'}, {'title': 'Smoking status', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Current smoker', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}]}, {'title': 'Ex-smoker', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': 'Never smoked', 'measurements': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Educational level', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Doctoral degree', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': "Master's degree", 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}]}, {'title': "Bachelor's degree/Junior college", 'measurements': [{'value': '8', 'groupId': 'BG000'}, {'value': '8', 'groupId': 'BG001'}, {'value': '16', 'groupId': 'BG002'}]}, {'title': 'Senior/Vocational high school', 'measurements': [{'value': '4', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '5', 'groupId': 'BG002'}]}, {'title': 'Junior high school', 'measurements': [{'value': '0', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Working status', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Full time', 'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '5', 'groupId': 'BG001'}, {'value': '12', 'groupId': 'BG002'}]}, {'title': 'Part time', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}]}, {'title': 'Unemployed', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '13', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Marital status', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Single', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '8', 'groupId': 'BG001'}, {'value': '14', 'groupId': 'BG002'}]}, {'title': 'Married', 'measurements': [{'value': '7', 'groupId': 'BG000'}, {'value': '5', 'groupId': 'BG001'}, {'value': '12', 'groupId': 'BG002'}]}, {'title': 'Divorced', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Living status', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Living with family', 'measurements': [{'value': '8', 'groupId': 'BG000'}, {'value': '10', 'groupId': 'BG001'}, {'value': '18', 'groupId': 'BG002'}]}, {'title': 'Living alone', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '2', 'groupId': 'BG001'}, {'value': '7', 'groupId': 'BG002'}]}, {'title': 'Living in dormitory', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Use of laxatives', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '14', 'groupId': 'BG000'}, {'value': '13', 'groupId': 'BG001'}, {'value': '27', 'groupId': 'BG002'}]}], 'categories': [{'measurements': [{'value': '3', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '6', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants'}, {'title': 'Menstrual cycle status', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}]}], 'categories': [{'title': 'Menstruating', 'measurements': [{'value': '10', 'groupId': 'BG000'}, {'value': '7', 'groupId': 'BG001'}, {'value': '17', 'groupId': 'BG002'}]}, {'title': 'Peri-menopause', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '3', 'groupId': 'BG001'}, {'value': '4', 'groupId': 'BG002'}]}, {'title': 'Post-menopause', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants', 'populationDescription': 'Only the female participant had to answer this item in the questionnaire.'}, {'title': 'Gravidity', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}]}], 'categories': [{'title': '0', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '11', 'groupId': 'BG002'}]}, {'title': '1', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': '2', 'measurements': [{'value': '4', 'groupId': 'BG000'}, {'value': '4', 'groupId': 'BG001'}, {'value': '8', 'groupId': 'BG002'}]}, {'title': '3', 'measurements': [{'value': '1', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '1', 'groupId': 'BG002'}]}, {'title': '≥4', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '1', 'groupId': 'BG001'}, {'value': '3', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants', 'populationDescription': 'Only the female participant had to answer this item in the questionnaire.'}, {'title': 'Parity', 'classes': [{'denoms': [{'units': 'Participants', 'counts': [{'value': '13', 'groupId': 'BG000'}, {'value': '11', 'groupId': 'BG001'}, {'value': '24', 'groupId': 'BG002'}]}], 'categories': [{'title': '0', 'measurements': [{'value': '5', 'groupId': 'BG000'}, {'value': '6', 'groupId': 'BG001'}, {'value': '11', 'groupId': 'BG002'}]}, {'title': '1', 'measurements': [{'value': '2', 'groupId': 'BG000'}, {'value': '0', 'groupId': 'BG001'}, {'value': '2', 'groupId': 'BG002'}]}, {'title': '2', 'measurements': [{'value': '6', 'groupId': 'BG000'}, {'value': '5', 'groupId': 'BG001'}, {'value': '11', 'groupId': 'BG002'}]}]}], 'paramType': 'COUNT_OF_PARTICIPANTS', 'unitOfMeasure': 'Participants', 'populationDescription': 'Only the female participant had to answer this item in the questionnaire.'}]}}, 'documentSection': {'largeDocumentModule': {'largeDocs': [{'date': '2020-12-25', 'size': 108143, 'label': 'Study Protocol and Statistical Analysis Plan', 'hasIcf': False, 'hasSap': True, 'filename': 'Prot_SAP_000.pdf', 'typeAbbrev': 'Prot_SAP', 'uploadDate': '2023-07-15T08:32', 'hasProtocol': True}]}}, 'protocolSection': {'designModule': {'phases': ['NA'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL'}, 'enrollmentInfo': {'type': 'ACTUAL', 'count': 27}}, 'statusModule': {'overallStatus': 'COMPLETED', 'startDateStruct': {'date': '2021-01-01', 'type': 'ACTUAL'}, 'expandedAccessInfo': {'hasExpandedAccess': False}, 'statusVerifiedDate': '2024-02', 'completionDateStruct': {'date': '2022-07-31', 'type': 'ACTUAL'}, 'lastUpdateSubmitDate': '2024-02-23', 'studyFirstSubmitDate': '2020-12-03', 'resultsFirstSubmitDate': '2022-08-12', 'studyFirstSubmitQcDate': '2020-12-03', 'lastUpdatePostDateStruct': {'date': '2024-08-02', 'type': 'ACTUAL'}, 'resultsFirstSubmitQcDate': '2024-02-23', 'studyFirstPostDateStruct': {'date': '2020-12-10', 'type': 'ACTUAL'}, 'resultsFirstPostDateStruct': {'date': '2024-08-02', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2022-03-23', 'type': 'ACTUAL'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Severity of Constipation Symptoms', 'timeFrame': 'absolute values at 8 weeks', 'description': 'The Patient Assessment of Constipation Symptoms questionnaire will be used to assess the severity of constipation symptoms. This questionnaire includes a total of 12 items in 3 subscales: abdominal (4 items), rectal (3 items), and stool (5 items). Participant will be asked to rank the symptoms on a five-point Likert scale, ranging from 0 (absent) to 4 (very severe). The total score ranges from 0 to 48 which will be divided by the actual number of items answered. The higher score indicates the greater severity of constipation symptoms.'}, {'measure': 'Constipation Symptoms', 'timeFrame': 'absolute values at 8 weeks', 'description': 'A Seven Day Bowel Diary includes items regarding the stool frequency, presence of incontinence, excessive straining, manual maneuver, or pain during defecation, and the use of laxatives.'}, {'measure': 'Constipation Symptom-Stool Consistency', 'timeFrame': 'absolute values at 8 weeks', 'description': 'A Seven Day Bowel Diary includes the item regarding stool consistency. The Bristol Stool Form Scale describing the shapes and types of stools is used to evaluate stool consistency. This scale assigns a number (1-7) with 1 indicating hardest to 7 indicating loosest, to classify human feces based on its shape and and how formed or loose it is.'}, {'measure': 'Constipation Symptom-Time Spent During Defecation', 'timeFrame': 'absolute values at 8 weeks', 'description': 'A Seven Day Bowel Diary includes items regarding time spent during defecation.'}], 'secondaryOutcomes': [{'measure': 'The Pelvic Floor Muscle Coordination Measured by the Pelvic Floor Muscle Coordination Scale', 'timeFrame': 'absolute values at 8 weeks', 'description': 'The Pelvic Floor Muscle Coordination Scale including 5 items, respiration, pelvic floor muscle contraction, extrapelvic muscle activation, pelvic floor muscle expansion, and cough will be used to evaluate pelvic floor muscle coordination. All will be evaluated by observation. The total score ranges from 0 to 10 and a higher score indicates the poorer pelvic floor muscle coordination.'}, {'measure': 'The Pelvic Floor Muscle Strength Will be Measured by Digital Rectal Examination.', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Resting tone, maximal voluntary contraction (MVC) of external anal sphincter and puborectalis, voluntary relaxation, and three components of defecation attempts (push effort, anal relaxation, and perineal descent) will be measured.\n\nResting pressure was scored as "0=decreased", "1=normal", or "2=increased". Maximal voluntary contraction of external anal sphincter and puborectalis were scored separately for each muscle based on the International Continence Society scale criteria as "0=absent", "1=weak", "2=moderate", "3=strong". Voluntary relaxation was assessed after MVCs and scored as "0=absent", "1=partial", or "2=complete". Push effort was scored as "0=weak", "1=normal", or "2=excessive", anal relaxation was scored as "0=impaired", "1=normal", or "2=paradoxical contraction", and perineal descent was scored as "0=absent", "1=normal", or "2=excessive".'}, {'measure': 'The Pelvic Floor Muscle Function Will be Measured Using Anorectal Manometry.', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Participants will be asked to relax for 10 seconds, squeeze 3 times by holding 5 seconds with 5 seconds of rest in between, and squeeze by holding the contraction for 30 seconds. Anorectal pressure will be recorded in unit of millimeter of mercury (mmHg).'}, {'measure': 'The Pelvic Floor Muscle Endurance Will be Measured Using Anorectal Manometry and Stopwatch.', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Participants will be asked to voluntarily squeeze their pelvic floor muscles by holding the contraction for 30 seconds. Anorectal squeeze pressure is measured using an anorectal manometry. The pelvic floor muscle endurance is recorded as the time (seconds) holding at \\>50% of maximal voluntary contraction (squeeze pressure) in 30 seconds.'}, {'measure': 'Physical Activity Levels', 'timeFrame': 'absolute values at 8 weeks', 'description': "The International Physical Activity Questionnaire will be used to measure participants' physical activity levels. This questionnaire includes seven questions on different physical activity levels of duration and frequency and then calculated in metabolic equivalent-minutes/week. A higher score indicates a greater physical activity levels."}, {'measure': 'Constipation Quality of Life', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Patient Assessment of Constipation Quality of Life Questionnaire will be used to evaluate the quality of life in constipation patients. This questionnaire includes a total of 28 items in 4 subscales: worries and concerns (11 items), physical discomfort (4 items), psychosocial discomfort (8 items), and satisfaction (5 items). Participants will be asked to rank how constipation affects their quality of life on a five-point Likert scale, ranging from 0 to 4. A higher score indicates greater impact on quality of life.'}, {'measure': 'Adherence', 'timeFrame': 'absolute values at 8 weeks', 'description': 'Participants in intervention group will be asked to record the number of completed home exercises (pelvic floor muscle training and walking) in the exercise diary. Adherence will be calculated separately for pelvic floor muscle training and walking as the days of home exercises completed over 56 days.'}]}, 'oversightModule': {'isFdaRegulatedDrug': False, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'keywords': ['constipation', 'resistance exercise', 'aerobic exercise', 'pelvic floor muscle training'], 'conditions': ['Constipation']}, 'referencesModule': {'references': [{'pmid': '27144630', 'type': 'BACKGROUND', 'citation': 'Rao SS, Bharucha AE, Chiarioni G, Felt-Bersma R, Knowles C, Malcolm A, Wald A. Functional Anorectal Disorders. Gastroenterology. 2016 Mar 25:S0016-5085(16)00175-X 10.1053/j.gastro.2016.02.009. doi: 10.1053/j.gastro.2016.02.009. Online ahead of print.'}, {'pmid': '30843436', 'type': 'BACKGROUND', 'citation': 'Gao R, Tao Y, Zhou C, Li J, Wang X, Chen L, Li F, Guo L. Exercise therapy in patients with constipation: a systematic review and meta-analysis of randomized controlled trials. Scand J Gastroenterol. 2019 Feb;54(2):169-177. doi: 10.1080/00365521.2019.1568544. Epub 2019 Mar 7.'}, {'pmid': '30945991', 'type': 'BACKGROUND', 'citation': 'Virtuoso JF, Menezes EC, Mazo GZ. Effect of Weight Training with Pelvic Floor Muscle Training in Elderly Women with Urinary Incontinence. Res Q Exerc Sport. 2019 Jun;90(2):141-150. doi: 10.1080/02701367.2019.1571674. Epub 2019 Apr 4.'}, {'pmid': '10522604', 'type': 'BACKGROUND', 'citation': 'Frank L, Kleinman L, Farup C, Taylor L, Miner P Jr. Psychometric validation of a constipation symptom assessment questionnaire. Scand J Gastroenterol. 1999 Sep;34(9):870-7. doi: 10.1080/003655299750025327.'}, {'type': 'BACKGROUND', 'citation': "Sadowy AM, Brouwer HL, Finseth DL, Hagener KM, Lawrence AE, Hollman JH. Development of a Pelvic Floor Muscle Coordination Scale. Journal of Women's Health Physical Therapy. 2010;34(3):81-8."}, {'pmid': '31094054', 'type': 'BACKGROUND', 'citation': 'Gosling J, Plumb A, Taylor SA, Cohen R, Emmanuel AV. High-resolution anal manometry: Repeatability, validation, and comparison with conventional manometry. Neurogastroenterol Motil. 2019 Jun;31(6):e13591. doi: 10.1111/nmo.13591.'}, {'pmid': '2058632', 'type': 'BACKGROUND', 'citation': 'Kaushal JN, Goldner F. Validation of the digital rectal examination as an estimate of anal sphincter squeeze pressure. Am J Gastroenterol. 1991 Jul;86(7):886-7.'}, {'pmid': '12900694', 'type': 'BACKGROUND', 'citation': 'Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB.'}, {'pmid': '16036506', 'type': 'BACKGROUND', 'citation': 'Marquis P, De La Loge C, Dubois D, McDermott A, Chassany O. Development and validation of the Patient Assessment of Constipation Quality of Life questionnaire. Scand J Gastroenterol. 2005 May;40(5):540-51. doi: 10.1080/00365520510012208.'}]}, 'descriptionModule': {'briefSummary': 'Constipation is a common problem in the general population. Defecation disorders caused by abnormal contraction or insufficient relaxation of the pelvic floor muscles during defecation may be one of the most possible causes of constipation. Although constipation is not life-threatening, it may have a significant impact on the quality of life. Aerobic exercise has been shown to improve symptoms of constipation in adults with constipation. However, there is no research investigating the effects of a multimodal exercise training on pelvic floor symptoms and pelvic floor muscle function in this population and only few studies have evaluated the pelvic floor muscle function using objective assessment tools among this population. The aim of the study is to investigate the effect of a multimodal exercise training program on constipation symptoms and pelvic floor muscle function in adults with constipation. The investigator will conduct a randomized controlled trial to evaluate the effectiveness of exercise training for adults with constipation. This study hypothesizes that (1) a multimodal exercise training can improve pelvic floor symptoms and function in adults with constipation, and (2) the improvement in exercise training group will be higher than that in control group.', 'detailedDescription': "This is a randomized controlled trial. Adults with constipation will be recruited and randomly assigned to either the intervention group or the control group. The intervention group will receive 16 sessions of therapist-supervised, combined resistance (including pelvic floor muscle training) and aerobic exercise training twice weekly for 8 weeks. The control group will receive usual care. All participants will be assessed at baseline and post-intervention. The primary outcome measure is the severity of the patient's self-reported constipation symptoms measured using the Patient Assessment of Constipation Symptoms Questionnaire (PACSYM). The secondary outcomes are pelvic floor muscle function assessed through the Pelvic Floor Muscle Coordination Scale (PFMCS), digital rectal examination, and anorectal manometry; quality of life measured by the Patient Assessment of Constipation Quality of Life Questionnaire (PACQOL); and physical activity levels measured using the International Physical Activity Questionnaire (IPAQ). Intention-to-treat analysis will be performed to preserve the sample size and original randomization. Mann-Whitneyand Chi-square testsest will be used for continuota and categorical data to compare the baseline characteristics between the two groups. Wilcoxon signed-rank test and the Mann-Whitney U test will be used for intragroup and intergroup comparison of outcome variables. The p-value of \\< 0.05 will be considered statistically significant."}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT'], 'maximumAge': '64 Years', 'minimumAge': '20 Years', 'healthyVolunteers': False, 'eligibilityCriteria': 'Inclusion Criteria:\n\n* Aged between 20 years and 64 years\n* Participants who fulfill the Rome IV criteria for constipation which include two or more of the following: a) straining \\> 25% of defecations; b) lumpy or hard stools \\> 25% of defecations; c) sensation of incomplete evacuation \\> 25% of defecations; d) sensation of anorectal obstruction/blockage \\> 25% of defecations; e) manual maneuvers to facilitate \\> 25% of defecations; f) \\< 3 spontaneous bowel movements per week\n* Participants who have sufficient language skills to participate\n\nExclusion Criteria:\n\n* Participants who have received exercise or pelvic floor muscle training under supervision in the past 12 months\n* Participants with previous abdominal surgery, anorectal trauma or surgery, or previous diagnosis of neuropathy or anal sphincter dysfunction\n* Presence of malignancies, severe cardiovascular disease or other severe physical/psychiatric impairments that prevent participation in the study\n* Pregnant or within 12 months postpartum'}, 'identificationModule': {'nctId': 'NCT04661202', 'briefTitle': 'Effects of Exercise Training on Pelvic Floor Symptoms and Function in Adults With Constipation', 'organization': {'class': 'OTHER', 'fullName': 'National Cheng Kung University'}, 'officialTitle': 'Effects of Exercise Training on Pelvic Floor Symptoms and Function in Adults With Constipation: A Randomized Controlled Trial', 'orgStudyIdInfo': {'id': 'B-BR-109-090'}}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Exercise training group', 'description': '* Aerobic exercise\n* Resistance exercise (including pelvic floor muscle training with biofeedback)\n* Stretching exercise\n* Home exercise', 'interventionNames': ['Other: multimodal exercise training']}, {'type': 'NO_INTERVENTION', 'label': 'Control group', 'description': '・Usual care\n\nAfter baseline assessment, the participants will receive health and lifestyle advices related to bowel symptoms, which include maintaining moderate physical activity, healthy diet, and ideal defecation posture, and establishing a personal bowel schedule and other behavioral changes that promote regular bowel movements.\n\nUpon request, the participants will be provided with the same intervention program as the exercise training group after 8 weeks participation.'}], 'interventions': [{'name': 'multimodal exercise training', 'type': 'OTHER', 'description': "A supervised moderate-intensity exercise training session, which will include aerobic exercise with a stationary exercise bike, resistance exercise using dumbbell, theraband band, or gym ball for each major muscle groups and core muscles (including pelvic floor muscle (PFM) training with biofeedback), and stretching exercise, twice a week for 8 weeks. All exercises will be individualized based on participant's heart rate reserve and Rate of Perceived Exertion (RPE). An oximeter and a sphygmomanometer will be used to monitor the heart rate, oxygen saturation and blood pressure of the participants to ensure safety.\n\nA home exercise program will include a walking exercise for 30 minutes per day and a PFM training with the aim of completing 1\\~3 sets of 8\\~12 submaximal contraction of PFM by holding 6\\~10 seconds with 12\\~20 seconds of rest between each contraction, and it will end with 3 maximal PFM contractions by holding 1\\~3 seconds 3\\~6 seconds of rest between each contraction.", 'armGroupLabels': ['Exercise training group']}]}, 'contactsLocationsModule': {'locations': [{'zip': '704', 'city': 'Tainan', 'country': 'Taiwan', 'facility': 'National Cheng Kung University', 'geoPoint': {'lat': 22.99083, 'lon': 120.21333}}], 'overallOfficials': [{'name': 'Kuan-Yin Lin, PhD', 'role': 'PRINCIPAL_INVESTIGATOR', 'affiliation': 'National Cheng Kung University'}]}, 'ipdSharingStatementModule': {'ipdSharing': 'NO'}, 'sponsorCollaboratorsModule': {'leadSponsor': {'name': 'National Cheng Kung University', 'class': 'OTHER'}, 'responsibleParty': {'type': 'PRINCIPAL_INVESTIGATOR', 'investigatorTitle': 'Assistant professor', 'investigatorFullName': 'Kuan-Yin Lin', 'investigatorAffiliation': 'National Cheng Kung University'}}}}