Ignite Creation Date:
2025-12-25 @ 3:30 AM
Ignite Modification Date:
2025-12-26 @ 2:12 AM
Study NCT ID:
NCT04973605
Status:
RECRUITING
Last Update Posted:
2025-12-17
First Post:
2021-07-07
Is NOT Gene Therapy:
False
Has Adverse Events:
False
Brief Title:
A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma
Sponsor:
Organization:
Raw JSON
{'hasResults': False, 'derivedSection': {'miscInfoModule': {'versionHolder': '2025-12-24', 'removedCountries': ['France', 'New Zealand', 'Switzerland']}, 'conditionBrowseModule': {'meshes': [{'id': 'D009101', 'term': 'Multiple Myeloma'}], 'ancestors': [{'id': 'D054219', 'term': 'Neoplasms, Plasma Cell'}, {'id': 'D009370', 'term': 'Neoplasms by Histologic Type'}, {'id': 'D009369', 'term': 'Neoplasms'}, {'id': 'D020141', 'term': 'Hemostatic Disorders'}, {'id': 'D014652', 'term': 'Vascular Diseases'}, {'id': 'D002318', 'term': 'Cardiovascular Diseases'}, {'id': 'D010265', 'term': 'Paraproteinemias'}, {'id': 'D001796', 'term': 'Blood Protein Disorders'}, {'id': 'D006402', 'term': 'Hematologic Diseases'}, {'id': 'D006425', 'term': 'Hemic and Lymphatic Diseases'}, {'id': 'D006474', 'term': 'Hemorrhagic Disorders'}, {'id': 'D008232', 'term': 'Lymphoproliferative Disorders'}, {'id': 'D007160', 'term': 'Immunoproliferative Disorders'}, {'id': 'D007154', 'term': 'Immune System Diseases'}]}, 'interventionBrowseModule': {'meshes': [{'id': 'D003907', 'term': 'Dexamethasone'}, {'id': 'C524865', 'term': 'carfilzomib'}, {'id': 'C556306', 'term': 'daratumumab'}, {'id': 'C467566', 'term': 'pomalidomide'}], 'ancestors': [{'id': 'D011246', 'term': 'Pregnadienetriols'}, {'id': 'D011245', 'term': 'Pregnadienes'}, {'id': 'D011278', 'term': 'Pregnanes'}, {'id': 'D013256', 'term': 'Steroids'}, {'id': 'D000072473', 'term': 'Fused-Ring Compounds'}, {'id': 'D011083', 'term': 'Polycyclic Compounds'}, {'id': 'D013259', 'term': 'Steroids, Fluorinated'}]}}, 'protocolSection': {'designModule': {'phases': ['PHASE1', 'PHASE2'], 'studyType': 'INTERVENTIONAL', 'designInfo': {'allocation': 'RANDOMIZED', 'maskingInfo': {'masking': 'NONE'}, 'primaryPurpose': 'TREATMENT', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Participants will be assigned sequentially in Part 1. In Part 2 participants will be assigned in parallel'}, 'enrollmentInfo': {'type': 'ESTIMATED', 'count': 246}}, 'statusModule': {'overallStatus': 'RECRUITING', 'startDateStruct': {'date': '2021-09-16', 'type': 'ACTUAL'}, 'statusVerifiedDate': '2025-02', 'completionDateStruct': {'date': '2026-11', 'type': 'ESTIMATED'}, 'lastUpdateSubmitDate': '2025-12-15', 'studyFirstSubmitDate': '2021-07-07', 'studyFirstSubmitQcDate': '2021-07-20', 'lastUpdatePostDateStruct': {'date': '2025-12-17', 'type': 'ESTIMATED'}, 'studyFirstPostDateStruct': {'date': '2021-07-22', 'type': 'ACTUAL'}, 'primaryCompletionDateStruct': {'date': '2026-11', 'type': 'ESTIMATED'}}, 'outcomesModule': {'primaryOutcomes': [{'measure': 'Part 1: Number Of Participants Experiencing Dose-limiting Toxicities (DLTs)', 'timeFrame': 'Up to 28 days', 'description': 'DLTs will be based on National Cancer Institute Common Terminology Criteria for Adverse Events (NCI CTCAE) version 5.0 and will include most grade 3 or higher events, as defined in the protocol.'}, {'measure': 'Part 1 And 2: Number of Participants Reporting One or More Treatment-emergent Adverse Events (TEAEs), Serious Adverse Events (SAEs), Adverse Events Leading to Discontinuation and Adverse Events of Special Interest (AESIs).', 'timeFrame': 'Up to 30 days after last dose of study drug'}, {'measure': 'Part 2: Overall response rate (ORR) as Assessed by Investigator', 'timeFrame': 'Approximately 4 years', 'description': 'Defined as the percentage of participants who achieved a stringent complete response (sCR), complete response (CR), very good partial response (VGPR), or partial response (PR) per International Myeloma Working Group (IMWG) criteria'}, {'measure': 'Part 2: Very Good Partial Response (VGPR) or Better Response Rate as Assessed by Investigator', 'timeFrame': 'Upon study termination (Baseline up to first documentation of disease progression [PD] or death from any cause [approximately 4 years]', 'description': 'Defined as the percentage of participants with a documented VGPR or better (including sCR, CR, and VGPR)'}, {'measure': 'Part 2: Complete Response (CR) or Stringent Complete Response (sCR) as Assessed by Investigator', 'timeFrame': 'Upon study termination (Baseline up to first documentation of disease progression [PD] or death from any cause [approximately 4 years])', 'description': 'defined as the percentage of participants with a documented CR or sCR'}], 'secondaryOutcomes': [{'measure': 'Part 1: Area under the plasma concentration-time curve time 0 to the last measurable concentration (AUClast) After a Single Dose of Sonrotoclax', 'timeFrame': 'Cycle 1 (each cycle is up to 28 days)'}, {'measure': 'Part 1: Maximum observed plasma concentration (Cmax) After a Single Dose of Sonrotoclax', 'timeFrame': 'Cycle 1 (each cycle is up to 28 days)'}, {'measure': 'Part 1: Time to reach Cmax (tmax) After a Single Dose of Sonrotoclax', 'timeFrame': 'Cycle 1 (each cycle is up to 28 days)'}, {'measure': 'Part 1: At Steady-state: AUC last, ss', 'timeFrame': 'Cycle 2 (each cycle is up to 28 days)'}, {'measure': 'Part 1: At Steady-state: Cmax, ss', 'timeFrame': 'Cycle 2 (each cycle is up to 28 days)'}, {'measure': 'Part 1: At Steady-state: trough plasma concentration (Ctrough) ss', 'timeFrame': 'Cycle 2 (each cycle is up to 28 days)'}, {'measure': 'Part 1: At Steady-state: time to reach Cmax (tmax,ss)', 'timeFrame': 'Cycle 2 (each cycle is up to 28 days)'}, {'measure': 'Part 2: Time to response (TTR) as Assessed by Investigator', 'timeFrame': 'Approximately 4 years', 'description': 'TTR is defined as the time from start of treatment (for nonrandomized cohorts) or date of randomization (for randomized cohorts to first documentation of response of Partial Response (PR) or better'}, {'measure': 'Part 2: Duration of response (DOR) as Assessed by Investigator', 'timeFrame': 'Approximately 4 years', 'description': 'DOR is defined as the time from the date of the first documented response (PR or better) after treatment initiation until the date of first documented disease progression or death due to any cause, whichever occurs first. DOR will be analyzed only for patients who have achieved an overall response of at least PR. The distribution of DOR will be summarized by the Kaplan-Meier method.'}, {'measure': 'Part 2: Progression-free survival (PFS) as Assessed by Investigator', 'timeFrame': 'Approximately 4 years', 'description': 'PFS is defined as time from start of treatment （for nonrandomized cohorts） or date of randomization （for randomized cohorts） to the first documentation of disease progression or death, whichever occurs first'}, {'measure': 'Part 2: Overall survival (OS) as Assessed by Investigator', 'timeFrame': 'Approximately 4 years', 'description': 'OS defined as the time from start of treatment (for nonrandomized cohorts) or date of randomization (for randomized cohorts to the date of death due to any cause'}]}, 'oversightModule': {'oversightHasDmc': True, 'isFdaRegulatedDrug': True, 'isFdaRegulatedDevice': False}, 'conditionsModule': {'conditions': ['Relapsed/Refractory Multiple Myeloma']}, 'descriptionModule': {'briefSummary': 'The purpose of this study is to assess the safety, tolerability, and efficacy of sonrotoclax as monotherapy and in various combinations in patients with relapsed/refractory (R/R) multiple myeloma (MM) and chromosomal translocation t(11;14).\n\nThe study investigates sonrotoclax alone and in combination with dexamethasone and other agents, including carfilzomib, daratumumab, and pomalidomide.'}, 'eligibilityModule': {'sex': 'ALL', 'stdAges': ['ADULT', 'OLDER_ADULT'], 'minimumAge': '18 Years', 'healthyVolunteers': False, 'eligibilityCriteria': "Inclusion Criteria:\n\n1. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2\n2. A confirmed diagnosis of multiple myeloma (must have an M-component in serum and/or urine)\n3. Measurable disease defined as:\n\n i. M-spike ≥ 500mg/dL, or ii. Urine protein M-spike of ≥ 200 mg/day, or iii. Serum free light chains ≥ 10 mg/dL, and an abnormal κ:λ ratio\n4. Participant has documented relapsed or progressive MM on or after any regimen or who are refractory to the most recent line of therapy.\n\n i. Relapsed MM is defined as previously treated MM that progresses and requires initiation of salvage therapy but does not meet the criteria for refractory MM.\n\n ii. Refractory MM is defined as disease that is nonresponsive (failure to achieve minimal response or development of progressive disease) while on primary or salvage therapy or progresses within 60 days of last therapy.\n 1. In Part 1 and Part 2 Cohorts 1 and 2 participants should have relapsed or progressive disease and have had ≥ 3 prior lines of therapy including a proteasome inhibitor, an IMiD, and an anti-CD38 monoclonal antibody, and no more available approved therapies.\n 2. Participants in Part 2 Cohorts 3, 4, and 5 should have relapsed or progressive disease and have had ≥ 1 prior line of therapy. Prior treatment with carfilzomib is allowed but the patient must not be considered carfilzomib refractory by the investigator.\n 3. Participants in Part 2 Cohorts 6 and 7 should have relapsed or progressive disease and have had 1 to 3 prior lines of therapy and previously treated with a proteasome inhibitor and an IMiD\n5. Positivity for t(11;14) translocation must be confirmed by validated fluorescence in situ hybridization (FISH) testing assay in a pre-defined laboratory\n\n a. fresh bone marrow aspirate sample must be collected at screening and sent to central laboratory for t(11;14) FISH testing.\n6. Adequate organ function defined as:\n\n 1. Hemoglobin ≥ 8.0 g/dL within 7 days before first dose of study treatment, (transfusions, in accordance with institutional guidelines, are permitted)\n 2. Platelet count ≥ 75,000/μL, within 7 days before first dose of study treatment, independent of growth factor support and transfusions\n 3. Absolute neutrophil count (ANC) ≥ 1000/mm\\^3 within 7 days before first dose of study treatment\n 4. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 3 x upper limit of normal (ULN) and total bilirubin ≤ 2.0 x ULN N (total bilirubin must be \\< 3 x ULN for patients with Gilbert's syndrome)\n\nExclusion Criteria:\n\n1. Participant has any of the following conditions:\n\n 1. Non secretory MM (Serum free light chains \\< 10 mg/dL)\n 2. Solitary plasmacytoma\n 3. Active plasma cell leukemia (ie, either 20% of peripheral white blood cells or \\> 2.0 x 109/L circulating plasma cells by standard differential)\n 4. Waldenström macroglobulinemia (WM)\n 5. Amyloidosis.\n 6. Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, skin changes (POEMS) syndrome\n 7. Chronic respiratory disease that requires continuous oxygen\n2. Significant cardiovascular disease, including but not limited to:\n\n 1. Myocardial infarction ≤ 6 months before screening\n 2. Ejection fraction ≤ 50%\n 3. Unstable angina≤ 3 months before screening\n 4. New York Heart Association Class III or IV congestive heart failure\n 5. History of clinically significant arrhythmias (eg, sustained ventricular tachycardia, ventricular fibrillation, or torsades de pointes)\n 6. Heart rate-corrected QT interval \\> 480 milliseconds based on Fridericia's formula\n 7. History of Mobitz II second-degree or third-degree heart block without a permanent pacemaker in place\n 8. Uncontrolled hypertension at screening, defined as systolic blood pressure \\> 170 mmHg and diastolic blood pressure \\> 105 mmHg by ≥ 2 consecutive measurements. Prior therapy with sonrotoclax or other agents inhibiting BCL2 activity (eg, venetoclax)\n3. Known infection with human immunodeficiency virus (HIV)\n4. Serologic status reflecting active viral hepatitis B (HBV) or viral hepatitis C (HCV) infection as follows:\n\n 1. Presence of hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb). Participants with presence of HBcAb, but absence of HBsAg, are eligible if HBV DNA is undetectable (limitation of sensitivity \\< 20 IU/mL) ,), and if they are willing to undergo monthly monitoring for HBV reactivation.\n 2. Presence of HCV antibody. Participants with presence of HCV antibody are eligible if HCV RNA is undetectable (limitation of sensitivity \\< 15 IU/mL).\n\nNote: Other protocol defined Inclusion/Exclusion criteria may apply."}, 'identificationModule': {'nctId': 'NCT04973605', 'briefTitle': 'A Phase 1b/2 Study of Sonrotoclax (BGB-11417) as Monotherapy and in Various Combinations With Dexamethasone Plus Carfilzomib, Dexamethasone Plus Daratumumab, and Dexamethasone Plus Pomalidomide in Multiple Myeloma', 'organization': {'class': 'INDUSTRY', 'fullName': 'BeOne Medicines'}, 'officialTitle': 'A Phase 1b/2 Dose-Escalation and Cohort-Expansion Study to Determine the Safety and Efficacy of BGB-11417as Monotherapy, in Combination With Dexamethasone, Dexamethasone/Carfilzomib, Dexamethasone/Daratumumab, and Dexamethasone/Pomalidomide in Patients With Relapsed/Refractory Multiple Myeloma and t(11;14)', 'orgStudyIdInfo': {'id': 'BGB-11417-105'}, 'secondaryIdInfos': [{'id': '2023-507751-30-00', 'type': 'CTIS'}, {'id': '2021-003614-39', 'type': 'EUDRACT_NUMBER'}, {'id': 'U1111-1277-5444', 'type': 'OTHER', 'domain': 'UTN Number'}, {'id': 'CTR20231932', 'type': 'OTHER', 'domain': 'ChinaDrugTrials'}]}, 'armsInterventionsModule': {'armGroups': [{'type': 'EXPERIMENTAL', 'label': 'Part 1 Dose Escalation', 'description': 'Dose-escalation and de-escalation to determine maximum tolerated dose (MTD) of sonrotoclax plus dexamethasone, sonrotoclax plus dexamethasone plus carfilzomib, sonrotoclax plus dexamethasone plus daratumumab, and sonrotoclax plus dexamethasone plus pomalidomide.', 'interventionNames': ['Drug: Sonrotoclax', 'Drug: Dexamethasone', 'Drug: Carfilzomib', 'Drug: Daratumumab', 'Drug: Pomalidomide']}, {'type': 'EXPERIMENTAL', 'label': 'Part 2 Cohort Expansion', 'description': 'There will be up to 7 expansion cohorts to further evaluate the safety and efficacy of sonrotoclax monotherapy, sonrotoclax plus dexamethasone in combination with dexamethasone plus carfilzomib, and in combination with dexamethasone plus daratumumab', 'interventionNames': ['Drug: Sonrotoclax', 'Drug: Dexamethasone', 'Drug: Carfilzomib']}], 'interventions': [{'name': 'Sonrotoclax', 'type': 'DRUG', 'otherNames': ['BGB-11417'], 'description': 'Administered orally daily', 'armGroupLabels': ['Part 1 Dose Escalation', 'Part 2 Cohort Expansion']}, {'name': 'Dexamethasone', 'type': 'DRUG', 'description': 'Once weekly either orally or intravenously', 'armGroupLabels': ['Part 1 Dose Escalation', 'Part 2 Cohort Expansion']}, {'name': 'Carfilzomib', 'type': 'DRUG', 'description': 'Administered intravenously weekly', 'armGroupLabels': ['Part 1 Dose Escalation', 'Part 2 Cohort Expansion']}, {'name': 'Daratumumab', 'type': 'DRUG', 'description': 'Administered subcutaneously weekly', 'armGroupLabels': ['Part 1 Dose Escalation']}, {'name': 'Pomalidomide', 'type': 'DRUG', 'description': 'Administered orally daily', 'armGroupLabels': ['Part 1 Dose Escalation']}]}, 'contactsLocationsModule': {'locations': [{'zip': '35294-0004', 'city': 'Birmingham', 'state': 'Alabama', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Alabama At Birmingham Hospital', 'geoPoint': {'lat': 33.52066, 'lon': -86.80249}}, {'zip': '91010-3012', 'city': 'Duarte', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'City of Hope National Medical Center', 'geoPoint': {'lat': 34.13945, 'lon': -117.97729}}, {'zip': '92618-2377', 'city': 'Irvine', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'City of Hope At Irvine Lennar', 'geoPoint': {'lat': 33.66946, 'lon': -117.82311}}, {'zip': '94143', 'city': 'San Francisco', 'state': 'California', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of California At San Francisco', 'geoPoint': {'lat': 37.77493, 'lon': -122.41942}}, {'zip': '33136-2107', 'city': 'Miami', 'state': 'Florida', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Miami', 'geoPoint': {'lat': 25.77427, 'lon': -80.19366}}, {'zip': '30322-1013', 'city': 'Atlanta', 'state': 'Georgia', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Emory University Winship Cancer Center', 'geoPoint': {'lat': 33.749, 'lon': -84.38798}}, {'zip': '60637-1443', 'city': 'Chicago', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Chicago Medical Center', 'geoPoint': {'lat': 41.85003, 'lon': -87.65005}}, {'zip': '62781-0001', 'city': 'Springfield', 'state': 'Illinois', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Southern Illinois University School of Medicine', 'geoPoint': {'lat': 39.80172, 'lon': -89.64371}}, {'zip': '02114', 'city': 'Boston', 'state': 'Massachusetts', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Massachusetts General Hospital', 'geoPoint': {'lat': 42.35843, 'lon': -71.05977}}, {'zip': '63110-1010', 'city': 'St Louis', 'state': 'Missouri', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Washington University School of Medicine', 'geoPoint': {'lat': 38.62727, 'lon': -90.19789}}, {'zip': '07601-1915', 'city': 'Hackensack', 'state': 'New Jersey', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Hackensack University Medical Center', 'geoPoint': {'lat': 40.88593, 'lon': -74.04347}}, {'zip': '10065-4870', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Weill Cornell Medical College Newyork Presbyterian Hospital', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '10065-6800', 'city': 'New York', 'state': 'New York', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Memorial Sloan Kettering Cancer Center Mskcc', 'geoPoint': {'lat': 40.71427, 'lon': -74.00597}}, {'zip': '43210-1240', 'city': 'Columbus', 'state': 'Ohio', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'The James Cancer Hospital and Solove Research Institute At Ohio State University', 'geoPoint': {'lat': 39.96118, 'lon': -82.99879}}, {'zip': '84112-5550', 'city': 'Salt Lake City', 'state': 'Utah', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Huntsman Cancer Institute', 'geoPoint': {'lat': 40.76078, 'lon': -111.89105}}, {'zip': '98195', 'city': 'Seattle', 'state': 'Washington', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Washington', 'geoPoint': {'lat': 47.60621, 'lon': -122.33207}}, {'zip': '53792-0001', 'city': 'Madison', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'University of Wisconsin Carbone Cancer Center', 'geoPoint': {'lat': 43.07305, 'lon': -89.40123}}, {'zip': '53226-1222', 'city': 'Milwaukee', 'state': 'Wisconsin', 'status': 'RECRUITING', 'country': 'United States', 'facility': 'Medical College of Wisconsin', 'geoPoint': {'lat': 43.0389, 'lon': -87.90647}}, {'zip': 'ACT 2605', 'city': 'Garran', 'state': 'Australian Capital Territory', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'Canberra Hospital', 'geoPoint': {'lat': -35.34206, 'lon': 149.10846}}, {'zip': 'NSW 2747', 'city': 'Kingswood', 'state': 'New South Wales', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'Nepean Hospital', 'geoPoint': {'lat': -33.75614, 'lon': 150.72346}}, {'zip': 'VIC 3168', 'city': 'Clayton', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'Monash Health', 'geoPoint': {'lat': -37.91667, 'lon': 145.11667}}, {'zip': 'VIC 3065', 'city': 'Fitzroy', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'St Vincents Hospital Melbourne', 'geoPoint': {'lat': -37.79839, 'lon': 144.97833}}, {'zip': 'VIC 3004', 'city': 'Melbourne', 'state': 'Victoria', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'The Alfred Hospital', 'geoPoint': {'lat': -37.814, 'lon': 144.96332}}, {'zip': 'WA 6000', 'city': 'Perth', 'state': 'Western Australia', 'status': 'RECRUITING', 'country': 'Australia', 'facility': 'Royal Perth Hospital', 'geoPoint': {'lat': -31.95224, 'lon': 115.8614}}, {'zip': '70200-730', 'city': 'Brasília', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Sirio Libanes Brasilia', 'geoPoint': {'lat': -15.77972, 'lon': -47.92972}}, {'zip': '70390140', 'city': 'Brasília', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Instituto Dor de Pesquisa E Ensino Distrito Federal', 'geoPoint': {'lat': -15.77972, 'lon': -47.92972}}, {'zip': '90110-270', 'city': 'Porto Alegre', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Centro Gaucho Integrado de Oncologia Hospital Mae de Deus', 'geoPoint': {'lat': -30.03283, 'lon': -51.23019}}, {'zip': '41253-190', 'city': 'Salvador', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Sao Rafael (Rede Dor)', 'geoPoint': {'lat': -12.97563, 'lon': -38.49096}}, {'zip': '01308-050', 'city': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Hospital Sirio Libanes', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '04501-000', 'city': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Instituto Dor de Pesquisa E Ensino Sao Paulo', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': '05653-120', 'city': 'São Paulo', 'status': 'RECRUITING', 'country': 'Brazil', 'facility': 'Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein', 'geoPoint': {'lat': -23.5475, 'lon': -46.63611}}, {'zip': 'T6G 1Z2', 'city': 'Edmonton', 'state': 'Alberta', 'status': 'RECRUITING', 'country': 'Canada', 'facility': 'Cross Cancer Institute', 'geoPoint': {'lat': 53.55014, 'lon': -113.46871}}, {'zip': 'V5Z 4E6', 'city': 'Vancouver', 'state': 'British Columbia', 'status': 'RECRUITING', 'country': 'Canada', 'facility': 'British Columbia Cancer Agency the Vancouver Centre', 'geoPoint': {'lat': 49.24966, 'lon': -123.11934}}, {'zip': 'M5G 2M9', 'city': 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106.55771}}, {'zip': '350001', 'city': 'Fuzhou', 'state': 'Fujian', 'status': 'RECRUITING', 'country': 'China', 'facility': 'Fujian Medical University Union Hospital', 'geoPoint': {'lat': 26.06139, 'lon': 119.30611}}, {'zip': '361003', 'city': 'Xiamen', 'state': 'Fujian', 'status': 'COMPLETED', 'country': 'China', 'facility': 'The First Affiliated Hospital of Xiamen University', 'geoPoint': {'lat': 24.47979, 'lon': 118.08187}}, {'zip': '510060', 'city': 'Guangzhou', 'state': 'Guangdong', 'status': 'RECRUITING', 'country': 'China', 'facility': 'Sun Yat Sen University Cancer Center', 'geoPoint': {'lat': 23.11667, 'lon': 113.25}}, {'zip': '050000', 'city': 'Shijiazhuang', 'state': 'Hebei', 'status': 'COMPLETED', 'country': 'China', 'facility': 'The Second Hospital of Hebei Medical University', 'geoPoint': {'lat': 38.04139, 'lon': 114.47861}}, {'zip': '450000', 'city': 'Zhengzhou', 'state': 'Henan', 'status': 'RECRUITING', 'country': 'China', 'facility': 'Henan Cancer Hospital', 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